ライフサイエンスコーパス: extracellular loop

1 volving residues on H6 and within the second extracellular loop.

2 unction of transmembrane domain V and second extracellular loop.

3 lycosylated at five asparagines in the first extracellular loop.

4 ue constriction formed by Trp74 in the first extracellular loop.

5 the principal contact point with the CNIH-3 extracellular loop.

6 g primarily with glutamate 175 in the second extracellular loop.

7 transmembrane region and 5 A for the second extracellular loop.

8 interaction involves predominantly the beta1 extracellular loop.

9 1 have been found and localize to the second extracellular loop.

10 1 have been found and localise to the second extracellular loop.

11 integrins with traceable tags inserted in an extracellular loop.

12 tope of the receptor that includes all three extracellular loops.

13 ons serve to stabilize key substrate-binding extracellular loops.

14 ing to the eIF4F complex with its two middle extracellular loops.

15 the degree of structure and the role of long extracellular loops.

16 ng site located between the second and third extracellular loops.

17 and an extended binding pocket close to the extracellular loops.

18 r and inducing structural alterations in the extracellular loops.

19 to two mutations in different putative XPR1 extracellular loops.

20 ry cysteine scanning of intracellular versus extracellular loops.

21 R1 involves both amino-terminal residues and extracellular loops.

22 gle membrane-spanning domain and without any extracellular loops.

23 n to interact with binding partners in these extracellular loops.

24 ucturing of a barrel extension formed by the extracellular loops.

25 d by the quality of interactions between the extracellular loops.

26 e of the receptor, and further stabilized by extracellular loops.

27 beta-barrel wall with residues in one of the extracellular loops.

28 and indicates that rearrangement of the ECD/extracellular loop 1 (ECL1) interface is a critical step

29 ional changes in transmembrane segment 2 and extracellular loop 1 (EL1), which amplify the divergence

30 nal gate, the lumen of LptD channel, and the extracellular loop 1 and 4, providing the first direct e

31 Methods: (64)Cu-DOTA-extracellular loop 1 inverso (ECL1i) PET was used to ima

32 A 7-amino acid CCR2 binding peptide (extracellular loop 1 inverso [ECL1i]) was conjugated to

33 lododecane-1,4,7,10-tetraacetic acid]-ECL1i [extracellular loop 1 inverso]) that allosterically binds

34 and a negatively charged aspartate (D112) in extracellular loop 1 that helps determine Orai1 turnover

35 act cells, reporter cysteines were placed in extracellular loops 1 (A80C, N half) and 4 (R741C, C hal

36 r disulfide bridges and aromatic residues in extracellular loop 2 (ECL-2) for ligand binding and acti

37 e (TM) bundle, prior studies have implicated extracellular loop 2 (ECL2) as having a significant role

38 eport that N-linked glycosylation of PAR1 at extracellular loop 2 (ECL2) controls G12/13 versus Gq co

39 ic simulations, these structures reveal that extracellular loop 2 (ECL2) of GABA(B) has an essential

40 cellular side of transmembrane 3 (TM3), TM4, extracellular loop 2 (ECL2), and ECL3 to be involved in

41 the hydrogen-bonding networks (HBNs) in the extracellular loop 2 (EII).

42 ing kinetics may be due to a "lid" formed by extracellular loop 2 (EL2) at the entrance to the bindin

43 ction between positively charged arginine in extracellular loop 2 (K210) and a negatively charged asp

44 of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intrace

45 F194 in extracellular loop 2 and R304 in extracellular loop 3 al

46 pon flexibility in the C-terminal segment of extracellular loop 2 and that mutations or ligand bindin

47 this, we identified key residues within both extracellular loop 2 and the transmembrane domain region

48 hly dynamic, with spontaneous transitions of extracellular loop 2 from the helical conformation in th

49 g receptor structure, a beta-hairpin fold in extracellular loop 2 in conjunction with two extracellul

50 lphide bridge in GPCRs between helix III and extracellular loop 2 is not observed and appears to be d

51 Together, our structures reveal that extracellular loop 2 occupies the orthosteric binding po

52 f CPE in complex with a peptide derived from extracellular loop 2 of a modified, CPE-binding Claudin-

53 introducing an HA (hemagglutinin) tag in the extracellular loop 2 of SERT (HA-SERT).

