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1 t beta-catenin is required qualitatively for exocrine acinar but not endocrine development, precisely
2 ever, mice with beta1 syntrophin deletion in exocrine acinar cells exhibit increased severity of ceru
3 oform blocked the irreversible transition of exocrine acinar cells into pancreatic preneoplastic duct
4 and (4) aberrantly differentiated endocrine exocrine (ADEX) that correlate with histopathological ch
7 which are aliphatic amines, are reported in exocrine and endocrine cells, with insulin-producing bet
10 ent of a periampullary tumor and can lead to exocrine and endocrine insufficiency such as malnutritio
11 llow-up of 36 months, the rates of new-onset exocrine and endocrine insufficiency were 6%and 2%, resp
14 radiographs did not discriminate between the exocrine and endocrine pancreas in control animals, wher
15 humans resulted in a marked expansion of the exocrine and endocrine pancreatic compartments, the form
17 ssue replacement, resulting in chronic pain, exocrine and endocrine pancreatic insufficiency, reduced
18 mild exocrine pancreas disease, progressive exocrine and endocrine pancreatic loss during the first
20 letion attenuated the loss of PERK-deficient exocrine and endocrine pancreatic tissues and prevented
22 ficient embryonic pancreas, defects occur in exocrine and endocrine tissues shortly after differentia
23 an indispensible role in the development of exocrine and ocular surface disease in Aire knockout mic
24 he presence of periepithelial infiltrates in exocrine and parenchymal organs or resulting from immuno
26 ing from abdominal pain, acute pancreatitis, exocrine and/or endocrine dysfunction, and pancreatic ca
27 ue constellation of neurological, endocrine, exocrine, and haematological findings that is caused by
29 when administered concurrently, and reduces exocrine apoptosis (reducing the impact on potential isl
30 ibed in the literature, with an incidence of exocrine atrophy/inflammation seen in S-D (42-72%), HIP
31 -1R knockout mouse model to demonstrate that exocrine binding of exendin is exclusively via GLP-1R (~
32 l that central D2Rs mediate a neuroendocrine-exocrine cascade that controls the maturation of the GH
33 s new insights into pancreatic endocrine and exocrine cell differentiation landscapes and identifies
36 the 52-week study showed an increase in the exocrine cell mass in liraglutide-dosed animals, with no
38 d with incretin therapy, with both increased exocrine cell proliferation (P < 0.0001) and dysplasia (
39 non-endocrine cells that resemble pancreatic exocrine cells and a previously unreported population th
40 4 may play a role in the efflux of cAMP from exocrine cells and neurokinin receptors are important in
41 acute inflammatory stress by locking damaged exocrine cells in a permanently de-differentiated state.
44 cells (hPSCs) into pancreatic endocrine and exocrine cells through intermediates resembling in vivo
45 he nongenetic conversion of human pancreatic exocrine cells to endocrine cells is novel and represent
48 ecent studies report low levels of GLP-1R on exocrine cells, complicating beta-cell mass quantificati
49 protein content), as well as degeneration of exocrine cells, decreased zymogen granules, and alterati
50 (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellul
56 lear form of Yap are apparent throughout the exocrine compartment and correlate with increases in lev
59 s1 leads to the impaired regeneration of the exocrine compartment, accelerated fatty metaplasia, and
63 ontent or the number of Ki67(+) cells in the exocrine compartment; however, pancreatic protein conten
64 blocked differentiation of the endocrine and exocrine compartments, whereas loss of a single Yap alle
65 We found that serpin B13 is expressed in the exocrine component of the mouse pancreas, including the
69 reatic findings in all groups included focal exocrine degeneration, atrophy, inflammation, ductular c
70 in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancrea
73 ators Neurog3, MafA, Pdx1 and Pax6 converted exocrine duct cells into endocrine progeny with hallmark
74 a monogenic form of diabetes and pancreatic exocrine dysfunction due to mutations in the CEL gene en
75 s with severe developmental delay, endo- and exocrine dysfunction, impairment of the sensory and auto
76 the exocrine pancreas and, in the context of exocrine dysplasia, may accelerate formation of neoplast
77 minations and quantifications indicated that exocrine, endocrine and ductal compartments retained the
79 his study was to determine whether the human exocrine-enriched fraction from the islet isolation proc
82 controls the decision between endocrine and exocrine fates of multipotent progenitors in the develop
83 functions (including water/salt homeostasis, exocrine fluid secretion, and epidermal hydration) and h
84 per gram at 15 min), most likely due to the exocrine function and high protein turnover within the p
85 e high viability and preserved endocrine and exocrine function in HPS for at least 10 days after sect
86 rfusion, injury, as measured by amylase, and exocrine function of human pancreases using EVNP and dem
87 , quality of life [QoL]), medical (endo- and exocrine function), and clinical (reoperation) results r
92 pment and support a rationale for performing exocrine functional tests for patients with IRF6-damagin
93 nced by preservation of pancreatic endocrine/exocrine functions and a low rate of reoperation for tum
94 w-up of 50 months, both pancreatic endocrine/exocrine functions were preserved in 92% of patients.
