ライフサイエンスコーパス: excision

1 deposits were not used to guide the surgical excision).

2 platform based on Cre- and Flp-mediated DNA excision.

3 ly these inappropriately placed adenines for excision.

4 ed by removal of transgenes via Cre-mediated excision.

5 ny suspicious breast mass without any sample excision.

6 sed by chemical changes being masked by leaf excision.

7 are poised to facilitate acid-catalyzed caC excision.

8 ent surgical approaches exist for mesorectal excision.

9 ipping, a reversible step that precedes base excision.

10 iggers nucleophile activation for nucleotide excision.

11 total of 253 patients underwent a mesorectal excision.

12 ts with restrictive diplopia after pterygium excision.

13 o 90 specimens ex vivo immediately following excision.

14 nscription in the absence of dystrophin gene excision.

15 queried for VHR patients who underwent mesh excision.

16 eedle biopsy should be managed with surgical excision.

17 ied, exhibit wrong-way stomatal responses to excision.

18 ead to unnecessary biopsies or even cervical excisions.

19 psy (55.3%, n = 302/546) or lumpectomy (wide excision) (38.5%, n = 210/546).

20 lymphangiogenesis after full-thickness skin excision, a wound model that is not associated with sign

21 for the direct detection of damaged DNA base excision activity by a ratiometric fluorescence change.

22 bal assessment of margins during skin cancer excision, allowing same-day reexcision when needed.

23 irst is the FA pathway, which operates using excision-analogous to the mechanism used to repair the i

24 r 6458 ADHs (5911 were managed with surgical excision and 547 with follow-up).

25 ation, chemoradiotherapy, type of mesorectal excision and anastomosis.

26 o nick the error-containing strand, allowing excision and DNA resynthesis.

27 ct of the GRF-ZF domain on catalysis of base excision and ICL unhooking is unknown.

28 to nick the error-containing strand to allow excision and resynthesis.

29 The patient underwent wide excision and sentinel node biopsy, which showed absence

30 S-27 based diagnostics - time between tissue excision and staining, agent incubation time, and agent

31 Rabbits underwent a subtotal uterine excision and were reconstructed with autologous cell-see

32 bles the accurate and sensitive detection of excisions and inversions independent of length.

33 d unexpectedly high rates of large (> 20 kb) excisions and inversions, while also revealing a surpris

34 ory of recurrent pterygia requiring multiple excisions and previous amniotic membrane graft placement

35 All these cases were treated with lesion excision, and only two patients (28.5%) progressed with

36 d ICL resistance mechanisms establishes base excision as an alternate ICL repair pathway in bacteria.

37 To test this model, we used the in vivo excision assay and the excision repair sequencing genome

38 A recently developed in vivo excision assay and the excision repair-sequencing (XR-Se

39 enome by slot blot and repair capacity in an excision assay, and used excision repair sequencing (XR-

40 ), to induce a single DSB by Mos1 transposon excision at defined chromosomal locations in the C. eleg

41 on directionality factor (RDF), for prophage excision (attL x attR recombination).

42 al limitations of incomplete dystrophin gene excision became apparent that, in turn, tempered interpr

43 Boolean logic and arithmetic through DNA excision (BLADE) is a recently developed platform for im

44 (Ttherm_00499370) is necessary to direct the excision boundaries of particular IESs.

45 ICEKp2 was competent for excision, but self-mobilisation to recipient Escherichia

46 e need to remodel nucleosomes following base excision by DNA glycosylases but prior to handover to AP

47 After complete lesion excision by EMR, lesions were randomly assigned to therm

48 This leads to unrestrained DNA excision by Exo1, which causes increased single-strand D

49 that a conserved Ala residue limits thymine excision by hindering nucleotide flipping.

50 olyprotein, and either prior to or following excision by HIV-1 protease forms a 66 kDa chain (p66) ho

51 e nucleotides may protect the inhibitor from excision by the viral 3'-5' exonuclease activity.

