ライフサイエンスコーパス: exploit

1 ch BCR repertoire data have been or could be exploited.

2 of cancer cells that can be therapeutically exploited.

3 rypsin proteolytic enzymes, was successfully exploited.

4 ns between these features is often not fully exploited.

5 ive dependencies that can be therapeutically exploited.

6 adually, to reduce the risk of helpers being exploited.

7 acidic pH, redox reactants, and hypoxia, are exploited.

8 tential as a lead structure is not yet fully exploited.

9 ues, including when specific foodstuffs were exploited; (3) the chronology of sites in the absence of

10 The devices exploit a bioresorbable dynamic covalent polymer that fa

11 ysts derived from sperm whale myoglobin that exploit a carbene transfer mechanism for the asymmetric

12 Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in

13 The underlying idea of GOxploreR is to exploit a graph-theoretical perspective of GO as manifes

14 he number or origin of seed experiments; (4) exploit a high-dimensional, complex parameter space, and

15 Two proof-of-concept inorganic probes that exploit a novel mechanism for (19) F MR sensing based on

16 We exploit a sample consisting exclusively of particles wit

17 By exploiting a combination of frustrated total internal re

18 By exploiting a number of different labeling schemes, the t

19 g blocking, separation and washing steps and exploiting a single antibody.

20 Human immunodeficiency virus type 1 (HIV-1) exploits a number of specialized microtubule (MT) plus-e

21 he printed object new interesting properties exploited after the fabrication process.

22 Exploiting an analogy with long-range ferromagnetic spin

23 endent on Skp2, which can be therapeutically exploited and could provide the basis for promising nove

24 in nanoscale topography (PAINT) method that exploits aptamers as minimally invasive affinity probes.

25 et, excess copper is extremely toxic, and is exploited as a bacteriocide in medical and biotechnologi

26 In addition, bromotryptophan was exploited as a platform for late-stage diversification b

27 might also offer opportunities that could be exploited at the therapeutic level.

28 hip between temporal discounting and explore-exploit behavior that may be mediated by multiple factor

29 n Task to quantify two strategies of explore-exploit behavior: directed exploration, where informatio

30 Exploiting Bellymount's capabilities, we track intestina

31 ation from Ccl17(E/+) reporter mice; it also exploited both CCL17-dependent and unique CCL17-driven i

32 By exploiting both mode symmetry and far-field properties,

33 of APA isoforms from 3'-end RNA-Seq data by exploiting both paired-end reads for gene isoform identi

34 er these low-light conditions is achieved by exploiting both the refractive and absorptive properties

35 ntational abstraction are involved with, and exploit, both prediction and its rather distant cousin,

36 gateways that porins form in the OM are also exploited by bacteriocins to translocate into cells by a

37 identifies a non-canonical role of caspase-8 exploited by cancer cells to override the p53-dependent

38 w tumour cell-autonomous mechanisms might be exploited by combining DDR inhibitors, ICIs and radiothe

39 he type I IFN response, which is known to be exploited by L. monocytogenes during infection.

40 In many systems, host traits exploited by parasites are constrained by use in other f

41 sile, then this numerical advantage would be exploited by pathogens unless neutrophils from the blood

42 While it has been studied and exploited by supramolecular chemists for many years, mos

43 ecause host hexosamine biosynthesis is being exploited by the bacteria, in particular to assist their

44 d selectivity may be a general coding scheme exploited by the brain for reliable and efficient neural

45 This coupling mechanism is exploited by tumor cells to aberrantly sustain transcrip

46 etic lethality strategies for cancer therapy exploit cancer-specific genetic defects to identify targ

47 Our results demonstrate that glioblastomas exploit cell surface O-linked glycans for local and dist

48 As obligate parasites, all viruses exploit common cellular pathways, providing the possibil

49 Since the described system exploits conserved sex-specific splicing mechanisms and

50 hich extends the ability of these systems to exploit context and has contributed to remarkable breakt