54 Thus, CPM binding to extracellular loop 2 of the B1R results in positive allo

55 d by mutating as few as four residues in the extracellular loop 2 region of glycine receptors (GlyRs)

56 main(aa 363-458) interacts with the occludin extracellular loop 2(aa 194-241).

57 r-138/Phe-139), and the transition of TM3 to extracellular loop 2, ECL2 (Thr-141/Ile-142) and ECL2 (A

58 and pocket is tightly sealed from solvent by extracellular loop 2, leaving only a narrow channel betw

59 These cysteines are located in extracellular loop 2, the role of which in the structure

60 nist binding, with conformational changes in extracellular loop 2, transmembrane domain 5 (TM5), TM6

61 93(5.42) on TM5 but has no interactions with extracellular loop 2, which appears to be in contrast to

62 d in the tyrosine-sulfated amino terminus or extracellular loop 2.

63 action of its C-terminal domain with the B1R extracellular loop 2.

64 of transmembrane helices V, VI, VII and the extracellular loop 2.

65 s to the transmembrane bundle as well as the extracellular loop 2.

66 dered to be conducive to the conformation of extracellular loop 2.

67 nsmembrane regions 2 and 7 (TM2 and TM7) and extracellular loops 2 and 3 (EL2 and EL3).

68 mino acid moieties were coordinated close to extracellular loops 2 and 3.

69 Our data suggest that extracellular loops 2 and 4 come into close proximity to

70 nce of antibodies against the N terminus and extracellular loops 2/3 of CXCR4 confirm that the ubiqui

71 erminal receptor domain, whereas blockade of extracellular loops 2/3 prevents receptor binding and ac

72 d mutagenesis, we identified Asp(230) in the extracellular loop-2 as being critical for PAR4 activati

73 residues after the conserved Cys residue in extracellular loop 2b (ECL2b) associated with selective

74 the propensity for the C-terminal segment of extracellular loop 2b to form an extended alpha-helix wa

75 Extracellular loop 3 (and specifically amino acid K305)

76 brane helix 6 (TMH6) and TMH7 at the base of extracellular loop 3 (ECL3) is sufficient to allosterica

77 H/D exchange and modeling also showed that extracellular loop 3 (ECL3) serves as a gatekeeper for t

78 The extracellular loop 3 (EL-3) of SLC4 Na(+)-coupled transp

79 F194 in extracellular loop 2 and R304 in extracellular loop 3 also had minor effects.

80 led to Nb80, including an inward movement of extracellular loop 3 and the cytoplasmic ends of H5 and

81 we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central role in t

82 ptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helic

83 st-binding pocket in which reorganization of extracellular loop 3 and transmembrane helices 6 and 7 m

84 seesaw movement of helix VII and a shift of extracellular loop 3 are likely specific to A(2A)AR and

85 Glu mutation at position 406 (L406E) in the extracellular loop 4 (EL4) of human SERT, which induced

86 were introduced at positions 359 and 448 of extracellular loop 4 and transmembrane helix 10, respect

87 n the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pa

88 tween transmembrane domains 5, 7, and 8, and extracellular loop 4 of GlyT2.

89 binding, conformational changes mediated by extracellular loop 4, and cation-pi interactions.

90 occlusion of the extracellular vestibule by extracellular loop 4.

91 ins 1, 2 and 6, together with translation of extracellular loop 4.

92 extracellular vestibule, interposed between extracellular loops 4 and 6 and transmembrane helices 1,

93 The cork domain and four large extracellular loops (4L) were deleted to obtain an unusu

94 We obtained evidence that the predicted extracellular loop 5 of FadLSm and further alpha-rhizobi

95 In these structures, extracellular loop 6 extends away from the barrel wall a

96 an N-terminal alpha-helix and the conserved extracellular loop 6; these two elements adopt different

97 of altering the structural rearrangements of extracellular loop A.

