ライフサイエンスコーパス: exo-

1 with high selectivity (typically >98:<2 endo:exo).

2 ers (7-phenyl 51-96% exo and 7-acetyl 54-96% exo).

3 their imidazole-bearing sidechains outward (exo).

4 The tagged gene was named EXORDIUM (EXO).

5 oprecipitation-exonuclease methodology (ChIP-exo).

6 eated chromatin-immunoprecipitated DNA (ChIP-exo).

7 kinetic inducement for replication by Klenow exo-.

8 erformed in vitro utilizing DNA polymerase I exo-.

9 edral isomer energies (E(isom) = E(endo) - E(exo)).

10 ragment of Escherichia coli polymerase I (Kf exo+).

11 bus solfataricus P2 DNA polymerase B1 (PolB1 exo-).

12 as retained (exo+) or removed by sonication (exo-).

13 cretion of type 3 exotoxins (ExoU, ExoT, and ExoS).

14 ducts when replication was conducted with Kf exo(+).

15 ol(M) Exo(+)), and the double mutator Pol(M) Exo(-).

16 studies were conducted with Klenow fragment exo(-).

17 Several isomers of 7-methyl-2-exo-([(18)F]fluoropyridinyl-5'-pyridinyl)-7-azabicyclo[2

18 ocedures were developed for the synthesis of exo-(2'-chloro-5-pyridinyl)-7-(endo and exo)-amino[2.2.1

19 c-5 leading to the endo-[4 + 2] (endo-2) and exo-[2 + 2] (anti-3) cycloadducts.

20 Both exo (21) and endo (27) isomers of the metabolite 2 were

21 2-exo-(3'-Amino-2'-chloro-5'-pyridinyl)-7-azabicyclo[2.2.1

22 f the radiolabeled compounds, (-)-7-methyl-2-exo-[3'-(2-[18F]fluoropyridin-5-yl))-5'-pyridinyl]-7-aza

23 ding affinity (Ki = 0.3 nM) ((-)-7-methyl-2- exo-[3'-(6-[(18)F]fluoropyridin-2-yl)-5'-pyridinyl]-7-az

24 ction of 1-BF3 with Cp 2 yields the expected exo [4 + 2] cycloadduct, the reactions of these FHCs yie

25 The activation enthalpy for the concerted exo-[4 + 2] cycloaddition (exo-2TS, DeltaH(double dagger

26 ExoS (453 amino acids) is a bi-functional type III cytot

27 ExoS (453 amino acids) is a bi-functional type-III cytot

28 ExoS (453 amino acids) is a bifunctional type III cytoto

29 otonation and the formation of endo (4a) and exo (4b) isomers of trans-[HFe(PNHP)(dmpm)(CH(3)CN)](BPh

30 n solvents, "S(N)i" reactions lead mainly to exo- (4g) and endo-2-chloro-5-norbornenes (4g').

31 e doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the key step.

32 UDG that is incorporated into DNA by Klenow exo(-), a model replicative polymerase.

33 icase; LIG, an ATP-dependent DNA ligase; and Exo, a metallo-beta-lactamase-family nuclease.

34 Recently, MSC-derived exosomes (MSC-Exos), a type of microvesicle released from MSCs, were t

35 The polymerase (pol) and exonuclease (exo) activities are spatially separated in different enz

36 lymerase (pol) and proofreading exonuclease (exo) activities.

37 erally have a more potent 3'-5' exonuclease (exo) activity than A family DNA polymerases that mainly

38 ence of an associated 3'- to 5'-exonuclease (exo) activity.

39 ure cleanly and regioselectively via formal "exo" addition of the nitrogen-hydrogen bond to the pende

40 ts could be converted into the corresponding exo'-adducts by 1,8-diazabicyclo[5.4.0]undec-7-ene media

41 Pseudomonas aeruginosa exoenzyme S (ExoS) ADP-ribosylates multiple eukaryotic targets to pro

42 One of these effectors, ExoS, ADP-ribosylates several host cell proteins, includ

43 lar substrates of TTS-translocated ExoS (TTS-ExoS) ADPRT activity include proteins in the Ras superfa

44 s of exo-(2'-chloro-5-pyridinyl)-7-(endo and exo)-amino[2.2.1]heptanes (3a and 3b).

