ライフサイエンスコーパス: extinguish

1 these odors with odor-only presentations (F0-Extinguished).

2 r drug-associated cues that are difficult to extinguish.

3 nal salience, and thus are more difficult to extinguish.

4 d drug seeking behavior and are difficult to extinguish.

5 he environment long after the cigarettes are extinguished.

6 ost, although the current was not completely extinguished.

7 g but also change back when that learning is extinguished.

8 n test differences between C and A were also extinguished.

9 d was lost once nuclear Foxp3 expression was extinguished.

10 blocks cell cycle progression and how it is extinguished.

11 and c-MYC when exogenous c-MYC expression is extinguished.

12 ate AF, APD alternans arose transiently then extinguished.

13 and myeloid transcriptional programs rapidly extinguished.

14 he rate at which reward-seeking behavior was extinguished.

15 ogic appearance when TNF-alpha expression is extinguished.

16 intensified, E7 activity diminished and then extinguished.

17 subjects in which drug seeking behavior has extinguished.

18 U.1/Sfpi1 locus and PU.1/Sfpi1 expression is extinguished.

19 r particular blood lineages is progressively extinguished.

20 light step that persists after the light is extinguished.

21 Responding was then extinguished.

22 nases, residual HR in BRCA1mt cells might be extinguished.

23 fect if the memory was neither retrieved nor extinguished.

24 to the nucleus, and the viral life cycle is extinguished.

25 t-dependent fear and a diminished ability to extinguish a cued fear response, indicating defective as

26 CIE mice were also quicker to extinguish a stimulus-reward instrumental response and f

27 The ability to extinguish a viral population of fixed reproductive capa

28 Both were impaired in extinguishing a conditioned fear response, which was par

29 Furthermore, once extinguished, adolescents display a greater preference f

30 m) is sufficient to entrain and subsequently extinguish AF with a success rate of 93% (69 of 74 trial

31 by alternate morphine (10 mg/kg) injections, extinguished after a 10-day extinction training, and rei

32 erants, polyvinylidene fluoride (PVDF), fire-extinguishing agents, and foams, is a potent and stable

33 hippocampal neurons and that CTMP bound and extinguished Akt activity and was essential to ischemia-

34 rtex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of

35 ited during context-induced reinstatement of extinguished alcohol seeking in rats.

36 ventional techniques immobilize the subject, extinguishing all but the simplest behaviors.

37 at lead to reconsolidation of a young memory extinguish an older memory.

38 Although both extinguished and abstinent animals showed a reduction in

39 led to an increase of discrimination between extinguished and neutral stimuli, which was paralleled b

40 led to a recovery of discrimination between extinguished and neutral stimuli.

41 Subsequently, lever-pressing was extinguished and reinstatement of food seeking and mPFC

42 absorbance bands of the [2Fe-2S] cluster are extinguished and replaced by a new feature that slowly g

43 Rats were subsequently extinguished and spontaneous recovery of drug-seeking be

44 e of G. elephantopus has not been completely extinguished and still exists in an intermixed populatio

45 cocaine, after which self-administration was extinguished and then reinstated by cocaine-conditioned

46 endrites of reinstated animals compared with extinguished and yoked saline, and the p-FAK and cofilin

47 cterized by avoidance behaviors that fail to extinguish, and DBS could act, in part, by facilitating

48 f the transduction cascade after the step is extinguished, and an increase in guanylate cyclase activ

49 elf-administer cocaine, the operant response extinguished, and cocaine-seeking induced by a condition

50 Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter c

51 ere conditioned (skin conductance response), extinguished, and tested for extinction retention and re

52 during memory testing, only 57% of the fear-extinguished animals retained fear extinction memory.

53 nt of drug seeking by a cocaine injection in extinguished animals was suppressed by increasing neuron

54 synaptic strength and morphology in cocaine-extinguished animals were further augmented during cocai

55 on of mGluR5 was reduced only in the core of extinguished animals.

56 was sufficient to exacerbate nephritis while extinguishing anti-nucleosome antibodies, whereas Tlr9 d

57 demonstrate that CD4 T cell function is not extinguished as a result of viral persistence.

