ライフサイエンスコーパス: executioner

1 ase but shows key differences from the other executioners.

2 digm in which AIF can substitute for caspase executioners.

3 GSDMC, and GSDME, rather than GSDMD, are the executioners.

4 is setting function as downstream cell-death executioners.

5 well known as the core apoptotic cell death executioner, acts in early responses to neuronal injury

6 The executioners are members of a family of proteases founde

7 BHRF1 bound the Executioner Bak and, when cells were cultured without cy

8 eting their pro-apoptotic counterparts, the "executioners" BAX, BAK, and BOK that both initiate and c

9 Therefore, caspase-7 is not a conventional executioner but instead is a death facilitator that dela

10 ision-making process, by functioning both as executioner by damaging the biomolecules, or as savior b

11 Thus, no single executioner caspase (nor a combination of caspase-3 and

12 ez-Ruiz et al. emonstrate that the apoptotic executioner caspase 3 (CASP3) attenuates antitumor immun

13 ucing factor (AIF) nuclear translocation and executioner caspase 3 activation, in NBD rats.

14 neration, of the cleaved form of the central executioner caspase 3 is inhibited.

15 Given the presence of unusually long executioner caspase 3' UTRs in many metazoans, translati

16 ury, Drosophila wing disc cells that survive executioner caspase activation contribute to tissue rege

17 Thus, survival following executioner caspase activation is a normal tissue repair

18 post-mitochondrial signaling responsible for executioner caspase activation is controversial.

19 ints, including mitochondrial fragmentation, executioner caspase activation, and DNA damage, it is as

20 ene CIZ1, as essential for survival from the executioner caspase activation.

21 mediates cell-death response independent of executioner caspase activity and accompanied full-length

22 During apoptosis, executioner caspase activity has been considered a point

23 Caspase-6 is categorized as an executioner caspase but shows key differences from the o

24 neuronal degeneration is independent of the executioner caspase CED-3, but instead requires the acti

25 gh well known for its role in apoptosis, the executioner caspase DrICE has a non-apoptotic function t

26 During apoptosis, executioner caspase enzyme activation has been considere

27 Caspase-6 is an executioner caspase found directly regulated by p53, and

28 and its linker to determine the mechanism of executioner caspase inhibition by XIAP.

29 death: at the level of p53/CEP-1 and at the executioner caspase level.

30 rus that attacks lepidopterans, codes for an executioner caspase synthesized by 9 h after infection o

31 Caspase-7 is an executioner caspase that plays a key role in apoptosis,

32 l other DNA viruses, ascoviruses code for an executioner caspase, apparently involved in a novel cyto

33 ection, and the data further showed that the executioner caspase, caspase 3, does not become activate

34 Activation of the executioner caspase, caspase 3, is essential for many fo

35 ed forms of the classical apoptosis-inducing executioner caspase, Caspase 3.

36 In contrast, autoactivation of the executioner caspase-3 and -6 zymogens was not detected.

37 We show that BIRC6 directly restricts executioner caspase-3 and -7 and ubiquitinates caspase-3

38 epeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7.

39 ed IEC-specific knockout mice that lack both executioner caspase-3 and caspase-7 (Casp3/7(DeltaIEC)),

40 e EFES is homologous to a loop unique to the executioner caspase-3 and caspase-7 that are targeted by

41 IGF-I blocked activation of the executioner caspase-3 and the intrinsic initiator caspas

42 ivation concomitantly with activation of the executioner caspase-3 as the final step in the toxic cas

43 he apoptogen cytochrome c, and activation of executioner caspase-3 were determined by Western blottin

44 To dissect the nonredundant roles of the executioner caspase-3, -6, and -7 in orchestrating apopt

45 Apoptotic executioner caspase-3, -6, and -7, but not the inflammat

46 for an analogous intermediate of the related executioner caspase-3.

47 the proteolytic activation of the downstream executioner caspase-3.

48 d (iv) activation of initiator caspase-9 and executioner caspase-3.

49 are cleaved by caspases, most of them by the executioner caspase-3.

50 of cytochrome c and Smac, and activation of executioner caspase-3.

