ライフサイエンスコーパス: excision repair

1 as artifactually fragmented postsynthesis by excision repair.

2 ons are not mutagenically copied during base excision repair.

3 ally all DNA damages processed by nucleotide excision repair.

4 for transcription initiation and nucleotide excision repair.

5 ons more commonly associated with nucleotide excision repair.

6 cytidine deaminase, and an inhibitor of base excision repair.

7 kDa, TFIIH is also essential for nucleotide excision repair.

8 ch are removed from the genome by nucleotide excision repair.

9 ions, but through BER rather than nucleotide excision repair.

10 and trigger transcription-coupled nucleotide excision repair.

11 y discovered fidelity checkpoint during base excision repair.

12 with shielding of platinum-DNA adducts from excision repair.

13 nly altered in the absence of ribonucleotide excision repair.

14 thymine DNA glycosylase (TDG)-dependent base excision repair.

15 to 30 nucleotides during base or nucleotide excision repair.

16 s of homologous recombination and nucleotide excision repair.

17 ative products 5fC and 5caC, initiating base excision repair.

18 ug by removal of the damages with nucleotide excision repair.

19 d by DNA glycosylases that initiate DNA base excision repair.

20 n-coupled repair, a subpathway of nucleotide excision repair.

21 ng activity of AID when it overwhelms uracil excision repair.

22 nic/apyrimidinic endonuclease acting in base excision repair.

23 t performs short gap repair synthesis during excision repair.

24 5' and 3' margins of gapped DNA during base excision repair.

25 inds lesions in DNA and initiates nucleotide excision repair.

26 ides from genomic DNA through ribonucleotide excision repair.

27 e DNA glycosylase (TDG), and subsequent base excision repair.

28 remove modified nucleobases to initiate base excision repair.

29 branched-chain lesions relied on nucleotide excision repair.

30 by a TTF-1-imposed alteration on nucleotide excision repair.

31 However, ATMIN also has a role in base excision repair, a process that has been demonstrated to

32 n of the overall mechanism of ribonucleotide excision repair across domains of life.

33 ociated with reduced cellular ribonucleotide excision repair activity and increasedDNAdamage.

34 2) The excision repair activity itself is controlled by the cir

35 Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) p

36 these mutations lead to impaired nucleotide excision repair and basal transcription.

37 esent associations with DNA mismatch or base excision repair and cisplatin therapy mechanisms.

38 med to better define the roles of nucleotide excision repair and DNA damage in platinum chemotherapy

39 rcc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.

40 ear protein, participates in both nucleotide excision repair and mRNA transcription.

41 their proposed biological functions in base excision repair and nonhomologous end joining.

42 xo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutation

43 s with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) an

44 known, abasic (AP) sites, sourced from base excision repair and spontaneous base loss, are the most

45 ed in DNA repair pathways including the base excision repair and the interstrand cross-link repair pa

46 which has been implicated in both nucleotide excision repair and trans-lesion synthesis, required the

47 Mfd couples transcription to nucleotide excision repair, and acts on RNA polymerases when elonga

48 pecific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations ca

49 enome repair-specific elements of nucleotide excision repair, and suggests that TCR is a major force

50 te that together these factors constitute an excision repair apparatus capable of repairing damaged b

51 Mismatch and base-excision repair are important in the somatic expansion o

52 Here we used the in vivo excision repair assay developed in our laboratory to dem

53 nd human cancer cells by recruiting the base excision repair-associated apurinic/apyrimidinic endonuc

54 ependent on multiple pathways including base excision repair, ATR signaling, and splicing.

55 lls including an association with nucleotide excision repair, base excision repair, mismatch repair,

56 d cytidine deaminase (AID) and requires base excision repair (BER) and mismatch repair (MMR).

57 onstrate the complementary roles of the base excision repair (BER) and mismatch repair pathways, resp

58 into DNA double-strand breaks (DSBs) by base excision repair (BER) and then quickly repaired by ligas

59 tability, DNA repair pathways including base excision repair (BER) are also employed by mammalian cel

60 ses and their inefficient processing by base excision repair (BER) are among the factors suggested to

61 in promoter-coding strands, initiating base excision repair (BER) by 8-oxoguanine DNA glycosylase (O

62 nd deletion, and it has been shown that base excision repair (BER) can result in CAG repeat deletion

63 beta polymerase activity and increases base excision repair (BER) efficiency.

