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1 ng the polypeptide chains of Tmods and Lmods exquisitely adapt their functions for capping versus nuc
3 of whiskers, as well as their movements, are exquisitely adapted for tactile exploration in the dark
4 causative agent of tuberculosis (TB), is an exquisitely adapted human pathogen capable of surviving
5 resident chondrocytes in human cartilage are exquisitely adapted to hypoxia and use it to regulate ti
7 a marmota), a large ground-dwelling squirrel exquisitely adapted to the "ice-age" climate of the Plei
9 selectively binds c-di-AMP and discriminates exquisitely against other cyclic dinucleotides, such as
10 eral roots, and the CnAIP2 gene promoter was exquisitely auxin sensitive; and (3) CnAIP2 promoted the
13 hypersensitivity pneumonitis, reflecting the exquisitely bronchiolocentric micronodular lesions of or
14 ate granule cells (DGCs), which is regulated exquisitely by brain activity, renders the hippocampus p
15 ukaiyama cyclization"), which is shown to be exquisitely chemoselective for terminal alkenes, leaving
16 t of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional p
17 ulature the largest organ system, it is also exquisitely complex, with single muscles existing in dif
18 ments suggests that substrate recognition is exquisitely conserved among eukaryotic UGMs and distinct
19 e-like crystallites and show archeopyles and exquisitely constructed opercula, demonstrating the dino
20 proteins (MPs) embedded in lipid bilayers to exquisitely control communications across the insulating
24 , the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit l
25 ntial for immunity, their generation must be exquisitely controlled because a class-switched B cell c
26 mes with designer geometry: all of which are exquisitely controlled by a set of modular, reconfigurab
27 the mechanical response to dynamic shear are exquisitely controlled by the relative concentrations of
30 teeth are attached to the jawbone through an exquisitely controlled mineralization process: unmineral
31 gy, a platform within which reactions can be exquisitely controlled, has made the development of arti
40 lesions on which different myeloma subtypes exquisitely depend, and by informative preclinical model
41 viruses and suggests that miRNA function is exquisitely dependent not only on viral genomic context
43 scuous use of the available Gi/o proteins is exquisitely dependent on sequences within the H3C and su
44 driven by the transcription factor Gfi1 are exquisitely dependent on the enzyme lysine demethylase 1
45 id tumors carrying BRAF(V600E) mutations are exquisitely dependent on the oncoprotein for viability a
47 although T cell proliferation in culture was exquisitely dependent on xCT expression, xCT was dispens
48 ure B cells, mature anti-insulin B cells are exquisitely dependent upon BTK, because their numbers ar
51 In contrast, TRIM21 antiviral activity was exquisitely dependent upon off-rate, with sub-muM affini
52 ations are permitting researchers to collect exquisitely detailed information with little observer bi
53 Emerging data from these efforts offers an exquisitely detailed picture of disease-relevant neural
55 itAI loci thus serve as identify barcodes to exquisitely discriminate against nonself to ensure popul
56 ditions, fibrin-alpha2-PI1-8-VEGF164 allowed exquisitely dose-dependent angiogenesis: concentrations
58 f the order Chlamydiales comprise a group of exquisitely evolved parasites of eukaryotic hosts that e
62 prior to murine embryonic day (E) 14.5 to an exquisitely folded columnar epithelium in fetal stages.
63 thioredoxin-interacting protein (TXNIP), an exquisitely glucose-inducible gene previously identified
64 hioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed
65 s telomeric single-stranded DNA (ssDNA) with exquisitely high affinity to coordinate telomere mainten
67 g from the retina to the brain that exhibits exquisitely high sensitivity to high spatial frequency p
68 es, but also because they represent the most exquisitely investigated examples of highly correlated e
70 as BQCA offer an attractive solution, being exquisitely M1-selective over other muscarinic subtypes.
71 r machinery for solar energy conversion that exquisitely manages photon capture and conversion proces
73 l, Ca(2+) feedback of Ca(V) channels depends exquisitely on a single CaM preassociated with the alpha
74 function of human regulatory regions depends exquisitely on their local genomic environment and on ce
77 ptive field maps of the olfactory system are exquisitely organized and respond dynamically to cues in
78 ourishment and communication, as well as the exquisitely organized bone extracellular matrix, also de
85 lieu and chromatin environment, allowing for exquisitely precise spatiotemporal control of gene expre
86 spite extensive serial passaging and display exquisitely precise, cell-autonomous commitment to epith
96 utes the major barrier to a cure for AIDS is exquisitely redox sensitive and could be selectively tar
100 tenin/Wnt signaling in early development are exquisitely regulated by stage-dependent mechanisms.
101 importance of wing temperature and how it is exquisitely regulated by structural and behavioral adapt
102 es suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic fa
105 llular triglyceride (TG) stores requires the exquisitely regulated interaction of lipolytic enzymes w
110 that LTB(4) is a signal-relay molecule that exquisitely regulates neutrophil chemotaxis to formyl pe
111 rial respiratory chain by MCJ in macrophages exquisitely regulates the response of macrophages to inf
112 ndings underscore the critical importance of exquisitely regulating epithelial plasticity in developm
113 We had previously shown that RPLP1/2 are exquisitely required for replication of dengue virus (DE
114 evidence suggests that cancer stem cells are exquisitely resistant to conventional therapy and are th
117 shed, and the electrical conductance becomes exquisitely responsive to the structure of the surface a
118 ula syndrome, which is a clinical diagnosis, exquisitely reveals soft tissue changes such as muscle e
119 xamination, magnetic resonance imaging (MRI) exquisitely reveals soft tissue changes such as muscle e
120 strate that 4-phenylquinolin-2(1H)-one is an exquisitely selective Akt inhibitor with a distinctive m
121 clic molecules that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with
123 54 pseudogene lncRNAs, several of which show exquisitely selective expression in response to specific
125 We show using competitive-ABPP that ABLs are exquisitely selective for PME-1 in living cells and mice
127 The most potent compounds in the series were exquisitely selective for T. brucei over a panel of othe
128 nlinear responses to whole faces, and can be exquisitely selective for very specific parts of faces s
129 1b), a small cystine knot protein that shows exquisitely selective inhibition of insect V-ATPases.
130 inhibitors examined in an initial study, an exquisitely selective inhibitor for a poorly characteriz
132 -specific polymer conjugation resulted in an exquisitely selective Kv1.3 antagonist (>1000x over Kv1.
134 nitrosopyridine spin-trapping reagent and an exquisitely selective tertiary amine-mediated hydrogen-a
136 sordered region makes its inhibitory potency exquisitely sensitive and responsive to physiological ch
139 ital PCR (ddPCR) is a technique that enables exquisitely sensitive detection and quantification of DN
140 force microscopy (EFM) method to develop an exquisitely sensitive dual-resonance-frequency-enhanced
141 controlled luciferase expression detected by exquisitely sensitive EM-CCD imaging, to enable simultan
143 pendence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron
144 cal electronic structure of the proton is an exquisitely sensitive indicator of the limiting state in
146 rster resonance energy transfer (FRET) is an exquisitely sensitive method for detection of molecular
147 al intracerebral hemorrhages only visible on exquisitely sensitive MRI sequences were identified and
148 rostatic forces, this reaction represents an exquisitely sensitive probe of these effects in protein-
149 iding a quantitative interpretation of these exquisitely sensitive probes as a function of experiment
151 resulted in remarkable adaptations enabling exquisitely sensitive sound detection by the ear and sop
154 t self-tolerant T cell repertoire, but it is exquisitely sensitive to a range of insults during the t
156 data suggest that the degenerating brain is exquisitely sensitive to acute behavioral and cognitive
157 for a range of therapeutic proteins, proving exquisitely sensitive to alterations in protein sequence
158 Dn (Ts) mouse model of Down syndrome (DS) is exquisitely sensitive to an infantile spasms phenotype i
160 ervations suggest that endothelial cells are exquisitely sensitive to both magnitude and spatial grad
162 Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O(2) levels
163 TP-sensitive potassium (K(ATP)) channels are exquisitely sensitive to changes in cellular energy meta
164 nitude of the current, which makes the cells exquisitely sensitive to changes in intracellular pH.
165 ioles in the peripheral microcirculation are exquisitely sensitive to changes in PO2 in their environ
166 from the intestinal epithelium renders mice exquisitely sensitive to chemically induced colon carcin
168 ancement or inhibition of efferocytosis, was exquisitely sensitive to concentration effects of these
170 n stage V gametocytes, rendering these cells exquisitely sensitive to decreases in NADPH concentratio
172 ing within the endoplasmic reticulum (ER) is exquisitely sensitive to energy supply and amino acid so
177 neoplasms, chronic myeloid leukemia (CML) is exquisitely sensitive to graft-versus-leukemia (GVL) bec
179 arotid bodies of AMPK-knockout mice remained exquisitely sensitive to hypoxia, contrary to the view t
186 discovery that BRCA-mutant cancer cells are exquisitely sensitive to inhibition of poly(ADP-ribose)
187 e found that the capsid assembly pathway was exquisitely sensitive to initial assembly conditions.
190 nicotinic acetylcholine receptor (nAChR) is exquisitely sensitive to its membrane environment, the u
192 T5BN642H-expressing CD8+ T cells, which were exquisitely sensitive to JAK and Aurora kinase inhibitor
193 on is consistent with circadian period being exquisitely sensitive to levels of casein kinase I.
200 s perception, attention, and memory, and are exquisitely sensitive to metabolic and oxidative stress.