45 Chromatin immunoprecipitation-exo, an emerging technique using lambda exonuclease to d

46 omatin immunoprecipitation-exonuclease (ChIP-exo) analysis shows that Nap1 is required for H2A-H2B de

47 r(567) in the polymerase active site (Pol(M) Exo(+)), and the double mutator Pol(M) Exo(-).

48 quence: NNCA(G/C)TGNN decreasing), and Vent (exo(-)) and Vent DNA polymerase.

49 utilized for studying the activity of Klenow exo(-) and repair enzymes on templates containing the le

50 of the C2'-oxidized abasic site with Klenow exo(-) and repair enzymes suggest that the lesion will b

51 (Z-5-exo), E-3-methylenisoindolin-1-one (E-5-exo), and isoquinolinone (6-endo).

52 s derived from HCV-infected hepatocytes (HCV-exo), and the expression of fibrosis-related genes was e

53 flap endonuclease/5' exonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL).

54 em that includes a 5'-3' exonuclease (lambda Exo) and a single strand annealing protein (Redbeta).

55 erived from two protons [Fe(III)-bound C5-OH(exo) and C5-H(endo)] from camphor.

56 positions to form the isomeric exocyclic (1-exo) and endocyclic (1-endo) dienolates.

57 t, E176A, which is deficient in exonuclease (EXO) and gap endonuclease (GEN) activities but retains a

58 s mutant protein lacks the FEN, exonuclease (EXO) and gap endonuclease (GEN) activities of FEN1 but r

59 ition in H(2)O or D(2)O buffer, both ENDOR H(exo) and H(endo) signals are absent.

60 s of amino acid substitutions caused by POLE-exo* and compare them to other tumor types.

61 iabetic NOD mice for their reactivity to the EXO, and compared this reactivity between diabetes-susce

62 p analytic methods are not tailored for ChIP-exo, and thus cannot take full advantage of high-resolut

63 tes in PCR reactions catalyzed by Taq, Vent (exo-) and Deep Vent (exo-) polymerases, with 94.4%, 97.5

64 Type II archeon DNA polymerases Vent (exo-) and Pfu (exo-) can be utilized for PAP or a bidire

65 w that both exonuclease-deficient Pole (Pole-exo-) and Pole-P301R generate mutations in a strictly st

66 rformed with complete control of the regio-, exo-, and enantioselectivity under aminocatalytic condit

67 rgoes a [1,3] sigmatropic rearrangement to 5-exo- and 5-endo-methoxybicyclo[2.2.2]oct-2-enes, 2a and

68 The golden state: selective 5-exo- and 6-endo-cyclizations of an alkynyl benzothioamid

69 P-stereogenic heterocycles featuring both an exo- and an endocyclic double bond.

70 help explain how RNase BN can act as both an exo- and an endoribonuclease and also demonstrate that i

71 i, ionotropic and metabotropic P2 receptors, exo- and ecto-nucleotidases, second messengers, and gap

72 [(-)-cis-1 and (+)-trans-2] and two isomers, exo- and endo-3-isopropyl-6-methylbicyclo[3.1.0]hex-2-en

73 fy effectiveness of this array for detecting exo- and endo-acting glycoside hydrolase activity using

74 to CD166 was not disruptable by a variety of exo- and endo-glycosidases, implying recognition of a no

75 tion products, we successfully distinguished exo- and endo-hydrolases and found high taxonomic variat

76 c stromal Ser-type (S9D) peptidase with both exo- and endo-peptidase activity.

77 hat iridium and iron moieties have exchanged exo- and endo-polyhedral sites with respect to the 10-ve

78 itution of compounds 3-6 is such that latent exo- and endo-receptor properties are simultaneously pre

79 abidopsis chloroplast RNase J displaces both exo- and endo-ribonucleolytic activities and contains a

80 aptic vesicle endocytosis and may facilitate exo- and endocytic coupling.

81 Synaptic vesicle (SV) exo- and endocytosis are tightly coupled to sustain neur

82 Synaptic vesicle exo- and endocytosis are usually driven by neuronal acti

83 We monitored the spatial distribution of exo- and endocytosis at 37 degrees C in mouse motor nerv

84 We uncoupled the function of syt1 in exo- and endocytosis in mouse neurons either by re-targe

85 Here we review these exo- and endocytosis modes and their roles in regulating

86 urotransmission relies on repeated cycles of exo- and endocytosis of the synaptic vesicles (SVs), in

87 ciated protein involved in the regulation of exo- and endocytosis processes at presynaptic sites.

