ライフサイエンスコーパス: exotoxin

1 the remaining 25-kDa portion of Pseudomonas exotoxin.

2 of IL-13 and a truncated form of Pseudomonas exotoxin.

3 wo unrelated toxins, anthrax and Pseudomonas exotoxin.

4 coccal superantigen, streptococcal pyrogenic exotoxin.

5 -4 is fused to a mutated form of Pseudomonas exotoxin.

6 a colonization factor, and cholera toxin, an exotoxin.

7 ells reflects the action of a potent protein exotoxin.

8 /CaM-dependent kinase kinase and the anthrax exotoxin.

9 d that it decreases the release of pyocyanin exotoxin.

10 -causing GAS mediated by prophage PhiHKU.vir exotoxins.

11 in response to bacterial pathogens and their exotoxins.

12 IgG) and IgG antibody levels to 11 S. aureus exotoxins.

13 mammals are not the primary targets of these exotoxins.

14 e IL-17 after stimulation with gram-positive exotoxins.

15 prevent synthesis of Gram-positive bacterial exotoxins.

16 a family of exotoxins called staphylococcal exotoxins.

17 entral cell-binding component of the anthrax exotoxins.

18 ggregates on the HVEC surfaces, and produced exotoxins.

19 homology with known Streptococcus pyrogenic exotoxins.

20 cidogenesis but not by production of protein exotoxins.

21 cular characterization of PhiHKU.vir-encoded exotoxins.

22 required for the secretion of antiphagocyte exotoxins.

23 ivate several classes of unrelated bacterial exotoxins.

24 rains are attributed to higher prevalence of exotoxins.

25 lation of IL-31 receptor with staphylococcal exotoxins.

26 lation of IL-31 receptor with staphylococcal exotoxins.

27 or with a truncated fragment of Pseudomonas exotoxin 38 are able to specifically kill tumors in vitr

28 The catalytic moiety of Pseudomonas exotoxin A (domain III or PE3) inhibits protein synthesi

29 by a number of virulence factors, including exotoxin A (ETA) and the type III cytotoxins (ExoS, ExoT

30 Exotoxin A (ETA) is the most toxic virulence factor of P

31 termed diphtheria toxin (DT) and Pseudomonas exotoxin A (ETA) sensitivity required gene 1 (DESR1), en

32 NF2, which harbors exotoxin A (exoA) gene, was highly virulent when injecte

33 3, and NF4 strains were clonal and possessed exotoxin A (ExoA), the NF1 strain was determined to be p

34 d a truncated form of Pseudomonas aeruginosa exotoxin A (IL13-PE38QQR) was developed for the targeted

35 s, a nontoxic form of Pseudomonas aeruginosa exotoxin A (ntPE), Bacillus globigii, Mycoplasma hyopneu

36 composed of a nontoxic form of P. aeruginosa exotoxin A (ntPE), where the C-terminal loop amino acid

37 Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that com

38 Pseudomonas exotoxin A (PE) inhibits protein synthesis by NAD-depend

39 Pseudomonas exotoxin A (PE) is a bacterial toxin that arrests protei

40 A number of toxins, including exotoxin A (PE) of Pseudomonas aeruginosa, kill cells by

41 lating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE).

42 Both are fused to a fragment of Pseudomonas exotoxin A (PE38) to create immunotoxins.

43 Fv fused to a 38-kDa fragment of Pseudomonas exotoxin A (PE38).

44 ell fused to a 38-kDa portion of Pseudomonas exotoxin A (PE38).

45 eriae toxin (DT), and Pseudomonas aeruginosa exotoxin A (PEA).

46 (rPA), or recombinant Pseudomonas aeruginosa exotoxin A (rEPA).

47 ced M1 SF370 strain: streptococcal pyrogenic exotoxin A (SpeA) and a streptodornase D (SdaD) homologu

48 erotoxin B (SEB) and streptococcal pyrogenic exotoxin A (SPEA) delivered through the intranasal route

49 on of immunoreactive streptococcal pyrogenic exotoxin A (SpeA) increased.

50 Vbeta8-targeting SAg streptococcal pyrogenic exotoxin A (SpeA), or active immunization with either wi

51 rotein expression of streptococcal pyrogenic exotoxin A (SpeA; also known as scarlet fever or erythro

52 joined to a truncated portion of Pseudomonas exotoxin A (termed PE38) have been evaluated in clinical

53 at the P. aeruginosa translational inhibitor Exotoxin A (ToxA), which ribosylates elongation factor 2

54 itor cycloheximide, saponin, and Pseudomonas exotoxin A additionally confirmed that the resistance wa

55 Exotoxin A also prevented the transporter associated wit

56 f prophages encoding streptococcal pyrogenic exotoxin A and extracellular DNases and (2) the reciproc

57 w for penetration of streptococcal pyrogenic exotoxin A and possibly viable streptococci.

