ライフサイエンスコーパス: exocytotic

1 The exocytotic acrosome reaction (AR), which is required for

2 However, Syt-7's precise exocytotic actions in beta-cells remain unknown.

3 es for performing amperometric recordings of exocytotic activity and interpreting the results based o

4 -labeled beta cells followed the dynamics of exocytotic activity at subcellular resolution, even when

5 Frequenin/NCS-1 has been shown to enhance exocytotic activity in addition to altering Ca2+ channel

6 entify domains critical to the regulation of exocytotic activity to tomosyn that are outside the solu

7 features of ATP-evoked Ca(2)(+) dynamics and exocytotic activity.

8 in that associates with Q-SNAREs and reduces exocytotic activity.

9 s of neuronal activity with Ca(2+)-dependent exocytotic activity.

10 VMAT (dVMAT) null mutant to globally ablate exocytotic amine release and then restored DVMAT activit

11 d can operate in reverse mode, mediating non-exocytotic amine release.

12 Recombinant t-PA (rt-PA) induced exocytotic and carrier-mediated NE release from cardiac

13 sicle recycling by directly coupling to both exocytotic and endocytic machineries.

14 Inhibition of PI3Kgamma blunted the exocytotic and insulinotropic response to GIP receptor a

15 nverted hexagonal phase, which may influence exocytotic and membrane fusion processes within the cell

16 lymerization with latrunculin B restored the exocytotic and secretory responses to GIP during PI3Kgam

17 ormation is essential for membrane fusion in exocytotic and vacuolar trafficking pathways.

18 embly of a cytoplasmic scaffold to which the exocytotic apparatus is recruited.

19 communicates with the pancreatic beta-cell's exocytotic apparatus.

20 lar calcium-independent, suggesting that non-exocytotic ATP release from ciliated cells, which domina

21 ped lamellipodia protrusion and activated an exocytotic burst.

22 e, where SNAP25, but not SNAP23, supports an exocytotic burst.

23 NAP25/23 differential ability to control the exocytotic burst.

24 'graded' synapse, depolarization produces an exocytotic 'burst' that is largely complete within 20 ms

25 IV was essential for establishing the linear exocytotic Ca(2+) dependence in adult rodent IHCs and im

26 ed in both cell types despite the high-order exocytotic Ca(2+) dependence in IHCs and the near-linear

27 cell line, express multiple isoforms of the exocytotic Ca(2+) sensor synaptotagmin.

28 -hairpin RNA targeted to synaptotagmin I, an exocytotic Ca(2+) sensor, we show that the presence and

29 e delivery down ribbons and by properties of exocytotic Ca(2+) sensors.

30 ass A (P/Q-type) Ca2+ channels, the dominant exocytotic Ca2+ channel at most synapses in the mammalia

31 The depression of exocytotic capacitance changes exceeded depression of th

32 evoked by flash-photolysis of caged Ca(2+): exocytotic capacitance changes from individual rods and

33 on (PPD) at rates similar to the recovery of exocytotic capacitance changes in rods and cones.

34 t much faster exocytotic kinetics than rods, exocytotic capacitance changes recovered from PPD at sim

35 LI) of Ribeye caused only weak inhibition of exocytotic capacitance increases evoked by 200-ms depola

36 We conclude that EXO70I provides a specific exocytotic capacity necessary for development of the mai

37 tions of the molecular events underlying the exocytotic cascade.

38 ance energy transfer (FRET) microscopy while exocytotic catecholamine release from single vesicles wa

39 n excellent sensing activity for single-cell exocytotic catecholamine release, specifically dopamine.

40 ntillas are found in a variety of excitable, exocytotic cells.

41 two behavioral consequences of capacitation, exocytotic competence and altered motility, are therefor

42 vivo through effects on sperm transport and exocytotic competence and is a factor in postcopulatory

43 ed apical exocytosis and formation of apical exocytotic complexes (between Munc18b and Syntaxin-2, sy

44 fusion between ZGs by the formation of ZG-ZG exocytotic complexes (between Munc18b and Syntaxin-3, SN

45 iated primarily via formation of basolateral exocytotic complexes (between Munc18c and Syntaxin-4, SN

46 stimulation-induced increase in abundance of exocytotic complexes we previously demonstrated as media

47 C2-EF, or C2-DEF partially restores the fast exocytotic component in Otof (-/-) mouse IHCs.

48 The restoration of the fast exocytotic component in the transduced Otof (-/-) IHCs w

49 othesized that UDP-sugar release includes an exocytotic component.