88 a, we have obtained estimates of adiponectin exo- and endocytosis rates, and we have predicted adipon

89 The effect of these manipulations on exo- and endocytosis were analyzed using electrophysiolo

90 rprisingly, FM1-43 labeling indicates normal exo- and endocytosis, but a specific inability to mobili

91 e-associated processes, including autophagy, exo- and endocytosis, phagocytosis and immune response.

92 4-dependent signaling cassette and perturbed exo- and endocytosis.

93 ed either by membrane folding or by membrane exo- and endocytosis.

94 n cycle with SVs that parallels the cycle of exo- and endocytosis.

95 he reservoir is set by the relative rates of exo- and endocytosis.

96 priming of the vesicles for another round of exo- and endocytosis.

97 modulated in parallel with synaptic vesicle exo- and endocytosis.

98 lation of many cellular functions, including exo- and endocytosis.

99 o its neighbors, and exchanges cargo through exo- and endocytotic mechanisms.

100 mical analysis failed to uncover substantial exo- and endocytotic traffic of the channel.

101 , interacting (allosteric), and co-existent, exo- and endofacial GLUT1 ligand-binding sites.

102 advance RNA imaging probes for detection of exo- and endogenous RNA and for RNA process tracking.

103 utperforms mixtures of commercially relevant exo- and endoglucanases.

104 d 37 degrees C through absolutely quantified exo- and endometabolomics data.

105 nit and retains significant, albeit reduced, exo- and endonuclease activities but does not undergo ph

106 tructural differences between Mre11 bound to exo- and endonuclease substrates.

107 s of these substrates before and after their exo- and endonucleolytic cleavage, as well as structures

108 re functional diversity, while Gfh1 inhibits exo- and endonucleolytic cleavage, RNA synthesis, and py

109 Their interaction with exo- and endopolyphosphatases is described.

110 etabolised by a number of enzymes, including exo- and endopolyphosphatases.

111 The exo- and endoribonuclease RNase J, the only prokaryotic

112 ruments that permits differentiation between exo- and endothermic proton transfer reactions.

113 titutions, and tested their response to both exo- and endovanilloids.

114 ctors that funnel RNA substrates to abundant exo- and/or endonucleases.

115 type III secretion proteins (PopD, PcrV, and ExoS) and a flagellum-associated protein (FliD).

116 one of the miRNAs overexpressed in obese ATM Exos, and earlier studies have shown that PPARgamma is a

117 cterial strain that naturally secretes ExoU, ExoS, and ExoT were generated to carefully evaluate the

118 biochemical and enzymatic functions of ExoU, ExoS, and ExoT, three effector proteins secreted by this

119 e type III secretion system effectors (ExoU, ExoS, and PcrV) and for strain relatedness using randoml

120 e pathogenesis of P. aeruginosa keratitis in ExoS- and ExoT-producing strains is almost entirely due

121 omatin immunoprecipitation-exonuclease (ChIP-exo) approach, we find that agonist-liganded human andro

122 Exosomes (EXO) are secreted intracellular microparticles that can

123 Exosomes (EXOs) are secreted, nano-sized membrane vesicles that co

124 C2-AP lesion has a similar effect on Klenow exo(-) as do AP and C4-AP sites.

125 tion 4(R)Hyp in this structure is up (Cgamma exo), as has been found in other collagen peptide struct

126 atin at near-base-pair resolution using ChIP-exo, as RPGs are coordinately reprogrammed.

127 sociated with the ADP-ribosylating domain of ExoS, as bacteria expressing plasmids lacking expression

128 to 99 degrees C (T(end)) and 68 degrees C (T(exo)) ([AsF(6)(-)]:[PF(6)(-)] = 0.4:0.6).

129 at least ten times more mutagenic than Pole-exo- at each location analyzed.

130 hage lambda genome comprising the red genes (exo, bet and gam) under their native control.

131 s are used for the recombination, the lambda Exo, Beta, and Gam proteins are required.

132 situated metal binding site for an exterior (exo) binding site.

