ライフサイエンスコーパス: evolutionary conservation

1 eutral, perhaps unexpectedly in light of its evolutionary conservation.

2 protein-protein interfaces and a measure of evolutionary conservation.

3 ucleotide polymorphisms, gene expression and evolutionary conservation.

4 as independently correlated with measures of evolutionary conservation.

5 sstalk is evident from the analysis of their evolutionary conservation.

6 place their yeast counterparts demonstrating evolutionary conservation.

7 erved in Caenorhabditis briggsae, indicating evolutionary conservation.

8 ilarly across 5'TRs, indicating considerable evolutionary conservation.

9 ineage-specific lncRNAs indicated their weak evolutionary conservation.

10 ween signal intensity, genomic coverage, and evolutionary conservation.

11 y of diverse ParB homologs, suggesting broad evolutionary conservation.

12 ome organization, fast mutation rate and low evolutionary conservation.

13 determine the same stoichiometry, indicating evolutionary conservation.

14 vitro TF binding data, positional bias, and evolutionary conservation.

15 vivo occupancy, binding site prediction, and evolutionary conservation.

16 and a rationale for the minor spliceosome's evolutionary conservation.

17 tolerance to loss-of-function mutations and evolutionary conservation.

18 middle, in parallel with a higher degree of evolutionary conservation.

19 or all these functions, despite their strict evolutionary conservation.

20 be influenced by mechanisms that show strong evolutionary conservation.

21 d mouse, we demonstrate their functional and evolutionary conservation.

22 omic information such as gene annotation and evolutionary conservation.

23 tures, post-translational modifications, and evolutionary conservation.

24 regions, with greater than 95% showing clear evolutionary conservation.

25 map genetic risk for disease and to explore evolutionary conservation.

26 SCPs also occurred in zebrafish, indicating evolutionary conservation.

27 n are organ-specific and the extent of their evolutionary conservation.

28 ell as human neuroblastoma cells, suggesting evolutionary conservation.

29 romes and provide potential insight into its evolutionary conservation.

30 Many lncRNAs show poor evolutionary conservation.

31 pervasive in human and fruit fly, reflecting evolutionary conservation.

32 ion methods have been proposed that quantify evolutionary conservation among homologous proteins from

33 ic marks at their transcription start sites, evolutionary conservation among other schistosome specie

34 This role of RBD1 is consistent with its evolutionary conservation among photosynthetic organisms

35 However, due to the lack of evolutionary conservation amongst diverse viruses, it is

36 Structural and evolutionary conservation analysis identified a highly v

37 Gene ontology and evolutionary conservation analysis suggest that these T-

38 Here we use evolutionary conservation analysis to build a model stru

39 rimordial activity that explains their great evolutionary conservation and abundant expression in mos

40 he cis-eQTL genes exhibit lower-than-average evolutionary conservation and are depleted for developme

41 drogen deprivation therapy, highlighting the evolutionary conservation and clinical relevance of the

42 y across diverse species due to processes of evolutionary conservation and convergence.

43 retain wild-type fitness was correlated with evolutionary conservation and distance to active site, a

44 To evaluate the evolutionary conservation and divergence of APA patterns

45 of choriogenesis that takes into account the evolutionary conservation and divergence of the underlyi

46 s C4 grasses and cereals to identify broader evolutionary conservation and divergence.

47 Its importance is confirmed by the evolutionary conservation and diversification of alterna

48 sible 8-base-pair sequences, we examined the evolutionary conservation and enrichment within putative

49 c complexity enhances the potential for both evolutionary conservation and evolutionary innovation.

