ライフサイエンスコーパス: experimental animal

1 ifferent neurotoxic effects in humans and in experimental animals.

2 s can be recognized by the immune systems of experimental animals.

3 r monitoring cortical electrical activity in experimental animals.

4 inhibitors against coronavirus infection in experimental animals.

5 d antitumor efficacy against glioblastoma in experimental animals.

6 administration of either APC or Seprafilm to experimental animals.

7 ected by prenatal stress is possible only in experimental animals.

8 pression in diseased cells from patients and experimental animals.

9 T cell depletion can prevent hypertension in experimental animals.

10 roduce most of the typhoid fever symptoms in experimental animals.

11 focused on polyclonal antibody responses in experimental animals.

12 dministered (99m)Tc-MAG3 and (99m)Tc-DTPA in experimental animals.

13 significantly different between control and experimental animals.

14 significantly different between control and experimental animals.

15 nvironment and the motor capabilities of the experimental animals.

16 nsumption, it produces behavioral changes in experimental animals.

17 ivalent glycemic control in both control and experimental animals.

18 ponses, and increased addiction behaviors in experimental animals.

19 netic markers associated with impulsivity in experimental animals.

20 eptive itch through studies using humans and experimental animals.

21 t variations in pathogenicity for humans and experimental animals.

22 ocessing brain tissue coming from humans and experimental animals.

23 ne candidates against pneumonic tularemia in experimental animals.

24 furthermore, it had no apparent toxicity in experimental animals.

25 ulnerability to drug addiction in humans and experimental animals.

26 regulatory T cells (Tregs) prevents GVHD in experimental animals.

27 ate with chronic pain symptoms in humans and experimental animals.

28 ditioned media of Abeta-secreting cells into experimental animals.

29 la and converge with connectivity studies in experimental animals.

30 ng and prolong maximal lifespan up to 60% in experimental animals.

31 ured cells as well in the blood and urine of experimental animals.

32 in networks, which have been studied only in experimental animals.

33 ression of cytokines, eventually killing the experimental animals.

34 and consistently increase insulin action in experimental animals.

35 idly and reliably visualize blood vessels in experimental animals.

36 idely distributed pattern of synapses in our experimental animals.

37 gal keratitis not only in humans but also in experimental animals.

38 granularity of ECoG recording in humans and experimental animals.

39 tial effects of human cells in the brains of experimental animals.

40 n vivo roles of MYOCD comes exclusively from experimental animals.

41 effectively neutralised by the TiO(2)-NPs in experimental animals.

42 y has been advanced greatly using rodents as experimental animals.

43 i muscle confirm the androgenic treatment in experimental animals.

44 ern blot (WB) analysis in brain samples from experimental animals.

45 naphylaxis have been clearly demonstrated in experimental animals.

46 ons can be propagated in cell culture and in experimental animals, affording both in vitro and in viv

47 man lung cell injury in vitro and protecting experimental animals against lethal S. aureus pneumonia.

48 fic monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (

49 monary artery endothelial cells (HPAECs) and experimental animals [AMPK subunit alpha-deficient mice

50 y liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies.

51 Supporting a causal role of disturbed sleep, experimental animal and human studies have found that sl

52 Experimental animal and human studies that have probed t

53 hibitors, this article reviews the available experimental animal and human trial evidence that provid

54 The parallel between experimental animal and observational human data lends s

55 dy is an effective therapy against plague in experimental animals and could be developed as a rapidly

56 Hyperoxia contributes to lung injury in experimental animals and diseases such as acute respirat

57 Super-low-dose endotoxemia in experimental animals and humans is linked to low-grade c

58 way of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly unde

59 well as the diminished adiposity observed in experimental animals and humans.

60 ts for the different foam cell phenotypes in experimental animals and humans.

61 in the development of intestinal adenomas in experimental animals and in adenomas and colorectal canc

62 usively estrogen-dependent mammary tumors in experimental animals and in having E4 region-encoded ope

63 Increased levels of 20-HETE in experimental animals and in humans are associated with h

64 f the processing activity in the vitreous of experimental animals and in patients with PVR.

