ライフサイエンスコーパス: exceedingly

1 We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally deposited protein, is a

2 on of vacancies, and a proper control of the exceedingly active and anisotropic movement of the vacan

3 -Crry(flox/flox) mouse bone marrows revealed exceedingly active thrombopoiesis.

4 task to derive realistic network models from exceedingly advanced high throughput experimental data.

5 Therefore, Notch is an exceedingly attractive therapeutic target in cancer, but

6 tructural features renders the lomaiviticins exceedingly challenging targets for chemical synthesis.

7 et (both visually and via algorithms), it is exceedingly challenging to interpret dispersion plots fr

8 ng to their strong metal-nitrogen bonds, are exceedingly challenging to isolate through direct synthe

9 the development of the selective inhibitors exceedingly challenging.

10 om formation-flying telescopes--both require exceedingly clean wavefront control in the optics.

11 fore poorly understood gene implicated in an exceedingly common and complex sleep disorder and the de

12 sis uncovered that RAS pathway activation is exceedingly common in human RMS.

13 of electric heart diseases have proved to be exceedingly complex and in many respects contradictory.

14 ic patterns and stress history of Europa are exceedingly complex and many large-scale features remain

15 ent as well as those that promote repair are exceedingly complex and often superimposed.

16 need paradigm shifts as the unraveling of an exceedingly complex computational machine.

17 l one realizes that the cilia are themselves exceedingly complex machines that perform multiple funct

18 ere demonstrates that organic molecules with exceedingly complex structures can be covalently attache

19 discovery of advanced materials against the exceedingly complex synthesis-processes-structure-proper

20 urons in the ventral tegmental area (VTA) is exceedingly complex.

21 rts thus far reflect the initial stage of an exceedingly complicated program, one that will likely ta

22 The synthesis of the exceedingly congested amine tris(1,3-dihydroxy-2-propyl)

23 A short synthesis of exceedingly congested amines, with insertion of a rhodiu

24 The FluA-20 Ab has uncovered an exceedingly conserved protective determinant in the infl

25 le limiting unfavorable outcomes that can be exceedingly costly for application of gene editing in pr

26 Academic surgery is exceedingly deficient of minority residents, junior facu

27 persionless broadband, high permittivity, is exceedingly demanding.

28 ulatory information on a given RNA target is exceedingly dependent on the cell type.

29 E-cigarette aerosols are exceedingly different from conventional tobacco smoke, c

30 ause reproducible droplet generation becomes exceedingly difficult as the reagent droplet volume is d

31 al emitters at moderate temperatures, but is exceedingly difficult for hot emitters (>1,000 K).

32 o eat and increase caloric intake, making it exceedingly difficult for individuals to resist, especia

33 despite its long-standing importance, it is exceedingly difficult in generic cases to numerically ca

34 n function and pharmacology has proven to be exceedingly difficult in such large and complex proteins

35 mical properties, oncogenic Ras proteins are exceedingly difficult targets for rational drug discover

36 nrichment across large expanses, making them exceedingly difficult to define.

37 Many protein reactions are exceedingly difficult to dissect under standard conditio

38 It is exceedingly difficult to distinguish the two via convent

39 )H-(15)N correlation experiments have proven exceedingly difficult to implement on mAbs, and a number

40 free energy than nonnative structures but is exceedingly difficult to locate.

41 As a result, it is exceedingly difficult to record the activation of MMP-2

42 egation intermediates that are transient and exceedingly difficult to study.

43 c ripples in freestanding graphene have been exceedingly difficult to study.

44 ignificant roles in our evolution, but it is exceedingly difficult to understand the social behaviors

45 es, but their structural characterization is exceedingly difficult with standard technologies.

46 Measuring tuberculosis transmission is exceedingly difficult, given the remarkable variability

47 d temporal resolution that is impossible, or exceedingly difficult, using classical genetic methods.

48 mucosa (e.g. in ulcerative colitis) remains exceedingly difficult.

49 tter highly mobile animals to this source is exceedingly difficult.

50 ation and quantitation of individual glycans exceedingly difficult.