50 Here we reveal the evolutionary conservation and function of m(6)A by mappi

51 xamples, most (>95%) show little evidence of evolutionary conservation and have been suggested to rep

52 RBDs display a high degree of evolutionary conservation and incidence of Mendelian mut

53 om distantly related vertebrates, suggesting evolutionary conservation and indicating that this activ

54 dering by periodic structure (CYCLOPS), uses evolutionary conservation and machine learning to identi

55 elated cell-type dynamics exhibited striking evolutionary conservation and modulated behavior similar

56 lie in the intergenic region, which exhibits evolutionary conservation and open chromatin conformatio

57 motif scores, TF footprints, CpG/GC content, evolutionary conservation and other factors in an ensemb

58 We conclude that the patterns of long-term evolutionary conservation and permissible sequence diver

59 , "core" and "rim", which differ in terms of evolutionary conservation and physicochemical properties

60 To study the evolutionary conservation and physiological functions of

61 bination of cancer-related gene annotations, evolutionary conservation and pre-computed statistical s

62 various pathogenic strains, highlighting its evolutionary conservation and prime importance to contro

63 ombining in silico predictions of stability, evolutionary conservation and protein interaction models

64 At GGAA repeat elements, which lack evolutionary conservation and regulatory potential in ot

65 in vivo relevance of these targets, and the evolutionary conservation and relevance of these targets

66 ated start codon, and additional analysis of evolutionary conservation and ribosome footprinting sugg

67 Our analysis of evolutionary conservation and structural properties reve

68 of individual mutations were correlated with evolutionary conservation and structural stability.

69 otide "microexons" display the most striking evolutionary conservation and switch-like regulation.

70 I cleavage patterns mirror nucleotide-level evolutionary conservation and track the crystallographic

71 (SNPs) to areas of chromatin accessibility, evolutionary conservation and transcription factor bindi

72 approach consisting of searching lncRNAs by evolutionary conservation and validating their expressio

73 itution scores with measures of per-position evolutionary conservation and variant frequency across h

74 le in vitro assays, chromatin accessibility, evolutionary conservation, and pCRE combinatorial relati

75 Shared variants were filtered for rarity, evolutionary conservation, and predicted functional sign

76 tal signaling mechanisms and their potential evolutionary conservation are incompletely understood.

77 e genomic analyses based on the principle of evolutionary conservation are needed to enable a complet

78 the large nonkinase domain of Hsl1p by using evolutionary conservation as a guide, identifying region

79 ations with respect to the widespread use of evolutionary conservation as a surrogate for functionall

80 specific sequences recognized by the TFs and evolutionary conservation, as well as cell type-specific

81 been identified, little is known about their evolutionary conservation at the level of species and su

82 data, RNA secondary-structure stability, and evolutionary conservation at the protein and nucleic-aci

83 RF set: (1) coding-potential prediction, (2) evolutionary conservation between P. deltoides and other

84 rithms are used for verification in terms of evolutionary conservation, biological importance of bind

85 itional subset of transcripts that have high evolutionary conservation but may include short ORFs and

86 erforms not only previous tools that utilize evolutionary conservation, but also several highly used

87 to lymphocyte development but whose variable evolutionary conservation can obfuscate translation of k

88 of functional regulatory elements, including evolutionary conservation, chromatin accessibility, and

89 er purifying selection should show increased evolutionary conservation compared to typical protein-co

90 Translational evidence for 10 genes, evolutionary conservation data supporting 35 predictions

91 sidues in a dataset of 524 distinct enzymes: evolutionary conservation decreases approximately linear

92 ddressing functions, phenotypes, expression, evolutionary conservation, disease association, protein

93 , axosomatic synaptic endings whose size and evolutionary conservation emphasize their importance.

94 well defined and describe a unique story of evolutionary conservation extending from sequence identi

95 egrates RNA splicing, protein structure, and evolutionary conservation features.

96 redictors are based on protein structure and evolutionary conservation, following the assumption that

97 r to the Toll-like receptors (TLRs) in their evolutionary conservation from flies to mammals.

