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1                         We staged anthers at every 0.2 mm of development for one wheat and two barley
2        After adjusting for time on LVAD, for every 1 cm(2)/m(2) decrease in pectoralis muscle index,
3                                          For every 1-D increase in induced astigmatism, the resulting
4                                 However, for every 1-mmHg increase in GAT IOP, the difference between
5                                          For every 1-unit increase, body mass index was associated wi
6 , under conservative assumptions, 101 out of every 10 000 cases (99th percentile, 482) will develop s
7                                          For every 10 DOT/1000 PD increase in use of third- and fourt
8                    In adjusted analyses, for every 10 telestroke consults requested by a spoke, the s
9 sess children's numerical and spatial skills every 10 wk.
10 nset for change in EDSS versus age found for every 10 years of age, EDSS recovery is reduced by 0.15
11                                          For every 10 years of age, odds of EDSS not improving increa
12 this model by estimating population sizes in every 10- m grid cell in Nigeria with national coverage.
13  for all costs included in the analysis, for every 100 admissions, use of the WHO checklist was estim
14                                       One in every 100 patients without COVID-19 symptoms tested posi
15  rapidly accelerated, doubling approximately every 11 years.
16 arate occasion, 0.32 mg/kg MCAM was injected every 12 days for 5 total injections to evaluate the eff
17 ix sites in the Laurentian Great Lakes basin every 12 days from January to December 2017 (inclusive).
18 ation with cytarabine received intravenously every 12 h at either 100 mg/m(2) for 20 doses or 1000 mg
19 urrent viral load testing every 6 months and every 12 months.
20 en every 6 weeks in the ipilimumab group and every 12 weeks in the triplet therapy group.
21 only when Re >=1.6; when test cost was <=$3, every 14-day testing was cost-effective at all Re examin
22 dividual phenolic compounds were carried out every 15 days, and the most stable microcapsules were ac
23           Disease reassessment was performed every 2 cycles.
24 ly quantify the behavior of individual cells every 2 minutes during Phallusia mammillata embryogenesi
25 FL injections followed by regular injections every 2 months) and two irregular treatment interval coh
26  and central macular thickness were measured every 2 months.
27                           Nivolumab, 3 mg/kg every 2 weeks (28-day cycles) and 480 mg every 4 weeks a
28 venous daratumumab once weekly (cycles 1-2), every 2 weeks (cycles 3-6), and every 4 weeks thereafter
29 fusion of fluorouracil 2400 mg/m(2) repeated every 2 weeks (regimen one), or oxaliplatin 130 mg/m(2)
30  2, 6, or 20 mg), administered intravenously every 2 weeks for 12 weeks during hemodialysis.
31 emaining doses of the first two cycles, then every 2 weeks for four cycles (cycles 3-6), and every 4
32                  Adalimumab was administered every 2 weeks from baseline until week 50 as 40 mg per 0
33 ratumumab (DARA SC) weekly in cycles 1 to 2, every 2 weeks in cycles 3 to 6, and every 4 weeks therea
34              Therefore, MTD was 8 mg/kg once every 2 weeks or 12 mg/kg once every 3 weeks.
35 ily plus cetuximab 500 mg/m(2) intravenously every 2 weeks or afatinib alone.
36 SCLC received nivolumab monotherapy (3 mg/kg every 2 weeks).
37  on apheresis could be up-titrated to 420 mg every 2 weeks.
38 reast cancer received paclitaxel 175 mg/m(2) every 2 weeks.
39 ed on follow-up questionnaires approximately every 2 years.
40 any mosquito vectors that refeed frequently (every 2-3 d)(4).
41 can and were thereafter clinically evaluated every 2-4 months (years 1-2), then every 6 months (years
42 eased by 62% (CI, 48% to 81%; P < 0.001) for every 2-fold increase in IgG.
43  experiment, retinal blood flow was assessed every 20 s for 6 min during and after 3 min flicker ligh
44  and nivolumab at 3 mg/kg both intravenously every 21 days for 8 cycles.
45 75 mg/m(2) by body surface area) on day 1 of every 21-day cycle (control group; group 1); intravenous
46 y body surface area) on days 1, 8, and 15 of every 21-day cycle (group 2); or intravenous dose-fracti
47 y body surface area) on days 1, 8, and 15 of every 21-day cycle (group 3).