51 pathomechanisms of these acquired disorders exceedingly difficult.

52 rational and clinically beneficial manner is exceedingly difficult.

53 hus making the design of specific inhibitors exceedingly difficult.

54 ed prediction of microstructural performance exceedingly difficult.

55 an intuitive understanding of the situation exceedingly difficult.

56 ul proinflammatory mediator that displays an exceedingly diverse spectrum of biological effects.

57 es for their extraction and purification are exceedingly energy and chemical intensive.

58 Given that biological therapies are exceedingly expensive and pose an increased risk for inf

59 Exceedingly facile (23 degrees C) and chemoselective H-C

60 , we demonstrate that the mechanism leads to exceedingly fast diffusion that is 2-3 orders of magnitu

61 The exceedingly fast exchange in novel [(Ph(3)P)(3)Rh(CF(3))

62 ably, while ZBTB7A-deficient tumors progress exceedingly fast, they exhibit an unusually heightened s

63 m (herpes zoster) have been published, while exceedingly few investigations have been carried out in

64 By devising cryo-EM methodologies for exceedingly flexible and pleomorphic assemblies, we have

65 al skyrmions, however, are anticipated to be exceedingly fragile, suppressed by very small Zeeman ene

66 on velocity (CV), and wavelength (WL) at the exceedingly high activation frequencies that are relevan

67 s of ~100 bp near the 5' end of vlsE, and an exceedingly high concentration of G runs in vlsE and the

68 located far north of the industry, including exceedingly high concentrations in AR groundwater (A5w-G

69 tic cat (Felis catus) populations can attain exceedingly high densities and are not limited by natura

70 stem areas because decoding accuracy remains exceedingly high even when canonical face and place syst

71 ventional stroke is still associated with an exceedingly high in-hospital mortality rate.

72 tible solutes that accumulate in the cell at exceedingly high level under the conditions of high sali

73 ty in a nonlinear, biphasic way, so that for exceedingly high levels of pacing stochasticity, the ant

74 utation, revealing that P2P networks display exceedingly high levels of reciprocity.

75 number of highly unusual features including exceedingly high levels of somatic mutations.

76 ation occurs only when mTORC1 and S6K1 reach exceedingly high levels.

77 small endotherms like hummingbirds that have exceedingly high mass-specific metabolic rates.

78 template a plausible scenario to explain the exceedingly high measured conductance based on the elect

79 nds under exceptionally mild conditions with exceedingly high monoselectivity.

80 Collectively, the findings show that exceedingly high NO2(-) concentrations in nitritation sy

81 om Europe and United States have reported an exceedingly high number of children with a severe inflam

82 Small volume solutions of exceedingly high osmolarity, such as 23.4% saline, have

83 st and availability; however, because of the exceedingly high oxidation potential of trifluoroacetate

84 rom BTM generators very likely contribute to exceedingly high ozone concentrations in the Northeast C

85 rage capacity and do not require cryogens or exceedingly high pressures for operation.

86 ents, those with early HCV recurrence had an exceedingly high rate of LBAS (16%).

87 eficiency virus type 1 (HIV-1) recombines at exceedingly high rates, approximately 1 order of magnitu

88 The exceedingly high relative rate ratio (k(fast)/k(slow) up

89 ollowing K(+) stimulation, to be measured at exceedingly high resolution.

90 rs of versatile 2-vinyltetrahydrofurans with exceedingly high selectivity.

91 n of metal organic frameworks (MOFs) affords exceedingly high surface area materials with precisely i

92 therapy for AL amyloidosis, but there is an exceedingly high treatment-related mortality in patients

93 perience unprecedented warming, yet there is exceedingly high uncertainty about their potential respo

94 Exceedingly high viral loads and rapid loss of CD4(+) T

95 draped 20 um diameter copper particles with exceedingly high wicking rates compared to non-salt-temp

96 eritability estimated by both approaches was exceedingly high; h2FAM = 0.75-0.83 and h2SNP = 0.78.

