ライフサイエンスコーパス: evolutionarily

1 esidues and protein regions highly conserved evolutionarily.

2 biomolecular self-assembly may be optimized evolutionarily.

3 all the fitness maxima in the landscapes are evolutionarily accessible from the wild type.

4 This is a demonstration of an evolutionarily acquired miRNA in eutherians that refines

5 cations in two key functional domains, HCNL1 evolutionarily adapted to a low-Na(+) freshwater environ

6 rature has many examples of species that are evolutionarily adapted to hypoxia and have high affinity

7 As opportunistic omnivores, humans are evolutionarily adapted to obtain calories and nutrients

8 g the critical period can potentially impart evolutionarily adaptive, odorant-specific features to be

9 visual working memory representations is an evolutionarily ancient ability.

10 The cells are evolutionarily ancient and carry conserved principles of

11 ting that major interneuron classes are both evolutionarily ancient and conserved.

12 tivation of ubiquitin-mediated autophagy, an evolutionarily ancient cellular antimicrobial system.

13 ne cell provides the missing component of an evolutionarily ancient circuit using spectral informatio

14 We report that the disordered region of the evolutionarily ancient developmental regulator Vts1/Smau

15 vents are the Toll-like receptors (TLRs), an evolutionarily ancient family of pattern recognition rec

16 reciated, implicating phase separation as an evolutionarily ancient mechanism for cellular organizati

17 neural principles that can be implemented by evolutionarily ancient neural systems to generate escape

18 lity and phagocytosis, this work supports an evolutionarily ancient origin for these processes and es

19 An evolutionarily ancient plant hormone receptor complex co

20 lifestyles have led to an imbalance of this evolutionarily ancient process, coinciding with a steep

21 The 2H phosphoesterase motif defines an evolutionarily ancient protein domain present in several

22 ng peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and beha

23 les in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults, refe

24 ing ribozymes and retrotransposable elements evolutionarily and chemically related to the eukaryotic

25 ially to genetic diversity and are important evolutionarily and medically, but they are still underst

26 oid regulation of hydromineral balance is an evolutionarily basal trait among vertebrates.

27 suggesting maximum metabolic rates increased evolutionarily before basal metabolic rates.

28 s symptoms, an effect that is reminiscent of evolutionarily configured fear responses based on threat

29 An evolutionarily conserved "Pavlovian" learning mechanism

30 lying aggression generation, highlighting an evolutionarily conserved 'core aggression circuit' compo

31 lagging chromatin between dividing cells, an evolutionarily conserved abscission/NoCut checkpoint del

32 s (CME) and its core endocytic machinery are evolutionarily conserved across all eukaryotes.

33 Sleep is evolutionarily conserved across all species, and impaire

34 ological modulation of behavioral traits are evolutionarily conserved across species.

35 ting neuromuscular junctions, mediated by an evolutionarily conserved activity of presynaptic ENaC ch

36 nding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyl

37 sis and the eukaryotic splicing machinery is evolutionarily conserved among species of various phyla.

38 Mix23 is evolutionarily conserved and a homolog of the human prot

39 cture level, CAL1 thus binds CENP-A/H4 using evolutionarily conserved and adaptive structural princip

40 us-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis

41 The behavioral principles of escape are evolutionarily conserved and rely on elementary computat

42 We identified evolutionarily conserved and species-specific gene netwo

43 elements enabled the identification of both evolutionarily conserved and species-specific regulatory

44 that the cross-editing activity of ThrRS is evolutionarily conserved and that this intrinsic activit

45 ound in the outer mitochondrial membrane, is evolutionarily conserved and widely distributed across s

46 lled different pathways had a penchant to be evolutionarily conserved as equal counterparts in other

47 interacts with a previously unrecognized and evolutionarily conserved ATF-C/EBP composite site in exo

48 urons allows neural-specific splicing of the evolutionarily conserved Bak1 microexon 5.