48 and functional status assessments before and every 24 weeks after starting cART.
49                                              Every 25-nmol/L difference in 25(OH)D was related to an
50 ive intramuscular fulvestrant 500 mg (day 1) every 28 days (plus a loading dose on day 15 of cycle 1)
51  resonance images were obtained at baseline, every 3 days after exposure for 2 weeks, and then weekly
52 ed by repeated CCl(4) administration to rats every 3 days for 3 or 8 weeks, then challenged with LPS
53  for 0.5 h at 7 days and thereafter repeated every 3 days for 6 times.
54 r every 30 min, completed a sleepiness scale every 3 h, and filled a sleep diary every morning (rende
55 mensional descriptive system at baseline and every 3 months during treatment.
56                                              Every 3 months for 4 years, children were examined for c
57 illance in stage I-III NSCLC but may be used every 3 months for the first year and every 6 months for
58                     Biomarkers were measured every 3 months for three years treatment and every 6 mon
59                Eligible subjects were tested every 3 months with color fundus photography, spectral-d
60                    Both groups were assessed every 3 months.
61  once per day or doxorubicin 75 mg/m(2) once every 3 weeks (<= 6 cycles) after being randomly assigne
62   Trastuzumab was administered intravenously every 3 weeks (8 mg/kg loading dose at first cycle, and
63 00 mg/m(2) twice daily on days 1-14 repeated every 3 weeks (regimen two).
64  3 weeks), group 2 (carboplatin AUC5 or AUC6 every 3 weeks and 80 mg/m(2) paclitaxel weekly), or grou
65 usly plus pembrolizumab 200 mg intravenously every 3 weeks and six received the recommended phase 2 d
66 ose of 200 mg (n = 514) or placebo (n = 505) every 3 weeks for 1 year or until disease recurrence or
67 plus docetaxel (75 mg/m(2) body surface area every 3 weeks for 6 cycles) and RP.
68 isplatin (75 mg/m(2); investigator's choice) every 3 weeks for four cycles, followed by pemetrexed ma
69 ous pembrolizumab (200 mg) or saline placebo every 3 weeks for up to 2 years (35 cycles); all patient
70 retion, and intravenous pembrolizumab 200 mg every 3 weeks for up to 2 years or until disease progres
71 ollowed by maintenance bevacizumab (15 mg/kg every 3 weeks in both groups) until disease progression
72 dyweight, once weekly during cycle one, once every 3 weeks in cycles two through nine, and once every
73 lus gemcitabine (1000 mg/m(2), days 1 and 8) every 3 weeks or six cycles of bevacizumab (10 mg/kg, da
74 rated web-response to pembrolizumab (200 mg) every 3 weeks plus chemotherapy (nab-paclitaxel; paclita
75 5 mg/m(2) per dose intravenously on days 1-2 every 3 weeks with sequence adjusted on the basis of tim
76  AUC6 and 175 mg/m(2) intravenous paclitaxel every 3 weeks), group 2 (carboplatin AUC5 or AUC6 every
77 plus pembrolizumab 200 mg intravenously once every 3 weeks, in 3-week cycles.
78 brentuximab vedotin and nivolumab were given every 3 weeks, ipilimumab was given every 6 weeks in the
79 he clinical activity of pembrolizumab 200 mg every 3 weeks, without restriction on prior therapy.
80    All study drugs were given intravenously, every 3 weeks.
81  8 mg/kg once every 2 weeks or 12 mg/kg once every 3 weeks.
82 , followed by pemetrexed maintenance therapy every 3 weeks.
83  pembrolizumab at an initial dose of 2 mg/kg every 3 weeks.
84 ung adults receiving 1200 mg of atezolizumab every 3 weeks.
85 g/kg plus pembrolizumab 200 mg intravenously every 3 weeks.
86 xually transmitted infection (STI) screening every 3-6 months for men who have sex with men (MSM) usi
87  while patients were in the fasted state and every 30 min for 4 h following meal ingestion.
88 wk, 641 working adults logged their behavior every 30 min, completed a sleepiness scale every 3 h, an
89 bruary 2020, perfusate samples were obtained every 30 minutes during 50 dual-HOPE (D-HOPE) procedures
90 buprofen, ketoprofen, and tiaprofenic acid), every 30 minutes: 20%-30%-50% of daily therapeutic dose,
91 tic dose, for the moderate absorption group, every 30 minutes: for diclofenac 5%-15%-30%-50%, and for
92 tinuously up to ten minutes, with one sample every 30s.