51 A key aim in exploiting CRISPR-Cas is gRNA engineering to introduce a

52 framework of composable models that flexibly exploit cross-species information in the form of GI data

53 However, exploiting ctDNA to determine how a patient's cancer is

54 aus in the tails of survival curves, we also exploited "cure models" to estimate the fraction of pati

55 Explore/exploit decisions were modeled using reinforcement learn

56 -use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and

57 Our results suggest that the capacity to exploit different prey types enables species to thrive i

58 h for the synthesis of beta-keto sulfones by exploiting differential reactivity pattern of substrates

59 By taking a comparative approach that exploits Drosophila neurogenetics, our results provide a

60 This ability to exploit dynamic resources may translate to success in ur

61 eptide interactions with model peptides that exploit electrostatic complementarity and define a novel

62 of the key engineering approaches for better exploiting EVs in disease intervention.

63 pert chemists whose properties are now being exploited far beyond traditional applications.

64 sure a consistent larval supply to replenish exploited fish stocks.

65 ablished and emerging cell-based assays that exploit fluorescence for studies of DNA damage and its c

66 MINFLUX) microscopy in the localization mode exploit fluorophores that blink, i.e., switch on and off

67 As such, it has been successfully exploited for cancer immunotherapy.

68 Such genetic interactions may potentially be exploited for cancer therapies.

69 F-beta feedforward loop could potentially be exploited for cancer treatment.

70 natural molecular recognition process widely exploited for diagnostic, biotechnology, and nanotechnol

71 enerative diseases (NDs) and how this can be exploited for drug discovery.

72 These advantages could be exploited for large-scale industrial applications and na

73 pendent redox balance in PCa, which could be exploited for novel biomarkers and therapies.

74 NIS has been exploited for over 75 years in ablative radioiodine (RAI

75 This experimental platform was further exploited for studying with intravital microscopy the ex

76 These phenomena have been investigated and exploited for targeted drug delivery applications in the

77 n nicotine alpha7 nAChR interaction might be exploited for the design of new drugs based on the nicot

78 s and the conserved dimer interface could be exploited for the development of antiviral inhibitors.

79 Oncometabolites could potentially be exploited for the development of novel targeted therapie

80 tion and polarization properties that can be exploited for the quantum control of its interaction wit

81 These binding properties were exploited for the selective liquid-liquid extraction of

82 Finally, our findings can be exploited for the structure-assisted design of future A9

83 and PTEN functions as a rheostat that can be exploited for the treatment of PTEN loss-driven cancers.

84 propose that redox vulnerabilities could be exploited for therapeutic benefits and identify unsuspec

85 ss goes awry during autoimmunity or could be exploited for therapy.

86 Nonetheless, these PSFs have been drained, exploited for timber and land for agriculture, leading t

87 anisms compared with T cells, which could be exploited for treatment of nonresponders to current immu

88 The properties of gold nanoparticles were exploited for visual detection.

89 ceptoral substrate that could potentially be exploited for visual rehabilitation.

90 silon-Aurora B module provides a more widely exploited genome-protective control for the cell cycle,

91 Toward this end, we exploited gramicidin channels as molecular force probes

92 f molecular markers to utilise this trait to exploit homoeologous recombination in a crop.

93 evolved 'core environmental responses' which exploit host signals to trigger immune evasion strategie

94 ptide (OP; KKWWKKWDipK) for immunotherapy by exploiting (i) "flexible" linear polymer backbone to fac

95 -induced electronic structure changes can be exploited in COF platforms to give rapid, reversible sen

96 Results can be further exploited in design of microfluidic devices for rare cel

97 perties which are averaged out and cannot be exploited in disordered systems.

