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1 defined target through which its effects are exerted.
2 emerging, however, in which small molecules exert a biological effect by interacting with RNA, both
3 ssembly or disassembly at the site of action exert a critical impact on damage bypass, even though kn
4 biogeochemical cycling, soil microorganisms exert a critical role in mediating the direction and str
6 the identified mutations are demonstrated to exert a gain-of-function mechanism, augmenting transform
7 ts indicate that metal-rich groundwater will exert a greater control on stream water chemistry and me
8 avlovian drug-associated conditioned stimuli exert a major influence on the initiation and maintenanc
9 posttranslationally modified residues do not exert a major influence on the static structure of the e
10 global aspects of cortical development, and exert a persistent influence on brain development during
12 urrently a controversial debate whether MSCs exert a pro- or anti-tumor action, mathematical models s
13 is proposed in which non-nicotinic elements exert a proinflammatory effect that is functionally anta
14 e that maternal psychological resilience may exert a salubrious effect on offspring telomere biology
15 ered that miR-3668, miR-4732-5p and miR-6073 exert a selective effect on Shigella infection by impair
18 that both AEC- and NEC-based DNAm signatures exerted a lower classification error than the PBMC-based
20 d mainly for cell mass production, while DWB exerted a prebiotic effect, protecting and enhancing the
22 (DOPG), but not dioleoylphosphatidylcholine, exerted a similar inhibitory effect, completely blocking
25 rogenases that differ in "catalytic bias" by exerting a disproportionate rate acceleration in one dir
27 includes HY5, the phytochromes and the PIFs exerts a central function in coupling these growth respo
30 ion of miR-3085-3p, but in this instance, it exerts a feedback inhibition on signaling with SMAD3 and
31 rotein Signaling 6 (RGS6) revealed that RGS6 exerts a GPCR-dependent influence on GIRK-dependent sign
33 in which a single type of descending neuron exerts a high-level control to elicit a coordinated chan
34 esults show that ACh released by motoneurons exerts a hitherto unknown function independent of myofib
36 the recruitment of cells of innate immunity exerts a mechanistic role in disease progression, determ
37 eover, Ribo-Seq analysis uncovered that CDK1 exerts a particularly strong effect on the translation o
41 site towards the seep, suggesting that CO(2) exerts a strong control on isotopic fractionation in nat
43 the epsilon heteroatom in oxapipecolic acid exerts a strong trans substantiating effect through lone
44 over the Amazon, indicating that photolysis exerts a substantial control over the atmospheric SOA li
45 d differentially by the same stimulus, which exerts a synergistic effect on PDCD4 expression and ther
47 not just respond to exogenous cytokines, but exerts active "angiocrine" gatekeeper roles, controlling
49 ranging from enzymes to synthetic catalysts, exert adaptive motifs to maximize their functionality.
50 complaints on this risk were significant and exerted almost exclusively through a general sleep compl
52 ctive effects against cardiovascular disease exert an anti-atherothrombotic effect via inhibition of
54 y NK cells carry proteins and miRNAs able to exert an antitumoral effect, even within a highly immune
56 dicate that reduction of carbonate rocks can exert an important positive feedback on strain localizat
57 sphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt for
58 value = 598 vs. 514 mumol/L, respectively), exerted an antioxidant activity significantly better tha
59 The architecture of multivalent polymers exerts an amplified interaction between attached ligands
63 Thus, the old tuberculosis drug pyrazinamide exerts antibacterial activity by acting as a target degr
66 data indicate that sGC stimulation with PRL exerts antiinflammatory actions in the liver through mec
68 nnabinoid 2-arachidonoyl-sn-glycerol (2-AG), exert anxiolytic-like effects in rodent models via 2-AG-
73 simultaneously measure the force and torque exerted at the tip of the probe when contacting with the
74 acrophages to the discrete nervous niche may exert axon guidance and nerve regeneration and thus cont
75 rated fatty acids (PUFA) such as EPA and DHA exert beneficial effects on intestinal integrity in anim
78 lammation, and immune responses, and thereby exert both adaptive and maladaptive roles in disease pat
79 e that simulates the solid mechanical forces exerted by a growing tumor on the surrounding brain tiss
80 eet imaging with AFM, we measured the forces exerted by a macrophage during FcyR-mediated phagocytosi
81 tegy to harness the anti-inflammatory effect exerted by activation of the AHR pathway in the skin.
