ライフサイエンスコーパス: extensively drug-resistant

1 nal antibiotic classes were considered to be extensively drug resistant.

2 h a pet store puppy; 168 isolates (88%) were extensively drug resistant.

3 Of the 176 episodes of extensively drug-resistant A. baumannii bacteremia evalu

4 Breakthrough extensively drug-resistant A. baumannii bacteremia under

5 NG, PATIENTS, AND INTERVENTIONS: Adults with extensively drug-resistant A. baumannii bacteremia were

6 was to compare the outcomes of patients with extensively drug-resistant A. baumannii bacteremia, trea

7 ompared with colistin-carbapenem therapy for extensively drug-resistant A. baumannii bacteremia.

8 Extensively drug-resistant A. baumannii was defined as A

9 of macolacin proved to be effective against extensively drug-resistant A. baumannii with colistin-re

10 Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an e

11 Extensively drug-resistant Acinetobacter baumannii (XDR-

12 These Gram-negative bacteria include extensively drug-resistant Acinetobacter baumannii and i

13 elated left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and m

14 timicrobials are needed for the treatment of extensively drug-resistant Acinetobacter baumannii.

15 ania), 976 (75.1%) of which are multidrug or extensively drug resistant and 38.2%, 51.9%, and 36.3% o

16 The poor treatment outcomes for extensively drug-resistant and multidrug-resistant tuber

17 As a result, multidrug-resistant, extensively drug-resistant, and pandrug-resistant bacter

18 covered the significant associations between extensively drug-resistant bacteria (XDR) and pandrug-re

19 ity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii.

20 tro activity against multidrug-resistant and extensively drug-resistant bacteria, including ESBL, car

21 sistant Pseudomonas aeruginosa (CP-CRPA) are extensively drug-resistant bacteria.

22 is used to treat severe infections caused by extensively drug-resistant bacteria.

23 lity of CRGNIs, particularly those caused by extensively drug-resistant bacteria.

24 The recent increase in extensively drug-resistant bacterial pathogens and the a

25 en to this day, due to the rise of multi and extensively drug-resistant bacterial strains.

26 Conversely, 53% of extensively drug-resistant bloodstream CRGNIs at 2 of th

27 ld take action to help prevent the spread of extensively drug-resistant C jejuni from pet store puppi

28 Strains of extensively drug-resistant C jejuni have been circulatin

29 Extensively drug-resistant Campylobacter jejuni infectio

30 o against a panel of multidrug-resistant and extensively drug-resistant clinical isolates of M. tuber

31 s and that 30 drug-susceptible and multidrug/extensively drug-resistant clinical strains were suscept

32 geting tuberculosis therapy, particularly in extensively drug-resistant disease for which current ant

33 g numbers of urinary tract infections due to extensively drug-resistant Gram-negative bacilli.

34 for efficacy against multidrug-resistant and extensively drug-resistant gram-negative rods.

35 but not L1 (metallo beta-lactamase) from the extensively drug resistant human pathogen Stenotrophomon

36 The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the nee

37 (13%) among MDR strains (particularly among extensively drug-resistant isolates, 5%), but was positi

38 ncluding MDR (multi-drug resistant) and XDR (extensively-drug resistant) isolates.

39 Whole-cell proteome analysis of extensively drug-resistant K. pneumoniae, A. baumannii,

40 Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is

41 nfection and the emergence of multidrug- and extensively drug-resistant (MDR and XDR, respectively) T

42 the risk for the generation of multidrug- or extensively drug-resistant (MDR or XDR, respectively) va

43 , to our knowledge, the widest collection of extensively drug-resistant Morganella spp highlights the

44 This comparative genomic study included extensively drug-resistant Morganella spp isolates colle

45 he most potent antimicrobial against the 172 extensively drug-resistant Morganella spp isolates in ou

46 entified several independent acquisitions of extensively drug-resistant/multidrug-resistant-inducing

47 etting to investigate six cases of suspected extensively drug-resistant Mycobacterium tuberculosis (X

48 e collected and sequenced the genomes of 117 extensively drug-resistant, NDM-producing K. pneumoniae

49 ly drug-resistant (XDR) tuberculosis and non-extensively drug-resistant (non-XDR) tuberculosis are de

50 Implementing an extensively drug-resistant organism registry reduced CRE

51 bined CRE case information from the Illinois extensively drug-resistant organism registry with measur

52 Mycobacterium abscessus is an extensively drug-resistant pathogen that causes pulmonar

53 Gram-negative bacteria showing multi-drug or extensively drug resistant phenotypes.

54 nt (MDR), and 30 (5%) had pre-extensively or extensively drug resistant (pre-XDR or XDR) tuberculosis

55 edaquiline and pretomanid in adults with pre-extensively drug-resistant (pre-XDR) or treatment-intole

56 6 (25%) multidrug-resistant, and 24 (4%) pre-extensively drug-resistant (pre-XDR) or XDR.

