ライフサイエンスコーパス: eventually lead to

1 These results may eventually lead to a basis for the development of dietar

2 disruptions of the basement membrane, which eventually lead to a breakdown of epithelial organizatio

3 imer disease and other progressive dementias eventually lead to a complete loss of financial capacity

4 ng specific aspects of the immune system may eventually lead to a cure for HIV-infected patients.

5 importance of reservoirs of infection might eventually lead to a cure.

6 mpression decreases protein mobility and can eventually lead to a dramatic stalling of several unrela

7 Our experimental framework may eventually lead to a fully quantitative view of how cell

8 hemselves and to implement institutions that eventually lead to a higher welfare for all.

9 sent large lithospheric deformation that may eventually lead to a localized boundary between the Indi

10 It may eventually lead to a low-cost personal medical device fo

11 This model may eventually lead to a more unified conceptual understandi

12 infect and colonize the human host and could eventually lead to a novel drug target.

13 active interaction, no matter how weak, will eventually lead to a pairing instability.

14 l fluctuations, we show that such design can eventually lead to a superior energy-delay product.

15 hance the sensitivity of GMR biosensors, and eventually lead to a versatile and portable device for m

16 t's immune reaction to the microbial plaque, eventually leading to a decrease in the ratio of RANKL/O

17 ene loss, the pace of which slows over time, eventually leading to a paucity of genes, and stasis.

18 ion provided new insight into the mechanism, eventually leading to a refined catalytic cycle that als

19 data further show that excessive tooth wear eventually leads to a breakdown of the normal remodeling

20 However, it eventually leads to a castration-resistant disease that

21 aman data show that beta-lactam ring opening eventually leads to a complex mixture of reaction produc

22 ctivation of an sp(3) C-H bond, and reaction eventually leads to a doubly cyclometalated complex wher

23 hat cumulative, time-dependent tissue injury eventually leads to a fibrotic response.

24 in a branched three-dimensional fashion that eventually leads to a globular shape, thus mimicking glo

25 ntangled through time dilation effect, which eventually leads to a loss of coherence of a single cloc

26 ted exposure to a novel physical environment eventually leads to a mature adaptive response whereby f

27 stem to respond to new antigenic stimuli and eventually leads to a peripheral T-cell bias to the memo

28 G2 phase, mitotic inducers accumulate, which eventually leads to a switch-like rise in mitotic kinase

29 Further exposure of cysteine eventually leads to a zwitterionic multilayer film invol

30 ssive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell e

31 can develop a cytokine release syndrome that eventually leads to acute respiratory distress syndrome

32 ciated growth defects, but continuous growth eventually leads to aerobic respiration defects, reduced

33 rnover may induce Ag species interconversion eventually leading to Ag release on longer time scales.

34 secondary to other pathogenic processes that eventually lead to age-related neurodegeneration.

35 cell culture, collective migration of cells eventually leads to aggregation in large clusters.

36 onged activation of the immune system by HIV eventually leads to AIDS, and several lines of evidence

37 ct on the stem domain of the gamma HC, which eventually leads to alterations in mechanochemical inter

38 gns of severe chronic allograft vasculopathy eventually led to amputation of the graft.

39 iviral innate immunity within the lungs that eventually lead to an exacerbated inflammatory cascades

40 t in myoblast fate from epaxial to hypaxial, eventually leading to an excess of hypaxial body wall mu

41 egradation through the autophagy pathway and eventually leading to an open chromatin structure that f

42 olvent-exposed [4Fe-4S] enzyme clusters that eventually leads to an increase in hydroxyl radical prod

43 ecoming generalized over a 5-10 year period, eventually leading to aphonia, dysphagia and severe moto

44 ExoS ADPRT to modulate host cell signaling, eventually leading to apoptosis, but also establishes Ex

45 and caspase enzymes, inducing DNA damage and eventually leading to apoptosis.

46 ve oxygen species and nuclear fragmentation, eventually leading to apoptosis.

47 in activates caspase 1 in macrophages, which eventually leads to apoptosis.