93 isely aligned, with inter-sister connections every ~35 kilobase (kb).
94 JQ1 loaded ApoE- NPs at the dose of 10 mg/kg every 3rd day for a total of 8 injections.
95 ravenous haloperidol dose escalation at 2 mg every 4 h, neuroleptic rotation with chlorpromazine at 2
96 leptic rotation with chlorpromazine at 25 mg every 4 h, or combined haloperidol at 1 mg and chlorprom
97 eridol at 1 mg and chlorpromazine at 12.5 mg every 4 h, until death or discharge.
98                    Leukocytes were collected every 4 hours for 24 hours from 10 patients with moderat
99  at 12.5% maximal voluntary contraction once every 4 s and (2) high fibre recruitment, with contracti
100 ing every 8 weeks was non-inferior to dosing every 4 weeks (HIV-1 RNA >=50 copies per mL; 2% vs 1%) w
101 andomly assigned and treated with guselkumab every 4 weeks (n=128), guselkumab every 8 weeks (n=127),
102 were randomly assigned to receive guselkumab every 4 weeks (n=246), every 8 weeks (n=248), or placebo
103 /kg every 2 weeks (28-day cycles) and 480 mg every 4 weeks after cycle 4, was administered intravenou
104 -acting antiretroviral regimen injected once every 4 weeks for treatment or every 8 weeks pending app
105 er proportions of patients in the guselkumab every 4 weeks group (156 [64%] of 245 [95% CI 57-70]) an
106 er proportions of patients in the guselkumab every 4 weeks group (76 [59%] of 128 [95% CI 50-68]) and
107 versus placebo of 37% (95% CI 26-48) for the every 4 weeks group and 30% (19-41) for the every 8 week
108 rences vs placebo 31% [95% CI 22-39] for the every 4 weeks group and 31% [23-40] for the every 8 week
109 ight (2%, every 8 weeks group) and two (<1%, every 4 weeks group) confirmed virological failures (two
110 cycles 1-2), every 2 weeks (cycles 3-6), and every 4 weeks thereafter (28-day cycles) until progressi
111 3 weeks in cycles two through nine, and once every 4 weeks thereafter as maintenance therapy until di
112  1 to 2, every 2 weeks in cycles 3 to 6, and every 4 weeks thereafter for up to 2 years.
113 ry 2 weeks for four cycles (cycles 3-6), and every 4 weeks thereafter.
114 arbepoetin given as a fixed dose (0.45 ug/kg every 4 weeks) versus administered according to a hemogl
115 ed liposomal doxorubicin (30 mg/m(2), day 1) every 4 weeks, both followed by maintenance bevacizumab
116 occurred in no patients receiving guselkumab every 4 weeks, four (3%) patients receiving guselkumab e
117               Prepregnancy diet was assessed every 4 y, from which we calculated dietary pattern scor
118 as assessed by food frequency questionnaires every 4 years.
119                During the household surveys (every 4-6 months), each household head was interviewed t
120 mon and by age 18 years, affects nearly 1 of every 5 children.
121 es and stable isotope ratios were quantified every 5 mm along the length of each whisker.
122         In the cross-sectional analysis, for every 50 DOT/1000 PD increase in total AU, there was a 4
123 ted in France, with interim analyses planned every 50 patients.
124                           Approximately 1 in every 50 to 100 people is affected with bipolar disorder
125 evaluated every 2-4 months (years 1-2), then every 6 months (years 3-5).
126 ng schemes to the current viral load testing every 6 months and every 12 months.
127 after their first arrest and then reassessed every 6 months for 36 months and again at 48 months.
128 mong 7 monitoring schemes tested, monitoring every 6 months for all subjects had the fewest months of
129                      Children were monitored every 6 months for signs and symptoms of diarrheal disea
130 e used every 3 months for the first year and every 6 months for the second year in patients with stag
131 every 3 months for three years treatment and every 6 months in the follow-up year.
132                                  Assessments every 6 months included computer-assisted self-interview
133 ccording to a standard protocol at baseline, every 6 months thereafter for 5 years, and subsequently
134 andomization and at 1.5, 3, and 6 months and every 6 months thereafter.