57 clofazimine was 0.4% in MDR-TB and 1% in pre-extensively drug-resistant (pre-XDR-TB)/XDR-TB populatio

58 .1 y (34.4, 35.8) assuming patients with pre-extensively drug-resistant (PreXDR) and extensively drug

59 We describe 2 cases of extensively drug-resistant Pseudomonas aeruginosa infect

60 treatment for rifampicin-resistant or multi/extensively drug-resistant (RR or M/XDR) TB reported to

61 extended-spectrum beta-lactamase producing, extensively drug resistant S. sonnei was reported in the

62 The recent identification of extensively drug resistant S. Typhi only highlights the

63 The ongoing outbreak of extensively drug-resistant Salmonella Typhi (S. Typhi) i

64 Multi- and extensively drug-resistant Shigella sonnei strains assoc

65 -1, BcII, and GOB-18) and, significantly, an extensively drug-resistant Stenotrophomonas maltophilia

66 utbreak involving 14 patients infected by an extensively drug-resistant strain of Pseudomonas aerugin

67 The emergence of multidrug resistant and extensively drug resistant strains necessitates the deve

68 th given the rise of multidrug resistant and extensively drug resistant strains of M. tuberculosis.

69 ographically diverse multidrug-resistant and extensively drug-resistant strains and could potentially

70 Multidrug and extensively drug-resistant strains are making disease co

71 on 38 susceptible, multidrug-resistant, and extensively drug-resistant strains compared with convent

72 istent" state and inhibited the growth of 13 extensively drug-resistant strains of M. tuberculosis at

73 The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium tube

74 recent emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tube

75 acy, and are vulnerable to being overcome by extensively drug-resistant strains of Mycobacterium tube

76 osis cases caused by multidrug-resistant and extensively drug-resistant strains of Mycobacterium tube

77 supported the development of multidrug- and extensively drug-resistant strains, demanding novel drug

78 gainst six clinical isolates, which included extensively drug-resistant strains.

79 ent of patients with multidrug-resistant and extensively drug-resistant TB (M/XDR-TB).

80 icrobiologically confirmed MDR/RR-TB and pre-extensively drug-resistant TB (pre-XDR-TB) initiated on

81 Pre-extensively drug-resistant TB (pre-XDR-TB) refers to MDR

82 is also resistant to a fluoroquinolone, and extensively drug-resistant TB (XDR-TB) isolates are addi

83 gence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains have furt

84 gence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains.

85 ycobacterium tuberculosis sequencing data on extensively drug-resistant TB cases in KwaZulu-Natal, So

86 as almost 90% of the multidrug-resistant or extensively drug-resistant TB participants were cured bu

87 ective cohort study of 172 subjects with MDR/extensively drug-resistant TB subjects and sequenced the

88 Extensively drug-resistant TB was defined as resistance

89 Extensively drug-resistant TB was diagnosed in 1 staff m

90 he accuracy of the Akonni Biosystems XDR-TB (extensively drug-resistant TB) TruArray and lateral-flow

91 nt TB, including multidrug-resistant TB, pre-extensively drug-resistant TB, and extensively drug-resi

92 these drugs is a defining characteristic of extensively drug-resistant TB.

93 t TB, pre-extensively drug-resistant TB, and extensively drug-resistant TB.

94 second-line injectable drugs, and not having extensively drug-resistant TB.

95 Due to the prevalence of the MDR-TB and extensively drug resistant tuberculosis (XDR-TB) cases,

96 bly as the number of multidrug resistant and extensively drug resistant tuberculosis cases continues

97 Treatment of multidrug-resistant or extensively drug-resistant tuberculosis (DR-tuberculosis

98 echnologies for rapidly detecting multidrug-/extensively drug-resistant tuberculosis (M/XDR TB), but

99 The emergence of multi- and extensively drug-resistant tuberculosis (MDR-TB and XDR-

100 ultidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) (M/XDR-

101 osocomial transmission has been described in extensively drug-resistant tuberculosis (XDR-TB) and HIV

102 Patients with extensively drug-resistant tuberculosis (XDR-TB) are als

103 Worldwide emergence of extensively drug-resistant tuberculosis (XDR-TB) has rai

104 istant tuberculosis (MDR-TB) and over 90% of extensively drug-resistant tuberculosis (XDR-TB) strains

105 Rationale: Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was def

106 terium tuberculosis (Mtb) have given rise to extensively drug-resistant tuberculosis (XDR-TB).