50 pool (RRP); that is, they encode the phasic exocytotic component.

51 by specific protein complexes, but the SNARE exocytotic core has not been defined in airway goblet ce

52 This endocytotic/exocytotic coupling requires a tight link between exocyt

53 Here, we describe a model of the exocytotic cycle of vesicles at excitatory and inhibitor

54 dentified cytolytic molecule associated with exocytotic cytolytic granules.

55 red stimulation-dependent DA release and non-exocytotic DA efflux from mouse striatal slices and extr

56 The real-time recording of the exocytotic DA induced by hypoxia reveals that the increa

57 To unequivocally determine the beta-cell exocytotic defects caused by Syn-1A deletion, EM and tot

58 roscopy, we demonstrate that the majority of exocytotic delivery events for a recycled membrane prote

59 he plasma membrane, suggesting a Golgi-based exocytotic delivery of TGase.

60 ection reflex was effective in supporting an exocytotic DeltaC(m) in isolated MNCs, indicating that t

61 of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays schizophrenic endoph

62 These findings identify upregulation of exocytotic dopamine release as a key AMPH action in beha

63 ype of microelectrode sensor for single-cell exocytotic dopamine release.

64 has been used for amperometric detection of exocytotic dopamine secretion from individual pheochromo

65 egranulation in WT goblet cells and improved exocytotic dynamics in CF goblet cells; however, there w

66 determined that CF goblet cells have altered exocytotic dynamics, which involved intrathecal granule

67 the middle of a stimulus train revealed that exocytotic efficacy (capacitance increase per amount of

68 Instead, the activity-dependent increase in exocytotic efficacy observed in control cells did not oc

69 Vesicle pool size, exocytotic efficiency (amount of exocytosis per Ca influ

70 he human sperm acrosome reaction (a modified exocytotic event essential to fertilization).

71 The acrosome reaction is a unique exocytotic event involving a series of prolonged membran

72 J) triggers sperm acrosome reaction (AR), an exocytotic event required for membrane fusion of the gam

73 ian eggs release billions of zinc ions in an exocytotic event termed the "zinc spark." The zinc spark

74 An exocytotic event then results in the recording of a curr

75 y occur in the precise location of the final exocytotic event(s), may directly trigger exocytosis.

76 Sperm of many animals must complete an exocytotic event, the acrosome reaction, in order to fus

77 lling the number of fusion pore flickers per exocytotic event.

78 Using zinc release as a direct marker for exocytotic events and a surrogate marker for glutamate r

79 acquisition and filtering, (ii) detection of exocytotic events and determining spike shape characteri

80 1 agonist, SKF-38393, enhanced the number of exocytotic events as did prior exposure of the cell to e

81 1 for 40 s resulted in 12.2 +/- 2.1 (n = 14) exocytotic events as measured by amperometry, whereas th

82 erneurons (MLIs) are not activated by single exocytotic events but can respond to glutamate spillover

83 etric detection demonstrates that individual exocytotic events can be recorded at these arrays with s

84 VAMP 2-positive ZGs mediate the majority of exocytotic events during constitutive secretion and also

85 The secretory responses and exocytotic events evoked by CCK-8 were mediated by CCK-A

86 x 4 muG-SCD MEA) for real-time monitoring of exocytotic events from cultured chromaffin cells and adr

87 the first time, the recording of individual exocytotic events from peptidergic NHT.

88 were used for electrochemical monitoring of exocytotic events from single PC12 cells.

89 nd dynamics depend on these residues, single exocytotic events in bovine chromaffin cells expressing

90 observed in 24 +/- 1% of glucose-stimulated exocytotic events in cells maintained at 10 mmol/l gluco

91 Single exocytotic events in chromaffin cells expressing this mu

92 re, we compare the "nanomechanics" of single exocytotic events in primary rat pancreatic beta-cells c

93 Spikes reminiscent of exocytotic events in secretory animal cells progressivel

94 changes were paralleled by a lower number of exocytotic events in the KO beta-cells in response to th

95 dysferlin has been linked to SNARE-mediated exocytotic events including cytokine release and acid sp

96 he plasma membrane, and that the majority of exocytotic events occur by full, not partial, fusion.