58 r growth and proliferation, is progressively extinguished as SCs differentiate during nerve developme

59 a randomised fixation period, the target was extinguished at motion onset, remaining invisible for 75

60 n the mouse cortex postnatally, is virtually extinguished at puberty.

61 In subsequent extinction training, WKHA rats extinguished at similar rates in comparison to WKHT rats

62 , we show that in the mouse, pluripotency is extinguished at the onset of somitogenesis, coincident w

63 l for the SAC, but primarily to restrain and extinguish autonomous PLK1 activity.

64 medial prefrontal cortex-projecting ensemble extinguished aversive responses to enable flexible behav

65 rug self-administration and reinstatement of extinguished behavior previously maintained by drug deli

66 In renewal paradigms, extinguished behavior recovers when tested outside the c

67 The effect of extinguishing beta2 subunit expression on the internaliz

68 When the mitotic checkpoint is extinguished, both APC/C-bound and free MCC pools have t

69 Discontinuation of dox extinguished BRAF(V600E) expression and reestablished th

70 increased fear and PL pyramidal activity in extinguished, but not in conditioned, rats.

71 in values, inducing an insulator that can be extinguished by a magnetic field.

72 vated in MYD88(L265P)-bearing lymphomas, and extinguished by Bim-dependent apoptosis.

73 Rats extinguished by cocaine methiodide substitution showed w

74 ith fetal specificity and fetal wastage were extinguished by CXCR3 blockade or in CXCR3-deficient mic

75 rons persists postnatally, En2 expression is extinguished by embryonic day 17.5.

76 Here we report that BCR signaling was not extinguished by endocytosis of BCRs; instead, BCR signal

77 When FMD outbreaks occur, they are often extinguished by massive depopulation of livestock due to

78 llections were all present at P20 and became extinguished by P90 (equivalent to human postnatal age 2

79 hypothesis posits that asexuality is rapidly extinguished by relentlessly coevolving parasites and pa

80 defensive reaction to a learned fear can be extinguished by repeated exposure to the CS alone (CS-on

81 In a separate group of mice, CL was extinguished by repeatedly exposing mice to the activity

82 r 21 d and then cocaine-seeking behavior was extinguished by replacing cocaine with saline.

83 aker cocaine-induced reinstatement than rats extinguished by saline substitution.

84 rther document that CXCR4 expression must be extinguished by TCR-mediated positive selection signals

85 All oncogenic signaling could be extinguished by the novel GNAQ/11 inhibitor YM-254890, i

86 ction had their self-administration behavior extinguished by vehicle substitution and were then given

87 the first time in the present study, and the extinguished C/EBPalpha expression through p38alpha inac

88 aired safety learning, relative to the (good-extinguishing) C57BL/6J (B6) strain.

89 Notably, CPP thus extinguished cannot be reinstated by drug re-exposure, e

90 s when mitotic cyclins are degraded, thereby extinguishing CDK activity.

91 mbined ablation of all A- and E-type cyclins extinguished cell division.

92 Loss of either site extinguished CFTR expression and abolished long-range in

93 tases, PP1 and PP2A-B56, that are thought to extinguish checkpoint signaling through dephosphorylatio

94 ion of aqueous film-forming foams (AFFFs) to extinguish chlorinated solvent-fueled fires has led to t

95 /- 17% more extinction trials than adults to extinguish cocaine place-preferences.

96 n and is potentially involved in learning to extinguish cocaine-seeking behavior in rats.

97 sion, social avoidance, and reinstatement of extinguished cocaine place preference behaviors by stimu

98 ned hyperactivity, and more robustly renewed extinguished cocaine seeking in GTs than STs.

99 uced reinstatement or drive reinstatement of extinguished cocaine seeking in the absence of cues or c

100 Reinstatement of extinguished cocaine seeking was elicited by cocaine-ass

101 prevented footshock-induced reinstatement of extinguished cocaine seeking.

102 ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference (CPP).