107 Extensively drug-resistant tuberculosis (XDR-tuberculosi

108 tivity against multidrug-resistant (MDR) and extensively drug-resistant tuberculosis and an excellent

109 We tested isolates from 651 patients for extensively drug-resistant tuberculosis and developed re

110 kers, and ethical and medicolegal aspects of extensively drug-resistant tuberculosis and other resist

111 ug combination for 26 weeks in patients with extensively drug-resistant tuberculosis and patients wit

112 We describe the management of extensively drug-resistant tuberculosis and treatment ou

113 Extensively drug-resistant tuberculosis can be cured in

114 The patients with extensively drug-resistant tuberculosis had undergone mo

115 ts with multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis has been noted,

116 Extensively drug-resistant tuberculosis has been reporte

117 with bedaquiline treatment in multidrug and extensively drug-resistant tuberculosis HIV might be com

118 t, management, and outcomes of patients with extensively drug-resistant tuberculosis in Tomsk, Russia

119 Extensively drug-resistant tuberculosis is a burgeoning

120 tuberculosis in these patients suggest that extensively drug-resistant tuberculosis may be acquired

121 f multidrug-resistant (MDR) tuberculosis and extensively drug-resistant tuberculosis poses a major th

122 Patients with extensively drug-resistant tuberculosis received daily,

123 eading frames in 240 multidrug-resistant and extensively drug-resistant tuberculosis strains and quan

124 idrug-resistant tuberculosis and over 90% of extensively drug-resistant tuberculosis strains are also

125 e among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treat

126 None of the patients with extensively drug-resistant tuberculosis were coinfected

127 ly for patients with multidrug-resistant and extensively drug-resistant tuberculosis where prognosis

128 fore the diagnosis of 20 downstream cases of extensively drug-resistant tuberculosis with almost iden

129 personalize treatment, the patient developed extensively drug-resistant tuberculosis, highlighting th

130 esistance, including multidrug-resistant and extensively drug-resistant tuberculosis, might become le

131 ohort study, 273 South African patients with extensively drug-resistant tuberculosis, or resistance b

132 resistant tuberculosis, or resistance beyond extensively drug-resistant tuberculosis, were followed u

133 growing pandemic of multidrug-resistant and extensively drug-resistant tuberculosis.

134 -positive and not on ART, and 1749 (15%) had extensively drug-resistant tuberculosis.

135 of the emergence of multidrug-resistant and extensively drug-resistant tuberculosis.

136 d 195 eligible participants, of whom 40% had extensively drug-resistant tuberculosis.

137 minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis.

138 including in HIV patients with multidrug and extensively drug-resistant tuberculosis.

139 osols, and posed a threat of transmission of extensively drug-resistant tuberculosis.

140 ble for treating many cases of multidrug and extensively drug-resistant tuberculosis.

141 nts with multidrug-resistant tuberculosis or extensively drug-resistant tuberculosis.

142 roved cure rates for multidrug-resistant and extensively drug-resistant tuberculosis.

143 Of the 651 patients tested, 48 (7.4%) had extensively drug-resistant tuberculosis; the remaining 6

144 The recent rise of extensively drug-resistant typhoid bears the biosocial f

145 xt of typhoid conjugate vaccine rollouts and extensively drug-resistant typhoid.

146 Infections with MDR and extensively drug resistant (XDR) E. coli, XDR K. pneumon

147 development of multidrug resistant (MDR) and extensively drug resistant (XDR) forms of tuberculosis (

148 he analysis of multidrug resistant (MDR) and extensively drug resistant (XDR) Mtb strains that emerge

149 1%) were positive for S. Typhi, and all were extensively drug resistant (XDR) S. Typhi.

150 Since its emergence in 2016, extensively drug resistant (XDR) Salmonella enterica ser

151 e the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predom

152 omoter and katG was associated with baseline extensively drug resistant (XDR) TB, increased acquired

153 uberculosis and the more recent emergence of extensively drug resistant (XDR) tuberculosis are great

154 stant (MDR) and 53.6% of these (15/28) being extensively drug resistant (XDR).