48 se early results affording nanoribbons could eventually lead to applications in fields of electronics

49 eatment of diabetic nephropathy, which could eventually lead to applications in renal transplantation

50 st cell immune and signaling pathways, which eventually lead to bacterial survival and replication in

51 of mammalian cardiomyocyte proliferation may eventually lead to better approaches for heart regenerat

52 y challenges remain, these interventions may eventually lead to better approaches to treat or prevent

53 the brain, fail to regenerate after damage, eventually leading to blindness.

54 revented complete neutralization escape, and eventually led to broadening of the response.

55 epigenetic programs and DNA repair) and may eventually lead to cancer development.

56 ane potential, and cytochrome c release that eventually led to cancer cell death.

57 ocesses include fibrotic reorganization that eventually leads to cardiac failure.

58 lium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via mul

59 ithin the tumor, eradicating this population eventually leads to castration-resistance, owing to the

60 ical function of key cellular structures and eventually lead to cell death.

61 as an accumulation of misfolded proteins and eventually lead to cell death.

62 ly oligomerize to form functional pores that eventually lead to cell lysis.

63 ased RP photoreceptors begin to deteriorate, eventually leading to cell death and, consequently, loss

64 ight-dark regime triggered stress responses, eventually leading to cell death, in leaves of Arabidops

65 fibrils increase cell membrane permeability, eventually leading to cell death.

66 dative responses to S Typhimurium infection, eventually leading to cell death.

67 ion of PstP is detrimental to cell survival, eventually leading to cell death.

68 ompetitors by a Type VI secretion apparatus, eventually leading to cell lysis and death.

69 This overexpression eventually leads to cell cycle arrest at the G1/S bounda

70 ll permeable to large organic cations, which eventually leads to cell death.

71 This eventually leads to cholestasis, and this causes bile sa

72 proliferation of growth plate chondrocytes, eventually leading to chondrodysplasia and reduced long

73 and subsequent tubulointerstitial fibrosis, eventually leading to chronic renal disease.

74 with loss of tolerance against liver tissue eventually leading to cirrhosis if left untreated.

75 O-O sigma bond makes reactions of O2, which eventually lead to cleavage of this bond, very favorable

76 er time to determine whether these anomalies eventually lead to clinical symptoms of schizophrenia.

77 vo experimental transplantation studies that eventually led to clinical PBSCT.

78 part of a cascade of pathologic events that eventually lead to cognitive decline and dementia.

79 tiform activity, some of the mechanisms that eventually lead to cognitive deficits in Alzheimer's dis

80 se (AD) begins as a malfunction of synapses, eventually leading to cognitive impairment and dementia.

81 the oscillations destabilize the population, eventually leading to collapse.

82 apacity for self-repair and focal damage can eventually lead to complete degradation of the tissue.

83 Further optimization eventually led to compound 37 that showed good TYK2 enzy

84 vatives to provide new inhibitors that could eventually lead to compounds with clinical usefulness ag

85 rucially important link in a chain that will eventually lead to consilience in reptile systematics, p

86 Eocene epoch, especially at high latitudes, eventually led to continental ice sheet development in A

87 caused oxidative stress in mitochondria that eventually led to cytochrome c release, proteolytic acti

88 w pyroptotic cell death drives pathogenesis, eventually leading to death of the host, is unknown.

89 orters, causing several cellular damages and eventually leading to death.

90 ng, most notably cardiovascular disease that eventually leads to death from myocardial infarction and

91 ucture and decreased cardiac function, which eventually led to death before 23 weeks of age.

92 uter segments and photoreceptor death, which eventually led to decline of visual function in older mi

93 riety of aging-associated abnormalities that eventually lead to decreased life expectancy.

94 2+) stores and alters mitochondrial fitness, eventually leading to decreased insulin release.

95 urn, triggers a gene regulation program that eventually leads to decreased myosin light-chain phospho

96 ane-bound and secreted fractions of Wnt3 and eventually led to defective brain development.

97 ssociated with impaired learning and memory, eventually leading to dementia.

98 beta (Abeta) initiate the neurotoxicity that eventually leads to dementia in Alzheimer's disease.

99 s-prone mice, but that persistent high doses eventually led to depletion and ameliorated lupus.