98 ce of information for fixed wavelength IRMPD exploited in dissociation protocols of peptides and prot

99 ling and lower abuse liability, which may be exploited in future therapeutic drug design for cocaine

100 lding blocks into higher-order structures is exploited in living systems to create functional complex

101 c example of quantum physics and it has been exploited in precision measurements of forces and fundam

102 a novel source of therapeutic targets to be exploited in the context of beta cell failure in diabete

103 ognized E-C coupling mechanism that could be exploited in the development of therapeutics to treat ob

104 uption of GPRASP/CXCR4 interactions could be exploited in the future to enhance the efficiency of HSC

105 ive optical technique has perspectives to be exploited in the multipurpose diagnostics and it can be

106 pstein-Barr virus (EBV), an oncoherpesvirus, exploits inflammasomes to activate its replicative or ly

107 maries of drug resistance mutations; it also exploits information on within-host viral diversity to c

108 Here we exploit intereffector generalization, the behavioral sig

109 proach to not only overcome, but better yet, exploit intra-tumoural hypoxia.

110 A direct path to exploit it is the generation of heat, for applications i

111 all tubby-like proteins, and explores how to exploit it pharmacologically using drugs.

112 Understanding this balance and how to exploit it therapeutically is one of the dominant themes

113 Though not being actually exploited, it is a source of polyphenols with antioxidan

114 We exploit its electro-optics to visualize the appearance,

115 The proposed method exploits knowledge from biological networks and longitud

116 Exploiting LCMV as a model system, we demonstrate that T

117 level to identify the number of commercially exploited marine species that are shared between neighbo

118 ses a challenge to developing therapies that exploit metabolic vulnerabilities.

119 By exploiting molecular characteristics, such as pK(a), we

120 Although this effect was exploited more than seven decades ago in Vonnegut's pion

121 scientific and industrial applications that exploit multi-mode fibers, a prior knowledge of spatial

122 To this end, it is important to exploit multiple data streams that are becoming abundant

123 These findings exploit murine organoid models to uncover the mechanism

124 Targeted therapeutics for cancer generally exploit "oncogene addiction," a phenomenon in which the

125 by frame-by-frame localization (FFL), which exploit only the spatial correlation and leave the tempo

126 ch refers to the problem of choosing between exploiting options with known values and exploring unfam

127 development of new pharmacologic agents that exploit or target TMPRSS6 to treat anemias and iron-rela

128 l basal ECM turnover during embryogenesis by exploiting our ability to live image de novo ECM develop

129 Thus, rotavirus exploited paracrine purinergic signaling to generate ICW

130 Exploiting perylene diimides (PDIs) as components in cyc

131 thologies), delivery vectors are designed to exploit physical and biological features of unhealthy ti

132 ve scatterer in a mechanical meta-layer that exploits piezoelectric sensor-actuator pairs controlled

133 Our method suggests that exploiting pleiotropy for applications in evolutionary m

134 ng theories suggest that organisms learn and exploit probabilistic models of their environment.

135 This work reveals that wtf parasites can exploit protein aggregate management pathways to selecti

136 and innovative functionalization method that exploit Protein-A/antibody affinity.

137 We exploited putative hypomorphic and EOfAD-like mutations

138 uantum coherent effects and opportunities to exploit QDs as platforms for quantum information science

139 Here, we exploited recent developments in virtual reality (VR) an

140 e-activity budgets and may lead the sexes to exploit regions with different wind regimes.

141 (IRIS), a mass-spectrometry-based technique exploiting resonant infrared multiple photon dissociatio

142 atory strategy to a more conservative way of exploiting resources, reducing both their year-round spa

143 en- and within-area exposure variability are exploited, RF may be preferred.

144 g approach for the construction of anilines, exploiting saturated cyclohexanones as aryl electrophile

145 st that our subject may have the capacity to exploit scent trails left by prey which can be tracked t

146 l and may inspire expanded applications that exploit sensitivity to DNA supercoiling.

147 Herein, we exploited spectral editing techniques to identify and qu

148 migrating cells, such classification did not exploit SPHARM spectra in their dynamics.

149 hieve this goal, 3D MSC sheets are prepared, exploiting spontaneous post-detachment cell sheet contra

150 Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected

151 and mechanisms are involved in acquiring and exploiting such contextual knowledge?

152 In addition, we exploit the absence of cross-talk with respect to the ma

153 hemometrics method facilitates scientists to exploit the advantages of chemometrics.

154 Here, we exploit the aqueous two-phase separation of dextran-in-P

155 community, or cheaters who do not and simply exploit the cooperators.

156 ortunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cel

157 diversity and followed by new treatments to exploit the eco-evolutionary vulnerability of small and/

158 Here, we exploit the enzyme-mimetic properties of platinum nanopa

159 on their functional determinants, we seek to exploit the evolutionary record of variation and diverge

160 ggest that the proposed framework may indeed exploit the hallmarks of spatially explicit ecological a

161 However, the virus rapidly evolves to exploit the IFN-alpha response for its replication, spre

162 s are similar to those of viruses, which can exploit the inflammasome to avoid IFN-I(12), are restric

163 s across different samples, failing to fully exploit the information available from HiChIP datasets.

164 nces in synthetic biology are enabling us to exploit the information-processing abilities of living c

165 natorial neuropharmacology approaches should exploit the interactions between OT and serotonin to reg

166 Here, we exploit the MSH1 system in Arabidopsis and tomato to int

167 Deep mutational scanning (DMS) studies exploit the mutational landscape of sequence variation b

168 ed VTA DA neurons perform multiplexing: they exploit the phasic and tonic activity modes to encode, r

169 ntification, and therapeutic techniques that exploit the physical principles of cavitation.

170 We exploit the possible link between structural surface rou

171 Here, we exploit the propagation of transition waves in a bistabl

172 Here we exploit the response dynamics of two functionally couple

173 lse mediated by an infrared laser pulse, and exploit the sensitivity of inelastic electron-light scat

174 However, such an approach does not exploit the similarity in two GRNs, and may sacrifice in

175 en this is not the case, the agent can still exploit the task solutions by using them to interact wit

176 We exploit the thermolytic decomposition of Mo(CO)(6) in th

177 oor outcomes have fuelled ongoing efforts to exploit the tumour microenvironment (TME) for therapy, b

178 To exploit the underlying stress-diffusive mechanism, a phy

179 Cancer cells exploit the unfolded protein response (UPR) to mitigate

180 conversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenv

181 hat efficient surface ligand engineering can exploit the unique electrochemical properties of individ

182 inosa strains including clinical isolates to exploit the versatility of the diterpene scaffold.

183 We exploited the ability to increase the local tissue conce

184 We exploited the anomalous scattering of bromine and iodine

185 Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in

186 The current study exploited the extremes of such variation to identify gen

187 In this study we exploited the hyaloid vascular network in murine eyes, w

188 any evidence that participants successfully exploited the prior distributions of targets.

189 In this study, we exploited the proximity-based biotinylation approach to

190 Potential biomaterials exploiting the CH-pai bond-based stabilization, as exemp

191 Exploiting the delay in viroplasm assembly, we found tha

192 -demand reverse the propulsion direction, by exploiting the different photocatalytic activities on bo

193 come symbionts by surviving phagocytosis and exploiting the eukaryotic intracellular environment.

194 By exploiting the fact that the antiferromagnetic order can

195 easing research and attention has focused on exploiting the intraspecific genetic variation within a

196 Dedicated post-processing exploiting the known CPMG spikelet frequencies allowed t

197 Exploiting the latter observation, we used a protein-pro

198 Selectivity is achieved by exploiting the lower barrier for C-CN oxidative addition

199 a unique 'fruits-on-a-vine' arrangement, by exploiting the metastable region of the phase diagram of

200 f MMEJ as well as new targets and approaches exploiting the MMEJ pathway in cancer therapy.