98 in the hydrophobic groove formed by the two extracellular loops abrogates channel inhibition by carb

99 rate, which harbors mutations in a conserved extracellular loop, accumulates on BamD during assembly,

100 allowed the first high resolution mapping of extracellular loop amino acids critical for NMO-IgG bind

101 phobic pocket at the interface of the second extracellular loop and fifth transmembrane segment of th

102 ith N-terminal residues (binding site-I) and extracellular loop and helical residues (binding site-II

103 ty of the channel, which is supported by the extracellular loop and involves two arginines (R68 and R

104 ) cotransporter NBCe1-A, EL-3 is the largest extracellular loop and is predicted to consist of 82 ami

105 or we found that E172 and E175 in the second extracellular loop and N419 in the third extracellular l

106 rface alters the configuration of the second extracellular loop and partially dissociates a spin-labe

107 study identifies subunit interactions in the extracellular loop and shows that dynamic changes of the

108 odifications of DxxG induce rearrangement of extracellular loops and alter interactions with the N-te

109 s comprise cylindrical beta-sheets with long extracellular loops and create pores to allow passage of

110 charged amino acids in the first and second extracellular loops and found that mutating Glu-361 in t

111 sis of a number of potential partners in the extracellular loops and outer parts of the transmembrane

112 The presence of information flow between the extracellular loops and the intracellular region of the

113 mokine initially forms interactions with the extracellular loops and transmembrane pocket of the rece

114 genesis approach to identify residues in the extracellular loops and transmembrane segments of hERG1

115 hydrophobic cavity of CCR5 under the second extracellular loop, and amino acids critical for their b

116 egree of conformational rearrangement in the extracellular loop, and desensitization was faster from

117 ond extracellular loop and N419 in the third extracellular loop are involved in allosteric binding of

118 Interestingly, most of the extracellular loops are also found to be involved in hom

119 me-scale dynamics measurements show that the extracellular loops are disordered and unstructured.

120 Moreover, our simulations reveal that the extracellular loops are highly dynamic, with spontaneous

121 Extracellular loops are not necessary for generating the

122 uctural and functional study establishes the extracellular loops as important structural motifs for i

123 in, is composed of three immunoglobulin-like extracellular loops as well as a cytoplasmic tail contai

124 es) are predicted in an environment of other extracellular loops being fully flexible and the transme

125 an immunoprecipitation method, we found that extracellular loops between the first and second transme

126 gments of TRPP2 and TRPP3 associate with the extracellular loops between the sixth and seventh transm

127 In contrast, the extracellular loop-binding or class 2 monovalent nanobod

128 E702 and E705 are predicted to be in an extracellular loop, but antigenic epitopes introduced in

129 wn that the ligand is tethered to the second extracellular loop by hydrophobic contacts.

130 ed a group of AQP4 rAbs targeting a distinct extracellular loop C epitope that demonstrated enhanced

131 ivity to neutralizing antibody or CD81 large extracellular loop (CD81-LEL) inhibition, entry factor u

132 hat an ambient-exposed region comprising the extracellular loop connecting TM4-TM5 and ambient-proxim

133 of exon 29 coding for 19 amino acids in the extracellular loop connecting transmembrane domains IVS3

134 these peptides often bind to hyper-variable extracellular loops, creating the potential for subtype

135 ions of our findings on the functions of the extracellular loop cysteines in SR-BI and compare our re

136 ain-of-function Stg carrying mutation in its extracellular loop, demonstrating that both the extracel

137 ansporter PfeA recognises enterobactin using extracellular loops distant from the pore.

138 The second extracellular loop domain (E2) is primarily responsible

139 AR synaptic transmission relies on the first extracellular loop domain and its carboxyl-terminus.

140 N and C termini and a large N-glycosylated, extracellular loop domain.

141 The transmembrane and the extracellular loop domains are highly conserved among di

142 There are three extracellular loop domains, and among them, the second l

143 Claudins contain two extracellular loop domains, with the second loop (ECL-2)

144 and PPADS was conferred by the nature of the extracellular loop (e.g. nanomolar for NF449 at P2X1 and

145 barrier is formed by a segment of the first extracellular loop (E1) (the parahelix) and appears to b

146 e EC2 orientation in CD53 is supported by an extracellular loop (EC1).

147 arated pairs of helices, capped by the large extracellular loop (EC2) at the outer membrane leaflet.

