ライフサイエンスコーパス: exemplify

1 roducts, and food science and technology are exemplified.

2 Here we exemplified a new process for converting aqueous lactose

3 Burn injury therefore exemplifies a superficial temporally dynamic pathology f

4 s shift, and suggest that chocolate conching exemplifies a ubiquitous class of powder-liquid mixing.

5 These results are the first to exemplify a ligand-induced GQ-GQ nanodevice as an aptase

6 Our method and results exemplify a new paradigm of multiscale measurement, wher

7 rinciples that underpin pHLA selectivity and exemplify a number of molecular approaches that can be u

8 The daily changes of light and dark exemplify a prominent cue for the synchronization of cir

9 eir involvement in homologous recombination, exemplifying a duplicate retention model in which one co

10 rther evidencing its essential function, and exemplifying a new approach for selective PLK1 inhibitio

11 crease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmen

12 nosomatids, a group of eukaryotic parasites, exemplifies alternate historical routes for cytokinesis

13 eling in combination with lithium pulses was exemplified among others by generating time-encoded SOS

14 Altogether, our findings exemplify an innovative computational-experimental appro

15 In addition, our results exemplify an under-recognized form of phenotypic expansi

16 eviously described allosteric inhibitors and exemplifies and extends the range of permissible chemica

17 e transcription regulators' tumor cistromes, exemplified at the 8q24 locus harboring both risk varian

18 This work exemplifies both the challenge of stabilizing highly dep

19 eries of 4-(aminomethyl)quinolin-2(1H)-ones, exemplified by 34, that inhibit bacterial DNA gyrase and

20 ctural alterations made within a lipid class exemplified by 4, which allow us to tune calculated and

21 ionship between hard work and prosperity, as exemplified by a conservative work ethic.

22 ter also possesses large magnetic anisotropy exemplified by a large, positive axial zero-field splitt

23 The versatility will be exemplified by a liquid chromatography-high resolution m

24 ed by a more glycolytic metabolic phenotype, exemplified by a more pronounced sensitivity to glycolys

25 tial energy landscape of the BiFeO(3) system exemplified by a rotation of the polar axis away from th

26 emical properties of a real drug scaffold is exemplified by a series of phosphorus-containing analogs

27 energy, our work reveals a potential pathway exemplified by a specific submolecular structure to achi

28 of NCMs in regulating the behaviour of CMs, exemplified by ACKR1(+)-endothelial cells, injection of

29 o assess the druggable genome in a disorder, exemplified by ADHD.

30 ulture can contribute to pollinator decline, exemplified by alarmingly high annual losses of honey be

31 ino acid is mischarged onto a wrong tRNA, as exemplified by AlaRS mischarging alanine to G4:U69-conta

32 This is best exemplified by alpha2/alpha3-GABA(A)R positive allosteri

33 characteristic of recessive KIF3B models as exemplified by an early-onset, autosomal-recessive, prog

34 ting the CH-pai bond-based stabilization, as exemplified by an enzyme-resistant hydrogel, may thus be

35 well-known tendency of sulfur to catenate is exemplified by an extensive series of polysulfide dianio

36 herapeutic possibilities in cancer, which we exemplified by an orthogonal pharmacological inhibition

37 ensitive detection of diverse ligand classes exemplified by antibodies, an E3 ligase, MDM2 proto-onco

38 long-term side effects of drugs as recently exemplified by association of LDL (low-density lipoprote

39 (AVIMM) for easy gene property extraction as exemplified by avian immune genes.

40 importance of lipin 1 to lipid metabolism is exemplified by cellular defects and lipid-based diseases

41 Exemplified by chromosome instability-mediated carcinoge

42 OTAC degraders of androgen receptor (AR), as exemplified by compound 34 (ARD-69).

43 covery of highly potent menin inhibitors, as exemplified by compound 42 (M-89).

44 We evaluated advanced lead molecules, exemplified by compound 52, in an in vivo cynomolgus mon

45 This is exemplified by correspondence between grid cell spatial

46 genetically manipulated with ease, which was exemplified by creating genetic knockouts in the tumor s

47 l, or pathological attributes of ADE disease exemplified by dengue viruses (DENV).

