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1 erty, while time poverty is often ignored or exacerbated.
2 and the neurologic deficits are dramatically exacerbated.
3 zation of naive mice with RSV-infected BMDCs exacerbate a live challenge with RSV infection but was i
4 D symptoms, attention to the bodily self may exacerbate a predisposition to focusing on external rath
5 appaB activation, indicating that Tax likely exacerbates a physiological process where RELA provides
6 bited, (5) optogenetic inhibition of the STN exacerbated abnormal GPe activity, and (6) exaggerated b
7 aberrant LysRS-P542R function and mast cell-exacerbated activation with increase in proinflammatory
14 agree with previous reports showing obesity exacerbates AD-related pathology and symptoms in mice.
16 dipocyte-specific Raptor KO mice experienced exacerbated alcohol-induced steatosis, but neither adipo
17 uli in a sensitive developmental period show exacerbated alertness in nonstressful conditions while f
19 Curli expression is required for E. coli to exacerbate alphaSyn-induced behavioral deficits, includi
21 wide H3K27ac and H3K9ac in a fly model of AD exacerbated amyloid-beta42-driven neurodegeneration.
24 ly and locally suppresses the development of exacerbated and pathogenic responses and contributes to
26 /-)) in mice during TLR9-driven inflammation exacerbates and accelerates the onset of fulminant sHLH,
27 rinciple that differentiates between disease-exacerbating and -protective pathways and chemokine-sele
28 myeloid cells (HIF-2alpha(mye/-) ) markedly exacerbated APAP-induced liver injury (AILI) without aff
29 s to increased genomic instability, which is exacerbated at chromosome termini in the form of dysfunc
32 Ca(2+) leak and a CaMKII-independent uptake exacerbates atrial arrhythmogenicity, while helping to m
39 bolic and mitochondrial alterations that are exacerbated by anomalies in PINK1/Parkin-mediated mitoph
42 mortality in Salmonella-infected humans, was exacerbated by CD4 depletion in infected mice and was ac
43 heart, hERG channel block by fentanyl can be exacerbated by certain conditions, such as hypoxia, hypo
51 n vitro confirmed that DNA damage was indeed exacerbated by extracellular ATP, subsequent P2Y(2)R act
53 eQ-induced loss of E. coli proliferation was exacerbated by heat shock but was nearly eliminated in a
55 se of resistant bacteria, a problem possibly exacerbated by inappropriate and non-optimal application
56 rk signs of fescue toxicosis (FT), a disease exacerbated by increased temperature and humidity (+temp
57 cause of morbidity and mortality worldwide, exacerbated by increasing antibiotic resistance in many
59 ation of HD-related pathways in striatum was exacerbated by JQ1 in R6/2 mice, but not in NTs, and JQ1
62 nd an increased lysosomal content, which was exacerbated by mitochondrial stress and could be amelior
66 romosome replication in Dna2-mutant cells is exacerbated by Pif1, which triggers the DNA damage check
67 about the privacy of banked genomic data are exacerbated by recent projects that demonstrate the abil
71 owever, due to the complexity of the system, exacerbated by the diverse set of electrolyte compositio
73 ced an economic shock that is simultaneously exacerbated by the need to restrict the availability of
74 enetic or inducible depletion of eosinophils exacerbates cardiac dysfunction, cell death, and fibrosi
75 tosis, whereas heavy ethanol consumption may exacerbate cerebral I/R injury by suppressing autophagy.