97 The two-dimensional position of single exocytotic events occurring in the center gap area separ

98 utilized in this study to measure individual exocytotic events of secretion of serotonin and histamin

99 The frequency and number of exocytotic events per stimulus, however, was lower for b

100 Netrin-1-dependent regulation of exocytotic events requires the activation of the Erk1/2

101 Thus, individual exocytotic events result in spontaneous GPCR-mediated tr

102 conditions, a second stimulation evoked more exocytotic events than the first.

103 terized the spatial and temporal dynamics of exocytotic events that occur spontaneously or in respons

104 embrane lipid microdomains and the number of exocytotic events were decreased and the fusion kinetics

105 cytotic events; and, conversely, spontaneous exocytotic events were not preceded by syntillas.

106 Approximately 75% of the exocytotic events were represented by compound granule f

107 um electrodes are thus able to record single exocytotic events with high resolution and should be sui

108 resolve the waveform of different subsets of exocytotic events, and (iii) monitoring quantal secretor

109 uclein accelerate the kinetics of individual exocytotic events, promoting cargo discharge and reducin

110 -evoked exocytosis by reducing the number of exocytotic events, without modifying vesicle size.

111 processes along the cell surface, including exocytotic events.

112 that there were no defects in Ca2+-dependent exocytotic events.

113 eformation and stabilize fusion pores during exocytotic events.

114 UT drastically increases the quantal size of exocytotic events.

115 Syntillas failed to produce exocytotic events; and, conversely, spontaneous exocytot

116 try is a popular method for measuring single exocytotic events; however, the functional interpretatio

117 els in the apical plasma membrane as well as exocytotic export of enzymes.

118 usion pore is an important driving force for exocytotic extrusion of granule contents from secretory

119 potential for systematic studies showing how exocytotic function is influenced by nanoparticle size,

120 am of Ca2+ entry and may directly target the exocytotic fusion machinery at the presynaptic terminal.

121 yed a major role in elucidating the synaptic exocytotic fusion machinery with ever increasing detail.

122 [glutamate]o increases induce formation and exocytotic fusion of glutamate-containing large astrocyt

123 ng of these granules to the plasma membrane, exocytotic fusion of granules with the plasma membrane,

124 yotic cells, polarized secretion mediated by exocytotic fusion of membrane vesicles with the plasma m

125 proximately 40 fC) were compatible with full exocytotic fusion of small clear and dense core vesicles

126 through voltage-gated channels initiates the exocytotic fusion of synaptic vesicles to the plasma mem

127 A, and SNAP-25 is the key step that leads to exocytotic fusion of synaptic vesicles.

128 -cells than its previously purported role in exocytotic fusion per se.

129 ted that the greater stability of an initial exocytotic fusion pore associated with larger vesicles r

130 ge was abrupt and preceded the opening of an exocytotic fusion pore by approximately 90 ms.

131 photon microscopy imaging, we found that the exocytotic fusion pore was generated from the SNARE-depe

132 icle volume can modulate the activity of the exocytotic fusion pore.

133 ts dose-dependent effects on dilation of the exocytotic fusion pore.

134 Opening of individual exocytotic fusion pores in chromaffin cells was imaged e

135 ransmitters are released through fluctuating exocytotic fusion pores that can flicker open and shut m

136 d membranes and promote the stabilization of exocytotic fusion pores.

137 Exocytotic fusion was monitored by capacitance measureme

138 vesicles and is thought to facilitate their exocytotic fusion.

139 ellar granule cells: action potential-evoked exocytotic GABA release, non-vesicular release, and ACh-

140 dicate that VGLUTs play a functional role in exocytotic glutamate release from astrocytes.

141 2+)-dependent processes in astrocytes (i.e., exocytotic glutamate release, in vitro wound closure, an

142 ocyst subunits, indicates the presence of an exocytotic gradient with a tip-high maximum that dissipa

143 ion-repulsion mechanism, we suggest that the exocytotic Hofmeister series effect originates from a lo

144 recordings or (2) by direct measurements of exocytotic increases in membrane capacitance.

