ライフサイエンスコーパス: exocyst

1 etory vesicles where they act to recruit the exocyst.

2 Ciliogenesis and cystogenesis require the exocyst, a conserved eight-protein trafficking complex t

3 The exocyst, a conserved multiprotein complex, tethers secre

4 Gain of function of the exocyst, a conserved protein complex involved in tetheri

5 Here, we show that the exocyst, a conserved protein complex that facilitates do

6 The exocyst, a eukaryotic tethering complex, coregulates tar

7 We previously showed that the exocyst, a highly conserved trafficking complex, is nece

8 Sec5 is a subunit of the exocyst, a protein complex that is involved in vesicle t

9 We previously showed that the exocyst, a protein trafficking complex, is essential for

10 rtant in regulating ciliogenesis through the exocyst, a shuttling complex that chaperones cilia cargo

11 en together, these results indicate that the exocyst, acting through the primary cilium, is necessary

12 es before membrane fusion is mediated by the exocyst, an essential phylogenetically conserved octamer

13 The exocyst, an octameric protein complex, is an essential c

14 g the conventional secretory function of the exocyst, analogous to EXO70A1 (At5g03540) in the sporoph

15 itment of both recycling endosome-associated Exocyst and ESCRT machinery during late telophase, and t

16 sequentially, with tethering mediated by the exocyst and fusion driven by assembly of soluble NSF att

17 We observe sub-complexes in exocyst and intraflagellar transport complexes, which we

18 ine the functional relationships between the exocyst and PAR proteins, we show that RAL-1 recruits th

19 gative mutant of Rab8a strongly binds to the exocyst and prevents recruitment to the bladder, suggest

20 These results indicate that perturbations in exocyst and primary cilia affect EV number and protein c

21 Interactions between exocyst and SNARE protein complexes are known, but their

22 te directs exocytosis of lysosomes using the exocyst and SNARE SNAP-29 to form a large protrusion tha

23 uggested functional interactions between the exocyst and the DDR.

24 We conclude that the exocyst and TRAPP-II complex have distinct localizations

25 s for complexes without known structure (the exocyst and tRNA multi-synthetase complex) and by establ

26 o subunits of other MTCs including the Dsl1, exocyst, and Golgi-associated retrograde protein (GARP)

27 We found that WASH and exocyst are required for matrix degradation by an exocyt

28 gly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis

29 Our studies also implicate the exocyst as a Rab11 effector in this process and that Rab

30 These data support the exocyst as required for normal ciliogenesis during aorti

31 is proposed to release Sec9 in favor of Sec6-exocyst assembly and to simultaneously recruit Sec1 to s

32 Elucidating the mechanisms regulating exocyst assembly is important for the understanding of e

33 omotes RhoA activation, which then regulates exocyst assembly/localization and exocytosis.

34 Exo70 targeting and orient the tethering of exocyst-associated E-cadherin.

35 nization of microtubules, and trafficking of exocyst-associated membranes.

36 the small GTPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst

37 d by a hierarchy of SNARE recruitment to the exocyst at the plasma membrane, dominated by the R-SNARE

38 Based on these data, we propose that exocyst-based mechanisms regulate Neph1 and Nephrin sign

39 TP-bound form of Arl13b, consistent with the exocyst being an effector of Arl13b.

40 Exocyst biogenesis is regulated by several processes, bu

41 e direct phosphorylation of a subunit of the exocyst by a specific cyclin-dependent kinase complex.

42 cretory canal and other polarized cells, the exocyst co-localizes with the PAR polarity proteins PAR-

43 fects were dependent on interaction with the exocyst complex and impacted on the rate of SC migration

44 Here, we describe an interaction between the exocyst complex and the endosomal Arp2/3 activator Wisko

45 Immunoprecipitation of BLOC-2 identified the exocyst complex as a binding partner.

46 hus, this work implicates a fully functional exocyst complex as a component of the compatible pollen

47 Systems analysis identified the exocyst complex as a key network hub, rich in genetic in

48 ternalization in cell lines, and uncover the exocyst complex as a previously unidentified-but essenti

49 erged as mammalian alternatives to the yeast exocyst complex as essential RAB3/SEC4 effectors and org

50 We demonstrate that organization of the exocyst complex at the appressorium pore is a septin-dep

51 was not required for the accumulation of the exocyst complex at the midbody.