77 r results show that inadequate water quality exacerbates China's water scarcity, which is unevenly di
78 erioration of the periodontal environment by exacerbating chronic inflammation and reducing regenerat
79 treated mice did not ameliorate, but instead exacerbated cisplatin-induced DNA damage and tubular inj
81 on of one or both endogenous C9orf72 alleles exacerbated cognitive deficits, hippocampal neuron loss,
83 e becoming financially feasible but raise or exacerbate complex issues such as variants of uncertain
84 uggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhanceme
86 AIDs-exacerbated respiratory disease, NSAIDs-exacerbated cutaneous disease and NSAIDs-induced urticar
87 relatively low temperature and ambient CO(2) exacerbated damage induced by nanoplastics, while elevat
88 (4,5)-bisphosphate (PIP2), resulting in VEGF-exacerbated defects in angiogenesis and angiogenic signa
89 he intestinal barrier and that Mn deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis
94 Studies in Synpo-deficient mice demonstrated exacerbated disease susceptibility and increased intesti
95 Taken together, high levels of kallistatin exacerbate DN at least partly by inducing RAS overactiva
96 he provision of nucleotides to the host, and exacerbates DNA toxicity and host death without mitochon
98 light-induced circadian disruption and that exacerbated dyslipidemia may mediate atherosclerotic les
99 nduced more GM-CSF production by T cells and exacerbated EAE upon adoptive transfer than did wild-typ
102 systemic deletion hyperactivates tumor Akt, exacerbating ErbB2-mediated tumorigenesis, curbed by pha
106 can provoke cardiometabolic complications or exacerbate existing cardiometabolic disease and, convers
107 Although underlying perfusion heterogeneity exacerbates existing shunt and ventilation-perfusion mis
110 promote increased CD8(+) T cells, leading to exacerbated eye disease in HSV-1-infected mice.IMPORTANC
113 ted with these changes, axonal dystrophy was exacerbated from 6 to 7 months onward in PS2APP;Trem2(ko
114 ly, we uncover that CST complex inactivation exacerbates genome instability in BRCA2 deficient cells.
116 opathy in pregnancy, radioiodine therapy can exacerbate GO and surgery can result in hypoparathyroidi
118 rovides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hema
119 ese age groups from treatment and monitoring exacerbates health inequities and has long-term conseque
121 s show intestinal TLR9 deficiency results in exacerbated hepatic IR injury with increased small intes
123 of viral burden upon LCMV infection but show exacerbated HSC activation under systemic poly(I:C)-indu
124 ve been observed in many parts of the world, exacerbating hydrological uncertainties to predicting dr
126 ificant reduction in digging behavior and an exacerbated hyperlocomotor response to amphetamine.
130 atic activity in the skin, which resulted in exacerbated immune cell activation and skin pathology, m
131 Mice and human IECs lacking AP-1B showed an exacerbated immune response following apical stimulation
133 12 h shift pattern and negative effects are exacerbated in a stressful and dynamic acute mental heal
135 for 2 weeks, hepatic and biliary injury were exacerbated in comparison to KO given placebo, as shown
136 super elongation complex inhibitor KL-2 are exacerbated in DOT1L knockout cells, but not in catalyti
138 responses to repetitive ozone exposures are exacerbated in murine strains that are hyperglycemic and
142 entivize targeted new drug development, have exacerbated inequitable outcomes and reduced access, som
143 by extensive systemic inflammation that can exacerbate infection by potentially increasing the susce
146 ereby triggering microbiota disruptions that exacerbate inflammation and distinguish pre-IBD from IBS
149 um tuberculosis (Mtb) replication, they have exacerbated inflammation and lower ISG expression in the
150 infection, but the mechanisms underlying the exacerbated inflammation during DENV pathogenesis are un
151 showed that estrogen promotes involution by exacerbating inflammation, cell death and adipocytes rep
155 demonstrate how such inaccurate beliefs can exacerbate intergroup conflict and provide an avenue for
159 EHD1 accelerated internalization of Cx43 and exacerbated ischemia-induced lateralization of Cx43 in i
160 es show that RTEC-specific Vgf gene ablation exacerbates ischemia-, cisplatin-, and rhabdomyolysis-as
161 that renal proximal tubular P2X4 activation exacerbates ischemic AKI and promotes NLRP3 inflammasome
166 releasing drug payloads) and molecules that exacerbate LIP-induced oxidative stress to trigger ferro
167 pamide was associated with a decrease in age-exacerbated lipid peroxidation, demyelination and axon l
168 terious proinflammatory responses, which can exacerbate local tissue injury, lead to chronic inflamma
170 otable expansions of Enterobacteriaceae that exacerbated low-grade mucosal inflammation, suggesting t
173 transferase subunit METTL14 in myeloid cells exacerbates macrophage responses to acute bacterial infe
175 rise to chronic inflammation and potentially exacerbating morbidity and mortality in children living
176 in a preclinical mouse PD model resulted in exacerbated motor deficits and increased phosphorylated
177 during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpr
179 , blockage of proteolipid protein production exacerbated myelin thinning in the CNS of oligodendrocyt
180 e mechanism through which climate change may exacerbate negative impacts of biological invasions.