48 l and versatility of the AvidCAR platform is exemplified by designing ON-switch CARs, which can be re

49 Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and c

50 This is exemplified by EndMT in cardiac valves, which are lined

51 potent and effective PROTAC ER degraders, as exemplified by ERD-308 (32).

52 g the physical diffusion of small molecules, exemplified by F4TCNQ, in the passive polymer polystyren

53 This adaptation is exemplified by faster accumulation of glycine-modified l

54 uring secondary structure-forming sequences, exemplified by G quadruplex and H-DNA motifs, across the

55 a and other oncogenic transcription factors, exemplified by GATA3 and AP1, drive global enhancer gain

56 ling mechanisms normally operate in cells as exemplified by growth factors.

57 low-temperature aqueous alteration, such as exemplified by Hadean-aged detrital crystals from Wester

58 mechanism for the activation of O(2) is best exemplified by heme centers in biological systems.

59 tissue-specific gene expression patterns, as exemplified by highly regulated expression of RUNX trans

60 nd enriched for senescence-associated genes, exemplified by IL1B, where de novo cohesin binding is in

61 electively promotes beneficial gut bacteria, exemplified by increased R. intestinalis, and reduction

62 Climatic effects exemplified by irregular "dry" and "wet" periods in the

63 The robustness of the protocol is further exemplified by its implementation under UV, blue light o

64 viruses in the Reoviridae, a family that is exemplified by its simple, single-shelled member cytopla

65 bundance of taxa in the lower trophic level, exemplified by larger Hymenoptera connecting networks of

66 hat the collagen prolyl 3-hydroxylase family exemplified by Leprel1 and Leprel2 is subject to methyla

67 demonstrate that highly diverse phenotypes, exemplified by lizards and snakes, can and do arise from

68 igate the role of Myo18A in nonmuscle cells, exemplified by macrophages, which express more Myo18Abet

69 However, temporal coherence and control, as exemplified by manipulating a single quantum degree of f

70 and bHLH (basic helix-loop-helix) proteins, exemplified by MAX and TCF4 recognition of 5caC.

71 y for the mu-opioid-Gal1 receptor heteromer, exemplified by methadone.

72 delling to address global health challenges, exemplified by models for the HIV crisis, emerging patho

73 required for SCF(TIR1/AFB) functionality, as exemplified by mutants deficient in the NEDD8-activating

74 talline metals, and ensemble-type electrodes exemplified by nanoparticles on an electrode support sur

75 but diabetes accelerated lesion progression, exemplified by necrotic core expansion.

76 ncluding respiratory and enteric systems, as exemplified by newly emerged severe acute respiratory sy

77 le other phosphorylations are inhibitory, as exemplified by PB1 Thr223 modification.

78 This reactivity is exemplified by photoinitiated (with visible light and/or

79 nuclear mRNA metabolism is non-conventional exemplified by polycistronic transcription and mRNA proc

80 Its usefulness is exemplified by previous studies that used it to display

81 mune defense capacity during this period, as exemplified by production of type 1 and 3 interferons (T

82 rstanding of NE lineage plasticity dynamics, exemplified by prostate cancer, NSCLC, and SCLC.

83 nature and structure of psychopathology, as exemplified by psychodynamic, DSM/ICD, and HiTOP paradig

84 1 mW/cm(2)) and catalyst loadings (<50 muM), exemplified by reaction completion within 60 s of irradi

85 duction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common fun

86 anges driven by transcription factors, as is exemplified by reprogramming somatic cells to pluripoten

87 d a series of potent PROTAC STAT3 degraders, exemplified by SD-36.

88 Inter-EEC communication is exemplified by secretin-induced GLP-1 secretion.

89 very of potent and effective SHP2 degraders, exemplified by SHP2-D26.

90 r that higher order assemblies on membranes, exemplified by signalosomes, are a paradigm for the regu

91 ly meritorious members of advantaged groups, exemplified by social media campaigns centered around ha

92 ain long-lasting immortality, as prominently exemplified by stem cells.