58 (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids an

59 Production of streptococcal pyrogenic exotoxin A by Streptococcus pyogenes was unaffected by a

60 that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory

61 A recombinant immunotoxin, comprising exotoxin A domain III (PE-III) from Pseudomonas aerugino

62 sts by P. aeruginosa utilizes the well-known exotoxin A effector.

63 Interestingly, exotoxin A expression was unaffected in these mutants.

64 of the superantigen streptococcal pyrogenic exotoxin A from 90.9 +/- 12.7 ng/mL with the control fib

65 surface epitope, and the enzymatic domain of exotoxin A from Pseudomonas aeruginosa.

66 a PtxR as a transcriptional activator of the exotoxin A gene toxA.

67 Streptococcal pyrogenic exotoxin A levels at 9 hrs were 19.9 ng/mL in the contro

68 fic polysaccharide conjugated to recombinant exotoxin A of Pseudomonas aeruginosa (O157-rEPA) was saf

69 idate consisting of a genetically detoxified exotoxin A of Pseudomonas aeruginosa covalently linked t

70 Clostridium difficile, diphtheria toxin, and exotoxin A of Pseudomonas aeruginosa; however, this is t

71 th oprI primers, 11 of 13 were positive with exotoxin A primers, and 10 of 13 were positive with algD

72 gyrB or oprI primers, 96% were positive with exotoxin A primers, and 92% were positive with algD prim

73 ribed human diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1 and that DPH4 enc

74 SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen.

75 y antibodies (VHH) conjugated to Pseudomonas exotoxin A to deplete myeloid cells in vitro and in vivo

76 ciated with bacterial challenge, and reduced exotoxin A toxicity.

77 electin targeting domain, (ii) a Pseudomonas exotoxin A translocation domain, and (iii) a NF-kappaB E

78 portion of the bacterial protein Pseudomonas exotoxin A which consists of the toxin moiety of the RIT

79 or control cells with saporin or Pseudomonas exotoxin A whose intracellular mechanism of activation i

80 srupt T-cell epitopes in GFP and Pseudomonas exotoxin A without disrupting function.

81 ocation and enzymatic domains of Pseudomonas exotoxin A), showed limited promise in initial clinical

82 nly partially dependent upon it (Pseudomonas exotoxin A).

83 receptor-binding domain (Ia) of Pseudomonas exotoxin A, AdPEDI-(Abeta1-6)(11), is effective in induc

84 proteins: recombinant Pseudomonas aeruginosa exotoxin A, and ovalbumin, using amide, hydrazone, or th

85 era toxin, ricin, and Pseudomonas aeruginosa exotoxin A, are transported to the lumen of the endoplas

86 ice from lethal challenge with streptococcal exotoxin A, as well as from lethal GAS bacterial infecti

87 rived from the bacterial protein Pseudomonas exotoxin A, as well as to the model Ag keyhole limpet he

88 toxin, cholera toxin, Pseudomonas aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.

89 sed to PE38, a 38-kDa portion of Pseudomonas exotoxin A, has produced many complete remissions in dru

90 helin Fab fused to domain III of Pseudomonas exotoxin A, in which immunogenic B-cell epitopes are sil

91 including Sic, SpeB, streptococcal pyrogenic exotoxin A, Mac protein, and streptococcal phospholipase

92 ticulin, domain II of Pseudomonas aeruginosa exotoxin A, or the sorting signal of the lysosome-associ

93 invasive virulence factors, including T3SS, exotoxin A, protease IV, and TFP.

94 albumin, recombinant Pseudomonas aeruginosa exotoxin A, recombinant B. anthracis protective antigen

95 syndrome toxin-1 and streptococcal pyrogenic exotoxin A, respectively, across porcine vaginal mucosa

96 e, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T, U, or Y.

97 Exogenous Pseudomonas aeruginosa Exotoxin A, which inhibits protein translocation from th

98 cer cells joined to a portion of Pseudomonas exotoxin A, which kills the cell.

99 ne via the endocytosed translation inhibitor Exotoxin A, which leads to an increase in ZIP-2 protein

100 d ENaC activation and Pseudomonas aeruginosa exotoxin A-induced cell death.