145 is blocked by injecting botulinum toxin, an exocytotic inhibitor, into motor neurons before applicat

146 Kinetic ordering of exocytotic inhibitors has shown that E peptide acts late

147 We also demonstrate that the exocytotic insertion and activation of hTRPC4 following

148 ty of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane

149 racellular Ca2+ mobilization is required for exocytotic insertion of aquaporin-2.

150 that sensitization-induced Ca(2+)-dependent exocytotic insertion of transient receptor potential van

151 Although cones exhibit much faster exocytotic kinetics than rods, exocytotic capacitance ch

152 epression, via synaptic vesicles with slower exocytotic kinetics.

153 ied that sphingosine influences directly the exocytotic machinery by activating the synaptic vesicle

154 , suggesting a pathway for the regulation of exocytotic machinery by reduction of cytochrome c.

155 h and suggest differential regulation of the exocytotic machinery depending on pollen tube growth mod

156 Moreover, the exocytotic machinery in mutant IHCs does not develop nor

157 aptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt i

158 secretion in vivo, with dysregulation of the exocytotic machinery sensitizing beta-cells to overt dia

159 oncentrations, and intact sensitivity of the exocytotic machinery to Ca(2+).

160 emical messengers and employ known conserved exocytotic machinery to deliver them; therefore, the mec

161 the V-ATPase membrane domain would allow the exocytotic machinery to discriminate fully loaded and ac

162 examined the association of proteins of the exocytotic machinery with rafts purified from PC12 cells

163 ase is a complex process accomplished by the exocytotic machinery working in tandem with numerous reg

164 al AIS, lacks both sodium channels and local exocytotic machinery, and yet contains a dense cluster o

165 protein constituents of the neurotransmitter exocytotic machinery, are expressed in pancreatic beta c

166 f neurotransmission, from dendritic spine to exocytotic machinery, is in play, and defects of synapti

167 Because sulfonylureas directly activate the exocytotic machinery, we were interested in the extent t

168 mably at the level of vesicle trafficking or exocytotic machinery.

169 vels and modification of the proteins of the exocytotic machinery.

170 b3A is an essential component of human sperm exocytotic machinery.

171 cted, arguing against a direct action on the exocytotic machinery.

172 ally (ERG recordings, synaptic uptake of the exocytotic marker FM1-43, and light-induced translocatio

173 n the presence of AM251, suggesting that the exocytotic mechanism that produces WIN55,212-2 sensitive

174 can therefore be clearly dissociated from an exocytotic mechanism, a finding that is not easily recon

175 etting either to directly modulate intrinsic exocytotic mechanisms or to load mast cells with bioacti

176 idly triggers a combination of homotypic and exocytotic membrane fusion events.

177 Neuronal exocytotic membrane fusion occurs on a fast timescale an

178 nine nucleotide, and protein kinase C in the exocytotic membrane fusion process in chromaffin cells.

179 nd double C2 domain (Doc2) families regulate exocytotic membrane fusion via direct interactions with

180 e plasma membrane are crucial for triggering exocytotic membrane fusion.

181 r Zn(2+) regulates neuronal apoptosis via an exocytotic membrane insertion of Kv2.1-encoded ion chann

182 cate that the molecular identity of opposing exocytotic membranes is preserved by the sorting of synt

183 liquid domains, inducing them to form mainly exocytotic monodisperse smaller vesicle buds of this sam

184 some, which acts as a nexus in the endo- and exocytotic networks.

185 sporters can act as ion channels that affect exocytotic neurotransmitter release and can operate in r

186 Nevertheless, this type of exocytotic neurotransmitter release appears to fully ope

187 Both exocytotic (NSF) and endocytotic (dynamin) ATPase/GTPase

188 -glucose cotransporter SGLT1 by blocking the exocytotic pathway at the trans-Golgi.

189 esicle trafficking suggests that the ancient exocytotic pathway forming the periarbuscular membrane c

190 thesis that RS1-Reg(S20E) down-regulates the exocytotic pathway of SGLT1 at the trans-Golgi by inhibi

191 pendent disinhibition of the RS1-Reg-blocked exocytotic pathway of SGLT1 between meals.

192 he data indicate that QEP down-regulates the exocytotic pathway of SGLT1 similar to hRS1-Reg(S20E).

193 chronic nicotine act on nAChRs in the early exocytotic pathway, and that this pathway does not prese

194 nc18-1, which recruits syntaxin-1 within the exocytotic pathway, does not modulate Ca(2+) channels, w

195 ls and eosinophils, suggesting a role in the exocytotic pathway.

