ライフサイエンスコーパス: extracardiac

1 We conclude that extracardiac abnormalities of preload reserve serve as a

2 Significant extracardiac abnormalities were noted.

3 iteria are enriched in patients with CHD and extracardiac abnormalities, evidencing shared pathways i

4 complication of heterogeneous background and extracardiac activity adjacent to the heart, which cause

5 Corrections for extracardiac activity and partial-volume errors were per

6 n correction, which depends on the amount of extracardiac activity and pattern of attenuation.

7 of attenuation correction in the presence of extracardiac activity can have complex effects on ML rec

8 Increased extracardiac activity confounds conventional cardiac SPE

9 improvement of correlation was observed with extracardiac activity correction (R(2) = 0.85, y = 1.54x

10 uce a heuristic method for the correction of extracardiac activity into SPECT quantification and vali

11 also result in reconstruction artifacts when extracardiac activity is present.

12 orrections for the myocardial tissue weight, extracardiac activity, and partial-volume errors are cru

13 improved uniformity only in the presence of extracardiac activity.

14 s diminished with the addition of increasing extracardiac activity.

15 d less likely be affected by the presence of extracardiac activity.

16 l approaches, in the absence and presence of extracardiac activity.

17 and not for increased myocardial counts from extracardiac activity.

18 ere well without evidence of intracardiac or extracardiac amyloid accumulation, and median overall su

19 id dynamics modeling was performed in 60 (30 extracardiac and 30 lateral tunnel) patient models to qu

20 Extracardiac and neurodevelopmental comorbidities were s

21 ular diagnosis was more common in those with extracardiac and neurodevelopmental phenotypes than thos

22 Knowledge about extracardiac anomalies (ECA) in fetal congenital heart d

23 ains difficult because of the high number of extracardiac anomalies and chromosome defects in this gr

24 risk genes occurred in patients with CHD and extracardiac anomalies and/or neurodevelopmental delay.

25 t, gestational age, maternal race/ethnicity, extracardiac anomalies, sex, and maternal age and educat

26 clusion criteria included a major genetic or extracardiac anomaly other than 22q11 deletion syndrome

27 es without a documented chromosomal or major extracardiac anomaly, 13 (48%) died.

28 gy scores according to CHD class (P=0.0007), extracardiac anomaly-positive status (P<0.0001), female

29 Extracardiac anomaly-positive status remained a stronger

30 e an atrial septal defect through the use of extracardiac application of histotripsy in an open-chest

31 o, or more vs. none, odds ratio 1.75, 7.98), extracardiac arteriopathy (odds ratio 2.63), preoperativ

32 ngly associated with atrial tachyarrhythmia, extracardiac arteriopathy, and a high body mass index.

33 lassified as TTR-variant carriers (n = 123), extracardiac ATTR (n = 41), early-stage ATTR-CM (n = 70)

34 ECV was similar in carriers and extracardiac ATTR but rose from early-stage to ATTR-card

35 data indicate significant remodeling of the extracardiac autonomic nerve activity and structures aft

36 Infants with extracardiac birth defects or genetic disorders were exc

37 d 15+, respectively) was not significant for extracardiac but statistically significant for lateral t

38 Compared with those with extracardiac cancers of similar histopathology, patients

39 citation) OHCA and SCD (OHCA without obvious extracardiac causes) for >5 consecutive years from Janua

40 vide evidence for the involvement of another extracardiac cell population, the proepicardial cells.

41 l new model system for examining the role of extracardiac cell populations in cardiac morphogenesis a

42 is independent of the further recruitment of extracardiac cells from the secondary heart field and pe

43 The contribution of extracardiac cells to atrial septation has recently been

44 However, the contribution of extracardiac cells to CoE is thought to be minor and non

45 trial highlight predominant associations of extracardiac clinical and demographic variables with sig

46 In HFpEF, extracardiac comorbidities such as metabolic risk, arter

47 clinical picture that is closely related to extracardiac comorbidities such as obesity, hypertension

48 ular function, arrhythmias or cyanosis, have extracardiac comorbidities, and face additional challeng

49 FALD is an extracardiac complication that may lead to substantial c

50 essment of this complex scenario to rule out extracardiac complications and possible neoplasms.

51 infective endocarditis (IE), the presence of extracardiac complications has an influence on both diag

52 nifestations had a higher rate of IE-related extracardiac complications than patients without skin ma

53 One patient died because of multiple extracardiac complications, but with preserved allograft

54 s and should alert physicians to examine for extracardiac complications, notably with cerebral imagin

55 potent neural crest cells (NCCs) are a major extracardiac component of cardiovascular development.