96 nvolved in the generation and maintenance of exocrine gland acinar cells have not yet been establishe
97 Although IgG autoantibodies against various exocrine gland antigens have been described in IgG4-RD,
98 ion, our data report a novel role of Irf6 in exocrine gland development and support a rationale for p
99 ver 3 wk post-AdV infection, consistent with exocrine gland dysfunction as a consequence of the infla
100 lling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic movements of the
102 Characterizations of the myriad neuropteran exocrine gland systems, including prothoracic, metathora
103 s similar to CpMRP and assume therefore that exocrine gland-based defensive strategies, evolved by th
104 defined circuit by which a single compound, exocrine gland-secreted peptide-1 (ESP1), enhances repro
107 helial mononuclear cell infiltrates, both in exocrine glands and in other parenchymal organs (kidney,
108 In primary Sjogren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes inst
109 likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding
110 HAT-L4 was expressed in epithelial cells and exocrine glands in tissues including skin, esophagus, tr
112 oimmune disease involving salivary and other exocrine glands that leads to progressive lymphocytic in
113 lymphocytic infiltration and destruction of exocrine glands, followed by systemic organ damage and B
114 characterized by lymphocytic infiltration of exocrine glands, mainly salivary and lacrimal, resulting
115 -Higueras et al., 2014], suggesting that the exocrine glands, similar to the endocrine, develop from
116 identify the role of IRF6 in development of exocrine glands, specifically the major salivary glands.
117 ch as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and
118 c autoimmune disorder that typically affects exocrine glands--mainly labial and lacrimal--leading to
126 ophilic Cy-7 exendin to selectively preblock exocrine GLP-1R in healthy and streptozotocin-induced di
127 ort the idea that pocket shark's pockets are exocrine holocrine glands capable of discharging a biolu
128 ke peptide 1 (GLP-1) receptor agonist, is an exocrine hormone, which has potent insulinotropic action
129 l hernias (23% vs 53%; P = .004), pancreatic exocrine insufficiency (29% vs 56%; P = .03), or endocri
131 left-sided resection, the risk of developing exocrine insufficiency after surgery was higher after dr
134 ts with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in nutrient malabsor
137 mplications such as malnutrition, pancreatic exocrine insufficiency, and diabetes; refer to a special
139 adult-onset diabetes, with subclinical or no exocrine insufficiency, suggesting an important role for
143 ent-labeled red blood cells at the endocrine-exocrine interface revealed bidirectional blood flow, wi
144 apillaries were, however, found at the islet-exocrine interface, frequently located along blood capil
146 trates, independently of the severity of the exocrine lesion and in the absence of amyloid deposits.
148 st that POSTN is a crucial factor for proper exocrine lineage-specific regeneration after severe acut
149 s were located in fibrotic septa between the exocrine lobules and adjacent to the ductal system of th
151 gulate networks involved in KRAS activation, exocrine (NR5A2 and RBPJL), and endocrine differentiatio
153 ations such as pancreaticocutaneous fistula, exocrine or endocrine pancreatic insufficiency, need for
157 inhibition of polyamine biosynthesis reduces exocrine pancreas and beta cell mass, and that these red
159 herapy may induce focal proliferation in the exocrine pancreas and, in the context of exocrine dyspla
161 we report an unexpected role for SHP in the exocrine pancreas as a modulator of the endoplasmic reti
162 creatitis is an inflammatory disorder of the exocrine pancreas associated with tissue injury and necr
166 Expression of the homeobox gene Prox1 in the exocrine pancreas changes throughout development in mice
168 netic factors likely influence the extent of exocrine pancreas disease in CF ferrets and have implica
169 Although CF kits are born with only mild exocrine pancreas disease, progressive exocrine and endo
170 raumatic brain injury or cardiac arrest; and exocrine pancreas DNA was identified in patients with pa
171 eatorrhea was induced by embolization of the exocrine pancreas gland and pancreatic duct ligation in
172 pletion or inhibition of 12-LOX impairs both exocrine pancreas growth and unexpectedly, the generatio
173 dence of cellular heterogeneity in the human exocrine pancreas has not been yet established because o
176 e direct evidence that Men1 is essential for exocrine pancreas homeostasis in response to inflammatio
178 sizes an underappreciated involvement of the exocrine pancreas in the natural course of type 1 diabet
179 ment and underscore a potential role for the exocrine pancreas in the pathogenesis of type 1 diabetes
180 increased density of leukocytes) within the exocrine pancreas in this disease, but the mechanisms un
182 t collateral damage from inflammation in the exocrine pancreas is not a likely cause of DM in these d
184 y, we report that CD8 T cells infiltrate the exocrine pancreas of diabetic subjects in high numbers a
185 copy and immunohistochemical analysis in the exocrine pancreas of multiorgan donors with T1D (both at
188 ounts and chemotaxis as well as a diminished exocrine pancreas size in a SRP54-knockdown zebrafish mo
189 ctrum of fibro-inflammatory disorders of the exocrine pancreas that includes calcifying, obstructive,
190 ype 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular str
191 on and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreati
192 ancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a m
193 n order to reveal a possible requirement for exocrine pancreas tissue in endocrine development and/or
195 not suffer from DM links the disease in the exocrine pancreas to a pathological process in the endoc
196 that actin-coated secretory vesicles of the exocrine pancreas travel this distance over bundles of s
197 istorically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pan
198 cute inflammatory phase, the recovery of the exocrine pancreas was massively impaired in Postn-defici
200 s, dynamic topographies in the endocrine and exocrine pancreas, and principles of morphologic organiz
201 eatment did not exert any negative effect on exocrine pancreas, by inducing either pancreatic inflamm
202 itis is caused by inflammatory injury to the exocrine pancreas, from which both humans and animal mod
205 r tissues, including the heart, vasculature, exocrine pancreas, liver, and central nervous system.