101 g (QS)-dependent manner and independently of exotoxin A-mediated translational repression.

102 ti-CD22 Fv fused to a portion of Pseudomonas exotoxin A.

103 portion of the bacterial protein Pseudomonas exotoxin A.

104 he cytotoxic effects of diphtheria toxin and exotoxin A.

105 he prophage encoding streptococcal pyrogenic exotoxin A.

106 diphtheria toxin and Pseudomonas aeruginosa exotoxin A.

107 the SpeA4 variant of streptococcal pyrogenic exotoxin A.

108 fused to a truncated portion of Pseudomonas exotoxin A.

109 ctors, namely pyoverdine, PrpL protease, and exotoxin A.

110 ds to CD22 fused to a portion of Pseudomonas exotoxin A.

111 stent with this hypothesis, we found that C3 exotoxin (a Rho-specific inhibitor) and HA1077 (an inhib

112 d by treatment with Clostridium botulinum C3 exotoxin, a specific inactivator of RhoA family members.

113 Unlike the acute effects of superantigen exotoxins absorbed through the gut or vaginal mucosa, li

114 pre-existing neutralizing Abs to Pseudomonas exotoxin, allowing RIT treatment.

115 (S. aureus) that produce the staphylococcal exotoxin alpha-toxin.

116 asured humoral responses to 2 staphylococcal exotoxins, alpha-hemolysin (Hla) and Panton-Valentine le

117 MRSA exotoxins also caused neutrophil (polymorphonuclear leuk

118 Consistent with these results, C3 exotoxin, an inhibitor of RhoA activation, significantly

119 Inhibition of Rho with C3 exotoxin and a dominant negative Rho adenovirus and inhi

120 d the cytotoxic action of native Pseudomonas exotoxin and enhanced SS1P toxicity on several human cel

121 antigen and a fusion protein of Pseudomonas exotoxin and lethal factor was tested for anti-lung canc

122 systems to export virulence factors such as exotoxins and effectors(1-4).

123 tes examined produce one or more heat-labile exotoxins and may suggest that M. ovis plays a role in t

124 oxin-1 (TSST-1), and streptococcal pyrogenic exotoxins] and anthrax toxin are bioterrorism agents tha

125 sease, is lethal owing to the actions of two exotoxins: anthrax lethal toxin (LT) and oedema toxin (E

126 lls from the lytic effects of three of these exotoxins: anthrolysin O (ALO), listeriolysin O, and pne

127 Immunotoxins derived from Pseudomonas exotoxin are antibody-toxin fusion proteins that inhibit

128 The genes that encode these exotoxins are commonly found in bacterial viruses (bacte

129 that target the cytotoxic effects of anthrax exotoxins are needed.

130 Prior studies suggest Staphylococcus aureus exotoxins are not produced when the organism is cultured

131 Host mechanisms that protect against such exotoxins are poorly understood.

132 We also show that Prymnesium exotoxins are released independently of contact toxicity

133 Catalytic rate enhancements by the bacterial exotoxins are small, and thus transition-state analogues

134 Several exotoxins are synthesized as precursors containing amino

135 munity, but is also accelerated by bacterial exotoxins as a mechanism of immune evasion.

136 Infochemicals and exotoxins associated with P. aeruginosa are capable of c

137 ne protease known as streptococcal pyrogenic exotoxin B (SpeB) is a key virulence factor that is prod

138 Streptococcal pyrogenic exotoxin B (SpeB) is a protease secreted by group A stre

139 Streptococcal pyrogenic exotoxin B (SpeB) is an extracellular cysteine protease

140 The streptococcal pyrogenic exotoxin B (SpeB) is an important virulence factor of gr

141 racellular protease, streptococcal pyrogenic exotoxin B (SpeB), capsular hyaluronic acid, and protein

142 ar toxins, including streptococcal pyrogenic exotoxin B (SpeB), have been implicated in pathogenesis.

143 complement (Sic) and streptococcal pyrogenic exotoxin B (SpeB).

144 ns, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB).

145 plasmin receptor and streptococcal pyrogenic exotoxin B are currently considered major putative nephr

146 The exotoxin-based genotyping method was able to discriminat

147 SS1P, a Pseudomonas exotoxin-based immunotoxin, was chosen because it is now

148 or the inhibitors 1-butanol, Y-27632, or C3 exotoxin before stimulation with the cholinergic agonist

149 injury and mortality through the delivery of exotoxins by the type III secretion system (TTSS).