98 tional protein design that uses knowledge of evolutionary conservation from protein structural famili

99 Evolutionary conservation, functional genomics, chromati

100 ere, we confirm this unusual pattern and its evolutionary conservation in additional samples from var

101 r function of Hint and the rationale for its evolutionary conservation in bacteria have remained a my

102 The existence of evolutionary conservation in base pairing is strong evid

103 tional properties are correlated with higher evolutionary conservation in both DNA and RNA motifs and

104 The observation of extensive evolutionary conservation in copper homeostatic systems

105 , the purine salvage enzyme HPRT, suggesting evolutionary conservation in different enzymes.

106 Because of the evolutionary conservation in dopaminergic neurotransmiss

107 nteractions (SeedNet) that shows evidence of evolutionary conservation in flowering plants.

108 ion in A. thaliana, suggesting that there is evolutionary conservation in gene imprinting.

109 n the present study we took advantage of the evolutionary conservation in the biogenesis of beta-barr

110 These systematic measurements suggest that evolutionary conservation in the consensus sequence is d

111 Deep evolutionary conservation in the genetic programs of put

112 ands in gene transcription strongly suggests evolutionary conservation in the mammalian genome.

113 eceptors are at least partially dependent on evolutionary conservation in the structure and nature of

114 bines structural similarity and accounts for evolutionary conservation in the template interfaces.

115 these putative stem cells, along with their evolutionary conservation in vertebrates and the signall

116 Furthermore, evolutionary conservation is an important discriminating

117 ization on gene expression and its degree of evolutionary conservation is still poorly understood.

118 long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and cance

119 Thus ISE2's evolutionary conservation may be explained by its numero

120 esponses that targeted epitopes with greater evolutionary conservation (mean entropy [+/-SD], 0.32 +/

121 ving changes maintain enhancer activity; (2) evolutionary conservation, nucleosome exclusion, binding

122 a potential read-through candidate based on evolutionary conservation observed in the proximal regio

123 Here we show the evolutionary conservation of a molecular cascade that in

124 uracy during translation, and the widespread evolutionary conservation of aaRS proofreading pathways,

125 The evolutionary conservation of abundant miRNAs in normal p

126 This finding has implications for the evolutionary conservation of Ago proteins in the mammali

127 functional results are reflected in the high evolutionary conservation of all four glycosylation site

128 Here, we assess directly the evolutionary conservation of alphabeta TCR specificity f

129 edicted to contain SHF progenitors, based on evolutionary conservation of ALPM patterning.

130 The evolutionary conservation of amino acid residue serine 1

131 ground genotype of the strain used, and that evolutionary conservation of amino acids in eRF1 is only

132 The degree of evolutionary conservation of an amino acid in a protein

133 mparing the functional conservation with the evolutionary conservation of an important class of odora

134 genetic approach that takes advantage of the evolutionary conservation of AR signaling, we have condu

135 Considering the evolutionary conservation of ARFs and ARF-GEFs, this ini

136 ct of ARK1 binding on transcript levels, and evolutionary conservation of ARK1 binding loci.

137 etermined human ASC-PYD filament, suggesting evolutionary conservation of ASC-dependent inflammasome

138 The number, diversity, and apparent evolutionary conservation of autoantibody profiles sugge

139 TUNA showed striking evolutionary conservation of both sequence- and CNS-rest

140 This work identifies the evolutionary conservation of C(4) Ppc regulatory mechani

141 The method requires not only evolutionary conservation of candidate TFBSs and sets of

142 the geometry, physicochemical properties and evolutionary conservation of catalytic residue activity.

143 Evolutionary conservation of cellular pathways that resp

144 To test whether evolutionary conservation of cis-regulatory modules (CRM

145 Despite the deep evolutionary conservation of CK1 in eukaryotes, little i

146 uptake induced by dAMN knockdown, suggesting evolutionary conservation of Cubilin/AMN co-receptors fu

147 Given the general evolutionary conservation of developmental signaling mec

148 Our study reveals high evolutionary conservation of dorsal organizer formation

149 es comparative genomic analysis to study the evolutionary conservation of each cluster.