64 Further, depletion of the base excision repair (BER) enzyme DNA glycosylase augments PD

65 Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, eff

66 Base excision repair (BER) functions not only in the maintena

67 strand break repair, but a role in DNA base excision repair (BER) has not been described.

68 stone lysine acetylation contributes to base excision repair (BER) in cells, their exact mechanistic

69 that are supposed to be substrates for base excision repair (BER) in the framework of active demethy

70 ligonucleotide fragments in addition to base excision repair (BER) incision products.

71 Base excision repair (BER) initiated by alkyladenine DNA glyc

72 DNA alkylation damage is repaired by base excision repair (BER) initiated by alkyladenine DNA glyc

73 n the absence of APTX activity, blocked base excision repair (BER) intermediates containing the 5'-AM

74 Expression of genes associated with base excision repair (BER) is increased with prostate cancer

75 Base excision repair (BER) is one of several DNA repair pathw

76 Base excision repair (BER) is one of the most frequently used

77 Furthermore, base excision repair (BER) is responsible for causing CAG rep

78 Base excision repair (BER) is the major cellular DNA repair p

79 OGG1 initiated base excision repair (BER) is the major pathway for repair of

80 Base excision repair (BER) is the predominant pathway for cop

81 anine DNA glycosylase1 (OGG1)-initiated base excision repair (BER) is the primary pathway to remove t

82 Base excision repair (BER) maintains genomic stability throug

83 Analysis of these maps revealed that base excision repair (BER) of alkylation damage is significan

84 es and the subsequent activation of the base excision repair (BER) pathway drive the spatiotemporal f

85 The base excision repair (BER) pathway historically has been asso

86 The base excision repair (BER) pathway is an important DNA repair

87 The base excision repair (BER) pathway is mainly responsible for

88 Additionally, we find that the base excision repair (BER) pathway is required to maintain ex

89 The DNA base excision repair (BER) pathway is the frontline mechanism

90 Repair of these lesions via base excision repair (BER) pathway maintains genomic fidelity

91 The base excision repair (BER) pathway repairs oxidized lesions i

92 only used to kill cancer cells, but the base excision repair (BER) pathway they trigger can also prod

93 oguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.

94 ase (APE1), which functions through the base excision repair (BER) pathway.

95 (hUNG) perform the initial step in the base excision repair (BER) pathway.

96 he nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative man

97 Base excision repair (BER) processes non-helix distorting les

98 icularly sensitive to inhibitors of the base excision repair (BER) protein poly (ADP-ribose) polymera

99 beta (Polbeta), known as a key nuclear base excision repair (BER) protein, in mitochondrial protein

100 Base excision repair (BER) recognizes and repairs minimally h

101 d mutation, it is unknown if subsequent base excision repair (BER) steps function on replication-asso

102 olymerase (Pol) beta is a key enzyme in base excision repair (BER), an important repair system for ma

103 for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates DNA polymerase

104 (Pol-beta), a central player in the DNA base excision repair (BER), and this physical complex not onl

105 ation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA gl

106 eacetylases contribute to DNA repair by base excision repair (BER), nucleotide excision repair (NER),

107 xoG), suggesting a noncanonical role in base excision repair (BER).

108 reactive DNA repair intermediate during base excision repair (BER).

109 ajority of these lesions are subject to base excision repair (BER).

110 ) patients is influenced by IFN-induced base excision repair (BER).

111 whether Rev1 could also be involved in base excision repair (BER).

112 P-ribosylation plays a critical role in base excision repair (BER).

113 (Pol lambda)-dependent MUTYH-initiated base excision repair (BER).

114 (pol) beta nucleotide insertion during base excision repair (BER).

115 e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER).

116 d breaks (DSBs) by perturbing canonical base excision repair (BER).

117 d bases that form in DNA are subject to base excision repair (BER).

118 pair enzymes responsible for initiating base excision repair (BER).

119 rentially repaired in promoters via the base excision repair (BER)/single-strand break repair (SSBR)

120 In nucleotide excision repair, bulky DNA lesions such as UV-induced cy

121 coupling factor whereas UvrD plays a role in excision repair by aiding the catalytic turnover of exci

122 ral transcription and UVR-induced nucleotide excision repair by transactivation of GTF2H1 as a core e

123 ests a more ancestral form of ribonucleotide excision repair compared with the eukaryotic pathway.