52 ire future works in which more complete gene excision can be demonstrated, and without significant of

53 the prostate, where unnecessarily wide local excisions can result in significant deterioration of pos

54 d immunodeficiency using the T-cell receptor excision circle assay.

55 Infants with T-cell receptor excision circle values of less than a designated cutoff

56 repertoire usage and diluted T-cell receptor excision circles confirm that DN T cells from lupus-pron

57 t of resection included complete macroscopic excision (CME) in 1,172 patients (77%) and incomplete ma

58 artial mesh excision (PME) and complete mesh excision (CME).

59 of being intractable to nucleotide-mediated excision compared with similar nucleoside analogs.

60 The excision deficient K249Q mutant was even a more potent a

61 Base excision DNA repair involves a number of enzymes and pro

62 itiation by RNA polymerase II and nucleotide excision DNA repair.

63 tments include endoscopic and surgical local excision, downstaging preoperative radiotherapy and syst

64 sight into the factors influencing MutY base excision efficiency.

65 Before and directly after tumor excision, fluorescence imaging was performed to monitor

66 ival after esophagectomy compared with local excision for all cases [hazard ratio (HR) 1.57, 95% conf

67 Local excision for cT1N0 esophageal cancer has increased over

68 ncluded patients undergoing total mesorectal excision for nonmetastatic rectal cancer after SC-TNT or

69 mproper and detrimental MutY-mediatedadenine excision from G:A or T:A base pairs.

70 molog AlkA revealed that Mag1 catalyzes base excision from known AlkB substrates with greater efficie

71 esityl azide in THF leads to terminal N-atom excision from the azide to yield the nitride complex ((t

72 ges the lytic phage ICP1, which triggers PLE excision from the bacterial chromosome, replication, and

73 We further demonstrated that P2 excision greatly hinders growth in seawater medium and i

74 Gross exam prompted re-excision in 166 cases (61%).

75 ) halves the rate of positive margins and re-excision in breast cancer patients undergoing partial ma

76 in skeletal muscles or by 6 months post gene excision in heart muscle.

77 However, diplopia after pterygium excision in primary position is surgically correctable w

78 Western blot analysis, at three months post excision in skeletal muscles or by 6 months post gene ex

79 m, small RNA amplification occurs before IES excision in Tetrahymena This study reveals the remarkabl

80 spatial-temporal control of dystrophin gene excision in vivo.

81 The proportion of patients undergoing local excision increased from 12% in 1998 to 50% in 2012 (P <

82 alcohol-derived metabolite, and identify an excision-independent mechanism.

83 We also demonstrate that DNA excision is dispensable for their biogenesis in this cil

84 ed by a prophage-encoded Rep protein and its excision is induced by the Cox protein.

85 standing of the factors that favor efficient excision is limited by the lack of a rapid, accurate mea

86 Surgical excision is one of the main treatments for malignant tum

87 fied the method to measure precise repair of excision junctions and allele-specific excision, with im

88 We also found that P2 genome excision leads to the disruption of wobble base pairing

89 Lacrimal gland excision (LGE) induced dry eye produces more severe corn

90 than with negative (19.4%, 95% CI 11.8-30.2) excision margin (OR 3.4, 95% CI 1.5-7.7).

91 Previous studies have uncovered NTP-mediated excision mechanisms that may be responsible for aiding i

92 o this end, we implemented an inducible-gene excision methodology using a floxed allele approach, dem

93 l T1N0 esophageal cancer who underwent local excision (n = 1625) or esophagectomy (n = 3255).

94 ic diagnosis confirmed at biopsy or surgical excision (n = 227) or masses that demonstrated imaging c

95 Here we address how N-terminal methionine excision (NME), a ubiquitous process crucial for the mat

96 pite evidence of significant dystrophin gene excision, no significant decrease in dystrophin protein

97 We demonstrate the excision of 023_CTnT and sub-elements 023_CTn2 and 023_C

98 ear-old girl several months after a subtotal excision of a brainstem pilocytic astrocytoma.