150 Here we report evolutionary conservation of EBV-encoded circRNAs determ

151 nserved heart enhancers and suggest that the evolutionary conservation of embryonic enhancers can var

152 Comparative genomic analysis revealed that evolutionary conservation of enhancers decreases followi

153 es have suggested a relatively low degree of evolutionary conservation of experimentally defined TF b

154 Moreover, the evolutionary conservation of fasting regulation of SREBP

155 with a loss of fertility, demonstrating the evolutionary conservation of flagellar function related

156 N) protein rescues asun flies, demonstrating evolutionary conservation of function.

157 ian cells and in Xenopus embryos, indicating evolutionary conservation of function.

158 s for zebrafish snrk-1 knockdown, suggesting evolutionary conservation of function.

159 n can contravene the well-known principle of evolutionary conservation of functionally important regi

160 se three GATA1 motifs, we demonstrate strong evolutionary conservation of GATA1 motifs in regulatory

161 of methylation profiles among species reveal evolutionary conservation of gene body methylation patte

162 isms have revealed a surprising depth to the evolutionary conservation of genetic modules.

163 These results demonstrate the evolutionary conservation of haem sensing among multiple

164 The evolutionary conservation of hepatovirus structure and p

165 This study demonstrates evolutionary conservation of inflammatory signaling and

166 The extensive evolutionary conservation of insomniac and Cul3 suggests

167 The biological relevance and evolutionary conservation of iT cells have recently been

168 ed on the secondary structure prediction and evolutionary conservation of its sequence.

169 We assessed the prevalence and evolutionary conservation of J-protein complexation and

170 both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional

171 Overall the results shed light on evolutionary conservation of Ku, X4, and L4 activities,

172 As one indication of the evolutionary conservation of Kv1 channel functions, muta

173 troyed there, providing a hypothesis for the evolutionary conservation of large CD1 families containi

174 of this interaction may be reflected in the evolutionary conservation of length and anionic charge i

175 Given the evolutionary conservation of let-7-C microRNA sequences

176 ce to study the development, physiology, and evolutionary conservation of mammalian ovarian follicles

177 Our studies demonstrate unanticipated evolutionary conservation of mature tRNA processing to t

178 ype 2a, type 2b, and type 3), suggesting the evolutionary conservation of milestones of neuronal deve

179 sight into organ-enriched expression and the evolutionary conservation of miRNA post-transcriptional

180 elegans and that this provides evidence for evolutionary conservation of molecular components of a p

181 ted in carcinogenesis, because of the strong evolutionary conservation of molecular mechanisms betwee

182 The extraordinary level of evolutionary conservation of MR1 and the limited known d

183 y, which transitions to apoptosis, revealing evolutionary conservation of myocardin function in SMCs

184 aracterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties

185 Ia antigen-processing and -presenting genes, evolutionary conservation of NKT-class Ib recognition, a

186 delays WD in human DRG neurons demonstrating evolutionary conservation of NMNAT function.

187 The positions and evolutionary conservation of O-Man glycans in cadherins

188 Despite the evolutionary conservation of omega and its role in assem

189 Given the high evolutionary conservation of pain, investigative approac

190 immunological memory and may account for the evolutionary conservation of parasite macrophage migrati

191 ched bins were analyzed for the presence and evolutionary conservation of Pitx2 consensus binding seq

192 re further analyzed for the presence and the evolutionary conservation of Pitx2 consensus binding seq

193 The marked evolutionary conservation of Pitx2 function in eye and c

194 trating the specificity of the knockdown and evolutionary conservation of pitx2a function.

195 Our results describe a link between the evolutionary conservation of plant MIRNAs and the mechan

196 The evolutionary conservation of Pol III affirms its potenti

197 bation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances

198 ifies a gene's intolerance to mutation using evolutionary conservation of protein sequences and can i

199 The evolutionary conservation of Rad23 and similar substrate

200 ntact and cell-free preparations demonstrate evolutionary conservation of regulation.