97 cess in PDAC due to a poorly immunogenic and exceedingly immunosuppressive tumor microenvironment, wh

98 R) region of the electromagnetic spectrum is exceedingly important for photovoltaics, telecommunicati

99 Lipid metabolism is exceedingly important in maintaining cellular homeostasi

100 d as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond formi

101 To date, this approach has proved exceedingly inefficient.

102 ents indicate that in its few-layer form, an exceedingly large electric field in the order of several

103 pG-A, but not CpG-B, can multimerize to form exceedingly large lattices.

104 on of the naphthopyran molecules leads to an exceedingly large order parameter in the open form, whic

105 e, and structural data are now available for exceedingly large sample sizes.

106 is needed to characterize the role of these exceedingly large, non-locus-specific deletions in epile

107 algorithm, provided that the network is not exceedingly large.

108 sive research, systemic treatment for HCC is exceedingly limited, with only a handful of drugs provid

109 pment; as a result the antifungal arsenal is exceedingly limited.

110 ta(15)N of various NO(x) emission sources is exceedingly limited.

111 ion and the reversal of established IDDM are exceedingly limited.

112 premolars, combined with a very long muzzle, exceedingly long canines and evidence of highly speciali

113 The exceedingly long half-life of tiotropium (of more than 2

114 ond length of the single-electron bond is an exceedingly long metal-metal bond.

115 n of its housekeeping sortase SrtA generates exceedingly long pili, catalyzed by its pilus-specific s

116 e part, the sAHP's importance stems from its exceedingly long-lasting time-course, which integrates a

117 ervation that Esigma(70) RP(o) complexes are exceedingly long-lived at moderate to high Glu(-) concen

118 he triplet state of cyclo[8]pyrrole, also an exceedingly long-lived species.

119 latively high abundance in nucleus were also exceedingly long-lived.

120 Although TLE procedural mortality is exceedingly low at high-volume centers, postprocedural a

121 I-expressing gliomas in vitro (P < 0.001) at exceedingly low concentrations (10 ng/mL) and effector-t

122 cy leads to decay of HIV-1-infected cells to exceedingly low concentrations desired for HIV-1 remissi

123 Rs) alpha7, alpha9, and alpha10; exposure to exceedingly low concentrations of nicotine (nanomolar),

124 r assays, the sensitivity required to detect exceedingly low concentrations of waterborne pathogens c

125 errupt arterial-type thrombus propagation at exceedingly low doses (<2 ug/kg, IV), yet without substa

126 dherin bonds between cancer cells feature an exceedingly low energy barrier against tensile forces an

127 le because the extent of sumoylation appears exceedingly low for most substrates.

128 in-gel fluorescence detection, we quantified exceedingly low glycosylation rates that remained undete

129 Necl-5 is present at exceedingly low levels in adult epithelial tissues but i

130 on (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related ac

131 sphonate) lacks potential utility due to its exceedingly low membrane permeability at physiological p

132 , with a very low rate of adverse events, an exceedingly low rate of serious adverse events, and an u

133 owever, these techniques are associated with exceedingly low success rates.

134 he loss of secretions under conditions of an exceedingly low virus inoculum.

135 Long-range and nonsyntenic LD are exceedingly low, however, when evaluated by the standard

136 frequency of spontaneous random mutations is exceedingly low, less than 1 x 10(-8) per base pair.

137 pathological aggregates in neural tissue is exceedingly low, precluding examination by conventional

138 ght internal jugular vein catheterization is exceedingly low.

139 component absorbing at long wavelengths was exceedingly low.

140 act resistance of the resulting interface is exceedingly low.

141 from shipping containers were modelled to be exceedingly low.

142 th from breast cancer after surgery alone is exceedingly low.

143 ght internal jugular vein catheterization is exceedingly low.

144 e number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL c

145 The reaction proceeds under exceedingly mild conditions (rt, no additives) with a br

146 tivated secondary amides that proceeds under exceedingly mild conditions in the absence of any additi

147 rbenes enabled high catalytic efficacy under exceedingly mild reaction conditions.

148 peptides that are rapidly produced from the exceedingly minor fraction of protein mislocalized to th

149 ver, neither NLSDM patients nor AKO mice are exceedingly obese.