135 with inclisiran, administered subcutaneously every 6 months.
136 fundus autofluorescence images were acquired every 6 months.
137 re given every 3 weeks, ipilimumab was given every 6 weeks in the ipilimumab group and every 12 weeks
138               Blood specimens were collected every 6-9 months for analysis of plasma ctHPVDNA using a
139 e of 1 unique cross-linked position pair for every 7 amino acids at a 1% false discovery rate.
140 ns at 25% maximal voluntary contraction once every 8 s.
141 guselkumab every 4 weeks (n=128), guselkumab every 8 weeks (n=127), or placebo (n=126).
142 to receive guselkumab every 4 weeks (n=246), every 8 weeks (n=248), or placebo (n=247).
143  group (156 [64%] of 245 [95% CI 57-70]) and every 8 weeks group (159 [64%] of 248 [58-70]) than in t
144 s group (76 [59%] of 128 [95% CI 50-68]) and every 8 weeks group (66 [52%] of 127 [43-61]) than in th
145  every 4 weeks group and 30% (19-41) for the every 8 weeks group (both p<0.0001).
146                        There were eight (2%, every 8 weeks group) and two (<1%, every 4 weeks group)
147  every 4 weeks group and 31% [23-40] for the every 8 weeks group; both p<0.0001).
148 injected once every 4 weeks for treatment or every 8 weeks pending approval by regulatory bodies and
149 es, administered at one 4 week interval, and every 8 weeks thereafter) or placebo.
150    Cabotegravir plus rilpivirine long-acting every 8 weeks was non-inferior to dosing every 4 weeks (
151 eks, four (3%) patients receiving guselkumab every 8 weeks, and five (4%) patients receiving placebo.
152 lability, with a long-acting injection given every 8 weeks.
153 e was assessed by independent central review every 9 weeks per RECIST v1.1.
154 s a tragic event that causes 1 death roughly every 90 seconds worldwide.
155 ganisms, the plant microbiota, that colonize every accessible plant tissue.
156 genes that participate in the development of every anatomical component of the eye.
157                                              Every animal is in constant communication with populatio
158                                              Every antiseizure medication needs to be assessed indivi
159 ytohormone-mediated processes control almost every aspect of plant development from seed and bud dorm
160  ribonucleoprotein formation and function in every aspect of RNA metabolism, ranging from synthesis t
161 everal years toward understanding how almost every aspect of the immune system contributes to the exp
162                                 We show that every balanced network architecture admits stimuli that
163  is ubiquitous in nature and hard-wired into every biological system.
164                                              Every blood pressure category had a continuum of renin-i
165  An analysis of these models reveals that in every case the life cycle assumptions entail local repro
166                                           In every case, the described experimental setup was validat
167                 Cells confront DNA damage in every cell cycle.
168                                              Every cell in the human body has a unique set of somatic
169 the human herpesvirus 6A or 6B (HHV-6A/B) in every cell of their body.
170 because circadian genes operate in virtually every cell type in the body.
171 certainty levels (+/-40%) within portions of every census tract, with median concentration increases
172 dern standards exhibit rapid growth releases every circa 30 years, most likely caused by regular unde
173 oronavirus 2 (SARS-CoV-2) has reached nearly every country in the world with extraordinary person-to-
174 ts the inclusion and promotion of nursing in every country's cancer strategy.
175                                          For every county in 23 states and for each of 15 years, data
176  the CoGEF method to systematically evaluate every covalent mechanophore reported to date and compare
177                  Our analysis shows that for every COVID-19 death, approximately nine surviving Ameri
178 greed that living with Sjogren syndrome made every day a challenge (adjusted odds ratio [OR] 3.81, 95
179                         It is estimated that every day about 1600 youth aged 12 to 17 years smoke the
180                                 We find that every day ART initiation is delayed results in a 39% inc
181 c systems such that the ability to cope with every day or acute stressors is compromised.
182 ightning strikes thousands of tropical trees every day, but is commonly assumed to be a minor agent o
183                                              Every day, we are faced with the conflict between the te
184 tly renewed with new discs added at its base every day.
185 200 new HTLV-1 clones are created and killed every day.