148 onal antibodies (MAbs) and recombinant large extracellular loop (EC2) proteins to pretreat cells befo

149 duced into the conserved motif in the second extracellular loop (ECII) of EP3, resulting in acquisiti

150 op model by showing that the putative fourth extracellular loop (ECL 4) is intracellular and may cont

151 To assess involvement of the extracellular loop (ECL) 2 in ligand-receptor interactio

152 alanine-scanning mutagenesis, a key role for extracellular loop (ECL) 2 of the receptor in propagatin

153 In D(2)R(spi), the conformation of the extracellular loop (ECL) 2, which composes the ligand-bi

154 ating cysteines in every position along each extracellular loop (ECL) and adjacent parts of transmemb

155 L11 depends on the ACKR3 N terminus and some extracellular loop (ECL) positions for primary binding,

156 ridge between transmembrane (TM) helix 3 and extracellular loop (ECL)-2, chemokine receptors (CCR) co

157 eric receptors was created by exchanging the extracellular loops (ECL) of human NHE1 (huNHE1) and chN

158 rging helix, a Cys-Cys-bridge-linked IA, and extracellular loops (ECL).

159 embrane helices H1, H2 and H7, and the first extracellular loop ECL1.

160 The first extracellular loop (ECL1) of claudins forms paracellular

161 The topology of the second extracellular loop (ECL2) and its interaction with ligan

162 actions with residues Tyr-179, in the second extracellular loop (ECL2) and Trp-400(7.35) in transmemb

163 in transmembrane helix (TM) 2 and the second extracellular loop (ECL2) discriminated between the diff

164 the importance of its N terminus and second extracellular loop (ECL2) in binding gp120 and mediating

165 The second extracellular loop (ECL2) is a functionally important re

166 ngens enterotoxin (cCPE) binds to the second extracellular loop (ECL2) of a subset of claudins, e.g.

167 s an epitope in the N terminus of the second extracellular loop (ECL2) of beta2AR.

168 ined the effects of low pH and of the second extracellular loop (ECL2) of CD81, one of the four entry

169 nine-scanning mutagenesis of the A1AR second extracellular loop (ECL2) with radioligand binding and f

170 2 (TMII), Tyr-179 and Phe-182 in the second extracellular loop (ECL2), and Glu-397(7.32) and Trp-400

171 accurately restore the extremely long second extracellular loop (ECL2), which is also key for GPCR li

172 n the N-terminal (Nt) segment and the second extracellular loop (ECLII) of NK1.

173 ons formed between secretin and the receptor extracellular loops (ECLs) and TM helices.

174 between the open inward-facing (NBDs apart, extracellular loops (ECLs) close together) and the close

175 monoclonal antibodies to assess the roles of extracellular loops (ECLs) in LptD, an essential OMP tha

176 The extracellular loops (ECLs) showed reduced deuterium upta

177 in and in every position within the receptor extracellular loops (ECLs).

178 or receptors have also been described [e.g., extracellular loop (EL) 3 in the A(2A) adenosine recepto

179 TM6, Ala419 in the interface between TM8 and extracellular loop (EL) 4, and Leu481 in EL5.

180 nsmembrane helices (TMs) 1a and 7 as well as extracellular loops (ELs) 2 and 4.

181 ted lower affinity interaction involving the extracellular loops (ELs).

182 The first extracellular loop exhibits a beta-hairpin conformation

183 ancers bind to a pocket formed by the second extracellular loop, flanked by residues S150 and M162.

184 Extracellular loops followed a well defined path through

185 studies suggest that the stalk and the first extracellular loop have critical roles in modulating pep

186 eas the small molecule compound 43 activated extracellular loop I with downstream signaling dependent

187 loid A non-genomic responses were reliant on extracellular loops I and II, whereas the small molecule

188 Sequence alignments of the second extracellular loop identified single negatively charged

189 cells) to identify the N-terminal region and extracellular loop II as the FPR2/ALX domain required fo

190 rst transmembrane (TM) segment and the first extracellular loop in sensing zinc.

191 caution against excluding the N terminus and extracellular loops in structural studies of this 7 tran

192 ial role of these functionally underexplored extracellular loops in the assembly and function of the

193 al role of arginine(172), located in the 2nd extracellular loop, in the action of decanoic acid but n

194 Various positions in the first extracellular loop, in the fifth, seventh, eighth, ninth

195 correct position of the cap relative to the extracellular loops is also required for optimal photoch

196 with 13 additional amino acids in the first extracellular loop, is also expressed but its function i

197 Previous structures have failed to resolve extracellular loops, known in the TRPV subfamily as 'por

198 ed beta-barrel with a constriction formed by extracellular loops L2 and L3.

199 This site is located in the extracellular loop L3, showing that it is highly accessi

200 e of surface exposure of the conserved sixth extracellular loop (L6).