150 variants, whereas the Bonferroni and FDR are exceedingly over-conservative for rare variants associat

151 of host cells may be directly linked to the exceedingly passive obligate life style of M. leprae wit

152 Because of its exceedingly poor association constant and, in contrast w

153 an acute myocardial infarction (AMI) have an exceedingly poor prognosis, but it is unknown to what ex

154 report a second-generation synthesis of the exceedingly potent antimitotic agent N(14)-desacetoxytub

155 Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral poten

156 QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bar

157 ographic studies validate (D)PMI-delta as an exceedingly potent inhibitor of the p53-MDM2 interaction

158 Inhibitor 5 has exhibited exceedingly potent inhibitory activity (K(i) = 17 pM) an

159 mally stable, insensitive compounds that are exceedingly powerful but safe to handle and prepare.

160 Pain problems are exceedingly prevalent among psychiatric patients.

161 karyotic cells, into the contributions of an exceedingly promiscuous exportin and it provides a new b

162 first in a sequence of three reactions is an exceedingly rapid amine-induced assembly of an amino-BOR

163 The calculation is thus exceedingly rapid.

164 st phase, with leukemic transformation being exceedingly rare (3% risk at 10 years) in patients who r

165 Although this enzymatic activity is exceedingly rare among bacteria more broadly, analysis o

166 This arrangement is exceedingly rare among bacterial SSBs, which typically f

167 Food body rewards are exceedingly rare among eudicot flowering plants and are

168 elling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3

169 Fossil pentastomids are exceedingly rare and are known only from isolated juveni

170 The CNVs presented here are exceedingly rare and are not found in the Database of Ge

171 s to create wide solid-solutions fields with exceedingly rare and complex (3 + 3)-dimensional incomme

172 hat selection of sofosbuvir-resistant HCV is exceedingly rare and is associated with a significant re

173 ldest of which date to the Late Miocene, are exceedingly rare and likewise limited to the Southern He

174 udy of HSCs remains challenging, as they are exceedingly rare and methods to purify them are cumberso

175 cca syndrome, whereas cardiac involvement is exceedingly rare and neuropathy has not been reported.

176 Postoperative HORV is an exceedingly rare and potentially devastating condition t

177 roscopically characterized Fe(V) species are exceedingly rare and, so far, were produced by the oxida

178 ing germline targeting to prime specific and exceedingly rare bnAb-precursor B cells within a humanli

179 demonstrated the existence and importance of exceedingly rare but unusually richly connected cells in

180 ions caused by type emm59 GAS, heretofore an exceedingly rare cause of disease, spread west to east a

181 TKOS is an exceedingly rare clinical entity that does not contribut

182 Measuring the distribution of the exceedingly rare CO(2) isotopologue (16)O(13)C(18)O, in

183 Hurler syndrome-associated keratopathy is an exceedingly rare corneal disorder that requires corneal

184 -exome sequencing approach, we identified 19 exceedingly rare de novo CAMK2A or CAMK2B variants in 24

185 rors of immunity to HHV-8 might underlie the exceedingly rare development of classic KS in childhood.

186 ions associated with regional anesthesia are exceedingly rare events.

187 ion.IMPORTANCE In a morphogenic step that is exceedingly rare for nonenveloped viruses, immature rota

188 Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basi

189 Cushing disease is exceedingly rare in children, especially in those under

190 Pseudo-tetraploid cells are exceedingly rare in early meiotic prophase, but they are

191 mice, a similar degree of PU.1 impairment is exceedingly rare in human AML; yet, moderate PU.1 inhibi

192 rate that high-stoichiometry m(1)A sites are exceedingly rare in mRNAs and that previous mappings of

193 Metallic Pb is exceedingly rare in nature and previously has not been r

194 usands of insertions because such bursts are exceedingly rare in nature and therefore difficult to ob

195 ionality that is unprecedented in plants and exceedingly rare in nature; furthermore, the aryl cyanoh

196 ypes, but retinal ganglion cells (RGCs) were exceedingly rare in the Ascl1 lineage.