150 crystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) re

151 n-like proteins, which belong to a family of exotoxins called staphylococcal exotoxins.

152 Several staphylococcal exotoxins can act as superantigens and/or antigens in mo

153 The bacterial exotoxins, cholera toxin (CT), pertussis toxin (PT), and

154 anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activ

155 stridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic epith

156 , an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell li

157 on of CaM between two domains of the anthrax exotoxin (d) binding of Ca2+ ions to only one EF-hand pa

158 This 'Trojan Horse' mechanism of exotoxin delivery into predator cells allows intoxicatio

159 duces a potent bacteriophage-encoded protein exotoxin, diphtheria toxin (DT), which causes the sympto

160 that, in addition to Stx, the phage-encoded exotoxin, diphtheria toxin (Dtx) expressed by Corynebact

161 g that intoxication of Acanthamoeba by these exotoxins does not require a receptor.

162 ion of hyaluronic acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exot

163 cytotoxic strains use this system to secrete exotoxin (Exo)U and ExoT causing cytotoxicity and inhibi

164 ere assayed in vitro for secretion of type 3 exotoxins (ExoU, ExoT, and ExoS).

165 C3 exotoxin, expression of dominant negative RhoA, and inhi

166 t the site of the intramuscular injection of exotoxins from an invasive M-type 1 GAS, which caused a

167 tissue destruction, we investigated whether exotoxins from MRSA could stimulate formation of PNAs in

168 ric anthrax toxin lethal factor, Pseudomonas exotoxin fusion protein, was extremely toxic to mice, ca

169 iated isolates typically possessed different exotoxin gene profiles (eg, Panton Valentine leukocidin

170 Phage-carried exotoxin genes are widespread in the environment and are

171 ized by its ability to internalize bacterial exotoxins, GPI-linked proteins, and extracellular fluid.

172 Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding doma

173 Exotoxins have been implicated in the pathogenesis of th

174 s blooms coupled with the presence of potent exotoxins; however, no chemical standards are currently

175 Additional exotoxin identification studies of USA200 strain [S. aur

176 uman IL-13 and a mutated form of Pseudomonas exotoxin (IL-13-PE) might affect pathological features o

177 IL-13 and a truncated version of Pseudomonas exotoxin (IL13-PE), the proliferation of primary usual i

178 IL-13 and a truncated version of Pseudomonas exotoxin (IL13-PE), which targets and kills IL-13 recept

179 be useful in the management of Gram-positive exotoxin illnesses; its action appears to be membrane st

180 n composed of IL-4 and truncated Pseudomonas exotoxin in animal models of pancreatic ductal adenocarc

181 evels of the anthrax protective antigen (PA) exotoxin in biological fluids, we have developed a metal

182 first gene in this operon (rtxA) encodes an exotoxin in vibrios, while other genes code for proteins

183 reus can elaborate a variety of superantigen exotoxins in "carrier" or "pathogenic" states.

184 The expression of type 3 secretion system exotoxins in bacteremic isolates of P. aeruginosa confer

185 However, the role of these staphylococcal exotoxins in disease pathogenesis remains unclear.

186 strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.

187 ibosylation of RhoA by Clostridium botulinum exotoxin inactivated RhoA signaling and resulted in the

188 ins, leading to inhibition of staphylococcal exotoxins, included the two-component system SrrA-SrrB.

189 in vivo production of potent staphylococcal exotoxins, including Panton-Valentine leukocidin (PVL) a

190 in composed of IL-13 and mutated Pseudomonas exotoxin induced specific killing of IL-13Ralpha2(+) tum

191 markable features describing how a bacterial exotoxin induces virulence exclusively in specific cells

192 a 'Trojan Horse', carrying genes encoding an exotoxin into target organisms.

193 gy of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to

194 HNP-1 to HNP-3 to inhibit so many different exotoxins is proposed.

195 ch of these, the production of sophisticated exotoxins is the main cause of disease.

196 he prophage encoding streptococcal pyrogenic exotoxin K (SpeK) and extracellular phospholipase A(2) (

197 Bacterially derived exotoxins kill eukaryotic cells by inactivating factors

198 H. pylori secretes a pore-forming exotoxin known as vacuolating toxin (VacA).

199 anthrax toxin is the toxic component of the exotoxin (lethal toxin) secreted by toxic strains of Bac

200 he cell-binding component of the two anthrax exotoxins: lethal toxin (LeTx) and edema toxin.

201 ands in S. aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S.

202 cal superantigens, designated staphylococcal exotoxin-like (SET) proteins.