56 PC) (21.4%), lateral tunnel (LT) (41.8%), or extracardiac conduit (EC) (36.8%).

57 eral tunnel (LT) was performed in 92% and an extracardiac conduit (EC) in 8%.

58 during this period, only 6 (33%) required an extracardiac conduit as part of their complete repair.

59 The use of an extracardiac conduit can be avoided in the majority of p

60 the need for, and use of, fenestration of an extracardiac conduit Fontan.

61 , should not be performed routinely with the extracardiac conduit Fontan.

62 ith minimal intervention in patients with an extracardiac conduit Fontan.

63 es in a total cavopulmonary connection by an extracardiac conduit or a lateral tunnel connection.

64 ot necessary in most Fontan patients when an extracardiac conduit technique is performed as described

65 5), 271 lateral tunnels (1988-2006), and 532 extracardiac conduits (1997-2010).

66 Transcatheter procedures for those with extracardiac conduits (extracardiac-total cavopulmonary

67 ently predicted worse survival compared with extracardiac conduits (hazard ratio, 6.2; P<0.001; 95% C

68 opulmonary connections, 7 lateral tunnels, 2 extracardiac conduits).

69 th, transplantation, takedown, conversion to extracardiac conduits, New York Heart Association III/IV

70 erval [CI], 94%-99%) for lateral tunnels and extracardiac conduits.

71 HD) patients have an increased prevalence of extracardiac congenital anomalies (CAs) and risk of neur

72 easingly important to understand the role of extracardiac contributors and interorgan communication i

73 We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the

74 There is a functional, ischemia-reducing extracardiac coronary artery supply via ipsilateral but

75 esults Swine gross necropsy did not show any extracardiac damage related to atrial lesions.

76 olation (PVI), high-power ablation may favor extracardiac damage.

77 The presence of extracardiac defects increased the adjusted risk of deat

78 y CCHD type and study site, and infants with extracardiac defects were significantly less likely to h

79 e the functions of Csx/Nkx2.5 in cardiac and extracardiac development in the vertebrate, we have gene

80 ee consecutive patients with a biopsy-proven extracardiac diagnosis of systemic sarcoidosis (21 men;

81 cardiac sarcoidosis can also present without extracardiac disease (known as clinically isolated cardi

82 r and have worse survival than patients with extracardiac disease of similar histopathology (P<0.001)

83 sarcoidosis) or with previously unrecognized extracardiac disease.

84 function, (3) lymphatic dysfunction, and (4) extracardiac dysfunction.

85 zed sham-controlled study to investigate the extracardiac effects of EECP on peripheral artery flow-m

86 pmental abnormalities may be attributable to extracardiac effects of GRK2 ablation.

87 oth conferred an increased risk for nonfatal extracardiac events (hazard ratio of 1.52 per 1 SD [P <

88 al transgene expression and pose the risk of extracardiac expression.

89 Extracardiac factors (e.g., obesity and diabetes) influe

90 y present, increasing evidence suggests that extracardiac factors such as renal dysfunction and enhan

91 These data suggest that extracardiac factors, via volume overload, may contribut

92 t in a similar cardiac phenotype but lack in extracardiac features of the syndrome, suggesting that a

93 None of the 3 patients presented with extracardiac features suggestive of AFC.

94 y loops and initiate CPC generation in adult extracardiac fibroblasts using a CRISPR activation syste

95 T registry indicate that clinically relevant extracardiac findings are present at cardiovascular CT a

96 ermine the prevalence of clinically relevant extracardiac findings at cardiac CT and MRI examinations

97 esults The prevalence of clinically relevant extracardiac findings was 3.28% (6832 of 208 506) at car

98 teristics, including age, with prevalence of extracardiac findings was evaluated using incidence rate

99 Clinically relevant extracardiac findings were defined as findings requiring

100 Extracardiac findings were more common at CT examination

101 Extracardiac findings were more common at MRI examinatio

102 icantly associated with higher prevalence of extracardiac findings, with an IRR for both CT and MRI e

103 nd of operation, intracardiac Fontan (IF) or extracardiac Fontan (EF), days with chest tube output pe

104 innovations, such as the lateral tunnel and extracardiac Fontan modifications, and fenestration, as

105 The utility of fenestration with extracardiac Fontan operation has not been determined.

106 connection to a total cavopulmonary artery, extracardiac Fontan; arrhythmia surgery, typically with

107 eptal defects were successfully created with extracardiac histotripsy in a live canine model.

