ライフサイエンスコーパス: extracellular domain

1 slationally processed by cleavage within its extracellular domain.

2 that ADAM10, but not ADAM17 cleaves the RELT extracellular domain.

3 e kinase 1 (AKIK1), an active kinase with an extracellular domain.

4 al adhesive fragment of the zebrafish Pcdh19 extracellular domain.

5 which are missense mutations in the adhesive extracellular domain.

6 mbrane segments, which are linked by a large extracellular domain.

7 ion through trans interactions formed by its extracellular domain.

8 b2p was induced by underglycosylation of its extracellular domain.

9 l epidermal growth factor-like repeat in the extracellular domain.

10 rphisms at positions 58 and 92 within the D0 extracellular domain.

11 two extra pairs of cysteine residues in the extracellular domain.

12 ngstrom crystal structure of the human PD-1H extracellular domain.

13 that are genuine ligands binding to the RET extracellular domain.

14 three CS sugar chain attachment sites in the extracellular domain.

15 ), which is also heavily glycosylated at its extracellular domain.

16 y to a homology model of the alpha7 receptor extracellular domain.

17 ch may lead to epitope unmasking in the IA-2 extracellular domain.

18 uorogen activating protein (FAP) in the EGFR extracellular domain.

19 subfamilies based on the similarity of their extracellular domains.

20 pes from all known cardiac ion channels with extracellular domains.

21 odulators requires additional cytoplasmic or extracellular domains.

22 ined by two structurally distinct classes of extracellular domains.

23 ries of PLA2R1 deletion mutants covering the extracellular domains.

24 irectly to the Sema3A sema domain or to Nrp1 extracellular domains.

25 known convulsant sites in the ion channel or extracellular domains.

26 ages have increased the frequency of KLRA*02 extracellular domains.

27 The importance of the extracellular domain 2 (ECL2) in the selectivity toward

28 but not limited to: 1) shedding of the HER2 extracellular domain, 2) steric hindrance ( e.g., MUC4 a

29 36 in the kinase domain, and C300stop in the extracellular domain, a new mutation causing CIPA diagno

30 ndependently of the lipid-binding Smoothened extracellular domain, a region that is dispensable for P

31 ta1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a H

32 ontrast to a single TMD structure state, the extracellular domain adopts multiple conformations.

33 DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis an

34 Functionally, MICA-B2 contains two extracellular domains (alpha1 and alpha2) and is a novel

35 ved and the binding affinities between their extracellular domains, an improved kinetic assay is need

36 to an allosteric activation (AA) site in the extracellular domain and activate the alpha7 ion channel

37 The two receptor protomers, extracellular domain and amino terminal fragment (NTF),

38 Root-enriched CLE ligands bind the BAM1 extracellular domain and are necessary and sufficient to

39 ormed with pET20b plasmid encoded with CD200 extracellular domain and core streptavidin.

40 modality whereby the LAIR1 exon encoding the extracellular domain and flanking intronic sequences are

41 predicted membrane topology, CNIH3 lacks an extracellular domain and instead contains four membrane-

42 TpoR activation was dependent on its extracellular domain and its N-glycosylation, especially

43 m the size difference between the large CD45 extracellular domain and the smaller TCR-pMHC complex, a

44 ansition can be initiated by "unzipping" the extracellular domain and the transmembrane domain, media

45 t of monoclonal antibodies against the KCNK9 extracellular domain and their functional effects.

46 ture of full-length GCGR containing both the extracellular domain and transmembrane domain in an inac

47 udokinase1 (ARLPK1) and ARLPK2, both lacking extracellular domains and kinase activity, through mRNA

48 ations include those affecting the kinase or extracellular domains and those that result in exon 14 s

49 guidance roles by recognizing cues via their extracellular domains and transducing signals via their

50 rted mammalian display system to present TCR extracellular domains and used this to screen CDR3 libra

51 no terminus, first transmembrane domain, and extracellular domain) and sites (residues 130-132 and 13

52 SMO is associated with subtle motions in the extracellular domain, and larger intracellular changes.

53 nce of the "compact" conformation of the MET extracellular domain, and the relevance of this conforma

54 bes the roles of potential pH sensors in two extracellular domains, and it proposes a model of acidif

55 (-/-)) or selectively expressing its soluble extracellular domain (APPsalpha-KI).