100 olocalizes with microtubules when in excess, eventually leading to depolymerization, which is sequest

101 (Q) facilitates formation of htt aggregates, eventually leading to deposition of cytoplasmic and intr

102 terns of reproduction and connectivity which eventually lead to descendants returning to the patch fr

103 ts of genetic variants in studies that would eventually lead to development of diagnostic tests or dr

104 udies are needed to confirm our data and can eventually lead to development of more targeted treatmen

105 ions and the effect of graphene, which could eventually lead to development of novel methods to contr

106 ults in decreased responsiveness to insulin, eventually leading to diabetes and cardiovascular diseas

107 ge by an R loop-dependent mechanism that can eventually lead to different cellular consequences depen

108 Xerostomia can eventually lead to difficulty in swallowing, severe and

109 s the destruction of articular cartilage and eventually leads to disability.

110 n the underlying evolutionary processes that eventually lead to disease emergence.

111 Over years, both of these mechanisms eventually lead to diseased heart tissue and symptoms of

112 d structural changes of the protein molecule eventually lead to disorder in protein crystals.

113 ending and/or descending thoracic aorta that eventually leads to dissection or rupture.

114 etal remodeling, and retarding CSC motility, eventually led to drug resistance associated with a mark

115 ing the accumulation of cellular damage that eventually leads to dysfunction and, ultimately, the dem

116 in tissues such as the brain and the heart, eventually leading to early childhood death.

117 ic instability and neuronal apoptosis, which eventually lead to embryonic lethality.

118 per encoding of tone-shock associations that eventually lead to enhanced cue-specific fear.

119 the first steps in a cascade of events that eventually lead to epileptogenesis triggered by TBI.

120 hich can interfere with implant function and eventually lead to failure.

121 undergo actin-based motility in the cytosol, eventually leading to formation of actin-rich protrusion

122 n betatron oscillation in the channel, which eventually leads to formation of the ultradense electron

123 ysis, electron transport, and ATP formation, eventually leading to functional impairment or death of

124 y (eg, infectious diseases, addictions), can eventually lead to further advancements in correctional

125 Such a strategy could eventually lead to future efficacious treatments of meta

126 nhibition of beta-catenin and proliferation, eventually leading to GC suppression.

127 This eventually leads to genetic assimilation of the silent p

128 olecular mechanism for defective DNA repair, eventually leading to genome instability.

129 ity and intraglomerular pressure, the latter eventually leading to glomerular capillary dropout (rare

130 retrocorneal fibrous membrane was observed, eventually leading to graft failure.

131 re diagnosed with organ-specific SSIs, which eventually led to graft loss; six (31.5%) developed deep

132 h temperature mass growth processes that can eventually lead to graphene-type PAHs and two-dimensiona

133 rces in acutely painful conditions but could eventually lead to greater fatigue and stress of the mus

134 ediate that subsequently becomes protonated, eventually leading to HDMF.

135 c in several cardiac proteinopathies and can eventually lead to heart failure.

136 hypertrophy is initially beneficial, it can eventually lead to heart failure.

137 leads to stiffening of the heart, which can eventually lead to heart failure.

138 An MI induces irreversible tissue damage, eventually leading to heart failure.

139 is one of the complications of diabetes that eventually leads to heart failure and death.

140 , which results in myocardial stiffening and eventually leads to heart failure.

141 eless, this self-destructive conversion will eventually lead to hot-spot extinction.

142 l help to elucidate the pathogenesis and may eventually lead to identification of molecular markers f

143 ncapacity to suppress effector responses and eventually leads to immunopathogenesis.

144 ccumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastroph

145 As DCM eventually leads to impaired contractility, standard app

146 and allergic airways inflammation that could eventually lead to improved asthma control.

147 Further investigation may eventually lead to improved diagnosis, prognosis, and ma

148 esis of stroke in sickle cell disease should eventually lead to improved management of all central ne

149 This observation can eventually lead to improved red fluorescent proteins for

150 elopment of targeted nanoRx formulations and eventually lead to improved therapeutic efficacy.