65 g, cytokine-associated, flu-like syndrome in experimental animals and in patients, but the underlying

66 e incorporated into future vaccine trials in experimental animals and possibly in humans.

67 factor for hepatocellular carcinoma (HCC) in experimental animals and reveal opposing roles for the n

68 iogenesis and improve insulin sensitivity in experimental animals and, while overcoming hepatic steat

69 over the past 15 years on prebiotics through experimental, animal and human studies, with the aim to

70 nd characterized thousands of epidemiologic, experimental animal, and mechanistic studies, and addres

71 kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic app

72 ts of serotonin on dopaminergic circuitry in experimental animals, and preclinical findings have impl

73 type 9 exclusively elicits mammary tumors in experimental animals, and the primary oncogenic determin

74 However, recent findings in experimental animals appear controversial.

75 ish correlation, not causation, and existing experimental animal approaches alter multiple components

76 Prion incubation periods in experimental animals are known to vary inversely with ex

77 Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying d

78 ghrelin levels were measured in control and experimental animals as a change from baseline ghrelin v

79 d human sera, validating the use of nonhuman experimental animals as a model for determining antigeni

80 cine immunogenicity had not been assessed in experimental animals because fHbp binds human fH specifi

81 e cell wall of M. tuberculosis isolated from experimental animals because of the low amounts of bacte

82 iphenyl were examined based on evidence from experimental animal bioassays and mechanistic studies.

83 In experimental animals, BPA increases embryo implantation

84 gene product expression that is sustained in experimental animals but not in human subjects.

85 ys for associative conditioning are known in experimental animals, but have not been identified in pr

86 Several extrahepatic sites were tested in experimental animals, but many have practical limitation

87 ults in long-term expression of transgene in experimental animals, but only short-term expression in

88 d retinal photoreceptor damage in humans and experimental animals, but the mechanism(s) remain unclea

89 s contribute to alcohol-related behaviors in experimental animals, but their potential role in humans

90 adiposity and systemic insulin resistance in experimental animals, but what maintains eosinophils in

91 In recent years, studies carried out in experimental animals by morphological and physiological

92 animal care and use committee and adhered to experimental animal care guidelines.

93 ion of lens calcium occurs in both human and experimental animal cataracts, and opacification may res

94 ]methionine administered intraportally to an experimental animal; clarification of the intracellular

95 y a few nucleotides become more prevalent in experimental animal colonies.

96 AP was at the edge of detection, and in some experimental animals, completely eradicated.

97 In keeping with experimental animal data, the downstream functional cons

98 Aging of experimental animals demonstrated that constitutive reac

99 mized protocols were successfully applied to experimental animal-derived tissues.

100 n animals ?" and to rate the strength of the experimental animal evidence.

101 ost of the tracers have been studied only in experimental animals, except for radiolabeled antibiotic

102 asites of both sexes recovered from infected experimental animals exhibit vivid fluorescence througho

103 In addition, experimental animals exhibited significant downregulatio

104 al analysis of the literature for humans and experimental animals exposed to certain environmental ch

105 s will be necessary to further explore these experimental animal findings.

106 bbit (Oryctolagus cuniculus) is an important experimental animal for studying human diseases, such as

107 Compared to their matched controls, experimental animals had decreased posttransplant marker

108 d by different personnel and using different experimental animal handling equipment.

109 Decades of work in experimental animals has established the importance of v

110 s, plus preliminary evidence of virulence in experimental animals, has suggested that ST131's epidemi

111 Many cancer immunotherapies developed in experimental animals have been tested in clinical trials

112 Studies of neuropsychological patients and experimental animals have demonstrated that the striatum

113 Studies in experimental animals have provided evidence that consump

114 Studies performed in experimental animals have revealed that some of these im

115 onsistent with this general rule, studies in experimental animals have shown that broadly neutralizin

116 ons on the development of most behaviours in experimental animals housed in spatially enriched caging

117 come highly instrumental to induce tumors in experimental animals in a tissue-specific manner with th

118 first examination of Myh9 kidney disease in experimental animals, in the context of recent findings