103 potentiated cocaine-primed reinstatement of extinguished cocaine-induced conditioned place preferenc

104 They were then tested for reinstatement of extinguished cocaine-seeking behavior elicited by respon

105 erebroventricular infusion of NPS reinstates extinguished cocaine-seeking behavior in a dose-dependen

106 e than 2 in attenuating the reinstatement of extinguished cocaine-seeking behavior in rats, demonstra

107 ra-BNST PACAP infusion reinstated previously extinguished cocaine-seeking behavior in the absence of

108 Cue reinstatement of extinguished cocaine-seeking behavior is a widely used m

109 e shell regulate reinstatement of previously extinguished cocaine-seeking behavior.

110 p19(Arf) is limited to spermatogonia but is extinguished completely in spermatocytes, suggesting tha

111 rceived dangers, and the intent of ERP is to extinguish compulsions.

112 t not later, impaired the ability of mice to extinguish conditioned fear and select actions based on

113 The ability to extinguish conditioned fear memory is critical for adapt

114 reversal training in the water maze and they extinguish conditioned fear more slowly than their wild-

115 ffected; although schizophrenic patients can extinguish conditioned fear, they show a deficit in retr

116 any factors account for how well individuals extinguish conditioned fears, such as genetic variabilit

117 r hypofunction displays a reduced ability to extinguish conditioned responses to drug-associated stim

118 Of note, GAT1508 effectively extinguished conditioned fear in rodents and lacked card

119 that fear extinction training in rats, which extinguished conditioned fear, increased both slow-wave

120 Reinstatement--the return of an extinguished conditioned response (CR) after reexposure

121 nction and were tested for their fear to the extinguished conditioned stimulus (CS) in either the ext

122 The next day, the extinguished conditioned stimulus (CS+E) was re-presente

123 We found that SNI animals were unable to extinguish contextual fear and showed increased anxiety-

124 exhibited an equivalent IED relative to non-extinguished controls when tested 48 hours later.

125 --and spontaneous recovery--the return of an extinguished CR with the passage of time--are 2 of 4 wel

126 observed alterations in vmPFC gamma power to extinguished CS(+).

127 ance and heightened amygdala activity to the extinguished CS+ in the safety context.

128 e dPAG failed to reduce SR of the previously extinguished CTA.

129 ight a role for the dPAG in modulating SR of extinguished CTAs.

130 g, the THC group exhibited lower SCRs to the extinguished cue with no significant extinction-induced

131 ted significantly decreased responses to the extinguished cues within the vmPFC and amygdala, but sig

132 g/mL lipopolysaccharide for 24 hours did not extinguish DHRS9 expression.

133 be the impact of drug use on the ability to extinguish drug seeking after changes in expected outcom

134 hibiting relapse, and this can be modeled by extinguishing drug seeking in response to a drug-paired

135 ratio will become endemic while the other is extinguished due to competition.

136 Clinically HER4 expression is extinguished during breast tumorigenesis supporting a tu

137 uired for inhibition of unreinforced actions extinguished during learning of a cued appetitive task a

138 IL-15, suggesting that IL-15 expression was extinguished during lymphoid development.

139 ealed that Themis gene expression is rapidly extinguished during positive selection.

140 ression is lost in human skin cancers and is extinguished during progression of experimentally induce

141 f the developing embryo (E7.75-E9.5) and was extinguished during the latter stages of development.

142 rod-cone dysfunction as determined by almost extinguished electroretinogram in 2 of 3 siblings.

143 Lhx7-depleted cholinergic interneurons extinguish expression of several subtype-specific marker

144 fferentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes.

145 However, reinstatement of extinguished eyeblink CRs has never been demonstrated, a

146 en demonstrated, and spontaneous recovery of extinguished eyeblink CRs has not been systematically de

147 pontaneous recovery but not reinstatement of extinguished eyeblink CRs.

148 neutral stimuli, and inability to inhibit or extinguish fear after it is chronic and disabling.

149 n adolescent-specific diminished capacity to extinguish fear responses, suggesting that adolescents m

150 n are impaired in an enduring manner; unlike extinguished fear memories, they are not subject to rein

151 use safety context to sustain suppression of extinguished fear memory, but they also less effectively

152 ning is sufficient to reinstate a previously extinguished fear memory.