124 repair and suggest that Mag1-initiated base excision repair compensates for the absence of oxidative

125 well as human cells, and that the nucleotide excision repair complex, Rad10-Rad1(ERCC1-XPF), and the

126 into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent componen

127 In excision repair, coupled incisions are made in the damag

128 spective studies indicate that expression of excision repair cross complementing group 1 (ERCC1) prot

129 cate the exon alpha Pol beta variant is base excision repair deficient, but does conduct 5'-trimming

130 ur, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which enco

131 rotein cofactors involved in eukaryotic base excision repair, emphasizing the challenge of integratin

132 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epi

133 8-Oxoguanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition a

134 al of methylated cytosines requires the base excision repair enzyme TDG, but the mechanism by which T

135 e DNA glycosylase) is one such silenced base excision repair enzyme that can restore DNA integrity.

136 The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions f

137 c endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number o

138 We reasoned that the base excision repair enzyme thymine DNA glycosylase (TDG) cou

139 on-associated demethylation promoted by Base Excision Repair enzymes further modifies methylation of

140 but independent of the essential nucleotide excision repair factor XPA.

141 during replication, or incorrect nucleotide excision repair following oxidative damage.

142 function independent of canonical nucleotide excision repair, forming a novel excision repair pathway

143 reactions at DNA gaps generated during base excision repair, gap-filling DNA synthesis and lyase-dep

144 Additionally, mutations in a base-excision-repair gene (SMUG1) correlate with a C-to-T mut

145 Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1(/-)) show numerous acc

146 +) GC B cells to facilitate CSR-related base excision repair genes during the dark zone phase of GC B

147 creased expression of CSR-related novel base excision repair genes that were otherwise predominantly

148 Mutations in nucleotide excision repair genes were associated with subsequent th

149 the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-induced direc

150 y demonstrated that global genome-nucleotide excision repair (GG-NER) in chromatin is organized into

151 lesion sites in the global genome nucleotide excision repair (GG-NER) pathway.

152 Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting nucleotide l

153 hanism may also be operative in related base excision repair glycosylases and provides a critical fra

154 otein functions within and beyond nucleotide excision repair in cells.

155 Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the r

156 Nucleotide excision repair in Escherichia coli is stimulated by tra

157 e profiles of cisplatin damage formation and excision repair in mouse kidney, liver, lung and spleen.

158 In the absence of additional factors, base excision repair in NCPs will stall at the gap-filling st

159 photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsis and rice.

160 e enabled genome-wide analysis of nucleotide excision repair in various organisms at single-nucleotid

161 -negative manner and impairs long-patch base excision repair in vitro and in vivo.

162 that modulates the delicate process of base-excision repair independently of its glycosylase activit

163 n mouse fibroblast cells treated with a base excision repair-inducing agent, we questioned whether Re

164 anine (OG) to mark target promoters for base excision repair initiated by OG-glycosylase I (OGG1).

165 Nucleotide excision repair is a major DNA repair mechanism in all c

166 Taken together, UNG-initiated base excision repair is a major mechanism counteracting genom

167 Nucleotide excision repair is a versatile mechanism to repair a var

168 oxidation damage to the NER proteome and DNA excision repair is impaired in extracts prepared from FI

169 Base excision repair is initiated by DNA glycosylases that re

170 iates both ATR-CHK1 signaling and nucleotide excision repair is replication protein A, and we find th

171 a key factor in single-strand break and base excision repair, is recruited into nuclear bodies formed

172 recognized by Fanconi anemia and nucleotide excision repair machinery, although the mechanisms of th

173 ic if not properly removed by the nucleotide excision repair machinery.

174 Here we present the excision repair maps for CPDs and BPDE-dG adducts genera

175 iation with nucleotide excision repair, base excision repair, mismatch repair, and DNA double-strand

176 ated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pat

177 le in stabilizing DDB2 to promote nucleotide excision repair (NER) and govern cisplatin resistance in

178 damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair

179 Global nucleotide excision repair (NER) and transcription-coupled DNA repa

180 Given the use of nucleotide excision repair (NER) as a backup pathway for RER in RNa

181 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1 and XPF-1)

182 Nucleotide excision repair (NER) consists of global genomic NER (GG

183 TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to impaired tran

184 Nucleotide excision repair (NER) in eukaryotes is orchestrated by t

185 Nucleotide excision repair (NER) is a conserved and versatile DNA r

186 Nucleotide excision repair (NER) is a highly conserved pathway that

187 Nucleotide excision repair (NER) is a major DNA repair pathway for

188 Nucleotide excision repair (NER) is an evolutionarily conserved mec

189 Nucleotide excision repair (NER) is the key DNA repair system that

190 lding protein in the multiprotein nucleotide excision repair (NER) machinery.