99 oforms are produced, two of which arise from excision of a cryptic intron within the amyloid-forming

100 We sought here to induce the excision of a large intragenic segment within the intact

101 We do not recommend re-excision of a negative margin for benign PT, regardless

102 ombination procedure consisting of SLNB with excision of a pre-NST marked positive lymph node appears

103 t pulmonary cDC1s, Cd207 (Langerin)-mediated excision of A20/Tnfaip3 was used, generating Tnfaip3(fl/

104 as a composite of major surgery, endoscopic excision of advanced adenomas, diagnosis of high-grade d

105 which 33 (24.4%) were found to have complete excision of all contrast-enhancing tumour.

106 arding a protease/peptidase required for the excision of an early, cross-linked di-amino acid precurs

107 al process are poorly defined, including TDG excision of caC.

108 to repair leaking blebs without incision or excision of conjunctiva is described.

109 We show that excessive excision of correctly incorporated nucleotides is not du

110 d in future studies in women in whom radical excision of deep infiltrating lesions is obtained.

111 basis for management of patients after local excision of early CRC.

112 9S variant of AAG was 7-fold more active for excision of eG compared with the wildtype (WT) enzyme.

113 ed a thorough investigation of AAG-catalyzed excision of eG from several relevant contexts.

114 Excision of either the extraorbital gland (single LGE),

115 lcytosine (fC), or 5-carboxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG),

116 use model of cystinosis in which conditional excision of floxed megalin/LRP2 alleles in proximal tubu

117 during EAE using mice that had Cre-mediated excision of floxed Ppard driven by the lysozyme M (LysM)

118 The excision of genomic sequences using paired CRISPR-Cas nu

119 isualize PGs could lead to accidental damage/excision of healthy PGs or inability to localize disease

120 Consequently, excision of MANF from beta-cells of adult MIP-1Cre(ERT):

121 ort widespread heterogeneity in the circular excision of non-repetitive germline-limited loci.

122 limited rates, allowing immediate methionine excision of optimal substrates after deformylation.

123 three-arm trial of sorafenib after surgical excision of primary renal cell carcinoma (RCC) found to

124 A total of 1904 VHR patients underwent excision of prior mesh.

125 CRISPR-mediated excision of the corresponding CTCF motifs in an SDH-inta

126 was obtained, the patient underwent surgical excision of the epibulbar tumor and the facial nodule, a

127 patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective

128 re FXN intron 1 is removed, and not with the excision of the expanded GAA tract.

129 le by stabilizing the N-terminus of RAS upon excision of the iMet.

130 nslocation (TET) enzyme family dioxygenases, excision of the latter oxidation products by thymine DNA

131 Following a therapeutic excision of the primary tumor, longitudinal tracking of

132 Surgical correction involved excision of the scar tissue with muscle re-attachment to

133 etched scar -induced secondary strabismus by excision of the stretched scar and muscle fixation to th

134 thermal ablation, cryotherapy, or large loop excision of the transformation zone (LLETZ), using compu

135 The decision was made to attempt surgical excision of the tumor.

136 Consequently, genomic excision of this localisation element and perturbation o

137 These enzymes must minimize excision of thymine that is not generated by mC deaminat

138 In contrast to the precise circular excision of transposable elements, we report widespread

139 MP analogs are more slowly incorporated, the excision of UMP is slow and inefficient, and modificatio

140 2/200 (36.0%), P < 0.001), and to require re-excision or mastectomy for margin clearance (17/196 (8.7

141 lack of a rapid, accurate measurement of DNA excision outcomes that is free of amplification bias.

142 esophagectomy compared with 2.8% after local excision (P < 0.001).

143 is a potential complication after pterygium excision, particularly for patients with a history of re

144 ing mesh explantation following partial mesh excision (PME) and complete mesh excision (CME).