181 GluN2D(-/-) male mice exhibit evidence of exacerbated negative emotional behavior, and a deficit i
182 Tlr9 deficiency in B cells was sufficient to exacerbate nephritis while extinguishing anti-nucleosome
183 both neuronal beta1 and beta4 spectrin show exacerbated nervous system dysfunction compared to mice
188 single-allele deletion alone, respectively, exacerbated or did not improve splenomegaly in beta-thal
189 ctivity results in higher bacterial load and exacerbated organ damage, ultimately leading to prematur
190 experimental setups or in harbors and locks, exacerbates oscillations and modifies the asymptotic spe
192 s pattern of compounding processes will also exacerbate other environmental problems in temperature-s
193 ve constructs to modify pest populations has exacerbated our need to understand how drive spreads in
195 non-toxic, they can cause fish mortality by exacerbating oxygen deficiency and ammonification of sea
196 In contrast, a subset of benzodiazepines exacerbated p-tau cytotoxicity apparently via enhancing
198 Conversely, inhibition of CeA(GA) activity exacerbated pain, produced strong aversion and canceled
199 Antithetically, deletion of the Mcub gene exacerbated pathological cardiac remodeling and infarct
200 perturbs organismal homeostasis and usually exacerbates pathological responses to many types of insu
201 correlate with increased bacterial loads and exacerbate pathology during Mycobacterium tuberculosis i
202 mice (mdx(betageo)) presented with a mildly exacerbated phenotype but without an earlier onset, incr
203 ts increase in stature over time, suggesting exacerbated phosphorus limitation as forests recover.
204 x of 11 (55%) astronauts developed or showed exacerbated pituitary dome depression compared with base
205 q proteins, cell-surface D1-mGlu5 heteromers exacerbated PLC signaling and intracellular calcium rele
206 ce, circadian clock disruption significantly exacerbated post-IR systolic dysfunction (by ultrasound
207 the hypothesis that low vitamin D levels can exacerbate preexisting ophthalmic conditions, such as di
208 er, cardiac-specific overexpression of Gfat1 exacerbates pressure overload-induced cardiac hypertroph
213 lowers CHIP-S20 phosphorylation and protein, exacerbating proteotoxicity and heart dysfunction after
214 sfunction, and edema toxin may significantly exacerbate pulmonary pathologies in a systemic infection
215 with P2X4 allosteric agonist ivermectin had exacerbated renal IR injury whereas P2X4 WT mice treated
216 eported that deficiency of endothelial HIF-2 exacerbated renal ischemia-reperfusion injury, whereas i
221 Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) asthma is charac
224 LTC(4) synthesis similar to that in aspirin-exacerbated respiratory disease, completely blocked the
225 phenotypes fill into the first group: NSAIDs-exacerbated respiratory disease, NSAIDs-exacerbated cuta
226 d bronchoconstriction by challenging aspirin-exacerbated respiratory disease-like (ptges1(-/-)) mice
230 esponses to sensory pollutants counteract or exacerbate responses to other aspects of global change,
231 imals had worsened rod and cone function and exacerbated retinal degeneration compared with Prph2R172
232 r economic conditions and mental health, and exacerbate risk of food insecurity and intimate partner
233 rincipally within the stromal compartment to exacerbate sepsis pathogenesis via differential impacts
234 e demonstrate that hepatic gammadeltaT cells exacerbate SH, independent of IL-17 expression, by mitig
235 ulted in crop failures, famine, and disease, exacerbating social unrest and contributing to political
236 f the novel coronavirus (COVID-19) pandemic, exacerbating socioeconomic inequalities and overwhelming