56 ites of CD46 cassette exons 7 and 8 encoding extracellular domains are defined by noncanonical mechan

57 sting that all of the domains, including the extracellular domain, are necessary for complete rescue.

58 roof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well a

59 we solved the crystal structure of the beta2 extracellular domain at 1.35A.

60 EC14A and CD93 binding region blocks CLEC14A extracellular domain binding to the endothelial cell sur

61 further amplified because alpha-sarcoglycan extracellular domain binds eATP and displays an ecto-ATP

62 ly, radial migration requires the N-cadherin extracellular domain but not N-cadherin-dependent homoph

63 nits are, therefore, located not only in the extracellular domains but also in the lipid accessible s

64 and cornichon 3, are located not only in the extracellular domains but also in the lipid-accessible s

65 amples bound live hippocampal neurons or Kv1 extracellular domains, but 16 (59%) bound to permeabilis

66 hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yield

67 molar concentration of zinc that binds to an extracellular domain called an amino-terminal domain (AT

68 Its extracellular domain can be cleaved and released into th

69 ed in ovarian cancer tumors, and its cleaved extracellular domain can be detected in the serum of ova

70 ved protein is intracytoplasmic, whereas the extracellular domain carries two N-glycosidic side chain

71 We found that their purified extracellular domains co-exist in stable dimeric and mon

72 lie at the interface between NPC1L1's three extracellular domains comprise the drug's binding site.

73 aGPCR extracellular domains contain a conserved subdomain that

74 ed of intracellular N and C termini, a large extracellular domain containing the ATP binding site and

75 Unexpectedly, we found that the two extracellular domains (D1-D2) of DNAM-1 adopt an unconve

76 fferent domains of the protein; L213P in the extracellular domain, Delta736 in the kinase domain, and

77 epidermal growth factor repeats in the Notch extracellular domain, during pathogenesis of Kras-induce

78 ger these episodes, is mediated by the first extracellular domain (EC1) of cadherin-related protein 3

79 The large extracellular domain (EC2) of CD53 protrudes away from t

80 and a newly made peptide antibody to the gI extracellular domain (ECD) (amino acids [aa] 110 to 202)

81 otonin) to the binding pocket located on the extracellular domain (ECD) and allosteric regulation of

82 MY2 (CTR.RAMP2) receptors using purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2

83 nding to PTH1R involves binding to the large extracellular domain (ECD) and the orthosteric pocket, i

84 The soluble LGR4 extracellular domain (ECD) binds RANKL and inhibits oste

85 ptides, however, little is known about their extracellular domain (ECD) conformations in the absence

86 The PknB extracellular domain (ECD) consists of four repeats homo

87 N-glycosylation of asparagine 130 in its extracellular domain (ECD) enhances calcitonin hormone a

88 ligand-favored conformational change of the extracellular domain (ECD) from a closed, self-inhibited

89 We used an antibody that sheds the extracellular domain (ECD) of CD44 to study the role of

90 The extracellular domain (ECD) of class B1 G-protein-coupled

91 We hypothesized that the soluble extracellular domain (ECD) of long isoform of death rece

92 TcsL recognizes the extracellular domain (ECD) of SEMA6A/6B via a region hom

93 we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal alpha2

94 SecR exhibited a unique organization of its extracellular domain (ECD) relative to its 7-transmembra

95 t trastuzumab and chemotherapy augments HER2 extracellular domain (ECD)-specific antibodies.

96 for functionally synergizing with the beta3 extracellular domain (ECD).

97 g of DDR1b, a process partly mediated by its extracellular domain (ECD).

98 human ZIP proteins, is featured with a large extracellular domain (ECD).

99 receptor (GPCR) with a characteristic large extracellular domain (ECD).

100 formed of two helices (TM1 and TM2), and an extracellular domain (ECD).

101 ells and designed a peptide encompassing the extracellular domains (ECD) of PLP.

102 n of the noncovalently bound GPR56 or GPR110 extracellular domains (ECDs) from the respective seven-t

103 racterize this process, the large N-terminal extracellular domains (ECDs) of alpha1, alpha2, beta2, a

104 esidue beta3-Y442) subunits, adjacent to the extracellular domains (ECDs).