153 Extinguished fear often reappears after extinction throu

154 , thus, return of fear--is often observed if extinguished fear stimuli are encountered outside the ex

155 a number of factors, including stress, cause extinguished fear to relapse.

156 thways involved in the contextual control of extinguished fear.

157 ned freezing behavior, and causes relapse of extinguished fear.

158 ng a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated

159 Extinguishing fear toward Ace or Lyral of F0 male mice (

160 ated alkyl substances (PFAS) and are used to extinguish fires involving highly flammable liquids.

161 e acquisition of a conditioned stimulus, was extinguished following changes in reinforcement continge

162 urons is sufficient to reactivate previously extinguished food-seeking behavior in the absence of ext

163 ildfires can reignite from hidden embers not extinguished from an initial round of firefighting, leuk

164 ced reinstatement of cocaine seeking in rats extinguished from cocaine but not sucrose self-administr

165 Using rats extinguished from cocaine self-administration, we found

166 aine and conditioned cue combination in rats extinguished from cocaine self-administration.

167 g establishment of the cardiac crescent, and extinguished from the heart before CNC invasion.

168 Gene expression analyses reveal a failure to extinguish genes characteristic of the undifferentiated

169 APOBEC3G can extinguish HIV-1 infectivity by its incorporation into v

170 context of a 218,555-bp BAC reporter nearly extinguished Hoxb13-mediated transcriptional activity in

171 indow of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) e

172 oroalkyl substances (PFASs) that are used to extinguish hydrocarbon-based fuel fires.

173 A targeted Zfp318 null allele extinguished IgD expression on mature B cells and increa

174 minantly IL-17A(+) phenotype, whereas others extinguish IL-17 expression and acquire expression of IF

175 As the GC response evolved, TFH cells extinguished IL-21 production and switched to IL-4 produ

176 ull-field electroretinography responses were extinguished in 50% of patients, were pathologically att

177 eacquisition of the response, responding was extinguished in a new context (C).

178 Lever pressing was subsequently extinguished in a nondrug-associated context in the pres

179 Interestingly, Nkx2.1 was extinguished in Apc deficient epithelial progenitors bef

180 and 1 week of abstinence, lever pressing was extinguished in daily extinction sessions.

181 Expression is extinguished in fully mature splenic NK cells, and persi

182 these conditions, E(spl)mgamma was no longer extinguished in NSC progeny.

183 mouse in which pRb expression is efficiently extinguished in osteoblasts.

184 d pupil dilation was observed in phase 2 but extinguished in phase 3.

185 Precisely how the inhibitory SAC signal is extinguished in response to microtubule attachment remai

186 Lever responding was extinguished in separate groups of rats and animals were

187 vior and the immediate cue were subsequently extinguished in the absence of cocaine.

188 The cue was later extinguished in the drug-taking context (context A) or a

189 stitution of each phenylalanine specifically extinguishes its associated F(-) binding site in crystal

190 uitination and degradation of RUNX3, thereby extinguishing its ability to inhibit the transcriptional

191 508-CFTR, undergoes proteasomal degradation, extinguishing its anion channel function.

192 We then extinguished lever pressing and tested the rats for rein

193 ilm-forming foams (AFFFs) are widely used to extinguish liquid fires due to their film-forming proper

194 at disrupt the dystrophin open reading frame extinguish luciferase expression.

195 compared with F0-Exposed-Lyral sperm, and F0-Extinguished-Lyral sperm have methylation levels compara

196 the effects of negative memories, as well as extinguish maladaptive behaviors.

197 east CSC-targeting compound curcumin rapidly extinguished McTN in breast CSC, preventing reattachment

198 stered intravenous meth and reinstatement of extinguished meth seeking in male and female rats using

199 In contrast, morphine CPP extinguished mice that received a saline priming dose di

200 oinjection of orexin into VTA, reinstated an extinguished morphine preference.

201 ce (CPP) and stress-induced reinstatement of extinguished morphine-CPP in mouse models of opioid rewa

202 y self-administering nicotine nor reinstated extinguished nicotine-seeking behavior.