196 te the possibility that lipid rafts organize exocytotic pathways in neuroendocrine cells, we examined

197 We have compared two exocytotic peak populations obtained from PC12 cells wit

198 of the glycocalyx along the cell surface on exocytotic peaks, observed with single cell amperometry,

199 d-type, but not Kv2.1-DeltaC318, rescues the exocytotic phenotype in T2D beta-cells and increases ins

200 The exocytotic process can be further regulated by complexin

201 quired for the ensuing acrosome reaction, an exocytotic process essential for fertilization.

202 The effects of these mutations on the exocytotic process in chromaffin cells were assessed usi

203 iates the homologs of exocyst subunits to an exocytotic process in plant development and supports the

204 rganelles in the cytoplasm suggests that the exocytotic process is tightly coupled to a fast compound

205 ractivation) and to prepare the sperm for an exocytotic process known as acrosome reaction.

206 granules; however, little is known about the exocytotic process of goblet cells in the CF intestine.

207 induces the sperm acrosome reaction (AR), an exocytotic process required for animal fertilization.

208 During the exocytotic process, individual exocytotic release events

209 ransients, demonstrating a calcium-dependent exocytotic process.

210 Complexin is involved in a Ca(2+)-triggered exocytotic process.

211 n-induced phosphatidylserine demixing to the exocytotic process.

212 ophysical characteristics of the fundamental exocytotic process.

213 underlying biochemical mechanism of various exocytotic processes mediated by different SNARE protein

214 disease involves the use of MgApt2-dependent exocytotic processes that operate during plant infection

215 ificant (P < 0.05) increase in the number of exocytotic profiles from type II lactotrophs (characteri

216 of islet glucose phosphorylation as well as exocytotic protein VAMP-2 in Tlr3(-/-) islets.

217 No changes in gene transcription of key exocytotic protein were observed.

218 was shown to be an upstream regulator of the exocytotic protein, syntaxin.

219 Ca(2)(+) channel proximity to exocytotic proteins and vesicle clusters at active zones

220 Hypothesizing that exocytotic proteins might be targets of S-nitrosylation,

221 molecules and is comparable to the measured exocytotic quantal glutamate release in amperometric glu

222 Silencing of the exocytotic RAB family members RAB27A or RAB27B halted mi

223 These deficits in refilling and exocytotic rate in ashen beta-cells were absent when cAM

224 contribution of endocytosis to the measured exocytotic rate under different experimental conditions.

225 teps, including not only the endocytotic and exocytotic rates, but also the two rate coefficients cou

226 components after strong stimulation and high exocytotic rates.

227 ciceptors by abrogating its Ca(2+)-dependent exocytotic recruitment.

228 The exocytotic recycling of tPA by astrocytes is inhibited i

229 t evidence for a persistent curvature in the exocytotic region that is altered by inhibition of dynam

230 rgeted zinc indicator for monitoring induced exocytotic release (ZIMIR).

231 nces between behaviors regulated by standard exocytotic release and those regulated by other mechanis

232 In addition to action potential-evoked exocytotic release at neurohypophysial nerve terminals,

233 ydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission.

234 ally modified the kinetics of single-granule exocytotic release events, consistent with an accelerati

235 During the exocytotic process, individual exocytotic release events, measured as current spikes at

236 of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons.

237 dopaminergic drugs on imaging single vesicle exocytotic release from PC12 cell clusters is presented

238 aling pathway that interferes with vesicular exocytotic release machinery.

239 These findings suggest an exocytotic release mechanism similar to that of ATP, a c

240 e HVR in anaesthetized rats, indicating that exocytotic release of a gliotransmitter within the preBo

241 burst of DA on par with a quantum of DA from exocytotic release of a vesicle, this burst mode of rele

242 sporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters.

243 ic acid exporter also recently implicated in exocytotic release of aspartate.

244 This capacity to enhance exocytotic release of dopamine may be important for the

245 rescence microscopy, we directly observe the exocytotic release of EGFP-CD63 ILVs as discrete particl

246 The stimulated exocytotic release of ET-1 is dramatically increased in

247 determine whether VGLUT2 is required for the exocytotic release of glutamate from dopamine neurons.