105 brane proteins by cleaving their substrate's extracellular domain (ectodomain), a process known as sh

106 Regions of the extracellular domain essential to this phenotype were id

107 isting of the activin receptor-like kinase-1 extracellular domain, exacerbated PH and pulmonary vascu

108 rd isoform, Nrxn1gamma, that lacks all Nrxn1 extracellular domains except for the membrane-proximal s

109 mpact of a soluble TGF-beta type II receptor extracellular domain expressed as an immunoglobulin-Fc f

110 Stimulation with an EphB2 extracellular domain-Fc fusion protein (EphB2-Fc) induce

111 und states revealed molecular motions of the extracellular domain following agonist binding.

112 all GDD mutations known so far locate in an extracellular domain following the first transmembrane d

113 tions "mark" different regions in the Notch1 extracellular domain for activation or inhibition.

114 Additionally, removal of the extracellular domains from the receptor did not affect m

115 protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces ex

116 tructural analyses of ligand-occupied Klotho extracellular domains have provided important insights c

117 olecular dynamics simulations with an alpha7 extracellular domain homology model and two acetylcholin

118 gase domain and a subset of mutations in the extracellular domain hyperactivate Wnt/beta-catenin sign

119 Studies using chimeras of IR(extracellular domain)/IGF1R(intracellular-domain) or IGF

120 the necessity for broader screening of CSF3R extracellular domain in leukemia patients.

121 ding endostatin/collagen 18alpha1 and Notch3 extracellular domain in mice with the C455R mutation, a

122 c synaptic interaction partner of the Caspr2 extracellular domain in the molecular layer of the devel

123 g in the large class of receptors built from extracellular domains in tandem with single-span transme

124 nases (RTKs), which carry a truncated plexin extracellular domain, in several bilaterian clades, indi

125 ate a truncated TpoR mutant, which lacks the extracellular domain, indicating these mutations act on

126 The Tartan and Ten-m extracellular domains interact in vitro, and Tartan prom

127 analyses raise the possibility that the Lrp4 extracellular domain interacts with Wnt ligands, as well

128 lter the signal that is transmitted from the extracellular domain inward.

129 onformational changes in the agonist-binding extracellular domain, ion-conducting transmembrane domai

130 domain)/IGF1R(intracellular-domain) or IGF1R(extracellular domain)/IR(intracellular-domain) demonstra

131 ferent receptor chains, and reveals that the extracellular domain is merely the tip of a molecular ic

132 easurements in keratinocytes showed the Dsg3 extracellular domain is ordered at the individual desmos

133 rminal domains, indicating that the IL1RAPL1 extracellular domain is required for regulating dendrite

134 by binding of epidermal growth factor to the extracellular domain it dimerizes, followed by autophosp

135 of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of which shares

136 ugh a calcium-dependent interaction of their extracellular domains made of multiple extracellular cad

137 ng the balance between the intracellular and extracellular domains, mechanotransduction determines th

138 istidine residues along the rim of the VISTA extracellular domain mediate binding to the adhesion and

139 It is not clear why so many extracellular domains need to be evolved through natural

140 mediator, we showed chemical labeling of the extracellular domain of a cell surface receptor on livin

141 naling from the cell surface by engaging the extracellular domain of a GPCR and suggest that SMO acti

142 Here we reveal the structure of the extracellular domain of a PIR from Plasmodium chabaudi W

143 -surface lysosome-shuttling receptor and the extracellular domain of a target protein.

144 entry into the host, this virus binds to the extracellular domain of ACE2 in nasal, lung, and gut epi

145 Initial studies conducted on the extracellular domain of acetylcholine receptors, ion cha

146 of agonism through an allosteric site in the extracellular domain of alpha7 nAChR.

147 In summary, a mutation in the extracellular domain of alphaENaC causes Liddle syndrome

148 hibitors (RU-301 and RU-302) that target the extracellular domain of Axl at the interface of the Ig-1

149 Our findings suggest that while the extracellular domain of AXL has the highest affinity for

150 oton release complex (PRC), a complex in the extracellular domain of bacteriorhodopsin where an exces

151 vels; here, we combined this mutation in the extracellular domain of C99 with T43I and observed that

152 The extracellular domain of cadherins consists of extracellu

153 We determine that the extracellular domain of CADM1 mediates these effects by

154 nal data that relate the architecture of the extracellular domain of CASPR2 to a previously unknown l

155 .2 identified protein interfaces between the extracellular domain of CaValpha2delta1 and the extracel

156 inst activated glycoprotein IIb/IIIa and the extracellular domain of CD39 (targ-CD39).

