ライフサイエンスコーパス: explanation for how

1 cells to a duct-like phenotype, providing an explanation for how a characteristically ductal tumor ca

2 These observations provide a possible explanation for how a linear bacterial chromosome can ex

3 ening of the cytoplasmic gate and provide an explanation for how a missense mutation in the transport

4 The conventional explanation for how a morphogen patterns a tissue holds

5 And, there is now a testable explanation for how a protein can fold so quickly: A pro

6 These observations offer a harmonious explanation for how a single TAK1 kinase can mediate the

7 t model provides an attractive and plausible explanation for how a typical antigen presenting cell, e

8 tabolite-initiated amyloidogenesis offers an explanation for how Abeta aggregation could occur at phy

9 orepressor, HPr-Ser46-P, provide a molecular explanation for how adjunct corepressors G6P and FBP enh

10 Our work provides an explanation for how AIDA-1 dysfunction might contribute

11 This mechanism provides an explanation for how an agonist-bound nuclear receptor ca

12 More broadly, our study provides an explanation for how and why eccentricity emerges as a do

13 Still needed is a synthetic explanation for how and why growth rates vary as body si

14 These results offer an explanation for how and why unmethylated microsatellite

15 These results provide a simple evolutionary explanation for how ankyrin-B and ankyrin-G have acquire

16 ights into the function of ATDC and offer an explanation for how ATDC promotes cancer cell proliferat

17 Our results provide a possible explanation for how autophagy is regulated by MPP7 and M

18 production by cDCs and provides one possible explanation for how bacterial infection might precipitat

19 These findings provide an explanation for how beta-catenin localizes to the nucleu

20 amin A production and provides a mechanistic explanation for how both genetics and diet can affect th

21 a loss of protein motion may also provide an explanation for how calcium-ion-binding affinity is incr

22 of karyokinesis and cytokinesis provides an explanation for how cell cycle flexibility is achieved i

23 degeneration in SCA7 and thus may provide an explanation for how cell-type specificity is achieved in

24 Regulated tip growth provides an attractive explanation for how cells are able to synthesise very lo

25 h a multimodal assembly platform provides an explanation for how cells build a powerful yet transient

26 on-condensation dynamics creates mechanistic explanation for how cells properly respond to variable l

27 known about NP function, there is no obvious explanation for how changes in NP can selectively modula

28 The results provide one possible explanation for how chirality arises in nature by provid

29 neage specification, and suggest mechanistic explanations for how CIC mutations may impact the pathog

30 We believe that our data provide a molecular explanation for how circadian phases, such as wake-sleep

31 hese results provide a plausible mechanistic explanation for how closely related species exhibit quan

32 n of the coactivator and suggest a molecular explanation for how coactivators increase the transcript

33 This study provides a structural explanation for how CobT can phosphoribosylate most of t

34 hieve distinct cohesin functions provides an explanation for how cohesin mutations can specifically l

35 eurodevelopmental disorders, and provided an explanation for how common risk alleles persist in the p

36 This regular distribution provides an explanation for how complete chromosome replication can

37 pithelial differentiation, and they offer an explanation for how decreased levels of GLI1 are likely

38 al states of SERCA and provides a structural explanation for how dephosphorylated PLB decreases Ca(2+

39 fense (PATHOS-D) hypothesis provides a novel explanation for how depression can be nonadaptive in the

40 3 function as a PRROS provides a mechanistic explanation for how diastolic Ca(2+) influx specifically

41 These results offer a mechanistic explanation for how different detyrosinated alpha-tubuli

42 is finding is that it provides a mechanistic explanation for how different types (strains) of rhinovi

43 Information theory has offered explanations for how different types of neurons can maxi

44 ese findings provide a potential mechanistic explanation for how disruption of LINC complex may contr

45 re of these interactions provide a molecular explanation for how distinct SNX-BAR-decorated tubules a

46 One potential explanation for how divergent circuits have evolved is t

47 be mutually fruitful, e.g., by providing an explanation for how diverse ecological communities can a

48 ansfer rates.Our results provides a testable explanation for how diversity can be maintained by gene-

49 ction by pDCs in mice, providing a potential explanation for how DMPA impairs innate antiviral immuni