191 f repair factors in multi-protein nucleotide excision repair (NER) machinery.

192 In yeast, nucleosomes inhibit nucleotide excision repair (NER) of the nontranscribed strand (NTS)

193 ve diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs DNA damage

194 uld be subjected to repair by the nucleotide excision repair (NER) pathway.

195 protein that participates in the nucleotide excision repair (NER) pathway.

196 ion endonuclease in the bacterial nucleotide excision repair (NER) pathway.

197 n potentially be repaired via the nucleotide excision repair (NER) pathway.

198 Nucleotide excision repair (NER) plays a vital role in platinum-ind

199 Nucleotide excision repair (NER) protects cells against diverse typ

200 , we measured the distribution of nucleotide excision repair (NER) rates for UV-induced lesions throu

201 However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown.

202 Nucleotide excision repair (NER) removes a wide range of DNA lesion

203 Nucleotide excision repair (NER) removes chemically diverse DNA les

204 Nucleotide excision repair (NER) removes various DNA lesions caused

205 changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombination (HR)

206 DB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic sites and

207 trand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity.

208 ir by base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), non-homolo

209 extracts yields a characteristic nucleotide excision repair (NER)-induced ladder of short dual incis

210 a key initiator of global-genome nucleotide excision repair (NER).

211 tructure-specific endonuclease in nucleotide excision repair (NER).

212 c UVB-induced DNA photolesions by nucleotide excision repair (NER).

213 caused by exposure to UV light is nucleotide excision repair (NER).

214 (XPA) mice that are deficient in nucleotide excision repair (NER).

215 event required for cAMP-enhanced nucleotide excision repair (NER).

216 cancers, is primarily repaired by nucleotide excision repair (NER).

217 non-homologous end-joining (cku-80) or base excision repair (nth-1, exo-3), the Fanconi-related prot

218 In humans, short-patch base excision repair of 8-oxoG:dA base pairs requires human D

219 sylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out nucl

220 lycosylase (AAG) is thought to initiate base excision repair of both 1,N (6)-ethenoadenine (eA) and 1

221 ntially expressed in testes, uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastran

222 pair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidop

223 Nucleosomes inhibit excision repair of DNA damage caused by ultraviolet (UV)

224 known if histone acetylation modulates base excision repair of DNA lesions in chromatin.

225 in mammalian cells, and a key factor in base-excision repair of DNA.

226 sis for understanding the mechanisms of base excision repair of ICLs.

227 nzymes have been known only to initiate base excision repair of small adducts by extrusion from the D

228 XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabiliz

229 eplication are removed by RNase H2-dependent excision repair or by topoisomerase I (Top1)-catalyzed c

230 Vpr also interferes with the base-excision repair pathway by antagonizing the uracil DNA g

231 Mag1 initiates the base excision repair pathway by removing alkylated bases from

232 e on the efficiency and fidelity of the base excision repair pathway during the repair of opposing ba

233 grity and define the specificity of the base excision repair pathway for discreet, detrimental modifi

234 mors had at least one mutation in nucleotide excision repair pathway genes in African Americans, wher

235 whereas >40% of tumors had mutations in base excision repair pathway genes in Caucasians.

236 itro and in vivo and a robust ribonucleotide excision repair pathway is critical to keeping incorpora

237 nine DNA glycosylase-1 (OGG1)-initiated base excision repair pathway is primarily responsible for 7,

238 aged DNA utilizing genes from the nucleotide excision repair pathway without provoking PAEC apoptosis

239 We tested if inhibiting the ribonucleotide excision repair pathway would exacerbate the smc6 mutant

240 the LigC complex is directly involved in an excision repair pathway(s) that repairs DNA damage with

241 s well as a key intermediate during the base excision repair pathway, abasic sites are frequent DNA l

242 cosylase 1 (MAG1), which is part of the base-excision repair pathway, and the DNA photolyase gene PHo

243 Specifically, we show that the base excision repair pathway, the main pathway utilized for t

244 glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism fo

245 s also has an adverse effect on the DNA base excision repair pathway, the major DNA repair system tha

246 he lesion has been excised by the nucleotide excision repair pathway, while others participate in tra

247 nucleotide excision repair, forming a novel excision repair pathway.