157 himeric construct, SA-CD47, encompassing the extracellular domain of CD47 modified to include core st

158 egulate a conformational switch in the large extracellular domain of CD81.

159 Given the large size of the full extracellular domain of class I MHC molecules such as H-

160 in composed of the Fc region of IgG1 and the extracellular domain of CTLA4 (also known as abatacept,

161 acrylamide (PA) gels functionalized with the extracellular domain of E-cadherin (Ecad-Fc), we showed

162 and a vertical surface coated with purified extracellular domain of E-cadherin, and was designed for

163 ding capability of the new conjugates to the extracellular domain of EGFR was investigated using mole

164 C479 is a highly conserved residue in the extracellular domain of ENaC and likely involved in a di

165 report that the EGF-like domain I within the extracellular domain of EpCAM (EpEX) binds EGFR, activat

166 cytometry, and ChIP assays, we show that the extracellular domain of epithelial cell adhesion molecul

167 sely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be released into circula

168 ne did not affect the binding of FasL to the extracellular domain of Fas receptor.

169 Only SNP V39I, located in the extracellular domain of FcgammaRI, reduces immune-comple

170 of plant RALFs and can directly bind to the extracellular domain of FERONIA to modulate specific ste

171 Two candidate therapies target the extracellular domain of FGFR3.

172 d that exercise promotes the shedding of the extracellular domain of Fndc5, generating a circulating

173 hese data indicate that glycosylation of the extracellular domain of hCAR plays no role in CVB3 recep

174 armacokinetic profile compared with the full extracellular domain of HuCR1.

175 ng site revealed a linear epitope within the extracellular domain of human CD44, capable of blocking

176 a humanized monoclonal antibody against the extracellular domain of human epidermal growth factor re

177 ensitive to echovirus infection and that the extracellular domain of human FcRn directly binds echovi

178 ional-deficient mouse strain by deleting its extracellular domain of humanized NC16A (termed DeltaNC1

179 The release of the extracellular domain of IcsA through IcsP-mediated cleav

180 serine residues (but not 2 or 4) between the extracellular domain of IFNAR1 and the TMD had some effe

181 rface on the first fibronectin repeat of the extracellular domain of Ihog.

182 We also found that the extracellular domain of IL1RAPL1 is required for this ef

183 a well characterized B-cell epitope from the extracellular domain of influenza A virus M2 protein (M2

184 Two independent mutations in the extracellular domain of KIR, away from the HLA-C binding

185 a chimeric receptor molecule composed of the extracellular domain of KLA fused to the cytoplasmic dom

186 In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibi

187 s with heterologously expressed protein, the extracellular domain of LRRTM4 was found to engage in he

188 Here we characterize the structure of the extracellular domain of MapZ and show that it displays a

189 magglutinin (HA), neuraminidase (NA) and the extracellular domain of matrix protein 2 (M2e) fused to

190 The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-typ

191 We find that mutant CALR binds to the extracellular domain of MPL and that 3 tyrosine residues

192 o45 or another protein to SPRY motifs in the extracellular domain of N-cadherin.

193 ies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, bi

194 t assays (ELISAs) further confirmed that the extracellular domain of OATP1A2 directly binds with ap23

195 n the P0S63del (deletion of serine 63 in the extracellular domain of P0) mouse model of Charcot-Marie

196 utant P0S63del (deletion of serine 63 in the extracellular domain of P0), that causes Charcot-Marie-T

197 luble fragment generated from the N-terminal extracellular domain of PC-1 functions as an intrinsic a

198 receptor construct, comprising the truncated extracellular domain of PD1 and the transmembrane and cy

199 atumab) is a monoclonal antibody against the extracellular domain of PDGFRA.

200 and Ab37 to distinct epitopes on the distal extracellular domain of PECAM.

201 The extracellular domain of PKD2, a hotspot for ADPKD pathog

202 ding, they were also cocrystallized with the extracellular domain of PSMA.

203 er relapses and metastases by binding to the extracellular domain of PSMA.

204 re we report that a lysine-rich motif in the extracellular domain of PSR-1, the Caenorhabditis elegan

205 Ligand binding at the extracellular domain of RAGE initiates a complex intrace

206 v) was generated by phage display, using the extracellular domain of recombinant human CD44.

207 ally (half-maximal binding, 3 mug/mL) to the extracellular domain of SR-AI.

208 in-11/syndecan-4 complexes requires both the extracellular domain of syndecan-4, and the transmembran

209 to install the boronic acid reagent onto the extracellular domain of the Beta-2 adrenergic receptor i

210 his interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor.

211 equilibrium dissociation constant toward the extracellular domain of the ephrin A2 receptor, long cir

212 ons are used to examine the structure of the extracellular domain of the EPOR dimer in the presence a

213 8I), functionally defective mutations in the extracellular domain of the G-CSF receptor (CSF3R) have

214 crystal structure of the isolated N-terminal extracellular domain of the GLP-1R in complex with exend

215 fluorescent protein, pHluorin, tagged to the extracellular domain of the GluA2 subunit of AMPARs, we

216 o characterize conformational changes in the extracellular domain of the human 5-HT(3) receptor to id

217 The extracellular domain of the M2-ion channel (M2e) is an i

218 ) and the Myc epitope were introduced to the extracellular domain of the mature receptor alpha2 subun

219 strongly and specifically interacts with the extracellular domain of the receptor-like kinase FERONIA

220 epidermal growth factor-like repeats in the extracellular domain of the receptor: O-fucosylation, O-

221 CAIV-His-88 and a charged amino acid in the extracellular domain of the transporter's chaperone.

222 ding of tumor necrosis factor ligands to the extracellular domain of their corresponding receptors tr

223 s require a hydrophobic patch located in the extracellular domain of TpoR to induce TpoR thermal stab

224 in the kinase domain and one variant in the extracellular domain of TrkB led to a loss of function t

225 ver two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for AD

226 related tyrosine kinase-1 (rAAV.sFLT-1), the extracellular domain of VEGF receptor, and analyzed the

227 he intramolecular contacts between different extracellular domains of a CAM.

228 At the interface of the extracellular domains of adjacent subunits lies the acet

229 that electrostatic interactions between the extracellular domains of AMPAR and STZ play an important

230 ugh discovery of specific IgGs targeting the extracellular domains of antigens at nodal and synaptic

231 ted after immunization of an alpaca with the extracellular domains of both human and mouse MMR.

232 cellular approaches we demonstrate that the extracellular domains of BTN3A1 adopt a V-shaped conform

233 laevis embryos demonstrate that deletion of extracellular domains of Cadherin3 (Cdh3; formerly C-cad

234 A by directly binding and ubiquitinating the extracellular domains of Clec9A.

235 How the large extracellular domains of GPCRs regulate signalling by th

236 e present the first crystal structure of the extracellular domains of human IL-11Ralpha and a structu

237 Our results suggest that IFN binding to the extracellular domains of IFNAR1 and IFNAR2 promotes prox

238 likely pathogenic entities, which target the extracellular domains of leucine-rich glioma-inactivated

239 of these (56%) had antibodies targeting the extracellular domains of LGI1 or CASPR2.

240 compartments of the secretory pathway and on extracellular domains of membrane and secretory proteins

241 annexinA2 as a potential interactor with the extracellular domains of PLA2R.

242 opy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands

243 that USSN mediate their effect by binding to extracellular domains of the flanking CD3 regions of the

244 e A-Q complex) is an interaction between the extracellular domains of the forespore membrane protein

245 f a chimeric adaptor molecule comprising the extracellular domains of the human FcgammaRI (CD64) fuse

246 IL-33, termed IL-33trap, which combines the extracellular domains of the IL-33 receptor (ST2) and it

247 Among the 15 extracellular domains of the mannose 6-phosphate/insulin

248 interactions with both the intracellular and extracellular domains of the NMDAR.

249 ructures on the carbohydrate recognition and extracellular domains of the protein using sequential ex

250 ed a synthetic signaling system in which the extracellular domains of the TCR and pMHC were replaced

251 Autoantibodies against the extracellular domains of the voltage-gated potassium cha

252 nt with the possibility that highly extended extracellular domains of these proteins physically block

253 While the extracellular domains of TNFRs form trimeric complexes w

254 The amino acids Glu-282 and Phe-286 near the extracellular domain on the third transmembrane helix we

255 single disulfide bonds to constrain lumenal/extracellular domains or shortening a cytoplasmic loop a

256 eveals the architecture of KCCs including an extracellular domain poised to regulate transport activi

257 The variant in the extracellular domain potentially interferes with the bin

258 (Ndr)-expressing cells, bound soluble Notch1 extracellular domain, quantified by flow cytometry.