201 Improved cross-section data were obtained by exploiting the negligible cosmic-ray background deep und

202 Exploiting the power of electrochemical oxidations, this

203 method to detect SO(2) in wine is presented, exploiting the preferential binding of silver nanopartic

204 ns of PI distribution within intact cells by exploiting the properties of a bacterial enzyme, PI-spec

205 By exploiting the quantum capacitance model, we find that t

206 glycoprotein phases of connective tissues by exploiting the spatially distinct fascicular (collagen-r

207 pact of NPIs on mitigating disease spread by exploiting the spatio-temporal variations in policy meas

208 us (HCMV), generated via a similar mechanism exploiting the TENT4-ZCCHC14 complex.

209 By exploiting the thin-film growth mechanisms of aluminum d

210 o studies over an even larger pressure range exploiting the upgraded synchrotron machines, and direct

211 Functional studies reveal that PX exploits the antagonism between beta-arrestin isoforms;

212 Here, we propose a hybrid approach that exploits the best of both worlds by building a mapping b

213 This more fully exploits the biological information present in the virus

214 Allostery exploits the conformational dynamics of enzymes by trigg

215 The method exploits the difference in densities of cells for separa

216 ork, we present a forecasting algorithm that exploits the dimensionality of data in a nonparametric a

217 This method exploits the fact that the localized plasmon resonance (

218 work, we propose a data fusion approach that exploits the integration of complementary omics-data as

219 It exploits the large databases on plant traits and species

220 e develop a generally applicable method that exploits the large number of kinase inhibitors that have

221 Our biosynthetic strategy exploits the large number of naturally available methylt

222 an experimental and computational study that exploits the natural genetic variation across five close

223 Furthermore, CREST exploits the profound differences in sex-specific geneti

224 APTi exploits the prosurvival output of transiently silencing

225 Enhanced RIC exploits the stronger binding of locked nucleic acid (LN

226 Our results show that PTBP1 directly exploits the tendency of UPF1 to release RNA upon ATP bi

227 The low-cost 'THz Torch' technology, which exploits the thermal infrared spectrum (ca. 10 to 100 TH

228 This system exploits the thermosensitive characteristic of N-isoprop

229 The system exploits the toxicity of commonly used broad-spectrum an

230 tidase activity within junctional spaces can exploit their confinement and favorable electrostatic in

231 h they live, for the purpose of successfully exploiting their environment.

232 ility limits of various organic compounds by exploiting their pH-active carboxylic acid groups.

233 on monitoring (QCM-D), to detect exosomes by exploiting their surface protein profile.

234 provide a mechanistic approach that might be exploited therapeutically in alleviation and prevention

235 ential molecular vulnerabilities that can be exploited therapeutically.

236 nomic instability and targeted strategies to exploit these defects in the treatment of cancer.

237 To exploit these findings, we have adapted an impedimetric

238 straints and how environmental pressures may exploit these limitations.

239 Newer agents likewise exploit these pharmacological mechanisms, including tram

240 environment in search of vital resources to exploiting these resources once the search was successfu

241 , only recently has the chemistry emerged to exploit this altered state therapeutically, by targeting

242 By modifying Arioc's implementation to exploit this GPU memory architecture we obtained a furth

243 To fully exploit this method, we must move towards new alloys and

244 N) inducible, suggesting that SARS-CoV-2 may exploit this phenomenon to enhance viral spread and ques

245 Strategies that exploit this recent knowledge to combat infection will b

246 nd we show that machine learning models that exploit this representation outperform those trained dir

247 her physical parameters, will help to better exploit this sustainable resource.

248 We exploit this to generate a biosensing platform with a li

249 We aimed at exploiting this effect by combining RNT with immunothera

250 By exploiting this network, we identified literature-suppor

251 Temperature-dependent growth is thus exploited through protein dilution to provide the long-t

252 ozinc compounds in an acidic environment was exploited to accomplish the synthesis of alkenes using a

253 mational changes and enzyme activity that is exploited to achieve substrate selectivity.