145 resection margin (CRM), plane of mesorectal excision (PME), distal resection margin (DRM), and a com

146 95% CI 6.1-21.6) versus loop electrosurgical excision procedure (13.8%, 95% CI 8.9-18.7; P = .9), but

147 commends cryotherapy or loop electrosurgical excision procedure (LEEP) for histologically confirmed c

148 strand-specific hybridization, we show that excision-proficient E. coli generates leading-strand int

149 idence of significant intact dystrophin gene excision, ranging from ~ 25% in heart muscle to ~ 30-35%

150 R0 resection and complete mesocolic excision rate were 94% and 93%, respectively.

151 ve margin assessment tool may reduce this re-excision rate.

152 significantly reduces positive margin and re-excision rates in patients undergoing PM.

153 y, the magnitudes of decreased in vitro MutY excision rates with different A analogue duplexes do not

154 outcome measures were positive margin and re-excision rates.

155 e chain terminators by a nucleotide-mediated excision reaction that rescues RNA synthesis.

156 ed on DNA assembly and USER (Uracil-Specific Excision Reagent) cloning.

157 ed upon IGE integration and reactivated upon excision, regulating phenotypes of virulence, mutation r

158 stemic chemotherapy, radiation, and surgical excision remain the current treatment modalities for pat

159 t of DCIS; however, controversy regarding re-excision remains when managing negative margins <2 mm.

160 onstrate the complementary roles of the base excision repair (BER) and mismatch repair pathways, resp

161 tability, DNA repair pathways including base excision repair (BER) are also employed by mammalian cel

162 nd deletion, and it has been shown that base excision repair (BER) can result in CAG repeat deletion

163 beta polymerase activity and increases base excision repair (BER) efficiency.

164 Further, depletion of the base excision repair (BER) enzyme DNA glycosylase augments PD

165 Base excision repair (BER) functions not only in the maintena

166 DNA alkylation damage is repaired by base excision repair (BER) initiated by alkyladenine DNA glyc

167 Base excision repair (BER) initiated by alkyladenine DNA glyc

168 Expression of genes associated with base excision repair (BER) is increased with prostate cancer

169 Base excision repair (BER) is the major cellular DNA repair p

170 OGG1 initiated base excision repair (BER) is the major pathway for repair of

171 anine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to remove t

172 Base excision repair (BER) maintains genomic stability throug

173 es and the subsequent activation of the base excision repair (BER) pathway drive the spatiotemporal f

174 The base excision repair (BER) pathway is an important DNA repair

175 he nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative man

176 icularly sensitive to inhibitors of the base excision repair (BER) protein poly (ADP-ribose) polymera

177 (pol) beta nucleotide insertion during base excision repair (BER).

178 e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER).

179 d breaks (DSBs) by perturbing canonical base excision repair (BER).

180 d bases that form in DNA are subject to base excision repair (BER).

181 pair enzymes responsible for initiating base excision repair (BER).

182 P-ribosylation plays a critical role in base excision repair (BER).

183 rentially repaired in promoters via the base excision repair (BER)/single-strand break repair (SSBR)

184 y demonstrated that global genome-nucleotide excision repair (GG-NER) in chromatin is organized into

185 ated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pat

186 le in stabilizing DDB2 to promote nucleotide excision repair (NER) and govern cisplatin resistance in

187 damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair

188 Nucleotide excision repair (NER) in eukaryotes is orchestrated by t

189 Nucleotide excision repair (NER) is a major DNA repair pathway for

190 f repair factors in multi-protein nucleotide excision repair (NER) machinery.

191 In yeast, nucleosomes inhibit nucleotide excision repair (NER) of the nontranscribed strand (NTS)

192 n potentially be repaired via the nucleotide excision repair (NER) pathway.

193 ion endonuclease in the bacterial nucleotide excision repair (NER) pathway.

194 Nucleotide excision repair (NER) protects cells against diverse typ

195 However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown.

196 Nucleotide excision repair (NER) removes a wide range of DNA lesion

197 Nucleotide excision repair (NER) removes various DNA lesions caused

198 trand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity.

199 a key initiator of global-genome nucleotide excision repair (NER).

200 tructure-specific endonuclease in nucleotide excision repair (NER).