197 Preservation of soft-bodied organisms is exceedingly rare in the fossil record.

198 Finally, although ZAL2(m) homozygotes are exceedingly rare in the population, occurring at a frequ

199 7) CD4+ T cells, a requirement for detecting exceedingly rare latently infected cells.

200 Congenital cystic eye is an exceedingly rare ocular malformative disease, originated

201 carcinoma with normal overlying mucosa is an exceedingly rare presentation of primary ESCC with only

202 everal additional single case studies of the exceedingly rare rotational vertebral artery syndrome ha

203 fe span driven by environmental cues - is an exceedingly rare sexual system among angiosperms.

204 repair proteins is their ability to identify exceedingly rare sites of damage embedded in a large exc

205 It is exceedingly rare to have trans-splicing between protein-

206 Such outbreaks are exceedingly rare, and F. tularensis is seldom recovered

207 Fatal sting reactions are exceedingly rare, but certain factors may entail a consi

208 Ferroelectric ferromagnets are exceedingly rare, fundamentally interesting multiferroic

209 Such materials are exceedingly rare, however, owing to competing requiremen

210 ut their biology or host range: Isolates are exceedingly rare, known only from three obligate intrace

211 genetic exchange between plants and fungi is exceedingly rare, particularly among the angiosperms, bu

212 xomycete evolution is that their fossils are exceedingly rare, so evolutionary analyses of this suppo

213 As appendiceal signet ring cell carcinoma is exceedingly rare, the occurrence of this neoplasm in thi

214 ng Arg 54 in protein-ubiquitin complexes are exceedingly rare, these results provide additional insig

215 l examples of versatile metamaterials remain exceedingly rare.

216 s emergence of these structures in nature is exceedingly rare.

217 om living immunocompetent human subjects are exceedingly rare.

218 king examples of exclusive cation-pi bonding exceedingly rare.

219 exist, crippling mitochondrial mutations are exceedingly rare.

220 ed with germline KIT activating mutations is exceedingly rare.

221 repair mechanisms, deleterious mutations are exceedingly rare.

222 recurrence of the same mutation in a sibling exceedingly rare.

223 tion of team sizes in which larger teams are exceedingly rare.

224 DS-related deaths and new HIV infections are exceedingly rare.

225 eochemical course is completely reversed are exceedingly rare.

226 d the recently identified genetic causes are exceedingly rare.

227 presentation, cold panniculitis in adults is exceedingly rare.

228 genes involved in chromosome segregation are exceedingly rare.

229 Isolated CNS histoplasmosis is exceedingly rare.

230 linically significant intracranial injury is exceedingly rare.

231 s of non-marine origin in the Precambrian is exceedingly rare.

232 ization leading to speciation in mammals are exceedingly rare.

233 munodeficient mice; however, metastases were exceedingly rare.

234 developmental modes in a single species, is exceedingly rare.

235 fully infect and transmit between humans are exceedingly rare.

236 ), cyclobutadienyl (C(4) ) complexes remain exceedingly rare.

237 res or fractures of other mid-face bones are exceedingly rare.

238 rganometallic cerium(iv) compounds are still exceedingly rare.

239 c 1946 article describing arterial repair as exceedingly rare.

240 ent complexes apart from the ferrate ion are exceedingly rare.

241 spectroscopy and support the formation of an exceedingly reactive, high-valent Co nitrido species [(B

242 DNA phosphoester bonds are exceedingly resistant to hydrolysis in the absence of ch

243 s fragmentation behavior of [M - H](-) ions, exceedingly rich structural information on the compositi

244 FNAB proved effective and exceedingly safe.

245 sistant to chemical degradation copepods are exceedingly scarce in the geological record with limited

246 Bryostatin 1 is an exceedingly scarce marine-derived natural product that i

247 ges as to secure a meaningful supply of this exceedingly scarce natural product derived from a deep-s

248 ailable potent antibiotic drugs are becoming exceedingly scarce.

249 thin the ER-PM junctions, where they mediate exceedingly selective Ca(2+) entry.