52 Depletion of components of the exocyst complex by RNA interference inhibited the format

53 e 11 open reading frame (C11orf30/EMSY), and exocyst complex component 4 (EXOC4) reached a threshold

54 in human urinary EVs; that knockdown (KD) of exocyst complex component 5 (EXOC5), a central exocyst c

55 erved VXPX ciliary targeting motif of EXOC5 (exocyst complex component 5), a central exocyst gene/pro

56 g the small GTPases Cdc42 and Arl13b and the exocyst complex component Sec6.

57 nd RAB27b are recruited and activated by the exocyst complex components SEC6/SEC15.

58 a temporal interaction between Cdc42 and the exocyst complex during large particle uptake.

59 ereby establishing a functional role for the exocyst complex during phagocytosis.

60 The GTPase SECRETORY4 (SEC4) positions the exocyst complex during vesicle membrane tethering, facil

61 the dynamic assembly and disassembly of the exocyst complex during vesicle tethering and membrane fu

62 tly phosphorylated Exo84, a component of the exocyst complex essential for exocytosis.

63 h, increased migration, and dysregulation of exocyst complex formation.

64 The plant exocyst complex functions in cell wall biosynthesis, pol

65 Here, we investigated the functions of exocyst complex genes encoding the remaining seven subun

66 mmary, EXO70A2 is a crucial component of the exocyst complex in Arabidopsis pollen that is required f

67 components and promotes the assembly of the exocyst complex in response to epidermal growth factor (

68 cular dissection of the GTPase Rab8a and the exocyst complex in tethering of the contractile vacuole

69 ) generation controls the integration of the exocyst complex into an integrin-containing trafficking

70 The EXOCYST complex is central to this process, and in yeast

71 In fungal pathogens, the exocyst complex is required for growth, development, and

72 The exocyst complex is required for tethering of secretory v

73 determined that the presence of an octameric exocyst complex is required for the formation of a funct

74 uctural integrity and that impairment of the exocyst complex leads to disruption of the slit diaphrag

75 Here, we show that the exocyst complex localizes to the tips of growing hyphae

76 The assembly of the exocyst complex mediates the tethering of post-Golgi sec

77 fertility phenotype, as did mutants of core exocyst complex member sec15a, indicating that reduced e

78 e expression of phosphorylated ERK, p21, and exocyst complex members Sec8 and Sec10, in the remaining

79 boration is coordinated by deposition of the exocyst complex on bacteria-containing vesicles, an even

80 Depletion of the exocyst complex phenocopied BLOC-2 depletion, resulting

81 The exocyst complex plays a critical role in determining bot

82 of Listeria protrusions, suggesting that the exocyst complex promotes protrusion elongation.

83 nents Sec3, Sec5, Sec6, Sec8, and Sec15, and exocyst complex proteins Exo70 and Exo84 localize specif

84 We silenced genes encoding exocyst complex proteins specifically in Drosophila neph

85 The exocyst complex regulates the last steps of exocytosis,

86 plasma membrane, possibly forming different exocyst complex subpopulations.

87 Sec5, which is an exocyst complex subunit and localizes to ingressing furr

88 t Rab8 behaviors require the function of the exocyst complex subunit Sec5 as well as the recycling en

89 Since EXOC2 and other exocyst complex subunits are critical to neuronal functi

90 The evolutionarily conserved octameric exocyst complex tethers secretory vesicles to the site o

91 Here we report that Sec3, a component of the exocyst complex that mediates vesicle tethering during e

92 abidopsis thaliana Exo70B2, a subunit of the exocyst complex that mediates vesicle tethering during e

93 tes the spatial-temporal distribution of the exocyst complex to promote polarized lysosome secretion

94 , for localization of the GTPase Ral and the exocyst complex to this region.

95 ction by disrupting the interaction with the exocyst complex via Sec15p.