51 me c, and subsequently the processing of the executioner caspase-3.

52 We identified executioner caspase-6 as a transcriptional target of p53

53 initiator caspases 1 and 8 but not from the executioner caspase-6.

54 nd pattern of GrB-mediated activation of the executioner caspase-7 in vitro and in vivo.

55 We report here that the apoptotic executioner caspase-7 was activated in the splenocytes o

56 mature oligodendrocytes never activated this executioner caspase.

57 e a caspase cascade involving the downstream executioners caspase-3, -6, and -7.

58 s and their applications to directly monitor executioner (caspase-3 and -7) and initiator (caspase-8

59 Caspase-3 is the key "executioner" caspase, catalyzing the hydrolysis of a mul

60 Executioner-caspase activation has been considered a poi

61 Thus, cells can survive direct executioner-caspase activation, and variations in cellul

62 ns, we have designed an infrared fluorogenic executioner-caspase reporter, which reveals spatiotempor

63 Here, we test directly the role of executioner caspases (caspase-3, -6, and -7) in fiber ce

64 hways converge to activate common downstream executioner caspases (caspase-3, -6, and -7), resulting

65 Activities of executioner caspases (e.g., cas-6 and -3) became elevate

66 eolytic cleavage of apical caspases 8 and 2, executioner caspases 3 and 6, Bid cleavage, and release

67 MP also showed robust and fast activation of executioner caspases and apoptosis, the colorectal cance

68 hondrial factors necessary for activation of executioner caspases and apoptosis.

69 at displays attributes of both initiator and executioner caspases and includes a caspase recruitment

70 ngly suggest that Fas-mediated activation of executioner caspases and induction of apoptosis do not d

71 shion leading to activation of caspase-9 and executioner caspases and, surprisingly, activation of th

72 udy demonstrates the efficiency by which the executioner caspases are activated in vivo.

73 in many metazoans, translational control of executioner caspases by RBPs might be a strategy used wi

74 caspase 8 arose during evolution to trigger executioner caspases directly, circumventing viral suppr

75 Activation of executioner caspases during receptor-mediated apoptosis

76 orted here will enable direct control of the executioner caspases in apoptosis and in cellular differ

77 imaging to observe tangles and activation of executioner caspases in living tau transgenic mice (Tg45

78 eful in assessing the role of inhibiting the executioner caspases in minimizing tissue damage in dise

79 We tested the role of executioner caspases in organelle degradation by examini

80 the peptide linker by caspase-3, one of the executioner caspases involved in apoptosis, results in a

81 ose further processing is mediated by mature executioner caspases rather than initiator caspases.

82 that cleavage of Bid to tBid is mediated by executioner caspases suggests that a self-amplifying fee

83 s (KCs) activating the signaling kinases and executioner caspases that damage KCs, causing their shri

84 rt half-life may inhibit the activity of the executioner caspases toward specific substrates.

85 Executioner caspases were activated in detached pancreat

86 Transcripts for all three executioner caspases were identified in lens fiber cells

87 m activation of caspase-8 but not of distal, executioner caspases, and does not lead to apoptosis.

88 stricts the infection-mediated activation of executioner caspases, and inhibits virus propagation.

89 ssing, caspase-8 can be cleaved by activated executioner caspases, and reports of whether this cleava

90 ds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspase-7, and have

91 aying a nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspase-7, were iden

92 hway downstream of FLICE but upstream of the executioner caspases, caspase-3, -6, and -7.

93 Baculovirus p35, a suicide substrate of executioner caspases, is not cleaved by purified Dredd i

94 r of apoptosis protein (XIAP) suppression of executioner caspases, respectively.

95 aspase p10 subunit for initiator but not for executioner caspases, so that any free p20 formed by dea

96 Upon exposure to executioner caspases, TcapQ(647) was specifically cleave

97 demolition during apoptosis is completed by executioner caspases, that selectively cleave more than

98 We find that unlike the executioner caspases, which are readily activated by int

99 in the cytoplasmic release of mtRNA and that executioner caspases-3 and -7 (casp3/7) prevent cytoplas

100 caspases are predicted homologs of the human executioner caspases-3 and -7, but OfCasp3a (Orbicella f

101 is autoproteolysis, which directly activates executioner caspases-3 and -7, is unknown for the apical

102 ase specificity with the prototype apoptotic executioner caspases-3 and -7, suggesting that caspase-2

103 h regulates the initiator caspase-9, and the executioner caspases-3 and -7.