201 RNase H2-initiated ribonucleotide excision repair (RER) efficiently removes single rNMPs i

202 Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mech

203 y promoting transcription-coupled nucleotide excision repair (TC-NER) of cisplatin-induced DNA cross-

204 activity of transcription-coupled nucleotide excision repair (TC-NER).

205 2) The excision repair activity itself is controlled by the cir

206 Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) p

207 esent associations with DNA mismatch or base excision repair and cisplatin therapy mechanisms.

208 med to better define the roles of nucleotide excision repair and DNA damage in platinum chemotherapy

209 xo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutation

210 ed in DNA repair pathways including the base excision repair and the interstrand cross-link repair pa

211 well as human cells, and that the nucleotide excision repair complex, Rad10-Rad1(ERCC1-XPF), and the

212 cate the exon alpha Pol beta variant is base excision repair deficient, but does conduct 5'-trimming

213 8-Oxoguanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition a

214 The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions f

215 We reasoned that the base excision repair enzyme thymine DNA glycosylase (TDG) cou

216 +) GC B cells to facilitate CSR-related base excision repair genes during the dark zone phase of GC B

217 creased expression of CSR-related novel base excision repair genes that were otherwise predominantly

218 Mutations in nucleotide excision repair genes were associated with subsequent th

219 otein functions within and beyond nucleotide excision repair in cells.

220 e profiles of cisplatin damage formation and excision repair in mouse kidney, liver, lung and spleen.

221 e enabled genome-wide analysis of nucleotide excision repair in various organisms at single-nucleotid

222 that modulates the delicate process of base-excision repair independently of its glycosylase activit

223 anine (OG) to mark target promoters for base excision repair initiated by OG-glycosylase I (OGG1).

224 Taken together, UNG-initiated base excision repair is a major mechanism counteracting genom

225 Nucleotide excision repair is a versatile mechanism to repair a var

226 lycosylase (AAG) is thought to initiate base excision repair of both 1,N (6)-ethenoadenine (eA) and 1

227 pair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidop

228 Nucleosomes inhibit excision repair of DNA damage caused by ultraviolet (UV)

229 XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabiliz

230 mors had at least one mutation in nucleotide excision repair pathway genes in African Americans, wher

231 whereas >40% of tumors had mutations in base excision repair pathway genes in Caucasians.

232 aged DNA utilizing genes from the nucleotide excision repair pathway without provoking PAEC apoptosis

233 cosylase 1 (MAG1), which is part of the base-excision repair pathway, and the DNA photolyase gene PHo

234 d in an error-free manner by the uracil base excision repair pathway.

235 Genes encoding direct repair and base-excision repair pathways are required by B. abortus to f

236 Nucleotide excision repair prevents up to 99% of point mutations, a

237 ated into precise locations focuses the base excision repair process to read and catalyze removal of

238 damaged DNA binding protein 2), a nucleotide excision repair protein, is upregulated by hypoxia.

239 itive ubiquitylome identified the nucleotide excision repair protein, XPC, as a critical mediator of

240 cised oligomers, generated in the nucleotide excision repair reaction, are isolated by cell lysis and

241 pair capacity in an excision assay, and used excision repair sequencing (XR-seq) to map repair events

242 We developed excision repair sequencing (XR-seq) to study nucleotide

243 , we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping me

244 ATLs target alkyl lesions to the nucleotide excision repair system (NER).

245 like 1 (NEIL1) glycosylases followed by base excision repair to restore the unmodified state.

246 epair (TC-NER) is a subpathway of nucleotide excision repair triggered by stalling of RNA polymerase

247 Mfd couples transcription to nucleotide excision repair, and acts on RNA polymerases when elonga

248 ependent on multiple pathways including base excision repair, ATR signaling, and splicing.