151 nslation back to the bedside, is expected to eventually lead to improvements at the patient interface

152 which then recruits the destruction complex, eventually leading to inactivation of beta-catenin degra

153 These interactions eventually led to inactivation of the small GTPase, RhoA

154 re uncertain, we hypothesize that they could eventually lead to increasing regional-scale biotic homo

155 horts will have their own internal dynamics, eventually leading to independent demographic and evolut

156 e identification of biosignatures that could eventually lead to individual recommendations for the du

157 e use of Tat-fusion peptide transduction may eventually lead to innovative therapeutic modalities to

158 truction with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most p

159 nerating forces ( approximately 190 pN) that eventually lead to irreversible viral deformation.

160 oth drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retin

161 o both E- and Z-alkenyl iodides, which would eventually lead to isodomoic acid G and isodomoic acid H

162 arts from the center of the nanoparticle and eventually leads to its complete fragmentation.

163 3beta-inactivated prostate cancer cells that eventually leads to its enhanced proliferation and survi

164 Its domestication eventually led to its adoption as a model organism, aide

165 tigation on this activation principle, which eventually led to its elucidation.

166 ell gradually depletes its available energy, eventually leading to leader-follower transition.

167 nsversions or AT-->GC transitions, which can eventually lead to lethal mutations.

168 Long-term ectopic expression of Sox17 eventually led to leukemogenesis.

169 cirrhosis, an irreversible disease that may eventually lead to liver cancer development.

170 inherited juvenile macular degeneration that eventually leads to loss of vision.

171 eversible lung inflammatory disease that may eventually lead to lung cancer.

172 o potently induces centrosome amplification, eventually leading to mammary hyperplasia and malignant

173 rtex and neocortices independently of Abeta, eventually leading to memory loss.

174 ch guide cancer-cell migration and invasion, eventually leading to metastasis.

175 t cell cycle arrest and cytokinesis defects, eventually leading to mitotic catastrophe/apoptosis.

176 n of covalent bonds in the protein backbone, eventually leading to molecular fracture.

177 nd biological modeling, which together could eventually lead to more accurate diagnoses and treatment

178 food choices in the supermarket, which will eventually lead to more balanced diets and to more benef

179 vates a cascade of muscle disrupting events, eventually leading to muscle atrophy and apoptosis.

180 the inferobasal wall and papillary muscles, eventually leading to myocardial hypertrophy and scarrin

181 activated autophagy, blocked apoptosis, and eventually led to necrosis.

182 age, and reactive oxygen species production, eventually leading to necrotic death of U251 glioma cell

183 ndings have theoretical implications and may eventually lead to neural measures that allow early pred

184 terations of the brain parenchyma, which may eventually lead to neurological deficits or cognitive de

185 aggregation, disrupt cellular function, and eventually lead to neuronal death.

186 omote their entry into the cell cycle, which eventually leads to neuronal cell death.

187 itiates a devastating cascade of events that eventually leads to neuronal loss.

188 chondrial fusion and fission proteins, which eventually leads to neuronal stress.

189 the annotation of kidney-relevant data, and eventually lead to new definitions of kidney disease in

190 t of new antiangiogenic compounds that could eventually lead to new drugs suitable for the treatment

191 s reason to hope that these discoveries will eventually lead to new preventive and therapeutic agents

192 s these different host species, and this may eventually lead to new symbiont species over evolutionar

193 parasites, and it is likely that these will eventually lead to new therapeutic approaches.

194 The insights gained from this overview may eventually lead to new therapeutic interventions.

195 out underlying cellular pathways that should eventually lead to new therapies.

196 led insight into the pathogenesis of EBA may eventually lead to new treatment strategies for EBA and

197 tic applications in mouse models-which might eventually lead to new treatments for patients-as well a

198 racellular kinases, including Zap70 and Syk, eventually leading to NK cell activation.

199 iven by incremental changes that accumulate, eventually leading to oncogenic transformation.

200 If highly progressive, the fibrotic process eventually leads to organ malfunction and death.

201 n and proteasomal degradation of Mule, which eventually leads to p53 accumulation.