254 lated defects in 2D black phosphorus (BP) is exploited to achieve visual memory, wavelength-selective

255 demonstrate that spatial dependences can be exploited to address the limitations posed by the spatio

256 t pharmacological targeting of OCT2 could be exploited to afford neuroprotection in cancer patients r

257 the decaniobate ([Nb(10) ]) oxo-caps can be exploited to build 1D, 2D, and 3D inorganic frameworks.

258 n serum albumin as a model, its sequence was exploited to chemically transform a single cysteine, suc

259 So far, Earth observation data has not been exploited to complete or complement existing inventories

260 ons reveal how competing interactions can be exploited to control ferroic hallmark properties such as

261 -relevant thin films (<200 nm thickness), is exploited to deduce the precise composition of the inter

262 es that used the JRC method was additionally exploited to derive interlaboratory performance characte

263 Finally, the microalgae sensor was exploited to detect various light and heavy metal ions w

264 This knowledge may be exploited to develop more effective ASFV vaccines that t

265 se signaling properties might potentially be exploited to develop new therapeutic strategies for a ra

266 arsenic from the belowground environment is exploited to engineer plant nanobionic sensors for real-

267 lung, liver, and spleen can be strategically exploited to enhance drug delivery.

268 hat the time of glomerulus activation can be exploited to extract odor-related information, although

269 With these tools, GO can be exploited to functionally link BE events at endogenous g

270 s identifying extreme phenotypes that can be exploited to further understand the complex virus-host i

271 eans by which bacterial redox systems can be exploited to generate "unnatural" polymers in the presen

272 and temporal dissection of mutations can be exploited to identify novel tumor suppressor genes and t

273 fly, natural variation across orthologues is exploited to identify suitable cysteine replacements com

274 These properties can be exploited to impose circadian expression, which is asymm

275 ctors, such as light intensity, and could be exploited to improve crop performance.

276 ogether with emerging technologies, could be exploited to improve modern crop breeding and domesticat

277 of key sulfur assimilatory enzymes could be exploited to improve the nutritive value of soybean seed

278 nd so alternative physical processes must be exploited to modulate the QCL gain on ultrafast timescal

279 ly, targeting this population of CSCs can be exploited to potentiate immunotherapy and reduce tumor r

280 oupling of the ion to the cavity can also be exploited to provide a mechanism to efficiently cool the

281 As with invading eukaryotic organisms can be exploited to provide disease resistance.

282 ginating from the programmed site, which was exploited to reduce the P. aeruginosa genome by 837 kb (

283 in-situ and satellite-based climate data are exploited to study natural hazard triggers while the pot

284 hlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric

285 ase (PARP) inhibition and BRCA deficiency is exploited to treat breast and ovarian tumors.

286 unable formation kinetics and can be further exploited to trigger the controlled release of droplet c

287 xerted by flow on a translocating DNA can be exploited to tune the kinetics of DNA translocation.

288 boiling point, polarity, viscosity) could be exploited toward the synthesis of well-defined nanomater

289 o-C-H bond activation strategy has also been exploited toward tunable synthesis of densely functional

290 mportant component of RL is managing explore-exploit tradeoffs, which refers to the problem of choosi

291 (tier, composition, and structure) manner by exploiting underlying stochastic fracturing process.

292 that species inhabiting dynamic systems can exploit urban areas resulting in increased reproductive

293 attention but also the opportunities one can exploit using a crystal engineering approach, for exampl

294 munotherapy mediated by HPV E5, which can be exploited using the HPV E5 inhibitor rimantadine to impr

295 Experiments that exploit variable-temperature ground-state electronic abs

296 Biosensor development exploiting various transduction principles is characteri

297 However, they exploit wavefunctions relying on crystal band symmetries

298 uggest countermeasures that will prevent the exploits we describe.

299 greatly developed in the past few years and exploited widely for many applications, such as biosensi

300 in leader cells that can be therapeutically exploited with the mitochondria-targeting compound alexi