119 is review summarizes key recent studies from experimental animals, in vitro models, and human cohorts

120 Experimental animals infected by Trypanosoma cruzi showe

121 cterium tuberculosis bacteria in established experimental animal infections are acid-fast negative, c

122 Additionally, experimental animal investigations show that neuropathic

123 Studies conducted in experimental animals (laboratory rats) show that astrocy

124 In experimental animals, M. tuberculosis infects no fewer t

125 In experimental animals, maternal diet during the periconce

126 e a human metabolic disease is induced in an experimental animal model by human hepatocyte transplant

127 These ligands were tested in an experimental animal model containing tumors that express

128 Clinical, in-vitro and experimental animal model evidence continues to mount in

129 To review the clinical, in-vitro and experimental animal model evidence for the pathogenicity

130 iniature pigs in the world and is used as an experimental animal model for life science research.

131 g disease in mice provides a highly relevant experimental animal model for multiple sclerosis.

132 ammatory demyelinating disease, providing an experimental animal model for multiple sclerosis.

133 h Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis

134 to mediate collagen Ab-induced arthritis, an experimental animal model of immune complex-induced join

135 This daring conclusion that is based on an experimental animal model should now be confirmed in hum

136 is lacking, non-randomized observational and experimental animal model studies were used.

137 es in suppressing tumor cell regrowth in two experimental animal model systems.

138 Thus, in this experimental animal model, a high-titer vaccine-induced

139 Miniature pigs have been used as an experimental animal model, but they are still large and

140 In an experimental animal model, we show that in vitro knockdo

141 mechanisms underlying these events using an experimental animal model, we show that inflammation may

142 ing microembolization to migraine aura in an experimental animal model.

143 ites complication is hampered by the lack of experimental animal model.

144 y counteracted acute lung eosinophilia in an experimental animal model.

145 Experimental animal models and epidemiological data indi

146 ng in pain conditions.SIGNIFICANCE STATEMENT Experimental animal models and human psychophysical stud

147 istent critical determinant of PH and PAH in experimental animal models and humans.

148 g to the changes observed with aging in both experimental animal models and humans.

149 Drawing from experimental animal models and observational human studi

150 usibility for the link has been supported by experimental animal models and observational studies in

151 stroke pathology has been underestimated in experimental animal models and this may have contributed

152 Experimental animal models are indispensable to the fiel

153 Studies in humans and experimental animal models are revealing the genetic and

154 Experimental animal models demonstrate that maternal imm

155 i establishes long-term infection in various experimental animal models except for New Zealand White

156 that potentially regulate aging, and present experimental animal models for addressing these question

157 ssess or quantify NETosis in vivo, and other experimental animal models have failed to demonstrate a

158 Several lines of evidence in experimental animal models have indicated the central ro

159 Previous studies in experimental animal models have reported that administra

160 ified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfu

161 Experimental animal models of AKI demonstrate that renal

162 iting cardiomyocyte apoptosis in 2 different experimental animal models of AMI.

163 he functions of natural killer (NK) cells in experimental animal models of atherosclerosis, it is not

164 The most commonly used experimental animal models of CHIKV infection are mice a

165 he sympathetic nervous system alterations in experimental animal models of hypertension.

166 and Rhizopus oryzae has been demonstrated in experimental animal models of infection.

167 ded evidence of such processes in humans and experimental animal models of insulin-resistant diabetes

168 Immunologic studies involving experimental animal models of L. tropica infection are v

169 linical studies of liver disease and certain experimental animal models of liver injury conspicuously

170 cularization and pulmonary hypertension in 2 experimental animal models of PAH in vivo Up-regulation

171 view will focus on plexiform arteriopathy in experimental animal models of PAH.

172 genesis of PsA-related dactylitis comes from experimental animal models of PsA-like disease, as well

173 In experimental animal models of sepsis telavancin was show

174 hological activity in epileptic patients and experimental animal models of temporal lobe epilepsy.

175 Experimental animal models of type 1 diabetes mellitus (

176 Genome-wide association studies and experimental animal models point at a central role of th

177 Many fail because experimental animal models poorly predict human xenobiot

178 Experimental animal models show changes in the gut micro

179 ence derived from human clinical studies and experimental animal models shows a causal relationship b

180 Furthermore, arguments based on experimental animal models suggest a critical role of th

181 Recent studies involving experimental animal models suggest a role of the gut mic

182 Observational human studies and experimental animal models suggest that childhood exposu

183 Previous results from experimental animal models suggest that post-TBI hypergl

184 Accumulated evidence from experimental animal models suggests that neuronal loss w

185 We review the recent clinical trials and experimental animal models that provide evidence in supp

186 grating patient-based data with results from experimental animal models to gain deeper understanding

187 cilitates studies in platelets obtained from experimental animal models without the need of special d

188 In experimental animal models, administration of talactofer

189 sceptibility, the necessity for adjuvants in experimental animal models, and the often paradoxical ef

190 malformations have been produced in multiple experimental animal models, by perturbing selected molec

191 In experimental animal models, chronic stress leads to neur

192 Due to the paucity of experimental animal models, little is known about how ho

193 Importantly, in experimental animal models, low dietary potassium intake

194 dvanced, at least in part, due to the use of experimental animal models, particularly the model of ce

195 ition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identif

196 t and growth of carcinogen-induced tumors in experimental animal models, results from human studies a

197 As with all experimental animal models, they are flawed in one way o

198 mechanistic studies using human samples and experimental animal models, with technological and metho

199 rol transport, and prevented liver injury in experimental animal models.

200 dance with several studies done in different experimental animal models.

201 is infection in both humans and unvaccinated experimental animal models.

202 s of CD4(+) regulatory T cells in humans and experimental animal models.

203 iding effective reduction of tumor burden in experimental animal models.

204 ber D (NKG2D) mediates antitumor immunity in experimental animal models.

205 been developed for use in the clinic and in experimental animal models.

206 echanisms greater than that anticipated from experimental animal models.

207 mple of latent viral infection in humans and experimental animal models.

208 regs) to achieve this have been promising in experimental animal models.

209 brain injury and adversely affect outcome in experimental animal models.

210 d DC, and from analyses of their function in experimental animal models.

211 en studied extensively both in humans and in experimental animal models.

212 ions have also been identified in humans and experimental animal models.

213 ment and its disruption in human infants and experimental animal models.

214 is rare in animals and poorly reproduced in experimental animal models.

215 nset is limited by the lack of adjuvant-free experimental animal models.

216 has been hindered by a paucity of tractable experimental animal models.

217 inflammation in both human hypertension and experimental animal models.

218 inflammation in both human hypertension and experimental animal models.

219 omparing brain function between patients and experimental animal models; however, the relationship be

220 DNase I injected into experimental animals, moreover, results in significant i

221 Experimental animals (n = 45) were subjected to bending

222 st setting and (ii) it reduces the number of experimental animals needed.

223 , their use will also lead to a reduction in experimental animal numbers.

224 Clinical, in vitro, and experimental animal observations indicate that antineutr

225 enerating new mouse strains and multiallelic experimental animals often hinders the use of geneticall

226 that SPS increases fecal potassium losses in experimental animals or humans and no evidence that addi

227 osure of murine macrophages/human monocytes, experimental animals, or people to TLR ligands.

228 ls and decreased by 537.9 pg/dL +/- 209.6 in experimental animals (P = .004).

229 In experimental animals, PFAAs cause toxicity to the liver,

230 ent evidence from studies in both humans and experimental animals point to the involvement of TCE exp

231 for careful analysis of visual thresholds of experimental animals prior to therapeutic intervention.

232 Th2 inflammatory and profibrotic pathways in experimental animals provide a preliminary, mechanistic

233 Data from experimental animals provided crucial information on pla

234 This experimental animal (rats and mice) study shows that ast

235 Experimental animals received daily triple-drug immunosu

236 For each pair, experimental animals received islets cultured with 20 mi

237 s a control group, we compared outcomes with experimental animals receiving the same regimen with the

238 alamic sensitivity to brief gaps in noise in experimental animals relative to controls.

239 g on the development and task performance of experimental animals remains unclear.

240 We present relevant experimental animal research supporting this hypothesis.

241 allenge to the reproducibility of results in experimental animal research, because organisms' respons

242 gold standard of rigorous standardization in experimental animal research, we recommend the use of sy

243 , we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SE

244 Of note, various manipulations in experimental animals resulted in rather similar phenotyp

245 Experimental animals' seizures are often defined arbitra

246 Observations in thyroid patients and experimental animals show that the skin is an important

247 Studies in experimental animals show transmissibility of amyloidoge

248 ies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in huma

249 Experimental animal studies and limited epidemiologic ev

250 oproteins bind and neutralize endotoxin, and experimental animal studies demonstrate protection from

251 Both clinical trials and experimental animal studies demonstrate that chronic hyp

252 Experimental animal studies document an association of d

253 Results from experimental animal studies have suggested that an assoc

254 -term impact of cannabis exposure, for which experimental animal studies have validated causal relati

255 Systematic consideration of experimental animal studies of oral biphenyl exposure to

256 nic process or cortical hyperexcitability in experimental animal studies or those that can aggravate

257 d up to 8 March 2012 for epidemiological and experimental animal studies related to maternal smoking

258 Experimental animal studies revealed that only those ant

259 widely used in human clinical studies and in experimental animal studies to evoke allergic contact de

260 Clinical reports, experimental animal studies, and computational modeling

261 rgely due to advances in cell biology and to experimental animal studies, emphasis has been switched

262 Recently completed experimental animal studies, human biomarker data, and v

263 shown to adversely affect health outcomes in experimental animal studies, particularly following feta

264 reduce levels of free and total thyroxine in experimental animal studies, the direction of associatio

265 his hypothesis in clinical observational and experimental animal studies.

266 s are not well understood and rely mainly on experimental animal studies.

267 Experimental animal study.

268 Interventional controlled experimental animal study.

269 e sensitive to endotoxins when compared with experimental animals such as mice.

270 Overall, studies in human infants and experimental animals suggest that iron homeostasis is ab

271 experimental group by week 5, and 67% of the experimental animals survived for 12 weeks.

272 ence, the need to model these diseases in an experimental animal system.

273 However, it is clear from studies in experimental animals that rejection can be prevented thr

274 In the experimental animals that were subjected to extended per

275 ors have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of

276 slow down heart failure progression, and in experimental animals, the development of atherosclerosis

277 In experimental animals, the presence of brain-derived cons

278 eurons have been observed in PD patients and experimental animals, there is limited evidence linking

279 with the type A strains can be prevented in experimental animals through vaccination with the attenu

280 uch studies, however, physically tethers the experimental animal to an external light source, limitin

281 arious end points necessitating sacrifice of experimental animals to assess histological damage, thus

282 ce the translation of research findings from experimental animals to humans.

283 Exposure of experimental animals to purified recombinant CARDS toxin

284 We exposed experimental animals to stable isotope-labeled formaldeh

285 unts of human epidemiological, exposure, and experimental animal toxicity data (e.g., perfluorooctano

286 nt of chemical hazards away from traditional experimental animal toxicology studies to one based on t

287 Whether findings in the experimental animal translate into true benefit for pati

288 of HCC associated with EGFR was confirmed in experimental animals using the SB transposon system in a

289 significant impairment of renal function in experimental animals versus controls, with significant c

290 The average postprocedure weight gain in experimental animals was significantly lower than that i

291 al immunodominance hierarchies in humans and experimental animals, we defined the immunodominance hie

292 Two of the experimental animals were euthanized with nonviable lung

293 Experimental animals were inoculated intraperitoneally w

294 rrow and at tumor sites in most patients and experimental animals with cancer and inhibit both adapti

295 xpressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF)

296 Experimental animals with myelin disorders can be treate

297 s aiming to prove this concept by immunizing experimental animals with oxidized LDL particles unexpec

298 he bioactivity of vitreous from patients and experimental animals with PVR, and protected rabbits fro

299 are abundant in the vitreous of patients and experimental animals with PVR, they make only a minor co

300 pidemiological studies, as well as data from experimental animal work, are being summarized to provid