93 The utility of this approach is exemplified by synthesis of well-defined block copolymer

94 microorganisms exhibit nutrient preferences, exemplified by the 'hierarchical' consumption of certain

95 ctors: bZIP (basic leucine-zipper) proteins, exemplified by the AP-1 and CEBPbeta recognition of 5mC;

96 dy of the atmospheric autoxidation in amines exemplified by the atmospherically important trimethylam

97 The utility of this catalytic system is exemplified by the borylation of substrates containing p

98 Jahn-Teller-active transition-metal ions, as exemplified by the broad classes of respective oxides.

99 epitopes remains a substantial challenge, as exemplified by the case of lipid transfer polyproteins,

100 pproach to study orphan protein function, as exemplified by the characterization of TMEM41B as novel

101 mporary developmental quiescence (diapause), exemplified by the dauer larva stage of the nematode Cae

102 S5 polymerase is a promising drug target, as exemplified by the development of successful commercial

103 rkflow thereto from synthesis to validation, exemplified by the discovery of a covalent antagonist fo

104 highly pathological myelin proteome profile, exemplified by the discovery of reduced levels of the mo

105 are substantial threats to global health, as exemplified by the emergence of two severe acute respira

106 expansion of the dynamic range of synapses, exemplified by the enhancement of hippocampal long-term

107 eds can adapt rapidly to human activities as exemplified by the evolution of resistance to herbicides

108 This is exemplified by the extensive reporting of two-dimensiona

109 The flexibility of analytical approaches is exemplified by the fact that no two teams chose identica

110 ningless speech sounds and visual shapes, as exemplified by the famous correspondences between the ps

111 synthesizing polyacenes via ring annulation exemplified by the formation of pentacene (C(22) H(14) )

112 pancreatic ductal adenocarcinoma (PDAC), as exemplified by the frequent loss of the tumor suppressor

113 This transcriptional architecture is exemplified by the genes menE-menC-MW1733-ytkD-MW1731 in

114 the studies have used cytosolic domains, as exemplified by the groundbreaking studies that elucidate

115 associated with spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel

116 o the pathology of Alzheimer's disease (AD), exemplified by the identification of coding variants in

117 ed its usefulness in medicinal chemistry, as exemplified by the increasing number of protein targets

118 breadth of the genetic variation of SDP1 was exemplified by the intra- and inter-specific diversity o

119 ging landscape of beta-lactamase inhibitors, exemplified by the introduction to the clinic of combina

120 t of nearly all common functional groups, as exemplified by the late-stage derivatization of several

121 This situation is exemplified by the malaria parasite, which spends a subs

122 ther proteins on the microtubule lattice (as exemplified by the motor kinesin-1).

123 ed by different transcriptional networks, as exemplified by the mutually exclusive expression and cro

124 A class of translation inhibitors, exemplified by the natural product rocaglamide A (RocA),

125 The utility of the new chemistry was exemplified by the one-pot synthesis of a selection of N

126 improving the electrocatalytic activity, as exemplified by the oxygen evolution reaction.

127 This is exemplified by the plant-peptide hormone mimics, the CLA

128 rs fully retain their disorder and dynamics, exemplified by the positively charged linker histone H1.

129 The method is exemplified by the preparation of 2,3,6,7-anthracenetetr

130 as been made in each of these three areas as exemplified by the recent development of a CHD genetic r

131 This issue is exemplified by the recently re-established grey wolves o

132 This effect is perhaps best exemplified by the risk of developing arterio-occlusive

133 f-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet a

134 al applicability of the developed method was exemplified by the single-stage synthesis of commercial

135 ere we study a notorious biological model as exemplified by the sister relationships between mackerel

136 This new synthetic approach is exemplified by the synthesis and characterization of the

137 The strategy is exemplified by the synthesis of the marine natural produ

138 nctional group tolerance of this method were exemplified by the total synthesis of the neolignan natu

139 to the discovery of a novel chemotype series exemplified by the trans racemic compound 11i.