206 ctional blood flow between the endocrine and exocrine pancreas, not necessarily a unidirectional bloo
207 P) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointe
209 activity and duct cells within the liver and exocrine pancreas, whereas hepatocyte and acinar pancrea
210 were continuously integrated to those in the exocrine pancreas, which made the islet circulation rath
211 atic capillaries were regularly found in the exocrine pancreas, with small lymphatic vessels located
224 IL-1betaAb treatment also protected the exocrine pancreas; the number of infiltrating macrophage
225 and KCR8-16 mice developed dedifferentiated exocrine pancreata within 2 months of age and became mal
226 ficient hESCs and iPSCs manifest deficits in exocrine pancreatic and hematopoietic differentiation in
227 e of 51 y at baseline were included, and 865 exocrine pancreatic cancers were diagnosed after a media
229 imilar to those in people with CF, including exocrine pancreatic destruction, focal biliary cirrhosis
230 noreactive trypsinogen (IRT), a biomarker of exocrine pancreatic disease in cystic fibrosis (CF), is
231 le entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of
233 zed by bone marrow failure with neutropenia, exocrine pancreatic dysfunction and skeletal abnormaliti
236 ancreatic cancer, which affect endocrine and exocrine pancreatic function and impose a substantial di
241 utosomal-recessive disorder characterized by exocrine pancreatic insufficiency and hematopoietic dysf
242 the presence of epilepsy and the absence of exocrine pancreatic insufficiency and hypoplasia of nasa
243 perioperative management, a determination of exocrine pancreatic insufficiency are scarce in the lite
244 s with insulin-treated neonatal diabetes and exocrine pancreatic insufficiency requiring enzyme repla
246 an experimental approach to the induction of exocrine pancreatic insufficiency via pancreatic duct li
248 ve ribosome assembly and are associated with exocrine pancreatic insufficiency, chronic neutropenia a
253 Secretin is a hormone that stimulates the exocrine pancreatic secretion of bicarbonate-rich fluid
255 fat infiltration (P < 0.05) was noted in the exocrine parenchyma of IL-1betaAb-treated CDs-HSD rats c
256 dual pancreatic lipase knockouts are lethal, exocrine parotid acini lacking lipases were used to veri
257 on model physically links both endocrine and exocrine parts of the pancreas as a single organ through
261 o (INS-1 and PANC1 cells and human islet and exocrine preparations) and in vivo (nonhuman primates an
262 analyzed the function of POSTN in pancreatic exocrine regeneration after the induction of a severe ac
265 t preparation was used to measure pancreatic exocrine secretion (PES) and plasma insulin following mi
268 Recent studies have shown that pancreatic exocrine secretions (PES) are modulated by dorsal motor
269 roader binding profile, decreases pancreatic exocrine secretions and may prevent postoperative pancre
275 mor microenvironment and implicate endocrine-exocrine signaling beyond insulin in PDAC development.
276 es (sweat chloride concentration, pancreatic exocrine status, and lung function) to develop benchmark
277 logy of 21 exocrine glands and 13 supposedly exocrine structures recorded for lepidopteran larvae is
278 To do so, we quantified pancreatic islet and exocrine sympathetic nerve fiber area from autopsy sampl
280 Importantly, low-purity (30:70% endocrine:exocrine) syngeneic rat islet preparations displayed fun
283 ilar expression of HLA class I in islets and exocrine tissue in subjects with recent-onset type 1 dia
284 tudy, we generated mutant mice, in which the exocrine tissue is hypoplastic, in order to reveal a pos
285 nown but essential factor(s) in the adjacent exocrine tissue that regulates proper formation of endoc
286 ass I expression was found between islet and exocrine tissue using Western blot, flow cytometry, real
287 f insulin secretion, cold ischemia time, and exocrine tissue volume transplanted, accounted for 43% o
290 gnificantly higher CD8 T cell density in the exocrine tissue without the presence of prominent insuli
291 spontaneous inflammatory infiltration of the exocrine tissue, common to both T1D and T2D subjects.
298 of (67)Cu-CuSarTATE in AR42J (rat pancreatic exocrine) tumor-bearing mice was compared with (177)Lu-L
300 lls' containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells;