ライフサイエンスコーパス: expression site

1 s and the generation of novel alleles at the expression site.

2 gial variant surface glycoprotein (VSG) gene expression site.

3 ycoprotein (VSG), encoded in a telomeric VSG expression site.

4 bination into a single operon-linked genomic expression site.

5 a monocistronic variant surface glycoprotein expression site.

6 oding nucleotide sequences into the singular expression site.

7 or VSG copies into the actively transcribed expression site.

8 iple silent vls cassette sites into the vlsE expression site.

9 nefficiently direct recombination in the VSG expression site.

10 DNA break at a subtelomeric bloodstream form expression site.

11 ric locus, specifically the bloodstream form expression site.

12 tion of silent donor cassettes with the tprK expression site.

13 eater the switch rate of that locus into the expression site.

14 ci form a hierarchy of switch rates into the expression site.

15 s of variants at silent sites and the single expression site.

16 cei is encoded by genes located in different expression sites.

17 lycoproteins (VSGs) from telomere-linked VSG expression sites.

18 equences representing the VSG 10.1 donor and expression sites.

19 urface protein through switching between two expression sites.

20 of the CGRP receptor at endogenous or novel expression sites.

21 ibition between individual elements or novel expression sites.

22 activated by recombination into specialized expression sites.

23 are recombined in various combinations into expression sites.

24 t archive, by recombination into specialized expression sites.

25 at a time from one of multiple telomeric VSG expression sites.

26 rsion of chromosomal pseudogenes into single-expression sites.

27 ysis of the donor sites, as well as the tprK expression sites, among eight T. pallidum subsp. pallidu

28 cus, a complex system consisting of the vlsE expression site and an adjacent set of 11 to 15 silent v

29 nreciprocal gene conversion between the tprK expression site and donor sites.

30 The structure of the expression site and flanking regions was conserved excep

31 SG and its corresponding telomere-linked VSG expression site and forms the basis for studies on antig

32 achieved by recombination between the MG192 expression site and MgPar sequences via gene cross-over

33 explained by recombination between the mgpB expression site and putative donor MgPar sequences.

34 of pseudogenes into the single operon linked expression site and the diversity of variants is defined

35 the variants following recombination into an expression site and the donor loci themselves are under

36 silenced variant surface glycoprotein (VSG) expression sites and procyclin loci, indicating a disrup

37 owed that p44 multigenes have several active expression sites and the expression is regulated at tran

38 have strengthened the proposal that the VSG expression sites and the PARP genes represent naturally

39 genes-the variant surface glycoprotein (VSG) expression sites and the procyclin or the procyclic acid

40 We found that most of the YAC expression sites and tissues are directly reflective of

41 lly integrated bacterial chromosomal protein expression sites and variants.

42 Msp2 is encoded by a single expression site, and diversity is achieved by gene conve

43 pe 4 variant surface glycoprotein (VSG) gene expression site, and some appear to come from pseudogene

44 nked donor VSG 10.1 resembles metacyclic VSG expression sites, and is preceded by a cluster of 35 or

45 T. brucei has about 20 VSG expression sites, and it has been proposed that their ge

46 G is expressed exclusively from subtelomeric expression sites, and we have shown that telomere protei

47 ncated RNA polymerase pseudogenes as well as expression site associated (pseudo)genes (ESAGs) 3 and 4

48 n units, containing a variety of families of expression site associated genes (ESAGs) in addition to

49 glycosylphosphatidylinositol (GPI)-anchored expression site-associated gene 6 (ESAG6 or E6) and solu

50 mRNA species encoding related members of the expression site-associated gene I (ESAG-I) family occur

51 VSG expression sites (BESs), also containing expression site-associated genes (ESAGs) involved in hos

52 n site contains a promoter followed by seven expression site-associated genes (ESAGs), three pseudo E

53 A BES is a tandem array of expression site-associated genes and a terminal VSG gene

54 The other chromosome end carries VSG and expression site-associated genes and pseudogenes over 50

55 Two expression site-associated genes ESAG6 and ESAG7, encode

56 Three conserved expression-site-associated genes (ESAGs) appear to serve

57 s, which are co-transcribed with a number of expression-site-associated genes (ESAGs) from loci terme

58 loci of variant antigens copy into a single expression site at rates determined by extragenic featur

59 Monoallelic expression of BF Expression Site (BES)-linked VSGs and silencing of metac

60 glycoprotein (VSG) from 1 of 15 bloodstream expression sites (BESs) by virtue of a multifunctional R

61 n one of many telomeric bloodstream form VSG expression sites (BESs), also containing expression site

62 ream form Variant Surface Glycoprotein (VSG) expression sites (BESs), of which one is expressed at a

63 d from one of ~15 telomeric bloodstream form expression sites (BESs).

64 mere at one of fifteen so-called bloodstream expression sites (BESs).

65 ized subtelomeric PTUs, the Bloodstream-form Expression-Sites (BESs), which house the major antigenic

66 genes (ESAGs) from loci termed 'bloodstream expression sites' (BESs).

67 I in a singular nuclear structure called the expression site body (ESB), but how monoallelic VSG tran

68 In bloodstream form trypanosomes, the expression site body (ESB), spliced leader array body (S

69 in an extranucleolar compartment termed the expression site body (ESB), whereas silent BESs, located

70 ers and is abundant in the nucleolus and the expression site body subnuclear compartments.

71 unique extranucleolar Pol I body called the expression-site body (ESB).

72 d from one of approximately 20 subtelomeric 'Expression Sites', but the role telomeres might play in

73 lesions in, neurons that project to the gene expression site, but not in nearby structures that would

74 eric variant surface glycoprotein (VSG) gene expression sites, but not in the active expression site,

75 l segments of pseudogenes recombine into the expression site by gene conversion.

76 F-mediated conversion of a single MSP2 (P44) expression site by partially homologous donor sequences.

77 y combinatorial gene conversion of a genomic expression site by truncated pseudogenes.

78 The 45 kb telomere-linked VSG 10.1 expression site contains a promoter followed by seven ex

79 rived from the pseudogenes into the existing expression site copy, resulting in a combinatorial incre

80 somally encoded AphA protein activates tcpPH expression, site-directed mutagenesis was used to identi

81 Here, using recombinant protein expression, site-directed mutagenesis, fluorimetric and

82 Using expression/site-directed mutagenesis approaches, we now

83 ariant surface glycoprotein (VSG) genes into expression sites during immune evasion by antigenic vari

84 The various expression sites encode slightly different transferrin r

85 d substitutions in the region of the genomic expression site encoding the central hypervariable regio

86 oposed that T. brucei has developed multiple expression sites encoding different transferrin receptor

87 , but only one is expressed from a telomeric expression site (ES) at any given time.

88 one variant surface glycoprotein gene (VSG) expression site (ES) is active at any time.

89 nes, under the control of either rRNA or vsg expression site (ES) promoters, into various chromosomal

90 metacyclic variant antigen type 4 (MVAT) vsg expression site (ES) revealed an ES-associated gene (esa

91 gle RNA polymerase I (Pol I) transcribed VSG expression site (ES), necessitating extremely high level

92 VSG gene is in a Pol I-transcribed telomeric expression site (ES).

93 polycistronic transcription unit known as an expression site (ES).

94 only one VSG gene at a time from a telomeric expression site (ES).

95 chanism using marker genes in the active VSG expression site (ES).

96 Owing to developmental silencing of the VSG Expression Sites (ES), no VSG is transcribed in the inse

97 sg) among an estimated 20-40 telomere-linked expression sites (ES), only one of which is fully active

98 ous transcription of VSGs from all telomeric expression sites (ESs) and from silent subtelomeric VSG

99 ndreds of VSG genes at a time from telomeric expression sites (ESs) and periodically change the VSG e

100 its variant surface glycoprotein (VSG) gene expression sites (ESs) in a monoallelic fashion using RN

101 t only one of approximately 15 telomeric VSG expression sites (ESs) is transcribed at a time.

102 anscribed variant surface glycoprotein (VSG) expression sites (ESs) of Trypanosoma brucei.

103 are exclusively expressed from subtelomeric expression sites (ESs) where VSG genes are flanked by up

104 eric variant surface glycoprotein (VSG) gene-expression sites (ESs) while multiplying in the mammalia

105 monoallelically expressed from subtelomeric expression sites (ESs), and VSG switching exploits subte

106 -proximal variant surface glycoprotein (VSG) expression sites (ESs), suggesting a role in controlling

107 m 1 of 15 polycistronic bloodstream-form VSG expression sites (ESs), which are controlled in a mutual

108 ibed variant surface glycoprotein (VSG) gene expression sites (ESs), which are monoallelically expres

109 gene at a time from 1 of about 20 telomeric expression sites (ESs).

110 found adjacent to telomeres in polycistronic expression sites (ESs).

111 anscribed from one of about 15 telomeric VSG expression sites (ESs).

112 e I in one of approximately 15 telomeric VSG expression sites (ESs).

113 plex and a major regulator for silencing VSG expression sites (ESs).

114 d in one of 15 telomeric regions termed "VSG expression sites" (ESs), each of which contains a polyci

115 onserved domains, which are identical to the expression site flanking domains.