201 ck8(-/-)CX3CR1(+) mononuclear phagocytes are exquisitely sensitive to migration-induced cell shatteri
202 toriously difficult to control because it is exquisitely sensitive to monomer concentration, which ch
203 atients with TT genotype at rs116855232 were exquisitely sensitive to MP, with an average dose intens
206 and disease and whether network integrity is exquisitely sensitive to or efficiently buffered from pe
207 ltiple hepatitis C virus (HCV) genotypes are exquisitely sensitive to oxidative membrane damage, a pr
209 n that these synergy-dependent integrins are exquisitely sensitive to perturbations in the Fn integri
210 compositionally distinct lipid assemblies is exquisitely sensitive to plasma membrane phosphatidylser
215 inase 5 (ERK5), a protein kinase known to be exquisitely sensitive to redox stress, through a signali
220 ese results suggest that reassortment is not exquisitely sensitive to stochastic effects associated w
224 forms, Na(V)1.1, 1.2, 1.3, 1.6, and 1.7, are exquisitely sensitive to tetrodotoxin (TTX), and a funct
225 amily member ratio by acidosis renders cells exquisitely sensitive to the Bcl-2/Bcl-xL antagonist ABT
227 ations predict that rate constants should be exquisitely sensitive to the charge state of the His37 s
228 at NF-kappaB activation mediated by LUBAC is exquisitely sensitive to the expression level of UBE2L3.
229 ow that the mechanical profile of biofilm is exquisitely sensitive to the expression of different sur
230 d within the actin-binding cleft and is thus exquisitely sensitive to the global orientation and rota
231 (PGONs) showed that curvature generation is exquisitely sensitive to the guanidinium group spacing w
233 l lymph transport and these contractions are exquisitely sensitive to the K(ATP) channel activator pi
234 cating that dendrite size and complexity are exquisitely sensitive to the level of endogenous GDF5 sy
235 the nu(C=N) region of the F4TCNQ spectrum is exquisitely sensitive to the nature of the charge transf
237 esults illustrate how splicing modulation is exquisitely sensitive to the sequence context of 3' spli
239 nd their associated temperature increase are exquisitely sensitive to the shape and composition of th
240 esults indicate that Ag43 gene expression is exquisitely sensitive to the status of the Sec machinery
241 t the transcriptional response in neurons is exquisitely sensitive to the temporal nature of action p
242 ytes isolated from horses, a species that is exquisitely sensitive to the TLR4 ligand, LPS, and that
243 ssile lifestyle means that plants have to be exquisitely sensitive to their environment, integrating
244 t to a particular microscale trajectory, are exquisitely sensitive to their microenvironment, and off
247 igand-, and H(+)-gated cationic channels are exquisitely sensitive to transient fluctuations in pH el
248 20(ZF7) mice required T cells and MyD88, was exquisitely sensitive to tumor necrosis factor and inter
249 entire animal, the pancreatic beta-cells are exquisitely sensitive to VAD-associated apoptosis compar
250 As an example, a single organoid culture was exquisitely sensitive to Wnt secretion (porcupine) inhib
252 y on antibody-based platforms that, although exquisitely sensitive, are slow and costly to generate a
255 germline stem cells (GSCs) are maintained by exquisitely short-range BMP signalling from the niche.
256 tein, we generate with high yield and purity exquisitely site specific and selective bio-conjugates o
257 eccDNA accumulation on copper exposure to be exquisitely site specific, with no other detectable chan
264 many natural ligands, antibodies are stable, exquisitely specific, and are unaffected by the regulato
265 and that the transcriptome of thymic MCs is exquisitely suited for interactions with epithelial and
268 ariant natural killer T (iNKT) cells and are exquisitely susceptible to Epstein-Barr virus (EBV) infe
269 rated that IFN-alphabetagammaR(-/-) mice are exquisitely susceptible to liver infection following cor
271 ocytes, the myelin-forming cells of the CNS, exquisitely tailor the thickness of individual myelin sh
272 V-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade host immunity
274 offering alluring opportunities to generate exquisitely tailored materials with unparalleled control
275 nt hormones are specialized metabolites with exquisitely tailored perception and signaling systems, b
276 ape enables their resulting properties to be exquisitely tailored, which has led to the use of these
279 es of many bacteria are decorated with long, exquisitely thin appendages called type IV pili (T4P), d
286 complex and dynamic process orchestrated by exquisitely timed cell lineage commitment, divisions, mi
288 its analogs potently inhibit cruzain and are exquisitely toxic toward T. cruzi in the intracellular a
289 trate that DNA as a building block offers an exquisitely tunable means to engineer a potentially rich
290 d using DNA-programmable assembly, unveiling exquisitely tunable optical properties that are predicte
292 criptional regulatory site on DNA by BirA is exquisitely tuned by the equilibrium constant governing
293 CT-projecting cells are ultrasparse firing, exquisitely tuned to orientation and direction informati
294 NK receptors are key components of a system exquisitely tuned to sense any dysregulation in MHC clas
298 ly unaffected, and why the immature brain is exquisitely vulnerable, whereas the mature brain seems r
299 e about protein cores; they are hydrophobic, exquisitely well packed, and nearly all hydrogen bonds a