104 han a proteasome inhibitor at mobilizing the executioner caspases-3 and -7.

105 ded initiator caspases-8 and -10, as well as executioner caspases-3, -6, and -7.

106 on of caspase-8, consequently activating the executioner caspases-3, -6, and -7.

107 n contributes substantially to inhibition of executioner caspases.

108 te that tau is cleaved at D421 (DeltaTau) by executioner caspases.

109 937 cells that was preceded by activation of executioner caspases.

110 VXXDases, have short pro-domains, like human executioner caspases.

111 membrane permeabilization and activation of executioner caspases.

112 se of caspase-8 into the cytoplasm to engage executioner caspases.

113 f imaging, despite the presence of activated executioner caspases.

114 mmune circuits in which sensors, relays, and executioners cooperate to carry out pathogen clearance f

115 tion of novel reversible binders of the MLKL executioner domain by a protein NMR-detected fragment-ba

116 X-ray and NMR costructures of the human MLKL executioner domain covalently bound via Cys86 to a xanth

117 junction with phytic acid activates the MLKL executioner domain.

118 integrates into the plasma membrane via its executioner domain.

119 Caspase-8, an executioner enzyme in the death receptor pathway, was sh

120 tion of apical caspases 8 and 9 and also the executioner enzyme, caspase 3, whereas infection alone h

121 ed that Y-linked genes Zfy1 and Zfy2 act as 'executioners' for this checkpoint, and that wrongful exp

122 ace helix that connects the pseudokinase and executioner four-helix bundle domains.

123 ma 2 (AIM2) inflammasomes, or the pyroptosis executioner gasdermin D (GSDMD) contributes to atheroscl

124 some components or the downstream cell death executioner gasdermin D (GSDMD) led to an initial reduct

125 3CL proteases also inactivate the pyroptosis executioner Gasdermin D (GSDMD).

126 nents caspase 1 and 11, or of the pyroptosis executioner gasdermin D, reversed these adverse changes.

127 ormation from Texas and Virginia showed that executioners had no anaesthesia training, drugs were adm

128 with critical NADase activity, is a central executioner in a conserved programme of axon degeneratio

129 he PD-D/E(X)K nucleases that acts as a final executioner in parthanatos.

130 Since the aggression used by executioners is proactive, the execution paradox is solv

131 oediting, cancer cells deregulate cell death executioner mechanisms to escape immunotherapy-induced a

132 sible commitment to positive feedback in the executioner module.

133 Caspase-3 is an essential executioner of apoptosis responsible for regulating many

134 Caspase-3 is a main executioner of apoptotic cell death.

135 e alpha and TIR motif containing 1) is a key executioner of axon degeneration and a therapeutic targe

136 MLKL is the final executioner of canonical necroptosis; however, in axonal

137 Importantly, release of an executioner of caspase-independent apoptosis, apoptosis-

138 The C5b-9 complex is the executioner of CDC.

139 which leads to activation of caspase-3, the executioner of cell death.

140 Gasdermin D is an executioner of inflammatory cell death.

141 These findings place GSDMB as a central executioner of intracellular bacterial killing and revea

142 l-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death throug

143 lineage kinase domain-like pseudokinase, the executioner of necroptosis.

144 phosphorylation and aggregation of MLKL, the executioner of necroptosis.

145 We identify GSDME as an executioner of neuronal mitochondrial dysfunction that m

146 SARM1 is the central executioner of pathological axon degeneration.

147 Ninjurin-1 (NINJ1) is an active executioner of plasma membrane rupture (PMR), a process

148 ks at the level of NINJ1, a newly identified executioner of plasma membrane rupture in pyroptosis, ne

149 motif containing-1 (SARM1) acts as a central executioner of programmed axon death and is a possible t

150 SARM1 is a central executioner of programmed axon death, and this role requ

151 al factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration.