133 PolB1 exo- binds tightly to DNA (K(d)(DNA) = 1.8 nM) and a cor

134 Invasive P. aeruginosa secrete ExoT and ExoS, but exsA mutation has little impact on their short

135 e ADP-ribosyltransferase (ADP-r) activity of ExoS, but not the Rho-GAP activity nor the membrane loca

136 d cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung inj

137 ely charged residues establish the correct N(exo)/C(cyt) topology of the peptide, in accordance with

138 ons that are consistent with the Type III (N(exo)/C(cyt)) topology.

139 Nano-sized cellular vesicles like exosomes (Exo) can ferry GNP-therapeutic complexes without causing

140 We show that HCV-associated exosomes (HCV-Exo) can modulate HOTAIRM1, HOXA1, and miR124 expression

141 archeon DNA polymerases Vent (exo-) and Pfu (exo-) can be utilized for PAP or a bidirectional form of

142 e confirm our observations by analyzing ChIP-exo, chemical mapping, and ATAC-seq data from other labo

143 We applied high-resolution ChIP-exo (chromatin immunoprecipitation followed by 5'-to-3'

144 Using ChIP-exo (chromatin immunoprecipitation with lambda exonuclea

145 sylation of a non-G-protein substrate of TTS-ExoS, cyclophilin A (CpA), a peptidyl-prolyl isomerase (

146 k, termed MACE (model-based analysis of ChIP-exo) dedicated to ChIP-exo data analysis.

147 n the palm domain of the parental enzyme, an exo(-) derivative of RB69 DNA polymerase (gp43), a membe

148 dCDP onto a 13/20mer primer/template with an exo(-) derivative of RB69 DNA polymerase and have shown

149 report development of an Exposure Ontology, ExO, designed to address this information gap by facilit

150 Deep Vent (exo(-)) DNA polymerase accepted the nucleotide triphosph

151 catalyze endonucleolytic and exonucleolytic (EXO) DNA hydrolyses.

152 mplate for primer extension using deep vent (exo-) DNA polymerase, thereby enabling the regeneration

153 h could be synthesized in 1 h by the Klenow (exo-) DNA polymerase.

154 t in substitutions in the 3'-5' exonuclease (Exo) domain of the catalytic subunit of the viral DNA po

155 primer terminus between pol and exonuclease (exo) domains was compromised with the L415A and L415G mu

156 tion of 6 in extended products by Deep Vent (exo(-)) during PCR or by Sequenase during copying of sin

157 products: Z-3-methylenisoindolin-1-one (Z-5-exo), E-3-methylenisoindolin-1-one (E-5-exo), and isoqui

158 and excellent stereoselectivities toward the exo-(E) adducts are obtained on a wide range of substrat

159 concentrations by formation of E(2).Mg.(INT)(exo):E(1)[ATP].Mg.(H(+)) which is converted to E(2).Mg.(

160 g.(H(+)) which is converted to E(2).Mg.(INT)(exo):E(1)P.Mg.(H(+))(cyto), but this E(1)P form was K(+)

161 rases have a separate 3' --> 5' exonuclease (exo) editing activity that is involved in assuring the f

162 ps of translesion DNA synthesis by RB69 gp43 exo-, employing a non-natural purine triphosphate analog

163 When Pol delta-exo(-) encountered a downstream primer, it paused with 3

164 t three distinct hydrolytic modes of action: exo, endo-dissociative, and endo-processive.

165 He, Cs, and Bi, to probe the utility of the exo/ endo cages as host-guest systems.

166 ions, are key to reliably assigning the Cp*( exo/ endo-eta(4)-C(5)Me(5)H)Co(+) species.

167 ormation of the ring-protonated isomers Cp*( exo/ endo-eta(4)-C(5)Me(5)H)Co(+).

168 embrane protein turnover because they render exo-/endocytosis-associated pH changes to fluorescent si

169 ar cells was not affected by manipulation of exo-/endocytosis.

170 ns produced in vivo by the wild-type (Pol(+) Exo(+)) enzyme, an exonuclease-deficient mutator variant

171 incorporation of C versus G as the wild-type exo(-) enzyme; however, the k(pol)/K(d) ratio for G vers

172 lease domain of DNA polymerase epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly e

173 Lastly, PolB1 exo- exhibited a low processivity value of 15, thereby s

174 own to possess 5'-flap endo- (FEN) and 5'-3' exo- (EXO) nuclease activities.