203 We suggest that such exotoxins may have evolved for the purpose of bacterial

204 g a mutated human IL-13 fused to Pseudomonas exotoxin (mhIL-13-PE) that specifically binds to IL13Ral

205 ec61 inhibited by the Mycobacterium ulcerans exotoxin mycolactone via electron cryo-microscopy.

206 These results reveal how the exotoxin of an intracellular pathogen engages host pathw

207 hat thermostable direct haemolysin (TDH), an exotoxin of the food-borne pathogen Vibrio parahaemolyti

208 Many exotoxins of Gram-positive bacteria, such as superantige

209 Exotoxins of Staphylococcus aureus belong to a family of

210 he bicomponent pore-forming leukocidin (Luk) exotoxins of the major pathogen Staphylococcus aureus as

211 the ability of GML to inhibit the effects of exotoxins on mammalian cells and prevent rabbit lethalit

212 Inhibition of RhoA activity with C3 exotoxin or a dominant-negative RhoA blocks AMPH-induced

213 ment with Clostridium botulinum exoenzyme C3 exotoxin or expression of dominant negative RhoA blocks

214 complement-related membrane attack complex, exotoxins, or cytotoxic T cells.

215 s to contain various deimmunized Pseudomonas exotoxin (PE) domains.

216 oding a 38-kDa truncated form of Pseudomonas exotoxin (PE38) to generate the IT 8H9(scFv)-PE38.

217 (IL-13) and a truncated form of Pseudomonas exotoxin (PE38QQR).

218 Tetanus neurotoxin (TeNT) is an exotoxin produced by Clostridium tetani that causes para

219 Pertussis toxin (PTX) is an AB5-type exotoxin produced by the bacterium Bordetella pertussis,

220 tality risk, are due to diphtheria toxin, an exotoxin produced by the pathogen that inhibits protein

221 This report identifies a new exotoxin produced by this organism, termed SpyA, for S.

222 we examined the early role played by another exotoxin produced by this pathogen, adenylate cyclase to

223 tending toxins (CDTs) are tripartite protein exotoxins produced by a diverse group of pathogenic Gram

224 This is primarily due to the pathogenic exotoxins produced by Bacillus anthracis as well as othe

225 Interestingly, only exotoxins produced by bacteria internalized by the Acant

226 LKT), which is a member of the RTX family of exotoxins produced by many gram-negative bacteria.

227 Among the exotoxins produced by Staphylococcus aureus and Streptoc

228 GAS SAgs, namely the streptococcal pyrogenic exotoxins produced by the globally disseminated M1T1 GAS

229 Exotoxin production by both methicillin-resistant and me

230 bin (as low as 1 mug/mL) inhibited S. aureus exotoxin production while increasing production of prote

231 ability of alpha and beta globin to inhibit exotoxin production.

232 ructural rearrangement of sub-domains of the exotoxin protective antigen (PA).

233 hion and that a chimeric 5-Helix/Pseudomonas exotoxin protein recognizes cells expressing Env from a

234 us pyogenes (GAS) express superantigen (SAg) exotoxin proteins capable of inducing lethal shock.

235 Among these, the redox active exotoxin pyocyanin (PCN) is produced in concentrations u

236 g from many bacterial diseases are caused by exotoxins released by the bacteria.

237 six genes (rtxACHBDE), where rtxA encodes an exotoxin, rtxC encodes an RtxA activator, rtxH encodes a

238 hages were prestimulated with staphylococcal exotoxins (SEB, alpha-toxin) to up-regulate the IL-31 re

239 ed a transcytosis pathway used by cholix, an exotoxin secreted by nonpandemic forms of the intestinal

240 The exotoxins secreted by B. anthracis use capillary morphog

241 ct of SpeB on the activity of superantigenic exotoxins secreted by M1T1 GAS isolates.

242 his paper describes a biosensing concept for exotoxins secreted by Staphylococcus aureus and Pseudomo

243 Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptoc

244 lates into 22 distinct subgroups, designated exotoxin sequence types (ETST), while the standard seven

245 ed in pathogenesis (e.g., staphylocoagulase, exotoxin, Ser-Asp fibrinogen-binding bone sialoprotein-b

246 The bacterial exotoxin Shiga toxin is endocytosed by mammalian host ce

247 rulence factors, the streptococcal pyrogenic exotoxin (Spe) A and the cysteine protease SpeB, was rec

248 Streptococcal pyrogenic exotoxin (Spe) B, a streptococcal cysteine protease, is

249 superantigen (ssa), streptococcal pyrogenic exotoxins (speC, speH, and speI), and DNases (spd1 and s

250 lammatory cytokines following staphylococcal exotoxins' stimulation in human macrophages.