248 teps and over multiple steps of the DNA base excision repair pathway.

249 anslocation-catalyzed oxidation and the base excision repair pathway.

250 d in an error-free manner by the uracil base excision repair pathway.

251 Genes encoding direct repair and base-excision repair pathways are required by B. abortus to f

252 process of transcription-coupled nucleotide excision repair plays a role in the removal of epsilonC

253 Nucleotide excision repair prevents up to 99% of point mutations, a

254 ated into precise locations focuses the base excision repair process to read and catalyze removal of

255 The nucleotide excision repair protein complex ERCC1-XPF is required fo

256 tures and interactions with other nucleotide excision repair protein factors of the two enzymes.

257 CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to int

258 A polymerase subunit RpoB and the nucleotide excision repair protein UvrA.

259 damaged DNA binding protein 2), a nucleotide excision repair protein, is upregulated by hypoxia.

260 disposition gene NTHL1, which encodes a base excision repair protein, revealed a mutational footprint

261 itive ubiquitylome identified the nucleotide excision repair protein, XPC, as a critical mediator of

262 A feature of many base excision repair proteins is that they contain [4Fe4S] cl

263 and 5caC are recognized and removed by base excision repair proteins, the 5hmC base accumulates to s

264 ropriate DNA lesions also interact with base excision repair proteins, we investigated whether CREB1

265 n repair by aiding the catalytic turnover of excision repair proteins.

266 cised oligomers, generated in the nucleotide excision repair reaction, are isolated by cell lysis and

267 RNase H2-initiated ribonucleotide excision repair (RER) efficiently removes single rNMPs i

268 Ribonucleotide excision repair (RER) removes ribonucleoside monophospha

269 pair capacity in an excision assay, and used excision repair sequencing (XR-seq) to map repair events

270 We developed excision repair sequencing (XR-seq) to study nucleotide

271 , we used the in vivo excision assay and the excision repair sequencing genome-wide repair mapping me

272 repair maps of the human genome obtained by excision repair sequencing to gain insight into factors

273 We have termed this method translesion excision repair-sequencing (tXR-seq).

274 tly developed in vivo excision assay and the excision repair-sequencing (XR-Seq) method have enabled

275 y and at single nucleotide resolution by the Excision Repair-sequencing (XR-seq) method to better und

276 ecently, we reported that as measured by the excision repair-sequencing (XR-seq), UvrD plays no role

277 ATLs target alkyl lesions to the nucleotide excision repair system (NER).

278 dducts in TGCT cells by using the human TGCT excision repair system.

279 th impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B, D, F, and

280 Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mech

281 y promoting transcription-coupled nucleotide excision repair (TC-NER) of cisplatin-induced DNA cross-

282 activity of transcription-coupled nucleotide excision repair (TC-NER).

283 ption-blocking adducts to undergo more rapid excision repair than adducts located elsewhere in the ge

284 ide Retrieval Assay" designed to measure DNA excision repair that is capable of quantifying the rate

285 and well-conserved sub-pathway of nucleotide excision repair that preferentially removes DNA lesions

286 d for both transcription-coupled and general excision repair, the earliest repair occurred preferenti

287 that beyond the known pathways, such as base excision repair, the process of transcription-coupled nu

288 we show that E-cadherin promotes nucleotide excision repair through positively regulating the expres

289 like 1 (NEIL1) glycosylases followed by base excision repair to restore the unmodified state.

290 epair (TC-NER) is a subpathway of nucleotide excision repair triggered by stalling of RNA polymerase

291 to current ideas, that cellular uracil base excision repair (UBER) enzymes target and cleave A3G-edi

292 DNA products are degraded by the uracil base excision repair (UBER) machinery with less than 1% of th

293 o observed with RNA pol II using uracil base excision repair (UBER)-deficient human cells.

294 polymerase X family that is involved in base excision repair, uses a processive hopping search mechan

295 e report the sequence specificity of BPDE-dG excision repair using tXR-seq.

296 in removal of photo-damage (e.g. nucleotide excision repair uvrABC, recombinases recBCD and resolvas

297 to extend from 8-oxoG during long-patch base excision repair was unknown.

298 all DNA-templated processes, including base excision repair where Pol beta catalyzes two key enzymat

299 ntaining CRE by UNG2 and, therefore, to base excision repair, whereas UNG2 exposure prevented CREB1 b

300 and breaks that are formed during nucleotide excision repair, which primarily removes bulky lesions.