248 Flickering of fusion pores during exocytotic release of hormones and neurotransmitters is

249 duced electrical activity that culminates in exocytotic release of insulin, the cellular control of e

250 ugh diverse pathological stimuli can provoke exocytotic release of mucin from secretory cells of the

251 es allows for rapid and spatially restricted exocytotic release of neurotransmitter.

252 vity through a cooperative mechanism for the exocytotic release of neurotransmitter.

253 ptor (SNARE) core complexes that mediate the exocytotic release of neurotransmitters at chemical syna

254 Exocytotic release of neurotransmitters is mediated by t

255 e conversion of electrical impulses into the exocytotic release of neurotransmitters.

256 Quantal events, consistent with exocytotic release of norepinephrine, were registered at

257 Exocytotic release of the excitatory neurotransmitter gl

258 Exocytotic release of transmitters is mediated by the te

259 at the transients correspond to detection of exocytotic release of Zn2+.

260 e efficacious at inhibiting Ca(2+)-triggered exocytotic release than wild-type Gbetagamma were also s

261 y depleting vesicular stores and driving non-exocytotic release through reverse transport, this psych

262 ission by blocking reuptake and reducing the exocytotic release, respectively.

263 transmitter biosynthesis, vesicular storage, exocytotic release, stimulus coupling (signal transducti

264 hat SNAP25 and SNAP23 have distinct roles in exocytotic release, where SNAP25, but not SNAP23, suppor

265 ansport into synaptic vesicles for regulated exocytotic release.

266 o not support mechanisms involving increased exocytotic release.

267 h faces particular spatiotemporal demands on exocytotic release; large amounts of neurohormone need t

268 These exocytotic responses are believed to mobilize sequential

269 Immature mutant IHCs showed impaired exocytotic responses, which are likely to be due to the

270 As in other eukaryotic cells, exocytotic secretion from astrocytes involves divergent

271 Exocytotic secretion is promoted by the concerted action

272 ecessary for cytoskeletal reorganization and exocytotic secretion of insulin.

273 lcium-dependent, but not calcium-independent exocytotic secretion of peroxidase was eliminated in gla

274 Stimulation of exocytotic secretion revealed prompt, dynamic increases

275 to the efficacy of inhibition by tomosyn on exocytotic secretion.

276 oscillations likely require ATP release via exocytotic secretion.

277 tin SEPT5 at S327 plays a role in modulating exocytotic secretion.

278 brane, are also released from astrocytes via exocytotic secretion.

279 siological endpoints: in this case, fluid or exocytotic secretion.

280 tory organelles and on the regulation of the exocytotic secretory system in the context of healthy an

281 defining the rate-controlling step(s) of an exocytotic sequence, allowing interpretation of electroa

282 Exocytotic signals have been successfully recorded from

283 the secretory response, likely at the distal exocytotic site.

284 on of GM1-enriched lipid microdomains at the exocytotic sites in chromaffin cells.

285 In addition, approximately 10% of the exocytotic sites were much more likely to occur within a

286 s apparently essential for generating active exocytotic sites.

287 inc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reupt

288 be restricted to neuronal and neuronal-like exocytotic tissues, consistent with neuronally restricte

289 l may contribute to receptor endocytotic and exocytotic trafficking and recycling.

290 P-IRAP/WT but did not block the constitutive exocytotic trafficking of EGFP-IRAP/AA(76,77).

291 fles by inhibiting Rab5-mediated endocytotic/exocytotic trafficking of Rac1.

292 receptors (DORs) to plasma membrane through exocytotic trafficking, but the role of this new DOR and

293 d Rab GTPases, is believed to function as an exocytotic vesicle tether at the plasma membrane before

294 se VAMP72s as common symbiotic regulators in exocytotic vesicle trafficking suggests that the ancient

295 Here, we show that two highly homologous exocytotic vesicle-associated membrane proteins (VAMPs)

296 ubunit of the exocyst complex, which tethers exocytotic vesicles prior to their fusion.

297 In addition, inhibiting uptake of ATP into exocytotic vesicles with bafilomycin also reduced ATP re

298 d Sec4p, another Myo2p cargo associated with exocytotic vesicles, reside predominantly on different c

299 SR), GLUT4-storage endosomes (ST), and GLUT4 exocytotic vesicules (EV), respectively, prompting us to

300 resulting from increased ion fluxes and the exocytotic work load.