140 ovide an attractive target for therapeutics, exemplified by the use of SMO antagonists for the treatm

141 e human malaria parasites, this diversity is exemplified by the variant gene family called var, which

142 ular functions including membrane fusion, as exemplified by the yeast vacuole, which uses various PIs

143 ence of defects on the electronic landscape, exemplified by their impact on the device built-in poten

144 ected from LPS-induced acute inflammation as exemplified by their superior clinical score and effecti

145 eability relationships in the chemical space exemplified by these natural products, we generated a li

146 The multi-target approach that is exemplified by these types of strategies will probably b

147 roperty is expected to find multifaceted use exemplified by transportation and infrastructure applica

148 y(1), and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue re

149 These differences are exemplified by variations in susC genes involved in poly

150 ions can be tuned by band gap engineering as exemplified by various pristine fullerenes such as C(60)

151 e affinity between ligands and receptors, as exemplified by virus-cell binding and antibody-antigen i

152 ssemblies even if the building blocks - here exemplified by VSV M- and N-protein - are structurally c

153 sive co-association between TFs and RBPs, as exemplified by YY1, a known RNA-dependent TF, and RBM25,

154 emperor penguins Aptenodytes forsteri, which exemplify capital breeding, we hypothesized that the sta

155 The dried herbs market exemplifies complex supply chains attractive to criminal

156 d for nontrivial lattice model Hamiltonians, exemplifying convergence over a range of 13 orders of ma

157 T(H)17 cells exemplify environmental immune adaptation: they can acqu

158 Outcomes are exemplified for Diels-Alder cycloadditions, oxidative ad

159 ated for biotransformation using whole cells exemplified for the dehydration of n-octanaloxime to n-o

160 We describe and exemplify four fundamental approaches to the generation

161 Exemplified gray zones include a radiographically intact

162 nic processes of the incorporated materials, exemplified here by singlet exciton fission followed by

163 The protocol, exemplified here by stamping cultured neurons with adeno

164 eneral route to very large molecules, and is exemplified here by the synthesis and structural charact

165 The tools exemplified here could be broadly applied to delineate d

166 than 70% was realized using OFPMS-dI-ICP-qMS exemplified here.

167 The mechanism identified here in Drosophila exemplifies how adult functions can be modulated at the

168 ystem with its multiple different antitoxins exemplifies how ancient nucleotide-based signaling mecha

169 More generally, this work exemplifies how increasing genetic irregularities are re

170 differentiate sites of organ initiation and exemplifies how spatio-temporal positional information c

171 This work exemplifies how the genetic diversity of B. oleracea may

172 Thus, our findings exemplify how a cell-intrinsic developmental timing prog

173 The results exemplify how a structure-encoded synaptogenic protein c

174 ng drug Elesclomol.Collectively, our results exemplify how aberrant activation of a developmental tra

175 These results exemplify how genetic mutations can have an impact on de

176 nd gene regulation by T-box riboswitches and exemplify how higher-order RNA-RNA interactions achieve

177 These technologies exemplify how integrating techniques from multiple disci

178 Several studies discussed here exemplify how nonhuman primate research has enriched our

179 Our results exemplify how protein design can overcome impediments en

180 evelopment for most receptor complexes, they exemplify how receptor complexes can be drugged, and lay

181 We highlight a case study exemplifying how to integrate these resources.

182 This study thus exemplifies importance of the DMET protein abundance dat

183 otodiodes offer several design opportunities exemplified in a biometric monitoring application that u

184 This approach has been exemplified in a new synthesis of tesirine, including th

185 ered using our newly established workflow as exemplified in an experiment using UPR perturbation in a

186 This challenge is well exemplified in associative learning research.

187 Persians (539 BCE), who facilitated movement exemplified in Beirut by an ancient family with Egyptian

188 key ideas in organic chemistry, and are both exemplified in biphenylene(1-3)-a molecule that consists

189 ssion in multi-host systems is difficult, as exemplified in bovine tuberculosis (bTB) systems, but is

190 Exemplified in melanoma, LTR-overlapping transcripts wer

191 Altered UPR signaling, exemplified in Rnf5(-/-) mice, coincides with altered gu

192 Molecular features, as exemplified in the clinicogenetic risk model m7FLIPI, ar

193 ELINA is exemplified in the discovery of steroid sulfatase (STS)

194 e unit cell crystal size of MHs (1.2 nm), as exemplified in the experimental case study performed on