96 The exocyst complex was believed to target and tether post-G

97 These functions do not involve the exocyst complex, a common Ral guanosine triphosphatase (

98 Schwann cell process extensions through the exocyst complex, a known effector of Ral GTPases, consis

99 ladder epithelial cells (BECs) mobilized the exocyst complex, a powerful exporter of subcellular vesi

100 The exocyst complex, an effector of Rho and Rab GTPases, is

101 ruits Drainin, a Rab11a effector, Rab8a, the exocyst complex, and LvsA, a protein of the Chediak-Higa

102 focused on exoc5, a central component of the exocyst complex, by analyzing both exoc5 zebrafish mutan

103 ctivation of Sec10, a central subunit of the exocyst complex, in the epithelial cells of the ureter a

104 e demonstrate that Exo70, a component of the exocyst complex, induces tubular membrane invaginations

105 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis a

106 y, which stretches from Rab8 to RalA and the exocyst complex, that mediates rapid furrow formation in

107 ation of Exo84 disrupted the assembly of the exocyst complex, thereby affecting exocytosis and cell s

108 Here, we show that Exo70, a component of the exocyst complex, undergoes isoform switching mediated by

109 EF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of

110 igomerization as well as its assembly to the exocyst complex, which are needed for cell protrusion fo

111 assemble fluorescently tagged Sec8 into the exocyst complex, which was shown to be functional by bio

112 n-2 are dependent on IFT20, GMAP210, and the exocyst complex, while smoothened delivery is largely in

113 bly as a regulator of exocytosis outside the exocyst complex.

114 phorylation of Exo70, a key component of the exocyst complex.

115 (GEF) that precipitated the assembly of the exocyst complex.

116 isteria in a manner that depends on the host exocyst complex.

117 ge factor Sec2p regulate the assembly of the exocyst complex.

118 g axons expands in a process mediated by the exocyst complex.

119 s nuclear membrane expansion, actin, and the exocyst complex.

120 a predicted member of the vesicle-tethering exocyst complex.

121 cells by targeting the EXO70 subunit of the exocyst complex.

122 s stable and could bind other members of the exocyst complex.

123 Our data support the concept that the exocyst-complex subunits dynamically dock and undock at

124 and 3D reconstructions of negatively stained exocyst complexes reveal a structural change in the muta

125 ains regulated by different EXO70-containing exocyst complexes within a single cell.

126 ing requires cooperation between the PAR and exocyst complexes.

127 ia virulence factor InlC associated with the exocyst component Exo70 and mediated the recruitment of

128 overlaps with a region interacting with the exocyst component Exo70, is necessary for the associatio

129 In S. cerevisiae, phosphorylation of the exocyst component Exo84 by Cdk1-Clb2 during mitosis caus

130 d that STK38 supports the interaction of the exocyst component Exo84 with Beclin1 and RalB, which is

131 The exocyst component EXOC7-H4-1 is not expressed within the

132 olecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst comp

133 cyst at primary cilia and interacts with the exocyst component Sec10.

134 d was accompanied by the polarization of the exocyst component Sec15.

135 mechanism unrelated to its interaction with exocyst component Sec15p.

136 s the destruction of the formin Bni1 and the exocyst component Sec3.

137 SSR growth requires Ral and the exocyst component Sec5 and Ral-induced enlargement of th

138 ngly, we found that GEF-H1 directly binds to exocyst component Sec5 in a Ral GTPase-dependent manner.

139 omozygous podocyte-specific Exoc5 (a central exocyst component that interacts with Exoc4) knockout mi

140 ho3p-interacting proteins, such as Sec8p, an exocyst component, Apm1p, a subunit of the clathrin adap

141 ocyst complex component 5 (EXOC5), a central exocyst component, results in very short or absent cilia

142 icles with Myo2p, the GEF Sec2p, and several exocyst components allowed us to document a timeline for

143 ation enhances the binding of Exo70 to other exocyst components and promotes the assembly of the exoc

144 ted with a novel form of secretion involving exocyst components and the Sso1 t-SNARE.

145 Although most exocyst components are brought to these sites by riding

146 Inactivation of exocyst components in inner germarial sheath cells, whic

147 , or conditional mutation, of genes encoding exocyst components leads to impaired plant infection.