50 Our results provide an explanation for how DNA replication is linked to sister

51 oss promotes tumor progression, providing an explanation for how E-cadherin loss increases metastasis

52 for GMP-PCP-bound Cdc42, provides a possible explanation for how effectors can distinguish between th

53 In summary, NTA provides a parsimonious explanation for how excitatory-inhibitory co-tuning and

54 ream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated

55 ds to the 36-bp DNA fragment and provides an explanation for how FitB enhances the DNA binding affini

56 nctional compartmentalization may provide an explanation for how fluid flows are managed in an open c

57 a-2, and provide a comprehensive mechanistic explanation for how functional synaptic phenotypes contr

58 tibody was employed to provide a mechanistic explanation for how fundamental alloantibody biology inf

59 lpha/GPR-1/2 signaling pathway, providing an explanation for how Galpha-dependent force is regulated

60 These findings provide a strong biochemical explanation for how genetically driven alterations in ci

61 n the PBN, providing a potential mechanistic explanation for how GIPR agonist treatment reduces PYY-i

62 read among neuronal cells and may provide an explanation for how glucocerebrosidase mutations increas

63 LPL's large basic patch, providing a likely explanation for how GPIHBP1 stabilizes LPL.

64 he Antarctic green algae and offer potential explanations for how green plants adapt to extreme envir

65 ilize range boundaries and provide a general explanation for how groups of widely divergent sizes can

66 These results further provide a molecular explanation for how >50 mutations in BAP1 and ASXL1 foun

67 They also may provide a refined biochemical explanation for how H3K36me3 loss leads to genomic insta

68 hobic face of the epitope, thus providing an explanation for how HCV isolates bearing mutations at As

69 hromatin proteins and provides a mechanistic explanation for how Hmgb2 regulates gene expression and

70 ucleator TPX2 along the neurite, offering an explanation for how HMMR contributes to the promotion of

71 These observations provide a partial explanation for how homogenization of centromere DNA seq

72 These findings provide an explanation for how human cancers, which are often assoc

73 Here, we provide a novel explanation for how human time perception might be accom

74 to BCAA catabolism, providing a mechanistic explanation for how increased BCAA catabolic flux can ca

75 calcium entry pathways provided a plausible explanation for how inflammatory [Ca2+]i mediators may d

76 III by the DnaX complex provides a molecular explanation for how initiation complexes form when suppo

77 l via IRS1/PI3K/Akt2 activation, a potential explanation for how insulin is retarding the progression

78 to alter the Ab paratope, thus providing an explanation for how isotype can affect Ab specificity.

79 n the absence of ring stacking, providing an explanation for how it can reset the clock.

80 eviously appreciated and provide a molecular explanation for how it moves actin at fast speeds.

81 ular organisms, we hope to uncover proximate explanations for "how" it causes disease in humans.

82 These results provide a mechanistic explanation for how ketamine used for the treatment of d

83 al constraints but also provide a mechanical explanation for how large-scale interactions through cel

84 igomerize syt II offers a possible molecular explanation for how lead interferes with calcium-evoked

85 opeptidase access is determined and offer an explanation for how longer peptides may be displayed at

86 These data provide an explanation for how low levels of Beclin 1 facilitate tu

87 Together these results provide a plausible explanation for how male and female moths, and maybe oth

88 ovel hypothesis provides the first plausible explanation for how marine animals can navigate to natal

89 ion, the mechanism proposed here provides an explanation for how MDA5 uses filament assembly and disa

90 t on magnesium affinity provides a plausible explanation for how mechanical strain can alter this act

91 This nucleation mechanism provides one explanation for how mercury may be immobilized, and even

92 In addition, we provide a mechanistic explanation for how mesangial cells in primary culture a

93 tion and this mechanism provides a plausible explanation for how metal binding controls the DtxR repr

94 ia throughout the mouse lifespan provides an explanation for how microglial priming early in life can

95 We provide a possible physiological explanation for how microgravity can cause symptoms simi

96 These results provide an explanation for how mitotic HSF2 sumoylation is regulate

97 These results provide a molecular explanation for how Mtb impairs the adaptive immune resp

98 hread-width imbalance provides a mechanistic explanation for how multithread channels develop on Eart

99 nt kinetics in both cell types, providing an explanation for how mutations in the ubiquitously expres

100 alpha control provides a potential molecular explanation for how N-terminal Rb loss-of-function delet

101 is as well as recent evidence that offers an explanation for how NADPH required by the redox system m

102 d nucleoporin Nup160 at the NE, providing an explanation for how Ndc1 controls NPC number.

103 Our results provide a mechanistic explanation for how Nde1 and Lis1 synergistically activa

104 e measured orientation provides a structural explanation for how neck surface residues enhance proces

105 a clear framework and biological mechanistic explanation for how neighborhood disadvantage affects ca

106 Economic efficiency has been a popular explanation for how networks self-organize within the de

107 Altogether, these data provide a mechanistic explanation for how newborns may cope with an immunosupp

108 Our findings provide a molecular explanation for how newly assembled dyneins are packaged

109 Our model provides a mechanistic explanation for how nucleotides regulate the p97-ataxin3

110 These findings provide one explanation for how obesity worsens cancer outcomes and

111 although not necessarily mutually exclusive, explanation for how oncogenes initiate and sustain tumor

112 he cyclin-binding motif of p21, providing an explanation for how p21 is found associated with active

113 ycle checkpoint is activated and provides an explanation for how p53 is protected from degradation in

114 Our findings provide an elegant molecular explanation for how PAS sequences are recognized for mRN

115 They also provide an explanation for how pathologically increased TGF-beta si

116 recision of beliefs and provides a potential explanation for how patients could simultaneously show o

117 weight of evidence by providing a plausible explanation for how PCBs can cause NHL through immune dy

118 Together, these mechanisms provide an explanation for how phenologically variable annual plant

119 se interdomain contacts provide a functional explanation for how PIP(2) binding and tyrosine phosphor

120 ses lamina dynamics, providing a mechanistic explanation for how PKC activity influences nuclear size

121 Our findings provide a mechanistic explanation for how plants appropriately respond to tiss

122 ty of natural small molecules represents one explanation for how plants may rapidly recruit enzymes f

123 g in the short term and provides a plausible explanation for how plastic neural codes remain integrat

124 , with the dynein motor complex may offer an explanation for how poliovirus hijacks the cellular tran

125 These data provide a mechanistic explanation for how PPARgamma activation facilitates amy

126 -B at Ser(523) provides a possible molecular explanation for how pressor hormones inhibit CNP signali

127 Our results provide a novel explanation for how primates uniquely concentrate xantho

128 These results therefore provide an explanation for how proteins can misfold into soluble co

129 s psychologically and biologically plausible explanations for how psychological factors might influen

130 we use computational modeling to provide an explanation for how pulsatile stimulation affects axonal

131 ural and biochemical results thus provide an explanation for how receptor recognition, phospholipid b

132 They also give a molecular explanation for how rising CO(2) concentrations elicit i

133 This can provide a novel explanation for how risk influences action selection and

134 ments, this structure provides a mechanistic explanation for how S1 regulates formation of an inhibit

135 eins localized only at the OMM, providing an explanation for how select mitochondrial proteins are in

136 In this paper, we offer an explanation for how selectivity for orientation could be

137 Our data suggest compelling explanations for how senescent cells persist in dormancy

138 during the cell cycle, thereby providing an explanation for how 'silent' heterochromatin can be tran

139 These findings provide a mechanistic explanation for how Smk1 activity thresholds are generat

140 These findings suggest a possible structural explanation for how so many commonly used medications bl

141 ystems, wall deficiency provides a plausible explanation for how some bacteria may hide in their host

142 propose that normalization provides a simple explanation for how spatial and feature attention could

143 standing this link may provide a mechanistic explanation for how species can adapt to changing climat

144 ound apolipoprotein A-I which may provide an explanation for how specific domains of apolipoprotein A

145 These studies provide a simple mechanistic explanation for how stromal cell signals regulate both t

146 Our results provide an explanation for how structurally similar spectrin-like r

147 Our results provide mechanistic insight and explanation for how subthalamic stimulation modulates mo

148 aureus entry into the dermis and provide an explanation for how such dermal dysbiosis results in inc

149 hoto-alteration of DOM provide a mechanistic explanation for how sunlight exposure of terrigenous DOM

150 Here we provide an explanation for how Tax induces some Chk2 activities but

151 Our findings offer an explanation for how telomerase is recruited to telomeres

152 In this paper, we develop a theoretical explanation for how temperature robustness can emerge fr

153 nding and specificity, providing a molecular explanation for how the activin class accommodates low-a

154 We provide an explanation for how the AMO may drive physical changes i

155 This deformation pattern may provide an explanation for how the Arabidopsis leaf maintains a rel

156 Our findings provide a mechanistic explanation for how the brain assembles spatial represen

157 and network theories to offer a mechanistic explanation for how the brain moves between cognitive st

158 These results provide a new and novel explanation for how the calpain/calpastatin network is o

159 ptosis in thymocytes and provide a molecular explanation for how the cAMP stimulators, including the

160 nt ABC transporter activities and provide an explanation for how the comparable transporter in native

161 This provides one mechanistic explanation for how the epithelial-mesenchymal transitio

162 gnment of order, the JCI is now requiring an explanation for how the first-author position is determi

163 These findings offer a molecular-level explanation for how the HCM mutation cTnI-R145G reduces

164 H production provide a tentative mechanistic explanation for how the inhalation of PM2.5 induces oxid

165 This study represents the first detailed explanation for how the islet facilitates inhibitory act

166 eased by light, thereby providing a possible explanation for how the long-short Tim polymorphism adap

167 t serves to protect the genome, providing an explanation for how the loss of a survival pathway leads

168 The Nse1-Nse3-Nse4 structure provides an explanation for how the lung disease immunodeficiency an

169 (OCT2), a dopamine transporter, providing an explanation for how the membrane-impermeant dopamine acc

170 Missing was an explanation for how the movements of these domains are c

171 at a peripheral location, which provides an explanation for how the NAT protein structure is not sig

172 ctivities in homologues of OSBS and a likely explanation for how the OSBS from Amycolaptosis also can

173 r protease recognition provides a compelling explanation for how the oxidation-induced conformational

174 cognition specificity provides a mechanistic explanation for how the same effector function can be us

175 s (scleractinian corals) provides a possible explanation for how the site of gastrulation has changed

176 omewhat cross-reactive, thereby providing an explanation for how the specific recognition of a limite

177 Our data provide an explanation for how the stromal ECM encodes architectura

178 These data provide a mechanistic explanation for how the SUMOylation status of Drp1 acts

179 Our results provide an explanation for how the unique domain architecture of JA

180 emical shift mapping results also suggest an explanation for how the unstable dnaQ49 mutator phenotyp

181 Systems neuroscience seeks explanations for how the brain implements a wide variety

182 lated receptors by Nef is rising, so are the explanations for how their downregulation could contribu

183 nic in geothermal systems, offer a molecular explanation for how these algae tolerate arsenic in thei

184 ave been well characterized, a network-level explanation for how these changes lead to loss of consci

185 e of the two compounds provided a structural explanation for how these compounds are able to effectiv

186 yl)propane 1-phosphate provided a structural explanation for how these compounds are able to effectiv

187 The evolutionary explanation for how these polymorphisms are maintained h

188 The results challenge the traditional explanation for how these rapidly oscillating structures

189 ped strand displacement model as a potential explanation for how these stutter products are generated

190 tory and excitatory CIN pathways and suggest explanations for how these pathways maintain alternating

191 nd the cell surface and provide a functional explanation for how this association occurs.

192 , the 'ABC model' is a simple and satisfying explanation for how this conserved floral architecture i

193 It also provides the first explanation for how this increased potassium current ind

194 They also provide an explanation for how this small molecule can direct diver

195 These studies provide a mechanistic explanation for how this therapeutic strategy can select

196 on of the skin-homing receptor, providing an explanation for how thymic selection is coordinated with

197 may help resolve the debate by proposing an explanation for how training in rhythmic skills can impr

198 This study provides a molecular explanation for how Twist1-induced dissemination works a

199 Our results provide a long-awaited explanation for how Ubx controls morphogenetic transform

200 conformational ensemble model, providing an explanation for how VDR and possibly the estrogen recept

201 cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in

202 Our results provide a theoretical explanation for how virus antigenic evolution can be hig

203 P RBD RNA structure provides an atomic-level explanation for how ZAP selectively targets foreign, CG-