49 We also show chi-CNN predictions enrich for evolutionarily conserved bases, eQTLs and CTCF motifs, s

50 r number of active CREs than active TREs are evolutionarily conserved between mice and primates, incl

51 l-requiring enzyme 1 (IRE1) governs the most evolutionarily conserved branch of the unfolded protein

52 Thus, EGR2 is an example of an essential and evolutionarily conserved broad acting factor, linking tr

53 Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with

54 suggest that DOAG1 and DOAG2 not only act as evolutionarily conserved C- and D-class genes, respectiv

55 Apoptosis is an ancient and evolutionarily conserved cell suicide program.

56 Autophagy, an evolutionarily conserved cellular process by which cytop

57 T. brucei lacks many evolutionarily conserved centriolar protein homologs and

58 Two evolutionarily conserved centriole/basal body cartwheel

59 Cohesin is an evolutionarily conserved chromosome-associated protein c

60 Ankyrin binds indirectly to TMC-1 via evolutionarily conserved CIB proteins, which are require

61 Specificity is conveyed by two highly evolutionarily conserved clusters of ZNF410 binding site

62 Stress granules (SGs) are evolutionarily conserved condensates of ribonucleoprotei

63 ature in adults, representing a distinct and evolutionarily conserved control mechanism to ensure acc

64 GATA function at multiple levels, and reveal evolutionarily conserved cooperation between the GATA an

65 The evolutionarily conserved default mode network (DMN) is a

66 We measured IRE1-mediated splicing of its evolutionarily conserved downstream client as well as tr

67 Egr2 induction is evolutionarily conserved during alternative polarization

68 The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1-8) protein

69 ation of vertebrate genomes and the study of evolutionarily conserved elements of 3D genome organizat

70 ELP1 is the largest subunit of the evolutionarily conserved Elongator complex, which cataly

71 formation has identified the involvement of evolutionarily conserved endocrine signaling pathways, i

72 bolite for DNMT-catalyzed methylation, is an evolutionarily conserved epigenetic stress response, als

73 We identify the molecular function of the evolutionarily conserved ER protein FIT2 as a fatty acyl

74 es cerevisiae, a powerful model for studying evolutionarily conserved eukaryotic processes.

75 Here, we show that Sestrins, a family of evolutionarily conserved exercise-inducible proteins, ar

76 can differentiate between weakly and highly evolutionarily conserved exons, a proxy for functional i

77 We also demonstrate that members of the evolutionarily conserved facilitates chromatin transcrip

78 Galectins, an evolutionarily conserved family of glycan-binding protei

79 this dynamic gating mechanism and are likely evolutionarily conserved features in elongating KSs.

80 We discuss the possible roles of these evolutionarily conserved features, highlight recent find

81 ent evidence has implicated cryptochrome, an evolutionarily conserved flavoprotein receptor, in magne

82 Although sharing an evolutionarily conserved fold and related catalytic mech

83 lines exhibited deficits in habituation, an evolutionarily conserved form of learning, highlighting

84 ngtin-interacting protein family members are evolutionarily conserved from yeast to humans, and they

85 ture in cell types and tissues, and explains evolutionarily conserved functional features of genomes,

86 We identified cell type-specific and evolutionarily conserved gene modules from both neuronal

87 We report that the evolutionarily conserved gene product, Vip1, possesses a

88 rming functional characterization of the two evolutionarily conserved genes in Drosophila melanogaste

89 These findings identify several evolutionarily conserved genes, including ik2/TBK1, cut

90 teleost fish uncovered species-specific and evolutionarily conserved genomic responses to regenerati

91 In response to animal feeding, evolutionarily conserved growth signaling pathways are a

92 Although replacement of H2A with the evolutionarily conserved H2A.Z via the SWR1 histone chap

93 We show that mutants lacking hira-1, an evolutionarily conserved H3.3-deposition factor, have se

94 The evolutionarily conserved hedgehog (Hh) pathway is essent

95 Thus, the evolutionarily conserved HEM1 protein simultaneously reg

96 epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which direc

97 eventual hearing loss we discovered a set of evolutionarily conserved homeostasis genes.

98 een lizards, implying that this mechanism is evolutionarily conserved in amniotes.