83 Here, we reveal hypoxia-monitoring function exerted by astrocytes through an O(2)-regulated protein
85 as to quantify the dynamic traction stresses exerted by cells under different experimental conditions
87 ver, it is shown that the viscous drag force exerted by flow on a translocating DNA can be exploited
88 granulysin-mediated innate immune mechanism exerted by gammadelta T cells to kill late-stage blood-r
91 on the slowing-down of SCA at MLO is mainly exerted by intensified drought stress acting to offset t
96 evidence indicating how the mechanical cues exerted by the extracellular matrix (ECM), cell-ECM and
98 served expansion is due to internal pressure exerted by the gaseous product in the crystal lattices o
99 rongly influenced by deterministic selection exerted by the plant host, rather than stochastic proces
100 rescence quenching effect, greater than that exerted by the pyridazine arising from reaction with the
101 ion by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are oppo
103 e regulators of the renin-angiotensin system exerting cardioprotective effects in models of heart fai
105 aternally transferred thyroid hormones (THs) exert context-dependent effects on offspring survival an
106 w gene regulatory proteins and sigma factors exert control of gene expression in B. burgdorferi requi
108 neuronal activity and synaptic transmission, exerting control on circuit functions that may play dist
109 y accessible chiral carboxylic acid catalyst exerts control over asymmetric cyclizations of acyclic k
112 that the amyloid aggregation process per se exerts cytotoxic effects through the interaction of amyl
114 we investigate whether the SubM-VLO circuit exerts descending regulation over airway vagal reflexes
116 model for how individual pDCs are endowed to exert different functions in vivo during a viral infecti
117 lar targeting of synaptic inhibition able to exert different transformations of the neuronal input-ou
118 effects by promoting autophagic flux and by exerting direct effects on sodium transport and inflamma
121 We conclude that sHsp hetero-oligomerization exerts distinct regulatory effects depending on the sHsp
123 echanisms that allow IL-2-STAT5 signaling to exert divergent effects across CD4(+) T cell subsets and
125 t of LIN28B-an oncofetal RNA-binding protein exerting diverse effects via negative regulation of let-
129 cking Ship1/2 abrogated EMC cell survival by exerting dual effects on the BCR signaling cascade.
130 thermore, we show that cohesin and CTCF also exert effects on the host cell that promote antiviral de
131 [BPA(25)], or 250 mug/kg BW/d BPA [BPA(250)] exerted effects similar to that of EE2 at 0.5 mug/kg BW/
132 ow a single mutation in the KLF1 zinc finger exerts effects on erythroid physiology in CDA type IV.
133 Research on the mechanisms by which MeCP2 exerts effects on gene expression in neurons, studies of
134 eported to enhance oligodendrocyte survival, exerts effects on immune cells, specifically microglia a
136 disorders that show a reduced willingness to exert effort in the pursuit of reward.SIGNIFICANCE STATE
137 human behavior, and a reduced willingness to exert effort is a characteristic of many clinical disord
140 ganizes a dynamic cobalamin binding site and exerts exquisite control over coordination geometry, rea
141 P) sugar-polyolefin conjugate can be used to exert external control over thermotropic phase behavior
143 eases task engagement and the effort animals exert for reward, despite decreasing reward valuation.
144 Our findings suggest that mechanical forces-exerted from above and below progenitors of multilayered
146 feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humor
148 t-dependent production of IL-17A and IL-17F, exert homeostatic functions in the gut upon microbiota-d
150 est that the gastrointestinal microbiome may exert immunomodulatory effects in allo-HCT patients at l
151 ppressor cells (MDSCs) are immune cells that exert immunosuppression within the tumor, protecting can
152 h factor beta1 (TGFbeta1) is a cytokine that exerts immunosuppressive functions, as reflected by its
155 during infancy, and the role that experience exerts in promoting the maturation of the hippocampus-de
156 the forwards and backwards forces an animal exerts in response to rewards, suggesting a potential re
157 control of the mammalian auditory system and exert influence on cochlear mechanics to modulate percep
161 s with computation, we show that each isomer exerts intrinsic control by affecting distinct steps in
162 a selective innate repair receptor agonist, exerts islet protective and antiinflammatory properties
164 ylation site, cg05126514 within the BSN gene exert its effect on CAD through central nervous system-l
171 suggest a neural mechanism by which ketamine exerts its antidepressant efficacy, via rapid blunting o
175 hing is known about the extent to which CodY exerts its effect through small regulatory RNAs (sRNAs).
176 heral to the central nervous system and that exerts its effects on neurons by signalling through tyro
177 ffect: -2.70; p = 0.03), indicating that DUP exerts its effects on treatment response through affecti
179 pressor in mice and suggest that the protein exerts its function mainly by limiting the extent and du
180 n beta(7) function, suggesting that syndecan exerts its influence, at least in part, by coordinating
181 ays with these variants revealed that Cyt1Aa exerts its insecticidal activity and hemolysis through d
183 its Toll/interleukin-1 receptor (TIR) domain exerts its pro-neurodegenerative action through NADase a
188 volution of oxygenic photosynthesis, thereby exerting key influence on Earth's climate and the redox
191 exist in current understanding of how tumors exert local effects on resting-state functional MRI read
192 etic mechanisms respond to external signals, exert long-term effects on gene expression and have been
193 oth peptides act locally, the inhibitor EPF1 exerts longer range effects than the activator Stomagen.