148 with the outer macrovesicular layer, whereas exocyst components SEC-5, -6, -8, and -15 form a delimit

149 The exocyst components Sec3, Sec5, Sec6, Sec8, and Sec15, an

150 ible redundancy with Sec3p and Sec15p, other exocyst components that also interact with polarity dete

151 me of the spatially and temporally regulated exocyst components under transcriptional control by MAPK

152 These studies show that, although BLOC-2 and exocyst cooperate in WPB formation, only exocyst serves

153 We find that exocyst-deficient terminal cells have highly truncated b

154 6S proteasome subunit, Rpt2, indicating that exocyst degradation is controlled by the ubiquitin-prote

155 Here, to unravel the components of the exocyst degradation pathway, we screened for extragenic

156 ear membrane expansion, DNA replication, and exocyst-dependent anchoring of the nuclear envelope to t

157 used RalB-selective activation and Sec5- and exocyst-dependent engagement of mTORC1 and suppression o

158 rons increases dendritic spine density in an exocyst-dependent manner and increases Sec5 in spines.

159 ound that STK38 is stimulated in a MOB1- and exocyst-dependent manner.

160 sates of immature WPBs from either BLOC-2 or exocyst-depleted endothelial cells lacked high-molecular

161 though BLOC-2 depletion impaired exocytosis, exocyst depletion augmented WPB exocytosis, indicating t

162 These findings reveal that RAL-1 and the exocyst direct the polarized vesicle fusion events requi

163 whereas Sec2p and all the components of the exocyst disperse coincident with fusion.

164 inds directly to Exo70 and is sufficient for exocyst docking, membrane-protein delivery and cell surv

165 of injured podocytes identified significant exocyst down-regulation.

166 dent on RalBP1/RLIP76 but not Sec5 and Exo84 exocyst effector function.

167 elial cells to a small molecule inhibitor of exocyst, Endosidin2, reversibly augmented secretion of m

168 is thaliana) EXO70A2 (At5g52340) is the main exocyst EXO70 isoform in the male gametophyte, governing

169 sonance energy transfer analyses showed that exocyst EXO70 subunits bind preferentially to cognate pl

170 Exocyst foci partially overlapped with vesicles visualiz

171 Exocyst foci were independent of cytoskeleton, although

172 ur findings provide a mechanism by which the exocyst function and actin dynamics are modulated for EM

173 mplex member sec15a, indicating that reduced exocyst function bypassed the PT requirement for Hyp-Ara

174 vel biochemical assay for the examination of exocyst function in vesicle tethering.

175 Exocyst function in VWF maturation and release are separ

176 iscovery of mutations that partially disable exocyst function provides valuable insight into this ess

177 Furthermore, disruption of exocyst function through Exo70 depletion led to a defect

178 er, our results indicate that Arl13b and the exocyst function together in the same pathway leading to

179 associate with the cortex but cannot support exocyst function.

180 nthesis of TC10, a small GTPase required for exocyst function.

181 ug treatments, supporting the concept of the exocyst functioning as a dynamic particle.

182 However, the mechanism by which the exocyst functions and how it is regulated remain poorly

183 Here, this study shows that the exocyst functions in the niche to promote germline stem

184 To investigate the exocyst functions, here we exchanged proline for alanine

185 ering assay and increased v-SNARE binding to exocyst gain-of-function complexes.

186 Ultrastructural analysis revealed that exocyst gene silencing led to the striking appearance of

187 OC5 (exocyst complex component 5), a central exocyst gene/protein, and generated stable EXOC5 ciliary

188 Syncytium-expressed exocyst genes function in defense while some are under t

189 Silencing exocyst genes in nephrocytes led to profound changes in

190 re consistent with an important role for the exocyst in coordinating endocytosis and exocytosis.

191 , this study reveals a novel function of the exocyst in niche cells to promote stem cell progeny diff

192 complex assembly, and uncovers a role of the exocyst in promoting membrane fusion in addition to vesi

193 mponents of the DNA damage response (DDR) as exocyst-interacting proteins, together with the identifi

194 The exocyst is a heterooctomeric complex well appreciated fo

195 The exocyst is a highly conserved protein complex found in m

196 The exocyst is a multiprotein complex essential for exocytos

197 The exocyst is an essential component of the secretory pathw

198 To test the hypothesis that the exocyst is centrally involved in podocyte development/fu

199 l processes, but the mechanisms by which the exocyst is degraded are unknown.