99 The aromatic pathway residues are evolutionarily conserved in CLC channels where their ele

100 s of gene expression are cell autonomous and evolutionarily conserved in marine animals possessing a

101 This cilia-dependent predatory mechanism is evolutionarily conserved in Pristionchus pacificus, a ne

102 Nup153 and this interaction was found to be evolutionarily conserved in various SIV isolates and HIV

103 membrane protein complex (EMC) implicates an evolutionarily conserved insertion mechanism for diverge

104 EK complex through a mechanism that exploits evolutionarily conserved interface residues that disting

105 Additionally, we identify a critical and evolutionarily conserved intramolecular network connecti

106 Our work revealed that Shh signaling is an evolutionarily conserved key target in CIA pathobiology.

107 Our analysis uncovered an evolutionarily conserved let-7-5p-binding site within th

108 The evolutionarily conserved lethal-7 (let-7) microRNAs (miR

109 Wnts are evolutionarily conserved ligands that signal at short ra

110 However, the functional role of this evolutionarily conserved localization of cone nuclei is

111 re11 and Rad50 (M/R) proteins are part of an evolutionarily conserved macromolecular apparatus that m

112 obial vitamin B metabolites presented by the evolutionarily conserved major histocompatibility comple

113 pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes

114 Here we uncover an evolutionarily conserved mechanism by which CDK7 promote

115 ults suggest that photooligomerization is an evolutionarily conserved mechanism determining the photo

116 ndria via autophagy, termed mitophagy, is an evolutionarily conserved mechanism for mitochondrial qua

117 differentiation homeostasis, and could be an evolutionarily conserved mechanism for the development o

118 We propose integrin-mediated anchorage as an evolutionarily conserved mechanism of general relevance

119 (2020) identify an evolutionarily conserved mechanism of presynaptic homeos

120 d Ca(V)2.2 by protein kinase A, revealing an evolutionarily conserved mechanism that confers adrenerg

121 Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by prokaryotes a

122 Evolutionarily conserved mechanisms maintain homeostasis

123 lexes required for transport (ESCRT) mediate evolutionarily conserved membrane remodeling processes.

124 ess hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe

125 The evolutionarily conserved microtubule (MT)-severing AAA-A

126 that XIST RNA-protein complex folds into an evolutionarily conserved modular architecture.

127 Altogether our findings demonstrate an evolutionarily conserved modulation of immunity by speci

128 Heat shock protein 90 (Hsp90) is an evolutionarily conserved molecular chaperone that is inv

129 However, evolutionarily conserved molecular mechanisms that regul

130 demonstrates that the LHX:LDB complex is an evolutionarily conserved molecular regulatory device tha

131 The evolutionarily conserved multiprotein Mediator complex (

132 nce and functional robustness in the face of evolutionarily conserved muscle contractile physiology.

133 data additionally proposes a model in which evolutionarily conserved network motifs, or kernels, may

134 The evolutionarily conserved nonsense-mediated mRNA decay (N

135 serotonergic neurons and signals through its evolutionarily conserved NPY/NPF GPCR, NPR-11, in downst

136 The histone locus body (HLB) is an evolutionarily conserved nuclear body that regulates the

137 In addition to their evolutionarily conserved nucleosome acidic patch, we ide

138 arthropod and vertebrate brains may have an evolutionarily conserved organization.

139 The evolutionarily conserved p53 protein and its cellular pa

140 the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals; however, ho

141 y (hereafter referred to as autophagy) is an evolutionarily conserved pathway in which proteins and o

142 Key aspects of this evolutionarily conserved pathway remain uncharacterized,

143 Mitochondria house evolutionarily conserved pathways of carbon and nitrogen

144 We identified evolutionarily conserved patterns of gene expression dur

145 The structures revealed two evolutionarily conserved phosphatidylcholine-binding mec

146 ere, we show that photooligomerization is an evolutionarily conserved photoreaction characteristic of

147 Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants

148 The CAST/ELKS protein family are evolutionarily conserved presynaptic AZ molecules that r

149 We propose that epiblast partial MET is an evolutionarily conserved process among all amniotic vert

150 tRNAs can be returned to the nucleus by the evolutionarily conserved process called tRNA retrograde

151 Mitophagy is an evolutionarily conserved process involving the autophagi

152 Autophagy is an evolutionarily conserved process that plays a key role i

153 Myogenesis is an evolutionarily conserved process.

154 al circuit assembly, many of which belong to evolutionarily conserved protein families not previously

155 recently been shown to represent a novel and evolutionarily conserved protein family(4,5).