251 esembles secreted NAD(+)-dependent bacterial exotoxins, such as diphtheria toxin.

252 Bacterial exotoxins, such as Escherichia coli heat-labile enteroto

253 zolid resulted in significant suppression of exotoxin synthesis and improved survival outcomes in a r

254 coccal enterotoxin B (SEB), a shock-inducing exotoxin synthesized by Staphylococcus aureus, is an imp

255 nteracts with the type III-secreted effector exotoxin T (ExoT) and plays a key role in vivo in limiti

256 tokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner.

257 t, an albumin-binding domain and Pseudomonas exotoxin targeting PD-1-expressing cells, selectively re

258 The exotoxins TcdA and TcdB are the major virulence factors

259 The disease is caused mainly by two exotoxins, TcdA and TcdB, produced by the bacteria.

260 idium difficile infections are caused by two exotoxins, TcdA and TcdB, which target host colonocytes

261 major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the pr

262 se symptoms are caused by the two homologous exotoxins, TcdA and TcdB.

263 The exotoxin TcsL is a major virulence factor in Paeniclostr

264 rcularly permuted human IL-4 and Pseudomonas exotoxin termed IL4(38-37)-PE38KDEL, or IL-4 cytotoxin.

265 (Hp) secrete VacA, a diffusible pore-forming exotoxin that is epidemiologically linked to gastric dis

266 Here we identify cytolysin-a two-subunit exotoxin that is secreted by Enterococcus faecalis(5,6)-

267 ny pathogenic gram-positive bacteria release exotoxins that belong to the family of cholesterol-depen

268 s (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especiall

269 lentine leukocidin (PVL) and alpha-toxin are exotoxins that create lytic pores in the host cell membr

270 ubstrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans.

271 us has numerous virulence factors, including exotoxins that may increase the severity of infection.

272 esumably through the release of allelopathic exotoxins that offer advantages for Prymnesium in its in

273 ed and seems to be not valid for the anthrax exotoxin, the CaM-regulated K+-channel and possibly also

274 s from environmental exposure to Pseudomonas exotoxin, the component of the RIT that elicits the neut

275 Of these exotoxins, the superantigens (SAg) are likely most patho

276 ents using constitutively active Cdc42 or C3 exotoxin to inhibit Rho GTPase supported a role of Rho G

277 atory and skin infections, produces numerous exotoxins to establish infection.

278 particular toxin, allowing bacteria-bearing exotoxins to kill a broader spectrum of predators, incre

279 The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced

280 ile infection (CDI) is mediated by two major exotoxins, toxin A (TcdA) and toxin B (TcdB), that damag

281 C. difficile releases 2 structurally similar exotoxins, toxin A and toxin B, animal experiments sugge

282 CDAD pathology is induced by two exotoxins, toxin A and toxin B, which have been shown to

283 s primarily from the 2 C. difficile-secreted exotoxins-toxin A (TcdA) and toxin B (TcdB)-that disrupt

284 the T3SS apparatus itself, independently of exotoxin translocation.

285 ensitive) or their endotoxins (LTA + PGN) or exotoxins (TSST-1).

286 or a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus syste

287 A T3SS effector, exotoxin U (ExoU), can inhibit activation of the NLRC4 i

288 eria expressed the phospholipase A2 effector Exotoxin U (ExoU).

289 were tested for the genes encoding S. aureus exotoxins using polymerase chain reaction (PCR).

290 ously we found that pertussis toxin (PT), an exotoxin virulence factor produced by Bordetella pertuss

291 o determine whether pertussis toxin (PT), an exotoxin virulence factor produced exclusively by Bordet

292 ples of chemical entities designed to target exotoxin virulence factors from important human bacteria

293 c knockout mutants of the PhiHKU.vir-encoded exotoxins, we find that SpeC and Spd1 act synergisticall

294 hich point both IgG titers against S. aureus exotoxins were determined, and the functionality of the

295 Exotoxins which belong to the family containing the RTX

296 tibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in host response.

297 Transport of Pseudomonas exotoxin, which is transported to the ER by binding to t

298 ins is the NAD(+)-dependent ADP-ribosylating exotoxins, which include pertussis, cholera, and diphthe

299 ective antigen component of the B. anthracis exotoxin with high affinity and conjugated to polyethyle

300 Exotoxin Y (ExoY) is a type III secretion system effecto