200 The G. max exocyst is encoded by 61 genes: 5 EXOC1 (Sec3), 2 EXOC2

201 Although the exocyst is known to be important for protein membrane tr

202 onclude that septin-mediated assembly of the exocyst is necessary for appressorium repolarization and

203 and eyes of zebrafish and mice and that the exocyst is necessary for photoreceptor ciliogenesis and

204 The vesicle-tethering complex exocyst is one of the crucial cell polarity regulators.

205 The spatio-temporal regulation of the exocyst is only partially understood.

206 We propose that the exocyst is recruited to secretory vesicles by the combin

207 The exocyst is required for maintaining niche cells and prev

208 f the complex there, and mistargeting of the exocyst led to secretion defects in cells.

209 expression of Sec4p partially suppressed the exocyst localization defects of mutations in clathrin an

210 prolonged actin disruption led to changes in exocyst localization.

211 Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch

212 VWF, demonstrating the importance of BLOC-2/exocyst-mediated endosomal input during VWF maturation.

213 effector of Ral GTPases, consistent with an exocyst-mediated function of Ral GTPases in Schwann cell

214 p plasma membrane, consistent with a role in exocyst-mediated secretion.

215 txA-driven cAMP increase also inhibits Rab11/exocyst-mediated trafficking of host proteins including

216 The apical region of exocyst-mediated vesicle fusion, elucidated by the plasm

217 mics and membrane trafficking, their role in exocyst-mediated vesicle targeting is not very clear.

218 pecifically disrupts this interaction led to exocyst mislocalization and a block in exocytosis in viv

219 green fluorescent protein foci in an exo70A1 exocyst mutant.

220 Exocyst mutants displayed altered endocytic and post-Gol

221 Exocyst mutations cause nuclear positioning defects and

222 Loss of either the exocyst or RAL-1 prevents excretory canal lumen extensio

223 We found that exocyst perturbation resulted in resistance to ionizing

224 utations in genes encoding the eight-protein exocyst protein complex to kidney disease, but the under

225 localization of slit diaphragm proteins with exocyst protein Sec15 and with endocytosis and recycling

226 Depletion of exocyst proteins reduced the length of Listeria protrusi

227 PAR proteins concentrate membrane-localized exocyst proteins to a polarized domain.

228 ate the small GTPase Ral and thereby recruit exocyst proteins to postsynaptic zones.

229 We conclude that Par3 is the long-sought exocyst receptor required for targeted membrane-protein

230 n was seen, arguing against a direct role in exocyst recruitment.

231 ize the function and mechanisms by which the exocyst regulates eye development in zebrafish, we focus

232 ic studies indicated important roles for the exocyst regulators Rab8 and Rab11 in bacterial protrusio

233 c regulation of the evolutionarily conserved exocyst-related processes using mutants in genetically t

234 Thus, Ral regulation of the exocyst represents a control point for postsynaptic plas

235 Genetic dismantling of the exocyst resulted in impaired ciliogenesis, disrupted cil

236 vel electron-dense structures that we named "exocyst rods," which likely represent accumulated membra

237 tion mutations in the Exo70 component of the exocyst, selected for their ability to bypass Rho/Cdc42

238 and exocyst cooperate in WPB formation, only exocyst serves to clamp WPB release.

239 The exocyst serves to tether secretory vesicles to cortical

240 However, BLOC-2 and exocyst showed very different effects on VWF release.

241 r, during infection-related development, the exocyst specifically assembles in the appressorium at th

242 lize each other at endosomes and recruit the exocyst subcomplex containing Sec5.

243 ndings show that P. infestans manipulates an exocyst subunit and thereby potentially disturbs vesicle

244 ding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fis

245 One of the exocyst subunit genes, EXO70A1, was previously identifie

246 were used to suppress the expression of each exocyst subunit individually.

247 Both isoforms partly colocalized with the exocyst subunit NtSEC3a at the plasma membrane, possibly

248 Here, we show that a sec3a exocyst subunit null mutant cannot be transmitted throug

249 In zebrafish, depletion of arl13b or the exocyst subunit sec10 causes phenotypes characteristic o

250 ensitive fission yeast strain mutated in the exocyst subunit Sec3 (sec3-913).