156 Arginine methylation is an evolutionarily conserved protein modification catalyzed

157 reviously published data set that identified evolutionarily conserved rare codons in Escherichia coli

158 Our study uncovered an evolutionarily conserved recruitment of bHLH subfamily I

159 function effectively in yeast, and define an evolutionarily conserved region of the N domain involved

160 This identified two previously unannotated evolutionarily conserved regions of ZIC3 that are necess

161 ether, these results argue that AdoMet is an evolutionarily conserved regulator of SG composition and

162 hese results suggest that SCYL-1/SCYL1 is an evolutionarily conserved regulator of Slo2 channels.

163 both Drosophila and zebrafish, indicating an evolutionarily conserved requirement for PERK in sleep.

164 Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay mechanism that has em

165 Evolutionarily conserved RNA-binding protein Musashi1 (M

166 implicate that O-glycosylation might play an evolutionarily conserved role in modulating the circadia

167 nd H(+) move through physically distinct and evolutionarily conserved routes through the CLC channels

168 Here, we uncover evolutionarily conserved rules of engagement between RNA

169 le assembly and dynamics, we show that seven evolutionarily conserved S. cerevisiae proteins (actin,

170 cross or into the ER membrane occurs via the evolutionarily conserved Sec61 complex, a heterotrimeric

171 e master IFN-I inducer IRF3 by binding to an evolutionarily conserved sequence in the IFNB1 enhanceos

172 Bacterial transfer RNAs (tRNAs) contain evolutionarily conserved sequences and modifications tha

173 er that NuMA directly interacts with DNA via evolutionarily conserved sequences in its C-terminus.

174 Here, we investigate an evolutionarily conserved serine phosphorylation that occ

175 Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is hig

176 The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, p

177 Evolutionarily conserved signaling pathways are crucial

178 Hedgehog (Hh) is an evolutionarily conserved signaling protein that has esse

179 ticulum (ER) stress sensor that activates an evolutionarily conserved signalling cascade in response

180 The Hippo pathway is an evolutionarily conserved signalling pathway with key rol

181 WT HNF-1beta binds to two evolutionarily conserved sites located 94 and 30 kb from

182 We first used human evolutionarily conserved sites.

183 The evolutionarily conserved Ski2-Ski3-Ski8 (Ski) complex co

184 yogenesis, and that gastruloid cells exhibit evolutionarily conserved sorting behaviors.

185 nding of de novo variants in genes linked to evolutionarily conserved stress responses (STIP1 and REV

186 ypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes.

187 bidopsis (Arabidopsis thaliana) contains six evolutionarily conserved subunits and two plant-specific

188 The evolutionarily conserved Sucrose Non-Fermenting Related

189 This phosphosite is evolutionarily conserved suggesting post-translational r

190 imilar to those observed in aestivation - an evolutionarily conserved survival strategy that enables

191 on the basis of their numerousness using an evolutionarily conserved system for approximating numeri

192 R) and the heat shock response (HSR) are two evolutionarily conserved systems that protect plants fro

193 es a gene-regulatory program supported by an evolutionarily conserved type of nuclear receptor.

194 nd eukaryotes have revealed the functions of evolutionarily conserved uORF-encoded peptides.

195 The CL requirement of MCU is evolutionarily conserved with loss of CL triggering rapi

196 Thus, we propose that an evolutionarily conserved, dedicated molecular network ha

197 some segregation during the cell cycle is an evolutionarily conserved, fundamental biological process

198 Thus, calcium wave is an evolutionarily conserved, general regulatory mechanism o

199 strate translational read-through across two evolutionarily conserved, in-frame stop codons of MTCH2

200 Our results demonstrate an evolutionarily conserved, intricate network of transcrip

201 Eosinophils are evolutionarily conserved, pleotropic cells that display

202 This mechanism may be evolutionarily conserved, promoting the thinly condensed

203 isms controlling developmental processes are evolutionarily conserved, the speed at which the embryo

204 super-enhancer regions that are regulated by evolutionarily conserved, well-positioned nucleosomes an

205 d in Cyclin-dependent kinase substrates, and evolutionarily conserved, whereas the glutamic acids sur

206 g and that positions of some rare codons are evolutionarily conserved.