201 Protein fragments corresponding to the large extracellular loop (LEL) of each TSP were produced in re

202 Their rod-shaped structure includes a large extracellular loop (LEL) that plays a pivotal role in te

203 wer affinity for LqhII, indicating that this extracellular loop may form a secondary component of the

204 etion mutant (DeltagraS strain), a nonameric extracellular loop mutant (DeltaEL strain), and four res

205 teral frontoparietal polymicrogyria-inducing extracellular loop mutations (R565W and L640R) in the co

206 Hence, the C-terminal part of the first extracellular loop not only determines VRAC inactivation

207 green fluorescent protein is inserted in an extracellular loop of a voltage-sensing domain, renderin

208 cterize conformational changes in the second extracellular loop of BtuB upon ligand binding and compa

209 By stabilizing the first extracellular loop of CaV1.2, CaValpha2delta1 may up-reg

210 ne residues predicted to reside on the first extracellular loop of CD133.

211 monoclonal antibody that binds to the small extracellular loop of CD20 and has greater in vitro comp

212 amino acid residues of TIMP-1 and the large extracellular loop of CD63 are required for their intera

213 rst structural characterization of the large extracellular loop of CD81, expressed in mammalian cells

214 t to the exposed HCV interaction site in the extracellular loop of CD81.

215 e findings demonstrate the importance of the extracellular loop of CD98 in the innate host defense re

216 t E1E2 complexes can interact with the first extracellular loop of Claudin-1, whereas soluble E2 did

217 In addition, residues in the extracellular loop of CNIH-2/3 absent in CNIH-1/4 are cr

218 Chimeragenesis demonstrates that the first extracellular loop of Cx36 contains a Mg(2+)-sensitive d

219 Direct binding of CHL1-Fc to the first extracellular loop of DRD2 was shown by ELISA.

220 C by binding to glycosylated residues in the extracellular loop of ENaC-alpha, as well as to a hither

221 his interaction was likely through the large extracellular loop of FtsX(Spn) and the amino terminal c

222 stabilized lipids, and demonstrates that the extracellular loop of gamma8 modulates gating by selecti

223 ed motif, C165-E166-S167-F168, at the second extracellular loop of GPR81.

224 We also demonstrated that the partial extracellular loop of hCD98 was sufficient for direct bi

225 e residues experimentally introduced into an extracellular loop of hERG1a and hERG1b subunits and pro

226 These antibodies bound to the first extracellular loop of KIR4.1.

227 cific interaction, LptE contacts a predicted extracellular loop of LptD through the lumen of the beta

228 Introduction of the HA tag into the second extracellular loop of mouse DAT did not perturb its expr

229 causes significant structural changes in the extracellular loop of p22(phox) and reduces its interact

230 ne-aspartic acid (RGD) sequence in the first extracellular loop of P2Y2R.

231 hat are predicted to contribute to the first extracellular loop of Patched2.

232 After mutagenizing the predicted extracellular loop of SaeS, we discovered one methionine

233 opulation causes an R154Q substitution in an extracellular loop of SLC44A2 that is protective against

234 Autoantibodies directed against the second extracellular loop of the cardiac beta1-adrenergic recep

235 sis, we identified a cleft region within the extracellular loop of the delta-subunit that contains se

236 resulting p.Glu391Lys variation in the last extracellular loop of the equilibrative nucleoside trans

237 th a peptide sequence derived from the third extracellular loop of the first domain of NaV1.5.

238 s simultaneously at defined positions in the extracellular loop of the human P2X1 receptor during not

239 lso demonstrate that lysine 523 in the third extracellular loop of the M(3) receptors forms a hydroge

240 e ECD involves an interaction with the third extracellular loop of the receptor and suggest that gluc

241 n 2 probe labeled a residue within the first extracellular loop of the receptor, a region not previou

242 , we designed peptides inspired by the first extracellular loop of the TJ transmembrane protein CLDN1

243 We detected a T352P mutation in the third extracellular loop of the voltage-gated potassium channe

244 pan14 constructs demonstrated that the large extracellular loop of Tspan14 mediated its co-immunoprec

245 activity of ENaC depends on cleavage of the extracellular loops of alpha and gamma subunits.