152 dermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic

153 SARM1 is the central executioner of the axonal degeneration pathway that culm

154 Furthermore, NINJ1 is an important executioner of this cell death to release inflammatory m

155 ein 1 (SARM1) is an evolutionarily conserved executioner of this degeneration cascade, also known as

156 The executioners of apoptosis are caspase family proteases.

157 ve overlapping but nonredundant roles as the executioners of apoptosis in humans.

158 Caspases are critical executioners of apoptosis, and living cells prevent thei

159 ptotic proteins, including caspases, the key executioners of apoptosis, and review the nonlethal func

160 ce caspases-3 and -6 are the most downstream executioners of apoptosis, the constitutively active ver

161 s) can bind to and inhibit caspases, the key executioners of apoptosis.

162 tensively studied as critical initiators and executioners of cell death pathways.

163 mTORC1 and c-Jun may play a critical role as executioners of demyelination in the context of perturba

164 n, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), wh

165 ccrued to impugn the presenilins (PS) as the executioners of intramembranous processing of APP.

166 Caspases, the executioners of programmed cell death, are normally synt

167 on caspases and their putative role as sole executioners of programmed cell death.

168 ith an emphasis on the role of gasdermins as executioners of pyroptosis and potential mediators to al

169 ss of pore-forming proteins that play as the executioners of pyroptosis, a lytic pro-inflammatory typ

170 We also consider the important role that the executioners of these cell death pathways, GSDMD and MLK

171 d Arl6ip5, Tnfrsf10b, Traf2, and Ubc are key executioners of this program.

172 activates caspase-9 and then caspase-3, the "executioner" of the cell.

173 ors (pathogen detection) to intermediates to executioners (pathogen clearance) via soluble factors.

174 Caspase-3 carries out the executioner phase of apoptosis, however under special ci

175 Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell dea

176 SARM1 as a central metabolic sensor and axon executioner presents an exciting opportunity to develop

177 ator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km

178 stimulate procaspase activity, showing that executioner procaspase conformational equilibrium can be

179 Mechanistically, B-PAC-1 treatment activated executioner procaspases and not other Zn-dependent enzym

180 including B-PAC-1 (L14R8), convert inactive executioner procaspases to their active cleaved forms by

181 tions demonstrated that direct activation of executioner procaspases via B-PAC-1 treatment bypasses a

182 ted caspase-3 has properties of a cell death executioner protease.

183 of the antiapoptotic protein Bcl-2 and the "executioner" protease caspase-3 in sepsis-induced gut ce

184 ibitor 2A (Spi2A), an inhibitor of lysosomal executioner proteases dependent on transcription factor

185 The apoptotic executioner protein BAX and the dynamin-like protein DRP

186 apoptotic proteins such as the mitochondrial executioner protein BAX.

187 rminal pore-forming domain of gasdermin, the executioner protein of a highly inflammatory cell death

188 totic Bcl-2-associated X protein (BAX) is an executioner protein of the BCL-2 family that represents

189 its that proteolytically regulate engineered executioner proteins and mammalian cell death.

190 Gasdermin family, renowned for their role as executioner proteins in pyroptosis.

191 molecules, independent of other pore-forming executioner proteins, gasdermin D, gasdermin E, and MLKL

192 nous control of life and death by regulating executioner proteins, with emphasis on the prototype BAX

193 induced by different stimuli share a common executioner proteolysis cascade, including caspase-3 and

194 caspases 6 and 7, other important downstream executioners, remained unchanged.

195 r understanding of IRE1alpha as a cell-death executioner, showing that upon ER stress, IRE1alpha degr

196 In plant systems, the identities of the main executioners that orchestrate cell death remain elusive.

197 strates for the cysteine protease cell death executioners, the caspases.

198 PCD through the induction of the cell death executioner VPE.

199 ay into three modules (initiator, amplifier, executioner), we use computer simulation and bifurcation

200 tivation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (

201 itiator caspases-1 and -8 also functioned as executioners when all known effectors of cell death were