186                                              Every decrease in 10 mmHg SBP <=125 mmHg was associated
187                                          For every doubling in the inferior frontal lobe activation,
188 ylum on Earth and play vital roles in nearly every ecosystem.
189         Fungi have been isolated from almost every environmental niche across the planet, including f
190                                           In every example of transition metal mediated C-C sigma-bon
191 solution structures representative of nearly every family of mechanically activated channel described
192 s between mutually exclusive interpretations every few seconds, a phenomenon known as bistable percep
193 ages drawn from one semantic category except every fifth image (occurring at a rate of 1.2 Hz) which
194 y three cycles thereafter during year 1, and every four cycles during years 2-3.
195 he procedure estimates the z-displacement in every frame and applies an intensity correction in which
196 356) have been contacted appropriately after every FTC, in 243 patients (68.3%; n=356) at least one F
197 phenotypic series, the expression profile of every gene can be correlated with the strength of the tr
198 notyping Consortium (IMPC) aims to knock out every gene in the mouse and comprehensively phenotype th
199 ircadian rhythms is a core feature of nearly every genetic, dietary, or environmental model of metabo
200 -HT7Rs are broadly tuned to odors and target every glomerulus in the antennal lobe.
201 f-reports, medical records for all events at every hospital where the patient reported receiving care
202 eurological disability for one newborn child every hour in the United States.
203 sk genes, and explain, at least in part, why every HSV1-infected person is not equally likely to deve
204                                    Assigning every human gene to specific functions, diseases and tra
205 e (Gal) derived by systematically exchanging every hydroxyl group by a fluorine atom, we developed a
206                                          For every individual in the United States who died of a fire
207 g, SD-OCT and slit lamp examination prior to every injection.
208  and its surrounding milieu, and thus drives every interaction that this synthetic material has with
209                                          For every invasive GBS infection, 3.7 non-invasive infection
210 ty along each line of sight and accounts for every ionized baryon(11-13).
211              In sibling-controlled analyses, every kilogram per meter squared interpregnancy BMI chan
212 termine optimal growth temperature (OGT) for every known microbial species, organisms adapted to diff
213 mation but also quantitative information for every labeling channel and avoid the issue of ratio dist
214               In the beta-endorphin amyloid, every layer of the beta-solenoid is composed of a single
215 s vascular perfusion showed focal defects in every layer.
216      Since much of the biological history of every living creature is shaped by its diseases, recogni
217                                              Every major immune cell subset has been implicated in th
218 work disconnectedness index (SNDi), based on every mapped node and edge in the world.
219 es not require health care systems to report every measure.
220 ver operating curves (ROCs) were plotted for every measurement and contrasted with the proposed LDF.
221 eserve to be considered as a routine part of every medicinal chemist's toolbox.
222                                  Ultimately, every member of a research team has an important role in
223  circadian clocks and metabolism with nearly every metabolic pathway in the mammalian liver under cir
224           Behavioural reactions were tallied every minute and a disturbance score was calculated for
225 n; on day 2, retinal blood flow was measured every minute for 20 min during and after 10 min systemic
226 ss scale every 3 h, and filled a sleep diary every morning (rendering >292,000 activity and >70,000 s
227 rmine the parcel-specific neurite lengths of every neuron type from representative morphologic recons
228               Prostate cancer affects one in every nine men in the USA and is the second leading caus
229 available to host a geological repository in every nuclear waste-generating country, but carbonate ro
230                                Likewise, for every one-unit increase in the percentage of time points
231  the innate immune system and are present in every organ of the body.
232 mental for numerous biochemical processes in every organism.
233                      Responses were assessed every other cycle using RECIST (version 1.1).
234 to oral rimegepant 75 mg or matching placebo every other day for 12 weeks (double-blind treatment pha
235 randomly assigned to group 1 (1 TMP-SMZ dose every other day for 311 days) or group 2 (1 identical pl
236 containing starch with no active ingredients every other day for 311 days).
237 l CO(2) emission for the first two weeks and every other day in a week during the experiment.
238 (85% O(2)) were randomly assigned to receive every other day injections of recombinant Klotho or plac
239 injections of 15 mg pegcetacoplan monthly or every other month (EOM) or sham intravitreal injections
240 d Ventilator Free compares each patient with every other patient in a win-lose-tie for each compariso
241 croscopy were performed weekly for 10 weeks, every other week for an additional 6 weeks or until remo
242 tions in 67 phenotypes, and in 51 phenotypes every pairwise mutant interaction is epistatic.