203 of periostin in HCM mice reduced but did not extinguish non-myocyte proliferation and fibrosis.

204 ere trained to self-administer cocaine, then extinguished of this behavior.

205 th Ace or Lyral, respectively, results in F1-Extinguished offspring that do not demonstrate behaviora

206 ecific programs, yet expression is generally extinguished once neural crest cells migrate from the do

207 conditioning context.SIGNIFICANCE STATEMENT Extinguished operant behavior can recover ("renew") when

208 ctions, and safety maintenance which aims to extinguish or reduce patient aggression/agitation irresp

209 postsynaptic density of the shell in either extinguished or abstinent rats.

210 vernment records of wildfires that had to be extinguished or managed by state or federal agencies fro

211 Rats were either extinguished or withdrawn without extinction training (a

212 memory was then either briefly reactivated, extinguished, or not manipulated, followed immediately b

213 ponse factor-regulated myofibrillar genes is extinguished, or profoundly attenuated, in myocardin-def

214 in a significantly stronger CTA that did not extinguish over 13days.

215 heoretically and clinically, where drugs can extinguish pathogens by increasing their mutation rate.

216 ges during adolescence with the potential to extinguish pathological fears implicated in anxiety and

217 GM-CSF-dependent STAT5 signaling rapidly extinguished pDC-related gene expression in lin- Flt3+ p

218 Ret expression is extinguished perinatally but reemerges postnatally in a

219 ion, peripapillary atrophy, dyschromatopsia, extinguished photopic responses, and reduced scotopic re

220 issue, whereas restoration of Mip130 or E2F2 extinguished Polo expression.

221 Corticosterone failed to re-establish extinguished preference alone but produced a leftward sh

222 preference, extinction and reinstatement of extinguished preference in response to low-dose cocaine

223 imals must exhibit behavioral flexibility to extinguish prior learned associations.

224 ed post-translational mechanism that rapidly extinguishes proneural protein activity in neural precur

225 s displayed a CPP upon initial testing which extinguished rapidly over the course of subsequent test

226 Surprisingly, the brains of EU-extinguished rats and CSO extinguished rats did not diff

227 , the brains of EU-extinguished rats and CSO extinguished rats did not differ in the number of c-Fos-

228 Only extinguished rats had elevations of PSD-95, Homer1b/c, a

229 We found that in cocaine-extinguished rats pharmacological activation of MORs no

230 rats that retained their CTA, both groups of extinguished rats showed suppression in the number of c-

231 sion in yoked saline rats but not in cocaine-extinguished rats.

232 rotransmission in the VP was lost in cocaine-extinguished rats.

233 found to be tonically suppressed in cocaine-extinguished rats.

234 ed long-term depression was observed only in extinguished rats.

235 e accumbens shell induced cocaine seeking in extinguished rats.

236 st to respond to bacterial signals have been extinguished repeatedly during the extended monoculture

237 -fat diet on the context-specific renewal of extinguished responding.

238 duce long-lasting deficits in the ability to extinguish reward seeking.

239 evelop severe photoreceptor degeneration and extinguished rod and cone ERG responses by 9 weeks of ag

240 Extinguished SALL1 expression and marked dysgenesis of n

241 ifferential regulation of heroin seeking and extinguished seeking by different MMP subtypes on distin

242 h mice lacking D2 autoreceptors were able to extinguish self-administration behavior in the absence o

243 motes LSC activity in T-cell progenitors, it extinguishes self-renewal of LT-HSCs.

244 e-acting repressive function or functions to extinguish stem and progenitor-derived regulatory gene e

245 In the Recall Test, nonextinguished versus extinguished stimuli evoked an increased differential (C

246 e primary sensory cortex during retrieval of extinguished stimuli following mindfulness training.

247 ological systems, promotes adaptability, and extinguishes submissive behavioral traits developed duri

248 tes would suggest and that host immunity can extinguish subsequent infection foci.

249 cells even once the expression of G231D was extinguished, suggesting that it resulted as a consequen

250 ral disruptions disappeared when lights were extinguished, suggesting that selective removal of light

251 ll-derived embryoid body cells known to have extinguished TDH expression.