250 PNAs are used as exceedingly selective chemical tools that bind genomic D

251 oscopic (frequency resolved) and potentially exceedingly sensitive indicators of interfacial change (

252 ur electrophile because the S(VI) Cl bond is exceedingly sensitive to reductive collapse yielding S(I

253 analyse an extended data set that reveals an exceedingly sharp inner boundary for the ultrarelativist

254 Here, we demonstrate that exceedingly sharp spires also form under the far-simpler

255 ctions using light is challenging due to the exceedingly short lifetimes of energetic charge carriers

256 aphic phenotype of the proband, including an exceedingly short QT interval with merging of the QRS an

257 Two exceedingly short synthetic routes to the key intermedia

258 Current incident AVF practice falls exceedingly short years after recommendations were made

259 This article describes an exceedingly simple and low-cost method for metering the

260 The technique, which is exceedingly simple but highly useful, expands to a great

261 ere we report that an entirely different and exceedingly simple class of materials-doped small-bandga

262 Furthermore, exceedingly slow delivery of toluene from a high molecul

263 hTDG turnover is exceedingly slow for G.T (k(cat)=0.00034 min(-1)) and G.

264 with task-specific functionalities has been exceedingly slow-especially where polymers containing lo

265 ause the associated atomic displacements are exceedingly small and do not break symmetry.

266 much larger length scales, withstanding only exceedingly small compressive forces.

267 ity for analysis of decade-old materials and exceedingly small microdissected tissue fragments.

268 hat can selectively and specifically isolate exceedingly small numbers of circulating tumor cells (CT

269 Chemical information from this exceedingly small organism is usually accomplished by st

270 d identification of molecular partners using exceedingly small sample quantities under physiological

271 ic manifold and is highly accurate, even for exceedingly small sample sizes.

272 ave designed and developed zwitterion-coated exceedingly small superparamagnetic iron oxide nanoparti

273 As the early stages of nucleation involve exceedingly small time and length scales, atomistic comp

274 m activity during spontaneous respiration is exceedingly small.

275 elihood in the absence of global warming was exceedingly small.

276 es of crown bird evolution is hindered by an exceedingly sparse avian fossil record from the Mesozoic

277 opose that this property allows TmHU to form exceedingly stable associations in which DNA flanking th

278 ll four phases of molybdenum carbide, and is exceedingly stable in acidic solution.

279 novirus is unnecessary, vector production is exceedingly straightforward.

280 ses attribute the failure of gap laws to the exceedingly strong intermolecular interaction.

281 The effective increase in acidity of an exceedingly strong protic acid is greater for biscoordin

282 aA/PsaB heterodimer has evolved to ensure an exceedingly tight binding interface, thereby rendering t

283 ly by native interactions, knot formation is exceedingly unlikely.

284 or 1000 years, much less 10,000 years, seems exceedingly unlikely.

285 on, an ill-defined quantity in metals--it is exceedingly unusual to find a polar metal that exhibits

286 Fluorescent fusion proteins are exceedingly useful for monitoring protein localization i

287 Optical microscopy has been exceedingly useful in imaging cell microarchitecture.

288 rosis (CF) and nosocomial pneumonia could be exceedingly useful, but to date no effective immunothera

289 All-cause postoperative mortality rates are exceedingly variable within resource-constrained environ

290 All-cause postoperative mortality rates are exceedingly variable within resource-constrained environ

291 s of growth in surgical service delivery are exceedingly variable, but the largest growth rates were

292 lly characterized, and demonstrated to be an exceedingly versatile pentafluoroethylating reagent for

293 s from a standard media for the worms to the exceedingly viscous polyvinyl alcohol.

294 e robustness of the result implies that even exceedingly weak Ab-mucin affinity can markedly reduce t

295 ing between photons and acoustic phonons-are exceedingly weak in conventional nanophotonic silicon wa

296 lation of serine, threonine, and tyrosine is exceedingly well characterized, the role of histidine ph

297 Transgenic plants grew exceedingly well in soil contaminated with organic (appr

298 al role of microRNAs in plant development is exceedingly well supported; their importance in environm

299 mon and important elements in nature, has an exceedingly well-explored phase diagram under pressure,

300 We find that these trajectories are best-and exceedingly well-modeled by the proportional navigation