175 on with isogenic mutants secreting wild-type ExoS, ExoS defective in GTPase-activating protein (GAP)

176 ur different effector proteins, exoenzyme S (ExoS), ExoT, ExoU, and ExoY.

177 Similar to ExoS, ExoT and ExoY, ExoU requires either a eukaryotic-s

178 the three known type III effector molecules (exoS, exoT, and exoY) in P. aeruginosa PAO1 and assayed

179 ruginosa strain PAO1 or PAK, which expresses ExoS, ExoT, and ExoY, but not ExoU.

180 The impact in mortality of TTSS genotypes (exoS, exoT, exoU, and exoY genes) and resistance profile

181 ur known effector proteins of P. aeruginosa (ExoS, ExoT, ExoU, and ExoY) in wax moth killing.

182 xotoxin A (ETA) and the type III cytotoxins (ExoS, ExoT, ExoU, and ExoY).

183 nucleotide polymorphisms in four toxin genes-exoS, exoT, exoU, and exoY-of the Pseudomonas aeruginosa

184 ExoS, ExoT, ExoY, and ExoU all possess enzymatic activit

185 PAO1 strains with mutations in exoS, exoT, exoY, or combinations thereof were compared

186 we determined which of the three effectors (ExoS, ExoT, or ExoY) were required for bleb niche format

187 n addition, also detected were antibodies to ExoS, ExoU, or ExoS and ExoU, the latter indicating sequ

188 than methyl iodide approach from the convex (exo) face.

189 ion site (pol) and a 3'-5' exonuclease site (exo) for proofreading.

190 plementary and noncomplementary dNTPs by the exo(-) form of RB69 pol and its mutants.

191 The Klenow exo- fragment of Escherichia coli DNA polymerase I incor

192 ty, we isolated small microparticles, mainly EXO, from mouse insulinoma and examined their activities

193 nity (VDR-BVs) using a high-resolution (ChIP-exo) genome-wide analysis of 27 HapMap lymphoblastoid ce

194 One of the most commonly expressed toxins, ExoS, has two domains that are predicted to affect cytos

195 e of the wild-type or exonuclease-deficient (exo(-)) HSV-1 DNA polymerase (pol).

196 containing 5' flaps with either wild-type or exo(-) HSV-1 pol and Fen-1 led to the efficient producti

197 ficant strand displacement was observed with exo(-) HSV-1 pol.

198 hat are not susceptible to MMR, exonuclease (Exo)-I, ExoX, and RecJ exonuclease redundantly inhibit d

199 5Q) within the highly conserved exonuclease (Exo) III domain.

200 olymerase from bacteriophage RB69 (RB69 gp43 exo-) illustrated these properties, showing that the pol

201 inal domain (NTD) and exonucleolytic domain (EXO) in miRNA 3'-end trimming.

202 enow fragment of Escherichia coli DNA Pol I (exo-) in single-nucleotide insertions.

203 incorporation experiments indicated that Kf exo(-) incorporates all four nucleotides opposite M(1)dG

204 at are consistent with the Type II (N(cyt)/C(exo)) integral membrane protein topology, and extended h

205 Exoenzyme S (ExoS) is a bifunctional Pa TTS effector protein, with GT

206 Exoenzyme S (ExoS) is a bifunctional toxin directly translocated into

207 Pseudomonas aeruginosa Exoenzyme S (ExoS) is a bifunctional type-III cytotoxin.

208 Pseudomonas aeruginosa exoenzyme S (ExoS) is a type III secretion (TTS) effector, which incl

209 med the presence of plasma-derived exosomes (EXOs) isolated by differential centrifugation.

210 not required to observe the pI conformers of ExoS; it enhanced the resolution and formation of pI con

211 olymerase I large (Klenow) fragment, 3'-->5' exo(-) Klenow DNA polymerase, thermophilic Bst DNA polym

212 -mer) DNA and their reactions with the 3'-5' exo(-) Klenow fragment of DNA polymerase I demonstrate t

213 d for translesion synthesis catalyzed by the exo(-) Klenow fragment, the expected three-base deletion

214 The nucleotide preference of POLE-exo* leads to increased frequencies of recurrent nonsens

215 High-resolution exonuclease (ChIP-exo) mapping revealed that the majority of enhancers est

216 omatin immunoprecipitation-exonuclease (ChIP-exo) method allowed the identification of a previously u

217 performed small RNA sequencing of exosomes (EXOs), microvesicles (MVs) and source cells from 14 canc

218 n kidney and urine, we found that release of exo- miRs was a regulated sorting process.