243  time-consuming, I have become familiar with every paper that we publish.
244                                           In every parameter-estimation experiment, the final measure
245               In our Saving a Life paradigm, every participant either saved one human life in expecta
246                                              Every patient received visual acuity testing, SD-OCT and
247                                           In every patient with refractory focal epilepsy presumed to
248                                          For every patient with UC, we selected matched reference ind
249 ime prediction to build libraries containing every peptide in a proteome, and then refines those libr
250     Unfortunately, adverse effects accompany every pharmacologic intervention and may affect overall
251 wever, it can be a herculean task to measure every phenotype in a combinatorial map.
252 ication of diffusion or protein recovery for every pixel in a given 2D slice, thus moving FRAP measur
253          A score from 0 to 8 was assigned at every pixel of these maps, indicating the number of the
254                                  Analysis of every possible intermediate of the two best chlorampheni
255                 By cataloging the effects of every possible mutation within the TFBS motif, SEMpl can
256 ibosome synthesis platform to build and test every possible single nucleotide mutation within the PTC
257 on of fly strains to individually manipulate every proboscis muscle through control of its motor neur
258 ational modifications, controlling virtually every process in eukaryotic cells.
259                                              Every protein has a story-how it folds, what it binds, i
260                                              Every quantum algorithm is represented by set of quantum
261 developed using systematic reviews to inform every recommendation, as suggested by the Institute of M
262 rative model, the best possible template for every region of a target can be used expanding the confo
263                           During locomotion, every rib measured in both species rotated substantially
264 e found that no method performed the best in every scenario.
265                    The pandemic has impacted every scientist differently.
266                                              Every seventh patient in a Swiss ICU has some kind of tr
267  this flexibility results from the fact that every single gene of the GRN possesses its own functiona
268                                     However, every single method has its limitation in terms of polar
269           The participants' PLR was measured every six months until the age of 24 months.
270                                              Every stimulation site activated a distinctive pattern o
271                         PFOA was detected in every surface water sample with concentrations exceeding
272 create a world where cancer is prevented and every survivor is healthy.
273             Confocal microscopy reveals that every texture in contact with the liquid is deformed by
274 ssigned to the hypothalamus in the ARA-where every TH-ir neuron expressed EGFP(Vgat) .
275 doses given at baseline, alternate days, and every third day did not differ [12.7 (7.3, 21.9), 13.8 (
276  (QLQ-LC13) were administered at cycles 1-5, every three cycles thereafter during year 1, and every f
277 l components, netarsudil and latanoprost, at every time point assessed and an ocular tolerability pro
278 u-PSMA than for (177)Lu-DOTATOC treatment at every time point.
279 phages, and dendritic cells (DCs) present in every tissue in the body.
280 is that no single protocol is sufficient for every tissue type, fixation, and pretreatment.
281 le information about potential therapies for every tumor.
282 hich experiences major antigenic transitions every two to eight years.
283                                              Every type of plant tissue examined expresses some TPS g
284  universal vote-by-mail-a policy under which every voter is mailed a ballot in advance of the electio
285 ied for automated segmentation of fluid with every voxel classified by a convolutional neural network
286 ed the entire brain directly in 3D, labeling every voxel with a brain structure spanning 43 isocortic
287 authors have written and to pay attention to every word when you write.
288                    Millions of mice are used every year for scientific research, representing the maj
289 ransmit claim at least a million human lives every year globally.
290 ypanosomiasis is causing thousands of deaths every year in the rural areas of Africa.
291 rs in which up-calls were detected increased every year, both during the peak season (from 38% in 200
292  human immunodeficiency virus type 1 (HIV-1) every year, but not all acquire the virus, suggesting a
293 fungal pathogen that infects ~280,000 people every year, causing >180,000 deaths.
294 , and (flash) floods - that affect this area every year, damaging population and infrastructures, are
295 or more than 50 million infections worldwide every year, with an overall increase of 30-fold in the l
296 iasis is responsible for up to 30,000 deaths every year.
297 f people who die on the waitlist by over 500 every year.
298 a, Oreochromis niloticus, produced worldwide every year.
299 e animals are imported into the U.S.A. alone every year.
300 posed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates

 
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