207 r that is recessive to chromatin dynamics is evolutionarily conserved.

208 ng number of TFs whose effects on ageing are evolutionarily conserved.

209 hage migration-inhibitory factor (MIF) is an evolutionarily-conserved protein that has both extracell

210 NIP30 acts by binding to REGgamma via an evolutionarily-conserved serine-rich domain with 4-serin

211 Macropinocytosis is an evolutionarily-conserved, large-scale, fluid-phase form

212 recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in recepto

213 ne and related existing scores at predicting evolutionarily constrained non-exonic bases from such da

214 dence of each base in the genome being in an evolutionarily constrained non-exonic element from an in

215 rovide a cohesive view of a multifaceted and evolutionarily constrained system that allocates DSBs to

216 uch genetic diversity has arisen through the evolutionarily controlled balance between the host and p

217 oth an insect-specific visual circuit and an evolutionarily convergent circuit architecture, endowing

218 n the conclusion that all geographically and evolutionarily differentiated Cyclura species and subspe

219 Sec31 disordered region could be replaced by evolutionarily distant sequences, suggesting plasticity

220 rvation of sites of insulation of BEAF-32 in evolutionarily distant species, i.e. D. melanogaster and

221 We show that evolutionarily distinct bacterial species, L. monocytoge

222 graphy, we here show how Drosophila CAL1, an evolutionarily distinct CENP-A histone chaperone, binds

223 TMEM175 is evolutionarily distinct from all known channels, predict

224 on mechanism, the three main CA families are evolutionarily distinct.

225 squito receptor "the lock," which differs in evolutionarily divergent anopheline mosquitoes.

226 amming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGC

227 ave revealed a single Arl13b ortholog in the evolutionarily divergent Trypanosoma brucei, the causati

228 hemically and structurally characterized two evolutionarily divergent uridine phosphorylases, PcUP1 a

229 Accordingly, the vls locus is the most evolutionarily diverse genetic element in Lyme disease-c

230 rget enrichment and detection sensitivity in evolutionarily diverse organisms and allows identificati

231 ll conductance (MscS) is the prototype of an evolutionarily diversified large family that fine-tunes

232 alk region is relatively well conserved, the evolutionarily dynamic nature of influenza viruses(6) ra

233 to activity regulation in class I RNRs as an evolutionarily dynamic process.

234 ing protein like its paralog Oddjob, also an evolutionarily dynamic yet essential ZAD-ZNF gene.

235 t generally explain the essentiality of many evolutionarily dynamic ZAD-ZNF genes in insects.

236 We find that evolutionarily dynamic ZAD-ZNF genes, which encode the m

237 two-colored, undirected, regular graphs are evolutionarily equivalent (where "properly colored" mean

238 y graph connectivity and graph coloring, are evolutionarily equivalent.

239 nventional system is under the control of an evolutionarily extended N-terminal cytoplasmic tail.

240 potential metabolite exchanges to determine evolutionarily favorable interactions between members, a

241 athostomes can identify deeply conserved and evolutionarily flexible features of vertebrate developme

242 ASCC2-ASCC3 interfaces are evolutionarily highly conserved and comprise a large num

243 proteins from both Bacteria and Archaea are evolutionarily highly conserved, including catalytically

244 el by a set of miRNAs, among which let-7c is evolutionarily highly conserved.

245 NA binding (R) domain of the capsid diverged evolutionarily in order to recognize the different genom

246 t that impairs mitochondrial function-across evolutionarily independent lineages of a fish (Poecilia

247 We describe a variety of evolutionarily informed strategies designed to increase

248 hould allow for more rapid identification of evolutionarily inspired bioactive small molecules, in pa

249 Sociality is probably an evolutionarily labile trait that has arisen numerous tim

250 Discovery and repair of an evolutionarily lost lipid A modifying enzyme provides ev

251 gested the autoinhibitory mechanism has been evolutionarily maintained by NasR proteins.