202 ing groups and manipulation of the oxazoline eventually led to pactamycin, pactamycate, and their des

203 espite the presence of DNA-damaging insults, eventually leading to PAH.

204 role of Slug in ADM, an early event that can eventually lead to pancreatic cancer development.

205 edium and large stroke, brain reorganization eventually leads to (partial) normalization of neuronal

206 Age-related decay can eventually lead to pathology such as cardiovascular and

207 ent of pharmacological chaperones, which may eventually lead to PD therapeutics.

208 iscuss the most recent developments that may eventually lead to perioperative renal protection.

209 s (RA) is an inflammatory joint disease that eventually leads to permanent bone and cartilage destruc

210 signal a cascade of inflammatory events that eventually lead to permeability-reducing fibrotic encaps

211 These studies may eventually lead to pharmacologic strategies for regulati

212 ation of salicylic acid, reduced growth, and eventually lead to plant death, consistent with the curr

213 Further temperature increase eventually leads to poly-naphthalenes via reductive elim

214 regulator of breast cancer transitions that eventually lead to poor prognosis.

215 tropy gain for the rate-limiting step, which eventually leads to propene.

216 Abl-mediated tyrosine phosphorylations that eventually lead to protein kinase Cdelta (PKCdelta)-medi

217 ivity markedly increases pulse frequency and eventually leads to pulse termination.

218 t viral reservoirs within the CNS, which may eventually lead to rebound viremia.

219 ulfated Tyr335) into the FSH nascent pocket, eventually leading to receptor activation.

220 ures containing clathrin and other proteins--eventually leading to receptor internalization.

221 complexes, increasing the energy of N(beta) eventually leads to reduction from formally [W(VI) ident

222 es being practically relevant, challenge and eventually lead to refinement of theories concerning fun

223 le is compromised, delaying regeneration and eventually leading to regeneration failure.

224 regaining of normal developmental patterns, eventually leading to regeneration of a normal colony.

225 expansion during hematologic remission, and eventually lead to relapsed disease.

226 PARP-1 automodification eventually leads to release from DNA damage thus turning

227 kidneys and deterioration of their function, eventually leading to renal insufficiency.

228 ssive rise in pulmonary vascular resistance, eventually leading to right-heart failure and death.

229 ogic changes in the pulmonary arterial tree, eventually leads to right heart failure.

230 oth the precursors of the synthetic pathways eventually leading to RNA and to the key components of t

231 with significant atrophy of cell bodies and eventually leads to robust loss (approximately 50%) of s

232 zed Ca(2+) release events started to appear, eventually leading to sarcoplasmic reticulum (SR) Ca(2+)

233 However, prolonged collection of ions eventually leads to saturation of the amalgam accompanie

234 uctance with increasing on/off current ratio eventually leading to semiconducting behavior, adding co

235 This gradual shortening of telomeres eventually leads to senescence.

236 ts in hair follicle development and cycling, eventually leading to severe hair loss.

237 The unrestricted and chronic immune response eventually leads to severe pain, pus discharge, irrevers

238 gate markers and preventive treatments might eventually lead to so-called brain-check scans for deter

239 ome, thus blocking endocytic progression and eventually leading to stable residence.

240 tion is that all of phase space is explored, eventually leading to stationarity.

241 t--chemically hydrogenated plant oils--could eventually lead to substantial reductions in cardiovascu

242 energy balance within the protein structure, eventually leading to such conformational changes.

243 impairments in the hippocampal formation and eventually led to synaptic dysfunction.

244 early changes in pancreatic endocrine cells eventually leading to T1D.

245 Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to

246 a kinetic proofreading chain of events that eventually leads to TCR triggering and negative selectio

247 receptor interacting protein kinase-3, which eventually lead to the activation of mixed lineage kinas

248 ion, possibly transducing a signal that will eventually lead to the activation of peptidoglycan remod

249 issegregation and multipolar spindles, which eventually lead to the activation of the DNA damage resp

250 cs of ejaculatory and orgasmic function will eventually lead to the development of new, effective met

251 genome-wide association studies, which will eventually lead to the discovery of causal mutations tha

252 aps (or local folding defects), and this may eventually lead to the formation of disordered structure

253 a cascade of complex chemical processes that eventually lead to the generation of an electrical impul

254 petition-rate lasers (sub- to few MHz's) may eventually lead to the generation of high-flux, low-dive

255 lving different tautomers of Gln50 that will eventually lead to the light-adapted state.