252 fear toward Ace or Lyral of F0 male mice (F0-Extinguished) that had been fear conditioned with Ace or

253 y requires an efficient mechanism to rapidly extinguish the activity of self-renewal factors, but the

254 proposed to treat addictive disorders is to extinguish the association between environmental stimuli

255 their action, the ability to simultaneously extinguish the expression of a multitude of genes and ne

256 rnal exons of CHD1, were found to completely extinguish the expression of mRNA of this gene in PCa xe

257 duce the potentiated-startle response and to extinguish the fear response when the air-blast was abse

258 ent, corresponding to high strain rates that extinguish the flame.

259 Furthermore, this flexibility does not extinguish the innate preferences.

260 the macaques, which in return may lessen or extinguish the remarkable foraging technology employed b

261 ile timely FANCD2 deubiquitination serves to extinguish the response.

262 Therefore, TMS extinguished the effect of exogenous attention.

263 Exp. 2 with an additional 16 participants extinguished the ownership illusion by using visuomotor

264 egulatory networks in veg2-derived cells and extinguishes the endodermal gene regulatory network in m

265 Thus, the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu

266 a(q) association, but not a control peptide, extinguishes the waves.

267 ls, demonstrating an active role for TCF7 in extinguishing the effector program and forestalling term

268 ubic kilometers of magma into the rift zone, extinguishing the lava lakes, and feeding a submarine er

269 unt of sample that can be introduced without extinguishing the plasma is limited to about 4mg.

270 introduction of 8mg of solid sample without extinguishing the plasma.

271 When the light was extinguished, the circulating current transiently exceed

272 hocyte commitment from DN2 thymocytes and to extinguish their potential for alternative fates.

273 ear to the conditioned cue, and, finally, to extinguish their response to the fear conditioned cue we

274 e these odors with mild foot shocks and then extinguished their fear toward these odors with odor-onl

275 two food-reinforced learning paradigms, but extinguished their learned behavior normally.

276 to self-administer cocaine in Context A and extinguished their lever-pressing in a distinct Context

277 to self-administer cocaine in Context A and extinguished their lever-pressing in Context B.

278 pellets were removed, and lever pressing was extinguished; then the effect of bilateral dorsal mPFC l

279 The inability to extinguish these associations is a key factor contributi

280 , we demonstrate the therapeutic efficacy of extinguishing this signaling axis in endogenous SCCs usi

281 li with varying degrees of similarity to the extinguished threat cues.

282 hing threat responses.SIGNIFICANCE STATEMENT Extinguished threat responses often reemerge with time,

283 a suppression in response to conditioned and extinguished threat.

284 ntly, it remains unclear how AID activity is extinguished to avoid illegitimate mutations.

285 s presented synchronously with the sound but extinguished too quickly to provide this feedback, there

286 Rats were tone fear conditioned and extinguished under various systemic doses of Scop or the

287 Ag and costimulation within 24 h but is then extinguished unless a cytokine signal is available.

288 erposed at the time of e-prescription nearly extinguished unwarranted use targeted antibiotics for AR

289 pain, scalp tingling and headache that were extinguished upon follow-up.

290 such that averaging the neuronal population extinguished value coding.

291 suppressed skin conductance response to the extinguished versus nonextinguished CS(+) also failed to

292 Conversely, extinguished versus nonextinguished stimuli evoked an in

293 These defects led to extinguished visual response and dysregulated protein tr

294 hange of turbine speed from 9400 to 9000 rpm extinguished VT.

295 Cocaine self-administration was extinguished when cocaine methiodide or saline was subst

296 ly conditioned with both sigma(1)R agonists, extinguished when injections were discontinued, and reco

297 the persistence of the unrepaired DSB and is extinguished when repair is complete in a process termed

298 Animals showing CPP were successfully extinguished with repeated twice daily saline administra

299 show that although the mRNA was induced and extinguished within minutes in response to both signals,

300 were independent of plaque load and could be extinguished without altering deposited amyloid.