249 lls including an association with nucleotide excision repair, base excision repair, mismatch repair,

250 In nucleotide excision repair, bulky DNA lesions such as UV-induced cy

251 rotein cofactors involved in eukaryotic base excision repair, emphasizing the challenge of integratin

252 reactions at DNA gaps generated during base excision repair, gap-filling DNA synthesis and lyase-dep

253 a key factor in single-strand break and base excision repair, is recruited into nuclear bodies formed

254 iation with nucleotide excision repair, base excision repair, mismatch repair, and DNA double-strand

255 and breaks that are formed during nucleotide excision repair, which primarily removes bulky lesions.

256 nd human cancer cells by recruiting the base excision repair-associated apurinic/apyrimidinic endonuc

257 tly developed in vivo excision assay and the excision repair-sequencing (XR-Seq) method have enabled

258 y and at single nucleotide resolution by the Excision Repair-sequencing (XR-seq) method to better und

259 nic/apyrimidinic endonuclease acting in base excision repair.

260 t performs short gap repair synthesis during excision repair.

261 5' and 3' margins of gapped DNA during base excision repair.

262 inds lesions in DNA and initiates nucleotide excision repair.

263 ides from genomic DNA through ribonucleotide excision repair.

264 e DNA glycosylase (TDG), and subsequent base excision repair.

265 remove modified nucleobases to initiate base excision repair.

266 branched-chain lesions relied on nucleotide excision repair.

267 by a TTF-1-imposed alteration on nucleotide excision repair.

268 as artifactually fragmented postsynthesis by excision repair.

269 Here, we introduce ddXR (droplet digital PCR eXcision Reporter), a method that enables the accurate a

270 , only whole body with partial thoracic skin excision resulted in adequate reconstruction of the pulm

271 peats and they frequently undergo incomplete excisions, resulting in the deletion of one of the end s

272 Challenges of in vivo dystrophin gene excision revealed acute deleterious effects of tamoxifen

273 RT+chemotherapy [CT]), CT, observation after excision, rituximab and RT, and single-agent rituximab.

274 ere collected on the extent of primary tumor excision, severe operative complications, and outcome.

275 had a negative systemic workup, and surgical excision showed Periodic acid Schiff (PAS)-positive eosi

276 Unlike other transposons, its excision site can be precisely repaired without leaving

277 al lymph nodes excised from total mesorectal excision specimens of patients with rectal cancer using

278 nd validated in human keratinocyte carcinoma excision specimens that may provide simple, rapid, and g

279 sy target type, pathologic reports, surgical excision specimens when available, breast density, and i

280 argin (CRM) after transanal total mesorectal excision (TaTME).

281 extensive exonuclease-driven strand-specific excision that begins at a distant single-stranded DNA (s

282 When used in conventional excision, this approach may result in higher cure rates

283 United States) are treated with conventional excision, this surgical modality has much lower cure rat

284 TDG attains context specificity for thymine excision through modulation of nucleotide flipping.

285 e UTP ribose ring further decreased rates of excision to an undetectable level.

286 ination of ID is essential for ICL repair by excision, translesion synthesis and homologous recombina

287 Laparoscopic excision was done for all.

288 med in 58 out of 84 (69%) patients and local excision was performed in 26 (31%) patients.

289 ment of the local regrowth: total mesorectal excision was performed in 58 out of 84 (69%) patients an

290 Patients operated by abdominoperineal excision were excluded.

291 mors obtained immediately following surgical excision were explored.

292 9 patients (16 eyelids) who underwent wedge excision were included in the study.

293 s have been proposed: one is coupled to base excision, while the other only requires substrate bindin

294 Mohs surgery, frozen section or multi-stage excision with delayed closure, and 5-6 mm was the mostly

295 re were 64 patients who underwent 83 primary excisions with cryotherapy for conjunctival PAM who had

296 ease; 37% were staged concordant after local excision, with excess missing data (60%).

297 ir of excision junctions and allele-specific excision, with important implications for disease modeli

298 Surgical excision without systemic treatment resulted in successf

299 ith cT1N0 esophageal cancer undergoing local excision would have lower survival compared with esophag

300 taken from chronic wounds and placed in new excision wounds do not create chronic wounds.