201 We explored evolutionary conservation of regulatory elements and nat

202 o share co-expression is further evidence of evolutionary conservation of regulatory mechanisms.

203 Considering the evolutionary conservation of rOmpB and its crucial contr

204 In this study, we systematically studied the evolutionary conservation of SLiMs recognized by SH2, SH

205 sed on evidence from proteomics data and the evolutionary conservation of start and stop codons.

206 Here, we review the structure and evolutionary conservation of SUN and KASH domain-contain

207 Furthermore, we quantify the evolutionary conservation of surface patches by an index

208 To test the evolutionary conservation of SV sRNAs we examined isolat

209 The evolutionary conservation of T lymphocyte subsets bearin

210 Thus, despite evolutionary conservation of talin's integrin/cytoskelet

211 ls from human and mouse, we demonstrate that evolutionary conservation of TFBEs within orthologous pr

212 ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old ox

213 Given the evolutionary conservation of the asDOG1 promoter, we pro

214 Owing to evolutionary conservation of the ATP-binding site, most

215 The extreme evolutionary conservation of the BSL suggests that it re

216 Evolutionary conservation of the core Hh signaling pathw

217 The evolutionary conservation of the D3U-box motif within dm

218 We observed a remarkable evolutionary conservation of the DNA binding preferences

219 We investigated the evolutionary conservation of the dopaminergic repressor

220 Evolutionary conservation of the EDC and the transcripti

221 ction of its human counterpart suggested the evolutionary conservation of the elucidated architecture

222 Thus, despite evolutionary conservation of the entire MeCP2 protein se

223 This is reflected by the evolutionary conservation of the functional short altern

224 parathyroid glands, begging questions on the evolutionary conservation of the Gcm cascade in higher o

225 Given the evolutionary conservation of the genes involved in energ

226 0% of the genes tested, indicating extensive evolutionary conservation of the hypoxic regulatory acti

227 The high degree of evolutionary conservation of the identified mutation sit

228 respective Atg8 proteins, demonstrating the evolutionary conservation of the interaction.

229 Despite strong evolutionary conservation of the invariant TCR-alpha cha

230 These results reveal the evolutionary conservation of the lymphatic-like phenotyp

231 able controversy exists about the nature and evolutionary conservation of the molecular mechanisms th

232 Our findings highlight the evolutionary conservation of the myomaker-myomixer partn

233 , but not cardiac muscle, despite the strong evolutionary conservation of the P838 residue.

234 imal aging, together with the high degree of evolutionary conservation of the pathway, suggests that

235 onal predictions need to be sensitive to the evolutionary conservation of the positions harboring the

236 Our findings reveal evolutionary conservation of the positive Ret/Wnt signal

237 Despite the apparently high evolutionary conservation of the pre-rRNA processing pat

238 site regulation by HD-ZIPIII and KANADI, and evolutionary conservation of the regulator-target relati

239 We propose that evolutionary conservation of the single additional argin

240 ling that modular organization underpins the evolutionary conservation of the transcriptome structure

241 We demonstrate the evolutionary conservation of the translocon component Ti

242 Evolutionary conservation of the two routes to skeletal

243 This implies ~200 million years of evolutionary conservation of the underlying immune mecha

244 The evolutionary conservation of the vestibulo-ocular circui

245 Evaluation of the evolutionary conservation of the VNTR reveals a human li

246 Co-localized noisy gene pairs exhibit lower evolutionary conservation of their adjacent genome locat

247 We defined five RBP motifs based on the evolutionary conservation of their recognition sites in

248 Despite a strong evolutionary conservation of their sequences, the concom

249 r opisthokonts, provides a framework for the evolutionary conservation of these accessory subunits an

250 avian and non-human primate spleen, showing evolutionary conservation of these cells.