246 The extracellular loops of bacterial outer membrane (OM) tra

247 esonance to examine the conformations of the extracellular loops of BtuB, the Escherichia coli TonB-d

248 onstructed knock-in mice in which the second extracellular loops of CD81 and OCLN were replaced with

249 have been identified in the S1-S2 and S3-S4 extracellular loops of domain II.

250 The extracellular loops of domain III are also involved in t

251 eal that disease-associated mutations to the extracellular loops of G1 differentially alter receptor

252 engineered antibodies or nanobodies against extracellular loops of ion channels.

253 Concomitant sequence-based analysis of the extracellular loops of Na(v)s suggests that alpha-toxins

254 The size and dynamics of the extracellular loops of Opa60 required a hybrid refinemen

255 The structure and dynamics of the extracellular loops of OprH show distinct behaviors in d

256 ral analysis in a membrane revealed that all extracellular loops of rhomboid make stabilizing interac

257 iple interactions between GluA2 and variable extracellular loops of TARPs.

258 pe III domains of L1 and the first and third extracellular loops of the ANT proteins.

259 racellular domain of CaValpha2delta1 and the extracellular loops of the CaValpha1 protein in repeats

260 The cleavage of the extracellular loops of the epithelial sodium channel (EN

261 mprehensive mutational analysis of the three extracellular loops of the M23 isoform of human AQP4 usi

262 bled by conformational rearrangements of the extracellular loops of the protein.

263 een the cysteine-rich domains and the second extracellular loops of the receptor enable the rigid-bod

264 pocket is occluded by the amino terminus and extracellular loops of the receptor.

265 against chimeric channels, we identified the extracellular loops of the TRPA1 S1-S4 gating domain as

266 s that negatively charged amino acids in the extracellular loops of TRPML3 may interfere with the obs

267 Mutation of CopA extracellular loops or the electropositive surface of Cu

268 3)AR affinity by polar interactions with the extracellular loops, predicted using docking and molecul

269 intramembranous pocket as well as the second extracellular loop region (ECL2).

270 eptide (E-pore peptide) corresponding to the extracellular loop region connecting the S5 and S6 segme

271 , was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, tw

272 an additional unique segment in the CNIH-2/3 extracellular loop required for both physical interactio

273 electrostatic interaction between the third extracellular loop residue Lys-373 and D2.63(176).

274 We mutated extracellular loop residues hypothesized to compromise H

275 C requires precedent binding to glycosylated extracellular loop(s).

276 Based upon the conserved transmembrane and extracellular loop segments, our focus was on identifyin

277 als an unusually complex arrangement of long extracellular loops stabilized by four disulphide bonds.

278 solely in the length and composition of the extracellular loop that connects S4 to S3.

279 69 sterically blocks movements of the second extracellular loop that have been linked to receptor act

280 drogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to

281 ine-containing motif ((398)HTH) in the first extracellular loop that is required for high sensitivity

282 ) and M(3) receptors in the second and third extracellular loops that are involved in the binding of

283 he separate engineering of each of the seven extracellular loops that control access to the pore.

284 ing of ferredoxin occurs through specialized extracellular loops that form extensive interactions wit

285 ized structural latch spanning the first two extracellular loops that is highly conserved across Clas

286 beta-barrel outer membrane protein with four extracellular loops that mediates cell binding and resis

287 Following the deletion of each of the four extracellular loops that potentially interact with host

288 rs, but it has substantial rearrangements in extracellular loop three and the extracellular tip of tr

289 demonstrate that Y. pestis Ail uses multiple extracellular loops to interact with substrates importan

290 at the oligosaccharides of LPS stabilize the extracellular loops to some degree, apparently obviating

291 f the substrate, which ultimately becomes an extracellular loop, to the lumen of the forming beta-bar

292 The CASP first extracellular loop was found conserved in euphyllophytes

293 to localize correctly when either one of the extracellular loops was deleted.

294 containing a hemagglutinin tag in the second extracellular loop, we developed an assay to detect tran

295 The resulting ensemble revealed that the extracellular loops, which bind host receptors, occupy c

296 omains that constitute the pore, and a large extracellular loop with defined domains termed the finge

297 four times and has one intracellular and two extracellular loops with the amino and carboxyl termini

298 ved N-linked glycosylation site in the first extracellular loop, with complex glycosylation in COS-7

299 subsequent catalytic steps by, motions of an extracellular loop, with local contributions from active

300 ion of beta-barrel proteins is burial of the extracellular loops within the forming beta-barrel.