195 rade-off between precision and efficiency is exemplified in the state of the art editor REPAIR, which

196 ved islets while fostering immune tolerance, exemplified in Yoshihara et al., holds the promise of a

197 he method and present five case studies that exemplify its efficacy and speed for analyzing 3D struct

198 To exemplify its utility, PACT assessed two deep mutational

199 Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca(2+)](cyt

200 nanoscale Kondo lattices - Kondo droplets - exemplifying nanoscopic replicas of heavy-fermion materi

201 descriptors of monomer units to discover and exemplify novel, biofilm-resistant (meth-)acrylate-based

202 Here we exemplify one such network using our own data on differe

203 We also exemplify our approach by applying the framework to a da

204 We exemplify our design and development through our experie

205 plicated in the outbreak and review how they exemplify racial capitalism.

206 d-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability an

207 eomics datasets from two human pathogens, we exemplify several conclusions that can be drawn from a r

208 This work exemplifies significant progress towards the development

209 We exemplify SOM-RPM using ToF-SIMS imaging data from a mou

210 This clinical case exemplifies some of the practical challenges in manageme

211 input synchrony onto preBotC output neurons exemplifying synchronous propagation of network activity

212 The exemplified syntheses of several biologically and clinic

213 We also exemplify tactics that can increase the chance of succes

214 The three species exemplified that different mechanisms, i.e., swimming ac

215 the metal-insulator transition of VO(2), we exemplify that mobile dopants weakly coupled to the crys

216 We exemplify that viral-like accessory genome elements that

217 ing from novel spirocyclic intermediates, we exemplified the preparation of an undescribed class of c

218 Previous work has exemplified the use of bitopic ligands as a powerful str

219 piratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid dia

220 This study therefore exemplifies the high ability of fungal colonies to diffe

221 genomic basis of disease and complex traits exemplifies the importance of statistical methods in gen

222 This study further exemplifies the importance of weight loss and risk facto

223 t regulate senescence in polyploid wheat and exemplifies the integration of time-series data with pub

224 tric and multiferroic materials more broadly exemplifies the potential for novel insight into nanosca

225 n on an experimentally relevant length scale exemplifies the power of accurate and flexible ML-driven

226 This study exemplifies the power of function-oriented synthesis in

227 This study exemplifies the revolutionary potential of combined trad

228 Naegleria gruberi RNA ligase (NgrRnl) exemplifies the Rnl5 family of adenosine triphosphate (A

229 This body of work exemplifies the scientific power of a synergistic combin

230 This work therefore exemplifies the superiority of high-entropy materials fo

231 at are deficient in homologous recombination exemplifies the utility of synthetically lethal genetic

232 This work exemplifies the value of haplotype-resolved genomes to b

233 ion to rpl10a in the immune system, and thus exemplify the advantages of the zebrafish model to study

234 To exemplify the applicability of both tools, we analyzed t

235 These data also exemplify the applicability of targeting host factors up

236 Many of the studies described exemplify the application of new techniques and modeling

237 We exemplify the capability of this approach by 3D visualiz

238 it dynamics so that the fly walks backwards, exemplify the command-type mechanism.

239 These results exemplify the complex coupling between protonation of an

240 The results obtained in this study exemplify the complex mode of action of "multiaction" Pt

241 To exemplify the concepts and tools, two data sets were ana

242 talyst and use of simple starting precursors exemplify the economic viability of this method.

243 by high rates of neurological disorders and exemplify the global health burden associated with this

244 Results from this work exemplify the importance of competitive immobilization w

245 We also exemplify the importance of flexibility using a mesh-bas

246 tree along with a script and test dataset to exemplify the mapping strategy.