196 Here, we show that healthy human individuals exert more effort to minimize punishment than to maximiz
198 e transitions and how state-encoding neurons exert neuromodulatory effects on sensory perception and
199 S dysfunction, recent data suggest that they exert neuroprotective roles in CNS homeostasis through c
200 uroactive, modulating neuroplasticity and/or exerting neurotoxic effects in part through their effect
203 cellular NEC-associated factors that jointly exert nuclear lamina- and membrane-rearranging functions
204 ile forces that tumor spheroids collectively exert on highly nonlinear three-dimensional collagen net
205 evolved, offer a solution to the stress ROS exert on molecular targets at the bacterial cell envelop
207 that a significant portion of the selection exerted on microbes is explained by the environment and
209 wide-ranging array of impacts that exercise exerts on atherosclerosis and the cardiovascular system.
211 action and demonstrate the influence the SML exerts on emissions of iodine and potentially other vola
212 o the pharmacological effects that bupropion exerts on heteromeric 5-HT(3AB) receptors, in particular
214 neuronal populations and neuro-mediators can exert opposing effects, promoting or inhibiting tissue i
217 human MET receptor (LihMET), can be used to exert optical control over the insulin or MET signaling
220 malignant, viral, and bacterial disease, and exert pathological effects in autoimmune disorders.
221 rugs in clinical use and under investigation exert pharmacological effects or improve efficacy of coa
222 he D(1) agonist increased the willingness to exert physical effort for reward as well as reduced the
223 ilizes the rigidity of the outer membrane to exert pleiotropic effects on the functionality of gram-n
225 lysis, we show that MHC-IB reactive NK cells exert positive influence on the immunity, countering neg
229 epithelial-mesenchymal transition (EMT), VAL exerts potent pro-invasive and pro-metastatic effects th
230 uld be a prototype for a general approach to exert precise control over pore diameter in physisorbent
231 ted receptor-alpha (PPAR-alpha) agonist that exerts profound anti-inflammatory effects in animal mode
232 like 1 (NFE2L1) transcription factors, which exert proliferative and protective functions, respective
233 ty acids, in particular omega-3 fatty acids, exerts protective actions reducing vascular and systemic
234 Mechanistically, we demonstrate that APP-103 exerts protective effects by specifically targeting the
236 stimulation of 5-HT(1A) receptor in the mPFC exerts rapid and sustained antidepressant-like effects v
238 ult, we find that DNA-bridging proteins must exert rather strong constraints on their binding sites;
239 ustly in cells and that several together can exert regulation comparable to GCAUG in a trichromatic s
241 ible factors (HIF-1alpha and HIF-2alpha)-can exert renoprotective effects by promoting autophagic flu
242 also have virus restriction mechanisms that exert selective pressure on the viruses during sexual tr
244 t GnRH agonist treatment after puberty onset exerts sex-specific effects on social- and affective beh
251 of vital importance in materials science by exerting significant influence on various properties of
252 s who were disadvantaged by unequal payments exerted significantly less conservation effort than othe
253 that medicated Parkinson's disease patients exert similar effort to gain reward but less effort to a
254 es with 70 analogues, unveiling several that exert similar or higher activity against nSMase2 with fa
255 tional analysis revealed that people with PD exerted similar physical effort in return for a reward b
258 dicating that percolation of reducing fluids exerts strong control on the mobilization of carbon and
259 regarding how this tiny brainstem structure exerts such varied and significant influences over brain
260 y block both PI3K and RAS signaling, thereby exerting synergistic anti-tumor effects on ovarian cance
262 show that all of these YAP1 fusion proteins exert TEAD-dependent YAP activity, while some also exert
264 hereby the S-configuration on both generally exerted the highest activity and selectivity on DAT.
266 tanin to the microtubule while the AAA motor exerts the forces that extract tubulin dimers and sever
267 ty at genes implicated in lysosomal function exerts the largest effect on GBA associated risk for dis
270 ur experimental system, the host compartment exerts the strongest effects on mycobiome assembly, foll
272 ed sulfane sulfur compounds (H(2)S(n)), that exert their biological actions via cysteine S-sulfhydrat
281 l activity in vivo, while the glycooligomers exert their inhibitory function post attachment of virus
282 in interaction assays indicate that the PRRs exert their repressive activity by binding directly to t
284 chanism(s) activated by these supplements in exerting their protective actions remain poorly understo
285 nstrate that interneuron transplantation can exert therapeutic behavioral effects without necessarily
286 ction is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular ser
287 ion with the surrounding elastic bodies that exert these forces, raising the question of which are th
291 oncerns the role of the prefrontal cortex in exerting top-down control over mnemonic activity in the
292 ate (Anisotremus surinamensis), which may be exerting top-down pressure on C. abbreviata populations.
293 portant factor is that the foot's ability to exert torque on the support surface is limited by the be
294 irectly identified specific metabolites that exert transcriptional, translational, and posttranslatio
295 Activation of noncanonical inflammasome exerts two major effects: it activates the NLRP3-caspase
296 ochondrial pyruvate carrier MPC is poised to exert ultrasensitive control on the balance between resp
298 of substantial and sustained immune pressure exerted upon a developing tumor, suggesting that clinica
299 ese regulatory functions are suggested to be exerted via the selective interaction of GPA-3 with NPR-
300 ylococcus aureus relies on quorum sensing to exert virulence to establish and maintain infection.