155 Extensively drug-resistant (XDR) Acinetobacter baumannii

156 y of many of the new agents against the most extensively drug-resistant (XDR) and pan-drug-resistant

157 cs for the treatment of infections caused by extensively drug-resistant (XDR) bacteria, particularly

158 fections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing

159 of the few remaining therapeutic options for extensively drug-resistant (XDR) Gram-negative bacilli (

160 solates, 22 multidrug-resistant (MDR), and 1 extensively drug-resistant (XDR) M. tuberculosis strains

161 I >/= 16000), multidrug-resistant (MDR), and extensively drug-resistant (XDR) Mycobacterium tuberculo

162 aby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resista

163 erapy, and outcomes of bacteremia because of extensively drug-resistant (XDR) Pseudomonas aeruginosa

164 phi among children in an outbreak setting of extensively drug-resistant (XDR) S Typhi in Pakistan.

165 e emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains challenges TB t

166 e emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacteriu

167 TB), including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.

168 of cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB in South Africa like

169 -detection history of a successful strain of extensively drug-resistant (XDR) TB known as LAM4/KZN, f

170 pre-extensively drug-resistant (PreXDR) and extensively drug-resistant (XDR) TB received bedaquiline

171 TB, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, is no longer restri

172 tcomes are especially poor among people with extensively drug-resistant (XDR) TB, until recently defi

173 , particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB.

174 We enrolled participants with extensively drug-resistant (XDR) tuberculosis (i.e., res

175 treatments for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are a

176 Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are n

177 Extensively drug-resistant (XDR) tuberculosis (TB) canno

178 xemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) ident

179 Treating extensively drug-resistant (XDR) tuberculosis (TB) is a

180 The emergence of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis (TB) is a

181 Extensively drug-resistant (XDR) tuberculosis (TB), whic

182 ces, and treatment outcomes of patients with extensively drug-resistant (XDR) tuberculosis and non-ex

183 Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are emergi

184 l outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are increa

185 treatment-related outcomes in patients with extensively drug-resistant (XDR) tuberculosis are unknow

186 Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis continue t

187 r multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis depends up

188 e emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis during the

189 In the past 8 years, extensively drug-resistant (XDR) tuberculosis has emerge

190 and spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis has led to

191 Extensively drug-resistant (XDR) tuberculosis has spread

192 Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis have emerg

193 rugs for use in multidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis have focus

194 widespread multiple-drug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis have raise

195 onsequences of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in a rural

196 Extensively drug-resistant (XDR) tuberculosis is becomin

197 The prevalence of extensively drug-resistant (XDR) tuberculosis is increas

198 A widespread epidemic of extensively drug-resistant (XDR) tuberculosis is occurri

199 prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis was 12.6%

200 The proportion of MDR cases with extensively drug-resistant (XDR) tuberculosis was 16% ov

201 Nineteen (54%) had extensively drug-resistant (XDR) tuberculosis, and 14 (4

202 d of multidrug-resistant (MDR) tuberculosis, extensively drug-resistant (XDR) tuberculosis, and more

203 incidences of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis, highlight

204 le for kanamycin A resistance, a hallmark of extensively drug-resistant (XDR) tuberculosis, in a larg

205 tly needed for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis, which are

206 On multivariable analysis that adjusted for extensively drug-resistant (XDR) tuberculosis-MDR tuberc

207 ved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis.

208 uiline is especially likely in patients with extensively drug-resistant (XDR) tuberculosis.

209 sing burden of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis.

210 hole genome of multidrug-resistant (MDR) and extensively drug-resistant (XDR) V. cholerae to identify

211 4 patients, 7 (50%) had MDR, 4 (29%) had pre-extensively drug-resistant (XDR), and 3 (21%) had XDR TB

212 opulation size of fluoroquinolone-resistant, extensively drug-resistant (XDR), and azithromycin-resis

213 (MDR) to first-line antibiotics and 60% were extensively drug-resistant (XDR), resistant to first-lin

214 stant (MDR) and 53.6% of these (15/28) being extensively drug-resistant (XDR).

215 lcome complication of neurosurgery caused by extensively-drug resistant (XDR) A. baumannii, is extrem

216 ries, 7/14 (50%) had MDR, 4/14 (29%) had pre-extensively-drug-resistant (XDR), and 3/14 (21%) had XDR