116 ombination of msp2 pseudogenes into the msp2 expression site, followed by sequential segmental gene c

117 s surface antigen variation by acting as the expression site for a family of genes encoding isoforms

118 These variations in structure of an expression site for a major, immunoprotective outer memb

119 We define here a genomic expression site for MSP2(P44) in A. phagocytophilum.

120 hen the vsp33 expression site was active, an expression site for other variable proteins was silent.

121 The genomic expression site for this mRNA is polymorphic and encodes

122 ale and defined the structure of the genomic expression site for this transcript.

123 appear to have been the acquisition of novel expression sites for developmental genes, with its accom

124 examples of potential uses, we report novel expression sites for four potential therapeutic targets-

125 on of whole pseudogenes into the single msp2 expression site has been previously identified as one me

126 The 80 kb preceding the expression site has few, if any, functional ORFs, but co

127 lso analyzed the variability of this genomic expression site in Oklahoma strain A. marginale transmit

128 he structure and diversity of the MSP2 (P44) expression site in strains derived from the United State

129 locus encoding major outer membrane protein expression sites in both Anaplasma marginale and Anaplas

130 e at many, or even any, of a gene's specific expression sites in homozygous null mutant embryos.

131 ut not in some areas that are among the main expression sites in rodents, such as the brain areas whe

132 -trimester fetus, but has a limited range of expression sites in the adult.

133 erted into the mafF locus revealed prominent expression sites in the gut, lung, liver, outflow tract

134 Such interstrain diversity at the vlhA expression site, including major differences in the pred

135 milies colocalize within the same subnuclear expression site, indicating that the role that nuclear a

136 are typically silent, such as telomeric VSG expression sites involved in antigenic variation.

137 in A. marginale, the msp2(p44) gene in this expression site is polymorphic in all populations of org

138 The results show that a syntenic expression site is present in all strains of A. phagocyt

139 dynamics, we reveal that the transcribed VSG expression site is the only telomeric site that is early

140 In this study, we show that the same expression site is utilized in stages of A. marginale in

141 The alternative to this expression site model is that mRNAs acquire the UCS by R

142 elements were applied to the analysis of the expression site of relapse serotypes from 60 infected mi

143 Variation in the tandem repeats in the expression site of the human-derived Pneumocystis carini

144 1 closely reports most of the body and brain expression sites of the Satb1 chromatin remodeling gene

145 es and compared these profiles with the gene expression sites of their identified transporters, i.e.

146 This supports the hypothesis that the expression sites of these important immunogenic proteins

147 The vlsE expression sites of these two strains have not been isol

148 ariation through gene conversion of a unique expression site on a linear plasmid by an archived varia

149 omatin specifically at the single active VSG expression site on chromosome 6, forming an allele-selec

150 The second set of elements flanks the expression site on the 3' side and occurs at variable di

151 th a single targeting vector into permissive expression sites on all autosomes.

152 ant effect of locus position relative to the expression site or origin of replication.

153 f VSG expression, called the bloodstream VSG expression site, or recombination reactions that move si

154 of 150 (59%) had lesions with increased PSMA expression sites outside the prostatic fossa.

155 nking sequences tightly align and anchor the expression site sequence to the pseudogene.

156 gene expression sites, but not in the active expression site, suggesting a role for J in regulating t

157 , regulation of MSG expression uses a single expression site, termed the upstream conserved sequence

158 form variant surface glycoprotein (VSG) gene expression site that appears truncated and degenerate.

159 laborate, plasmid-encoded system involves an expression site that can acquire either variable large p

160 nit area of extracellular matrix protein low expression sites, the size of these regions was enlarged

161 of silent msp2 alleles into a single active expression site to encode unique Msp2 variants.

162 rom multiple alleles are recombined into the expression site to generate a novel msp2 mosaic not repr

163 ogenes can be recombined into the functional expression site to generate new antigenic variants.

164 sistence is segmental gene conversion of the expression site to link hypervariable msp2 sequences to

165 fficient to open the chromatin of silent VSG expression sites, to disrupt VSG monoallelic expression,

166 from a completely sequenced U.S. strain) and expression site variants infecting sheep and dogs in Nor

167 invariance of the pseudogenes, indicate that expression site variation is generated using gene conver

168 possesses 15 silent vls cassettes and a vls expression site (vlsE) encoding a surface-exposed lipopr

169 B31 consists of 15 silent cassettes and one expression site (vlsE), and the presence of the encoding

170 vel of transcription and that when the vsp33 expression site was active, an expression site for other

171 nation between this reservoir and its single expression site was predicted to result in lineages of M

172 origin of sequences recombined into the msp2 expression site, we demonstrated that the complexity of

173 e transcribed from polycistronic bloodstream expression sites with promoters which are located 45-60