256 MFG-E8 is mediated via the LPS-CD14 pathway, eventually leading to the accruement of apoptotic cells.

257 1 and receptor interacting protein kinase-3, eventually leading to the activation of mixed lineage ki

258 pcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease.

259 pread emission into the aquatic environment, eventually leading to the contamination of drinking wate

260 to multiple facets of inflammatory response, eventually leading to the development of several iP inhi

261 fixation and maintenance of gene duplicates, eventually leading to the evolution of sexually dimorphi

262 tes; it also has been shown to self-assemble eventually leading to the formation of homo-multimers.

263 pid synthesis enzymes and undergo expansion, eventually leading to the giant LDs characteristic of se

264 modulating PI3K/Akt/GSK-3beta signaling and eventually leading to the high expression and nuclear ac

265 This feedback mechanism eventually leads to the collapse of the foam layer and t

266 The tauopathy in Ch4 eventually leads to the degeneration of the cholinergic

267 the high mutation rate of influenza viruses eventually leads to the development of antiviral resista

268 et1 and concomitantly its catalytic activity eventually leads to the displacement of Mbd1 from methyl

269 This unrelenting replenishment process eventually leads to the exhaustion of the naive CD4+T-ce

270 clusters directly onto the electrode surface eventually leads to the formation of a dense forest of m

271 rs spontaneously before pollen mitosis I and eventually leads to the formation of diploid and polyplo

272 ic pouch only, which launch the pathway that eventually leads to the formation of the adult that emer

273 ed, causing wear and increasing shear, which eventually leads to the osteochondral degeneration.

274 This is mainly because recurrence of ACS eventually leads to the pandemics of heart failure and s

275 This contraction eventually leads to the restoration of the rest tension

276 ess, so posaconazole treatment was begun and eventually led to the cure of his infection.

277 with a decreased response to novel odors and eventually led to the demise of adult-born GCs.

278 elective Syk inhibitors and the efforts that eventually led to the desired improvements in physicoche

279 table agricultural extensification, and also eventually led to the development of a mounted warrior e

280 ls further eroded the beta-cell identity and eventually led to the development of undifferentiated pa

281 This eventually led to the discovery of a new capsid inhibito

282 duction of a m-fluorine in the benzyl moiety eventually led to the discovery of compound 21b, a poten

283 This research eventually led to the discovery of the clinical radiotra

284 sure the dimensions of oil monolayers, which eventually led to the formulation of the contemporary li

285 plants, including their medicinal uses, and eventually led to the plants' domestication.

286 ibuted to the mutant cell S-phase arrest and eventually led to the retarded cell growth.

287 1 and 2 (ERK1/2) and NF-kappaB pathways that eventually led to the secretion of proinflammatory cytok

288 tion of a partially folded intermediate that eventually leads to their increased oligomerization prop

289 s a test bed for cardiac medical devices and eventually lead to therapeutic tissue grafting.

290 favoring infection and inflammation that may eventually lead to tissue remodeling and respiratory dis

291 disease is managed using bisphosphonate, it eventually leads to total hip replacement due to collaps

292 .g., Yersinia) Abs cross-reactive with TSHR, eventually leading to TSAbs.

293 are known to form interacting circuits that eventually lead to various signaling events, detection o

294 s I alleles and that loss of these responses eventually leads to viremia.

295 in a dense vascularized corneal pannus, and eventually leading to visual impairment.

296 rofoundly affects their spatial distribution eventually leading to vortex cluster formation.

297 urn, triggers a cascade of oxidative events, eventually leading to water splitting and oxygen evoluti

298 overloads proliferating to downstream nodes eventually leading to widespread power outages, or syste

299 istant prostate cancer (ERPC) develops which eventually leads to widespread metastasis.

300 These false assignments will eventually lead to wrong conclusions on the structural i