251 ing transposases Hermes and Tn5 suggests the evolutionary conservation of these DNA rearrangements.

252 The evolutionary conservation of these domains indicates the

253 s and determined the regulatory function and evolutionary conservation of these variants.

254 Evolutionary conservation of this core recognition featu

255 an sulphotransferases, which illustrates the evolutionary conservation of this multifunctional enzyme

256 Despite the importance and evolutionary conservation of this pathway between insect

257 in dTORC2-deficient flies, highlighting the evolutionary conservation of this pathway.

258 The evolutionary conservation of this transcription factor a

259 Clear evidence of the evolutionary conservation of trained immunity in teleost

260 Together, these data are consistent with evolutionary conservation of TSP-mediated H2S as a media

261 Taken together, these data demonstrate evolutionary conservation of VDUP1 regulation and functi

262 lied to Vg-unsequenced species thanks to the evolutionary conservation of Vg-proteotypic peptide moti

263 Evolutionary conservation of Vpr suggests an important y

264 To address the evolutionary conservation of WT1 targets, we performed f

265 Finally, we describe the evolutionary conservation of ZFP708 in mice and rats, wh

266 The evolutionary conservation of ZP4 in other mammals, inclu

267 As the result of evolutionary conservation or convergence, lateralization

268 relatively distant species suggesting either evolutionary conservation or convergent evolution within

269 latory elements, as does the extent to which evolutionary conservation or integrative scores predict

270 nclude diverse supporting data types such as evolutionary conservation or nucleosome placement.

271 ingle type of data, such as sequence motifs, evolutionary conservation, or the binding of enhancer-as

272 Considering its extensive evolutionary conservation, our results suggest that glyc

273 type has so far been detected despite strong evolutionary conservation over at least 400 Myr.

274 related species, a probability model for the evolutionary conservation pattern of codons across diffe

275 We also find that footprints reveal a unique evolutionary conservation pattern that differentiates fu

276 e (FIS) for amino acid residue changes using evolutionary conservation patterns.

277 Because of its evolutionary conservation, peroxiredoxin signaling might

278 e complex-disease risk shows little signs of evolutionary conservation, possibly because this categor

279 entified using various approaches, including evolutionary conservation, regulatory protein binding, c

280 epigenome through this transition and their evolutionary conservation remain elusive.

281 ctivity and mitochondrial metabolism and its evolutionary conservation remain to be fully established

282 A recent bioinformatic analysis used evolutionary conservation signals to enhance prediction

283 The evolutionary conservation suggests a common role of Obst

284 Finally, as a striking example of evolutionary conservation, the Drosophila homolog of the

285 actions with different classes of RNA, their evolutionary conservation, their abundance and their tis

286 partners are subject to increased levels of evolutionary conservation, their more numerous partners

287 Despite its evolutionary conservation, this pattern of modification

288 on pheromone pathway components, and we used evolutionary conservation to assign priority to a list o

289 yed an approach that uses a relative lack of evolutionary conservation to inform epitope tag site sel

290 bution to multiple important factors such as evolutionary conservation, tumorigenesis, the length of

291 Evolutionary conservation was established using mouse er

292 Genome evolutionary conservation was used to predict important

293 -I hypersensitivity chromatin signatures and evolutionary conservation we identified seven candidate

294 Using evolutionary conservation, we identified a core set of f

295 ses in nematode and mammalian sperm suggests evolutionary conservation, we show PP1s have independent

296 or components of the genetic networks having evolutionary conservation with human biology.

297 impact of these variants rely primarily upon evolutionary conservation with little to no consideratio

298 The EMC structure reveals notable evolutionary conservation with the prokaryotic insertase

299 s less well understood, and whether there is evolutionary conservation with the proteins studied in f

300 across a variety of species revealed strong evolutionary conservation, with X. laevis and X. tropica