259 eutralizing acidic amino acids in the ASIC1a extracellular domain reduces BigDyn effects, suggesting

260 e motions featuring shearing/twisting of the extracellular domains relative to the TMD, reveal subuni

261 tion of original cysteine pairs in the CSF3R extracellular domain resulted in either gain- or loss-of

262 uctures of the ternary complex formed by the extracellular domains reveal that Lphn3 dimerizes when b

263 The Tiki extracellular domain shares homology with bacterial TraB

264 serum human epidermal growth factor 2 (HER2) extracellular domain (sHER2) in patients with advanced b

265 Excess of P-selectin extracellular domain significantly impaired Efb binding

266 lways consistent among the individual alpha7 extracellular domain simulations.

267 Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPalpha) play

268 actor 23 (FGF23) signaling, whereas its shed extracellular domain, soluble Klotho (sKlotho), carrying

269 The shed soluble VLDLR extracellular domain (sVLDLR-N) was detected in the cond

270 ateral (cis) interactions between E-cadherin extracellular domains tethered to supported lipid bilaye

271 the N-terminal domain of LCN2-R is a soluble extracellular domain that is intrinsically disordered an

272 noclonal antibodies to its intracellular and extracellular domains that enable the immunostaining of

273 Single-pass membrane receptors contain extracellular domains that respond to external stimuli a

274 Finally, when expressed in CaS lacking its extracellular domain, the CaS(S875A/T888A) double mutati

275 n the membrane after ligand binding to their extracellular domain, the TLR4-TLR6-CD36 complex assembl

276 Together with the inactive form of the CaS extracellular domain, these sites attenuate Ca(2+) (o) s

277 bunit uses its transmembrane alpha-helix and extracellular domain to bind to Nav1.5.

278 y attaching the TGF-beta-neutralizing TGFBR2 extracellular domain to ibalizumab, a non-immunosuppress

279 Diverse orientations of the extracellular domain to the receptor core in different r

280 soluble, monomeric protein by fusing the TCR extracellular domains to antibody hinge and Fc constant

281 ugh the removal or addition of cysteine-rich extracellular domains to produce a panel of chimeric mol

282 teract with nanomolar affinity through their extracellular domains to synergistically promote synapse

283 of domain motions, which propagate from the extracellular domains to the TMD.

284 3)CH(3)-epsilon-methionine probes in the M2R extracellular domain, transmembrane core, and cytoplasmi

285 n, is likely to be solvent-accessible at the extracellular domain vestibule.

286 Interaction of orthosteric ligands with extracellular domain was described at several aminergic

287 type of Met-like RTK with a complete plexin extracellular domain was detected in Lophotrochozoa and

288 rthermore, a binding site in a groove of the extracellular domain was proposed but not experimentally

289 ch is proteolytically cleaved to release the extracellular domain, was endocytosed by podocytes to in

290 A, a transmembrane protein with a very large extracellular domain, was found in terminal Schwann cell

291 bi-TPB-PPB antibodies binding with the HER2 extracellular domain, we showed that the obtained Kd val

292 of trans binding between soluble E-cadherin extracellular domains, we conducted simulations of cadhe

293 ically, IL-17R interacts with NOTCH1 via the extracellular domain, which facilitates the cleavage of

294 bute this function to a cleavage of the TLR2 extracellular domain, which prevented TLR2-induced trans

295 or intercellular signaling in which the PirB extracellular domains, which point away from the cell su

296 Exogenous EphA7 extracellular domain will rescue the null phenotype in v

297 The interaction of the Caspr2 extracellular domain with IP(3)R1 inhibits IP(3)R1-media

298 indicated that the agonists bind the IL-36R extracellular domain with micromolar affinity but do not

299 Neutralizing the Ncad extracellular domain with the monoclonal antibody GC-4 s

300 found structural rearrangements in the AMPAR extracellular domain, with ligand-binding domain dimers