108 application to the detection of cardiac and extracardiac IE-related lesions seems to be a strategic

109 m, underlining the importance of cardiac and extracardiac imaging experts in playing a key role in in

110 Extracardiac imaging is highlighted as an increasingly i

111 myocardial in 193 patients (definite CS) and extracardiac in 205 (probable CS).

112 fication of the Fontan procedure in which an extracardiac inferior cavopulmonary conduit is used in c

113 cardiac performance, cardiac pathology, and extracardiac intrathoracic abnormalities.

114 increasing diagnostic accuracy, identifying extracardiac involvement, and assessing cardiac implante

115 ith prenatal or early onset presentation and extracardiac involvement.

116 mmary artery device closure seems to augment extracardiac ipsilateral coronary supply to the effect o

117 There were 1 early death (1%) and 4 extracardiac late deaths.

118 ement, and (3) the pacing performance of the extracardiac lead.

119 surgical procedures were required to correct extracardiac lesions in 18 patients (75%).

120 Detection of extracardiac lesions is an essential component of the ma

121 cise performance are now well-characterized, extracardiac limitations to exercise performance have be

122 42 pregnancies that continued, 15 had major extracardiac malformations and/or chromosomal abnormalit

123 f these patients with those of patients with extracardiac malignancies of similar histopathology.

124 ion, coronary artery disease, and history of extracardiac malignancy (P < 0.001).

125 ral carpal tunnel syndrome (CTS) is a common extracardiac manifestation of amyloidosis and usually pr

126 lly not be discerned from the cardiac and/or extracardiac manifestations and requires molecular genet

127 With some genetic mutations, extracardiac manifestations are likely to be present.

128 Extracardiac manifestations were prominent in men but no

129 Such extracardiac manifestations, in addition to other late c

130 sis of HCM mimics in patients with no or few extracardiac manifestations.

131 d damaging variants in these genes often had extracardiac manifestations.

132 e to phenotypic diversity and the absence of extracardiac manifestations.

133 um, which influences its relationship to the extracardiac mediastinal mesoderm.

134 dge (the spina vestibuli) did not accumulate extracardiac mesoderm, nor did it undergo the pronounced

135 of the coronary vessels arise from a unique extracardiac mesothelial cell population, the proepicard

136 indings demonstrate multiphasic responses in extracardiac metabolism to pathogenic cardiac stress, wi

137 ar mortality and non-SCD but neither SCD nor extracardiac mortality in heart failure across the conti

138 plasia syndrome characterized by cardiac and extracardiac myxomas in the setting of spotty skin pigme

139 associated with cutaneous hyperpigmentation, extracardiac myxomas, and nonmyxomatous tumors.

140 Whether MI results in remodeling of extracardiac nerve activity remains unclear.

141 An extracardiac nerve trunk innervated the bulbus arteriosu

142 e heart failure that can be accompanied with extracardiac neurologic, skeletal, and ophthalmologic ma

143 ng into cardiomyocyte, endothelial cell, and extracardiac neuron-like cells.

144 ine the electrophysiological consequences of extracardiac neuronal remodeling in humans.

145 h PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation.

146 Aortic homograft type and extracardiac operative technique predicted homograft fai

147 f aortic homograft in the older patient, and extracardiac operative technique.

148 Autopsy-defined SADs had no extracardiac or acute heart failure cause of death.

149 S, regardless of whether that individual has extracardiac or neurodevelopmental phenotypes present.

150 ated; and whether there may be intracardiac, extracardiac, or intracranial neuropathological conditio

151 n circulatory properties are associated with extracardiac organ dysfunction, numerous gaps in our und

152 rophic cardiomyopathy because of the lack of extracardiac organ involvement.

153 However, the AAV genomes can be found in extracardiac organs after intramyocardial injection.

154 ine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD

155 inent in the heart but is also detectable in extracardiac organs.

156 nt studies have identified cardiomyocytes of extracardiac origin in transplanted human hearts, but th

157 tic areas containing fibroblasts of putative extracardiac origin.

158 uses multiple acknowledged SCD substrates of extracardiac origin: diabetes mellitus, hypercholesterol

159 support the feasibility for this completely extracardiac pacing method in a heterogeneous patient po

160 A completely extracardiac pacing system provides the potential for cl

161 ings highlight the importance of considering extracardiac pathogenesis when investigating arrhythmoge

162 The presence of cardiac and extracardiac pathologic indicators was also determined.

163 lung pathology, as well as the detection of extracardiac pathology afforded by computed tomography i

164 It helps detect extracardiac pathology leading to hypoxemia and may be u

165 y calcification were found to have important extracardiac pathology requiring additional work-up.