219 ation patterns arise from some of these POLE-exo* mutants during genome duplication.

220 xonuclease-deficient mutator variant (Pol(+) Exo(-)), mutator variants with substitutions at Tyr(567)

221 on expected from combining the pol L561A and exo(-) mutator activities.

222 4)-benzoylated 6'-F-tc-(5Me)C reavealed a 2'-exo (north) conformation of the furanose ring, character

223 r a 2'-endo, 3'-exo (South), or a 3'-endo,2'-exo (North) conformation.

224 ADP is a type III bitopic N(endo)C(exo) nuclear membrane and Golgi glycoprotein that is pro

225 possess 5'-flap endo- (FEN) and 5'-3' exo- (EXO) nuclease activities.

226 epted as a substrate by the Klenow fragment (exo(-)) of DNA polymerase I from E. coli.

227 extension studies using the Klenow fragment (exo(-)) of Escherichia coli DNA polymerase I demonstrate

228 erase alpha (pol alpha) and Klenow fragment (exo-) of DNA polymerase I (Escherichia coli).

229 somes derived from healthy Schwann cells (SC-Exos) on diabetic peripheral neuropathy (DPN).

230 The effect of activated monocyte exosomes (Exos) on endothelial cells is unknown.

231 lic pseudosugar locked in either a North (2'-exo) or South (3'-exo) ring pucker.

232 The exosporium spore layer was retained (exo+) or removed by sonication (exo-).

233 otonated isomers are formed (endo/endo, endo/exo, or exo/exo), which differ in the position of the N-

234 hos as ligands produces diastereodivergently exo- or endo-cycloadducts, respectively.

235 The exo- or endo-selectivity of bicyclic scaffolds depends o

236 nfiguration and backbone substitution either exo- or endo-stereoisomers were formed selectively with

237 Microvesicles (MVs), but not exosomes (Exos) or apoptotic bodies (Abs), are the main type of EV

238 nd together they reveal the dominance of the exo- over the endo-anomeric effect.

239 eles with low levels of 5'-->3' exonuclease (exo) overproduced DNA while those with either high or no

240 d the distribution of virulence genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance gene

241 However, an exonuclease-deficient (exo(-)) pol (D368A) was capable of slow strand displacem

242 er by alternative polymerases pol II, pol II exo(-), pol IV, and pol V was examined.

243 ) and processivity of strand displacement by exo(-) pol, the rate was slower than that for gap-fillin

244 he strand displacement activity of the Vent (exo-) polymerase to generate single strand flaps on nick

245 oration followed by primer extension by Vent(exo-) polymerase.

246 catalyzed by Taq, Vent (exo-) and Deep Vent (exo-) polymerases, with 94.4%, 97.5% and 97.5%, respecti

247 ion synthesis experiments showed that pol II exo(-) preferentially incorporates T opposite C4-AP, fol

248 ne of the major type III secreted effectors, ExoS, prevented triggering of type III secretion by bact

249 In contrast, with Kf exo(-), primers extended past M(1)dG contained T opposit

250 Herein, we investigated the effect of exo- Protoporphyrin based SDT (PpIX-SDT) on SAS cells in

251 cells, where Rac1 is ADP-ribosylated by TTS-ExoS, Rac1 was activated and relocalized to the membrane

252 Further genetic studies showed that pol3-exo(-) rad27 double mutants were sensitive to alkylation

253 of putative conformational changes with the exo(-) RB69 pol and its mutants using a primer-template

254 ciency of G versus G incorporation using the exo(-) RB69 pol.

255 Kf exo(+) removed dA, dG, and T opposite M(1)dG and N(2)OPd

256 Internal mismatches were recognized by Kf exo+ resulting in the excision of the correct base pairs

257 cked in either a North (2'-exo) or South (3'-exo) ring pucker.