247 These results not only exemplify the means to create extensive, self-strained n

248 We exemplify the method on sets of RNA-seq data from human

249 Thus, although Trichoplax and Hoilungia exemplify the morphologically simplest free-living anima

250 n polarization cell culture and mouse models exemplify the oversimplicity of in vitro cytokine treatm

251 We exemplify the performance of the protocol with three tes

252 We exemplify the power of covalent tethering using the natu

253 n inhibited state in the nucleus and further exemplify the role of the nucleosome in regulating diver

254 These results exemplify the role that Polkappa plays in cellular adapt

255 the Late Jurassic Eocaecilia, both of which exemplify the stepwise acquisition of apomorphies.

256 We exemplify the symmetry fibrations in gene regulatory net

257 The Heme III/IV and I/II pairs exemplify the T-shaped heme packing arrangement, prevale

258 We then exemplify the use of NATpare by identifying tissue and s

259 To exemplify the use of WLMC with real climate data, we ana

260 Finally, to exemplify the utility of LipidMS, we investigated the li

261 We exemplify the utility of our approach on two hormone dri

262 We exemplify the utility of this approach by reconstructing

263 We exemplify the value of understanding cancer-related prot

264 1 suggests a rare terpene cyclase machinery, exemplifying the chemical diversity in this phylogenetic

265 out mice also display an altered microbiome, exemplifying the dynamic relationship between host metab

266 decision-making about the therapies offered, exemplifying the implementation of precision medicine.

267 levels upon IAV infection or HA expression, exemplifying the importance of PARP1 for IAV-induced red

268 rogating regeneration of the diseased heart, exemplifying the importance of understanding the mechani

269 normalized abundances of their related ARGs, exemplifying the potential impact of selective pressures

270 ation and detection of three model proteins, exemplifying the promise of microring resonators arrays

271 and finally increased colistin consumption, exemplifying the vicious cycle.

272 w to facilitate forward engineering efforts, exemplify their broad-host-range applicability, and demo

273 Exemplifying their importance, the loss or dysfunction o

274 /manganese superoxide dismutase (SOD) family exemplifies this deficit, as the specific metal used by

275 nctional hydrogen bond donor (HBD) catalysis exemplifies this in which a broad collection of enantios

276 ding protein central to NF-kappaB signaling, exemplify this challenge.

277 We exemplify this concept with SIEC major histocompatibilit

278 Corals exemplify this concept, where shifts in the algal symbio

279 We exemplify this data integration issue for a chronic kidn

280 We exemplify this flexibility by uncovering the single-frag

281 We exemplify this instrument with up to 0.5 frames per seco

282 We exemplify this on LiNi(0.8)Mn(0.1)Co(0.1)O(2) (NMC811)/g

283 Inhibitors of essential mitotic kinases exemplify this paradigm shift, but intolerable on-target

284 We exemplify this point by using this approach to prepare r

285 ctors or in segmented flow systems, which is exemplified through stereoselective phase-transfer catal

286 vidence of the clinical relevance of stress, exemplified through the risk of infectious diseases.

287 ty Disorder (ADHD) and conduct disorder (CD) exemplify top-down dysregulation conditions that show a

288 i-IgLON5 and anti-NMDA receptor encephalitis exemplify two diseases in which sleep disorders are prom

289 neuron doctrine based on circuit features he exemplified using cerebellar basket cell projections.

290 However, it has not been exemplified with a supramolecular polymer that features

291 via a one-electron copper(I/II) shuttle, as exemplified with an aerobic alcohol oxidation.

292 d in parallel to protein glycation patterns (exemplified with hydroimidazolone modifications of argin

293 hem as references markedly alters results as exemplified with IFNG mRNA expression.

294 elationship of KDM1A inhibitors, as has been exemplified with ORY-1001 (iadademstat), a potent and ir

295 The application of both approaches has been exemplified with respect to substrate scope and also pre

296 ta-disubstituted beta-aminoalkylboronates is exemplified with the functionalization of the amino grou

297 The method is exemplified with the synthesis of a series of rare and b

298 velopment of HDAC10-selective inhibitors, as exemplified with the Tubastatin A scaffold.

299 er of bicyclic peptides as targeting probes, exemplified with the tumor-overexpressed matrix metallop

300 Reactions exemplified with this terminal ynimide reagent include a