166 Of 1326 patients, 103 (7.8%) had significant extracardiac pathology requiring clinical or imaging fol

167 congenital heart disease (CHD) and multiple extracardiac phenotypes.

168 in failing and nonfailing hearts, suggesting extracardiac production of the circulating hormone.

169 Extracardiac progenitor cells are capable of repopulatin

170 Extracardiac progenitor cells are capable of repopulatin

171 first time human bone marrow as a source of extracardiac progenitor cells capable of de novo cardiom

172 1-mm(2) "hot spots." Thus, adult humans have extracardiac progenitor cells capable of migrating to an

173 and further degradation of cardiac SPECT by extracardiac radioactivity and partial-volume effect.

174 ntified simultaneously with incorporation of extracardiac radioactivity correction, gaussian fitting,

175 xical embolization then may link cardiac and extracardiac right-to-left shunts to migraine aura.

176 oronary vessels and epicardium arise from an extracardiac rudiment called the proepicardium.

177 patients (mean age, 45.7 years) with proven extracardiac sarcoidosis and possible CS who were invest

178 vascular magnetic resonance in patients with extracardiac sarcoidosis and preserved left ventricular

179 -one consecutive patients with biopsy-proven extracardiac sarcoidosis were prospectively recruited fo

180 left ventricular ejection fraction >50% and extracardiac sarcoidosis who underwent cardiovascular ma

181 gnostic criteria, screening of patients with extracardiac sarcoidosis, and the use of pacemakers and

182 coronary vascular development, we show that extracardiac septum transversum/proepicardium (ST/PE)-de

183 f CS may continue to face cardiac as well as extracardiac sequelae of these therapies and complicatio

184 ization defects that appear to be induced by extracardiac signals.

185 r anomalous migration of epicardial cells to extracardiac sites.

186 The liver is likely the main extracardiac source.

187 ree of chimerism, averaging 24.3+/-8.2% from extracardiac sources.

188 her derived intracardially or immigrate from extracardiac sources.

189 Lamprey sympathoblasts populate the extracardiac space and extend along the length of the tr

190 , however, have suggested the presence of an extracardiac stem cell population, perhaps in bone marro

191 ic conditions, with little contribution from extracardiac stem cell sources.

192 ired reoperation to treat lead dislodgement, extracardiac stimulation, or infection during follow-up.

193 te and the common coexistence of cardiac and extracardiac stroke risk factors suggest benefits from g

194 CMRI allows clear delineation of cardiac and extracardiac structures as well as accurate and reproduc

195 detail its relationship to other cardiac and extracardiac structures.

196 ral remodeling in PVC-CM is characterized by extracardiac sympathetic hyperinnervation and sympatheti

197 n addition to cardiomyocytes, by cardiac and extracardiac sympathetic neurons, although not organized

198 A patient-specific, extracardiac TCPC with 85% DS was studied in its origina

199 monstrated the formation of intracardiac and extracardiac teratomas.

200 and rAAV2/8 demonstrate similar behavior in extracardiac tissue.

201 nrichment analysis, we highlight the role of extracardiac tissues in disease etiology.

202 ysiological effects on the heart, lungs, and extracardiac tissues, and introduction of new, easily im

203 the heart without significant expression in extracardiac tissues, including the brain.

204 thought to involve the myocardium as well as extracardiac tissues.

205 exerts proinflammatory effects, at least in extracardiac tissues.

206 rily limited to the heart but also involving extracardiac tissues.

207 al databases were explored for patients with extracardiac-total cavopulmonary connection and postoper

208 ubstantial proportion of patients undergoing extracardiac-total cavopulmonary connection in childhood

209 edures for those with extracardiac conduits (extracardiac-total cavopulmonary connection) are perhaps

210 In addition, extracardiac tumor manifestations were detected in 4 pat

211 (+/-) mice exhibited a marked propensity for extracardiac tumorigenesis.

212 Algorithm failure was caused by extracardiac uptake (10/24, or 41.7%) or inaccurate iden

213 In 24 of 51 patients with IE, we also found extracardiac uptake, indicating septic embolism in 21 of

214 foramen, through the internal jugular veins (extracardiac vagal stimulation [ECVS]), analyzing 15 s m

215 r prevalence of congestive heart failure and extracardiac vascular disease.

216 death, nonfatal cardiac events, and nonfatal extracardiac vascular events over a mean period of 7.8 y

217 expression in non pro-valve endocardium and extracardiac vasculature.