258 two proteins central to systemic/exogenous (exo)-RNAi pathway: the dsRNA importer, SID-1 and the arg

259 drogen peroxide when oxygen is bound on the "exo" side ("dock-on") of the catalyst, while four-electr

260 camphor in D(2)O, the magnitude of the C5-OH(exo) signal decreases via H/D exchange.

261 H(2)O buffer, H/D exchange causes the C5-OH(exo) signal to reappear during relaxation upon annealing

262 en the polymerization (pol) and exonuclease (exo) sites of DNAPs, even for perfectly complementary P/

263 cytosine sugar pucker is in the C2'-endo-C3'-exo (South conformation), in contrast to the previously

264 rinated sugar rings for either a 2'-endo, 3'-exo (South), or a 3'-endo,2'-exo (North) conformation.

265 ing a two- to threefold-higher response than exo+ spores.

266 induced a strong cytokine response, with the exo- spores eliciting a two- to threefold-higher respons

267 Rrp44 lacking 3'-exonuclease activity (Rrp44-exo) supports growth in S288c-related strains (BY4741).

268 ibution in human airway cells intoxicated by ExoS, -T, and -Y.

269 ene (BP), primarily blocks Sequenase 2.0, an exo(-) T7 DNA polymerase; however, a mismatched dATP can

270 6)-BzG) was assessed using T7 DNA polymerase exo(-) (T7(-)) and HIV-1 reverse transcriptase (RT).

271 nalysis on a strand-specific paired-end ChIP-exo (termed as ChIP-ePENS) data of FOXA1 in LNCaP cells

272 S and YopE share structural homology, unlike ExoS, the intracellular localization of YopE within mamm

273 biochemical properties that allow Pol delta-exo(-) to carry out strand displacement synthesis and di

274 on the ability of lambda exonuclease (lambda-exo) to efficiently digest parental DNA while leaving RN

275 to chromatin immunoprecipitates (termed ChIP-exo) to examine the precise location of 6,045 PICs in Sa

276 omatin immunoprecipitation-exonuclease (ChIP-exo) to resolve the organization of individual histones

277 The switch from 5-exo- to 6-endo-trig selectivity in the radical cyclizati

278 wn to have a dramatic impact on the ratio of exo- to endo-cyclization reactions, with bicyclo[4.1.0]

279 ExoS within T24 cells, but as with wild-type ExoS, translocation was limited in association with disr

280 ating the development of catalytic Sm(II) 5- exo- trig ketyl olefin cyclization reactions.

281 nown cellular substrates of TTS-translocated ExoS (TTS-ExoS) ADPRT activity include proteins in the R

282 Here, we identify POLE-exo* tumors in numerous cancers and classify them into t

283 it was proposed that P. aeruginosa secreting ExoS, upon infection, shuts down host cell survival sign

284 ructural data suggest how the preference for exo- versus endo-cleavage mode is linked with recognitio

285 Pol II exo(-) was most efficient.

286 rigid (S)-conformation (P = 126 degrees , 1'-exo) was consistent with molecular modeling.

287 nucleotide incorporation catalyzed by PolB1 exo- was limited by a protein conformational change whic

288 ation of an "induced fit" mechanism by PolB1 exo- was supported by the following: a small, alpha-thio

289 or the membrane localization domain (MLD) of ExoS, was required to elicit this phenotype.

290 Using ChIP-exo, we identified the subnucleosomal placement of 20 of

291 With the single bp accuracy provided by ChIP-exo, we show an unprecedented view into genome-wide bind

292 gate whether primary islet cells can produce EXOs, we isolated cells from the islet of Langerhans of

293 were collected, EVs subpopulations (MVs and Exo) were isolated and characterized by nanoparticle tra

294 Recently, MSC-derived exosomes (MSC-Exo) were thought to carry functions of MSCs.

295 The S-cdG deoxyribose exhibited the O4'-exo (west) pseudorotation.

296 Here we describe ChIP-exo, where an exonuclease trims ChIP DNA to a precise di

297 observed for the ADP-ribosylation of Ras by ExoS, where ADP-ribosylated Ras loses the ability to bin

298 mers are formed (endo/endo, endo/exo, or exo/exo), which differ in the position of the N-H bond's wit

299 bese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resis

300 ulate synaptic endocytosis and hence couples exo- with endocytosis.