238 pecifically in midbrain neurons, and further exacerbates SV trafficking defects in Synj1+/- midbrain
240 g LSD1 in these mice is sufficient to highly exacerbate tau-mediated neurodegeneration and tau-induce
244 For example, cerebellar patients present exacerbated temporal variability during multijoint movem
246 ntly modulated various important events that exacerbate the allergic microenvironment, including the
247 is minimization also creates trade-offs that exacerbate the effects of metal depletion and human toxi
248 t the apolipoprotein E epsilon4 allele might exacerbate the effects of soccer ball heading on cogniti
249 w peripheral cytokines to leak into the CNS, exacerbate the gliosis, and result in the vicious neuroi
254 ease-associated mutations in the pathway may exacerbate the slow kinetics of neuronal mitophagy, lead
257 s in 5xFAD male mice, an AD mouse model, and exacerbated the deficits in neurotransmission, synchrony
258 ore clock protein REVERBalpha in these cells exacerbated the development of bleomycin-induced fibrosi
259 tland clustering and attribute heterogeneity exacerbated the differences between C2C and P2P networks
260 s of GPAT3 in seipin-deficient preadipocytes exacerbated the failure of adipogenesis in these cells.
261 ex 2 (PRC2), an H3K27 tri-methyltransferase, exacerbated the impairment in differentiation and plurip
263 biquitous genetic deletion of Map3k8 in mice exacerbated the modeled disease, whereas bone marrow tra
264 islets cultured at 5 mm glucose for 72 h and exacerbated the negative effect of 20 mm glucose on the
267 ering RNA or the blockade of IL-6R signaling exacerbated the TGF-beta-induced dysregulation of tight
268 regeneration following acute damage; it also exacerbates the chronic injury-induced dystrophic phenot
269 This indicates that preexisting hypertension exacerbates the development of secondary neurodegenerati
271 by increasing the genome-wide mutation load, exacerbates the effects of mutation accumulation and cum
272 significantly decreases MAOA expression and exacerbates the expression of impulsive-aggressive behav
273 sitting time is an emerging risk factor that exacerbates the health consequences of physical inactivi
275 mate chaos' and how this intersects with and exacerbates the top issues of our time-from immigration
276 hyperactivity, and addiction to starvation, exacerbating the dieting and exercising, thus further ac
277 Sig-1Rs rescues, whereas the Sig-1R knockout exacerbates, the (G4C2)-RNA repeats-induced aberrant cyt
279 Infectious diseases have the potential to exacerbate these contributions by elevating methane outp
280 nd knockout of S1pr1, 2, and 3 genes further exacerbated these phenotypes, suggesting compensatory fu
286 orced by sea surface temperatures (SSTs) and exacerbated through human-induced deterioration of land
287 ipid accumulation in peripheral tissues, and exacerbates tissue-specific and whole-body insulin resis
288 epair after cisplatin-induced DNA damage and exacerbates tubular injury through the upregulation of p
290 esponse to an energy stress was additionally exacerbated under fasting conditions and by AMPK deficie
292 n lymphocytes, with loss of STAT3 in B cells exacerbating uveitis whereas Stat3 deletion in T cells c
294 hat consuming a Western diet accelerates and exacerbates vascular ageing across the lifespan in seden
295 clusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from inc
298 ad no effect on rotarod or grip strength but exacerbated weight loss and worsened performance on the
300 bral blood flow (CBF) in the PFC, which were exacerbated with chronic exposure and with escalation of