252 y harmful SGEs, the uptake of foreign DNA is evolutionarily maintained by the hosts, explaining the c

253 While GRNs are evolutionarily modified by natural genomic variation, th

254 Moreover, JNK mediated phosphorylation at an evolutionarily more recent site diminishes p38 binding a

255 Broadening the substrate scope of this evolutionarily naive catalyst proved much easier than pr

256 high-amplitude fractal fluctuations, whereas evolutionarily newer parvocellular and magnocellular LGN

257 mbinations of protein domains, suggestive of evolutionarily novel aphid-specific functions.

258 Overall, our methods link an evolutionarily novel aspect of human anatomy to its path

259 e) produce both ancestral glucosinolates and evolutionarily novel cardenolides as defenses.

260 Anthropogenic changes create evolutionarily novel environments that present opportuni

261 (UBPs), unnatural backbones, tags, or other evolutionarily novel features of unnatural DNA.

262 utant lys- encountered lysine limitation, an evolutionarily novel stress, cells suffered nutrient-gro

263 We speculate that evolutionarily novel stresses can trigger atypical relea

264 show that nearly all AD-associated-genes are evolutionarily old and did not originate later in evolut

265 lved in the recognition and reaction to both evolutionarily old and new enemies.

266 ynamically evolving clusters containing both evolutionarily old and young CTCF sites as a result of t

267 that modern human abilities are supported by evolutionarily old, lateralised sensory-motor processes.

268 Moreover, the evolutionarily optimized autonomous MtCM, which had 11 o

269 Bacterial functional amyloids are evolutionarily optimized to aggregate, so much so that t

270 Symbioses are evolutionarily pervasive and play fundamental roles in s

271 d only three times in vertebrates, making it evolutionarily rare.

272 lanking FMF-associated mutations, indicating evolutionarily recent positive selection of FMF-associat

273 h elusive in synthetic materials, Nature has evolutionarily refined macromolecular synthesis with per

274 de therapeutic modulation of SERCA and other evolutionarily related ion-motive ATPases.

275 structural and paramagnetic analysis of two evolutionarily related SODs with different metal specifi

276 s can be detected only in a limited group of evolutionarily related species, called "lineage-specific

277 tron splicing, but also provide parallels to evolutionarily related spliceosomal splicing.

278 ealed more than one type of viruses that are evolutionarily related to dicistronic viruses but contai

279 of fructosamine-3-kinases (FN3Ks), which are evolutionarily related to eukaryotic protein kinases, is

280 some, thus reinforcing the notion that these evolutionarily-related molecular machines share the same

281 ons in abiotic factors over ecologically and evolutionarily relevant timescales in the ocean, leading

282 ve behavior under ecological conditions with evolutionarily-relevant features in which mutual aid and

283 These lineages may have been evolutionarily replaced by the ecological revolution lau

284 s or traits relevant to the establishment of evolutionarily resilient communities.

285 We identified five evolutionarily significant units, which are estimated to

286 We then prove the uniqueness of interior evolutionarily singular strategies for power-law and exp

287 perhaps surprisingly, at least one unstable evolutionarily singular strategy.

288 We found that evolutionarily SOC appears in animals conquering the lan

289 , and prove to be crucial for ecological and evolutionarily stable coexistence in all the models we e

290 onditions that guarantee either at least one evolutionarily stable strategy (ESS) at zero, some, or m

291 ctors, RAPTOR and LST8, have been remarkably evolutionarily static since they arose in the unicellula

292 of immunity supported the emergence of this evolutionarily successful group of vertebrates.

293 s suggest that serial homologues may diverge evolutionarily through replacement of, rather than tinke

294 ndow, suggesting that synthesis rates may be evolutionarily tuned to optimize folding.

295 nistic step is driven by conserved residues, evolutionarily variable residues are key to initial JDP/

296 ue amino acid sequence in humans that is not evolutionarily well conserved in rodents.

297 of protein-coding genes, with enrichment for evolutionarily young genes and genes involved in stress

298 howed preferential activation of a subset of evolutionarily young transposable elements (TE), includi

299 Activation of specific classes of evolutionarily young transposable elements can lead to a

300 focus on the Nicknack ZAD-ZNF gene, which is evolutionarily young, poorly retained in Drosophila spec