251 previously that the Saccharomyces cerevisiae exocyst subunit Sec6 directly bound the plasma membrane

252 We observe a direct interaction between the exocyst subunit Sec6p and the latter half of the SNARE m

253 yst via a direct interaction with Exo70, the exocyst subunit that guides the polarized targeting of e

254 ow that an otherwise nuclear and cytoplasmic exocyst subunit, EXO70H4, systematically co-localizes wi

255 We report pathogenic variants in an exocyst subunit, EXOC2 (Sec5).

256 We focused on the EXO70H4 exocyst subunit, one of the most up-regulated genes in t

257 ic lines to evaluate the requirement of each exocyst subunit.

258 n-based transport mediate the recruitment of exocyst subunits and secretory vesicles during exocytosi

259 In land plants, several exocyst subunits are encoded by double or triple paralog

260 rovide comprehensive evidence that all eight exocyst subunits are necessary in the stigma for the acc

261 Two distinct localization patterns of exocyst subunits at the hyphal tip suggest the dynamic f

262 ce microscopy, we visualized the dynamics of exocyst subunits at this domain.

263 inal NOI domain of AtRIN4 interacts with the exocyst subunits EXO70B1, EXO70E1, EXO70E2, and EXO70F1.

264 Our study helps to establish the role of the exocyst subunits in tethering and allows the investigati

265 The absent EXO70C2 interactions with core exocyst subunits in the yeast two-hybrid assay, cytoplas

266 Exocyst subunits localize to secretory-active regions of

267 Here we report that the exocyst subunits Sec8, Exo70, and Sec5 bind preferential

268 ng assay in yeast in which each of the eight exocyst subunits was expressed on the surface of mitocho

269 We find that most of the exocyst subunits were able to recruit the other members

270 hypothesized that EXO70A1, along with other exocyst subunits, functions in the Brassicaceae dry stig

271 elucidated by the plasma membrane-associated exocyst subunits, indicates the presence of an exocytoti

272 this study was to examine the requirement of exocyst subunits, which function in docking secretory ve

273 Thus, the exocyst supports DNA repair fidelity by limiting the for

274 the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carrying ciliary prot

275 t site for plasma-membrane insertion through exocyst-tethered vesicles during cytokinesis.

276 l wall remodeling, likely through control of exocyst tethering and the targeting of other polarity-en

277 They further identify an exocyst tethering complex mediator of outer lateral memb

278 d Sec1 may have functions independent of the exocyst tethering complex on the plasma membrane at the

279 on at a growing pollen tube tip requires the exocyst tethering complex responsible for specific targe

280 eam effector of Sec4p and a component of the exocyst tethering complex, thus forming a positive-feedb

281 e cell surface through interactions with the exocyst tethering complex.

282 ructures along the cleavage furrow while the exocyst tethers vesicles at the rim of the division plan

283 xes reveal a structural change in the mutant exocyst that exposes a binding site for the v-SNARE.

284 However, the mechanism by which the exocyst, the exocytosis-specific multisubunit tethering

285 ired for proper membrane localization of the exocyst, thus identifying a molecular link between the b

286 al expressed in Drosophila muscle causes the exocyst to be concentrated in the region surrounding syn

287 osphorylation, resulting from failure of the exocyst to deliver basolateral proteins to the cortex.

288 In accord with the ability of the exocyst to direct delivery of post-Golgi vesicles, const

289 Exo84 by Cdk1-Clb2 during mitosis causes the exocyst to disassemble.

290 ese results suggest that Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets

291 mutations that affect the recruitment of the exocyst to secretory vesicles identified genes encoding

292 edes the nucleotide-dependent arrival of the exocyst to the bladder by a few seconds.

293 AR proteins, we show that RAL-1 recruits the exocyst to the membrane, while PAR proteins concentrate

294 bunit that guides the polarized targeting of exocyst to the plasma membrane.

295 uption of the highly-conserved eight-protein exocyst trafficking complex could have a role in podocyt

296 hown that the highly conserved eight-protein exocyst trafficking complex is required for ciliogenesis

297 The exocyst vesicle-tethering complex functions in polarized

298 h localizes to vesicles and acts through the exocyst vesicle-tethering complex.

299 te 5-kinase (PIPKIgamma) associates with the exocyst via a direct interaction with Exo70, the exocyst

300 rmin) and membrane trafficking (myosin-V and exocyst) were dynamic during cytokinesis.

301 extensively studied tethering complex is the exocyst, which spatially targets vesicles to sites on th

302 owever, no significant colocalization of the exocyst with clathrin was seen, arguing against a direct