ライフサイエンスコーパス: extracellular space

1 30-100nm in diameter) secreted by cells into extracellular space.

2 inflammatory activity upon release into the extracellular space.

3 of synaptically-released glutamate from the extracellular space.

4 increasing the diffusion of dopamine in the extracellular space.

5 in reduces the release of proteasomes in the extracellular space.

6 pendent uptake of neurotransmitters from the extracellular space.

7 ules is greater than diffusional loss to the extracellular space.

8 VLVs are produced and are released into the extracellular space.

9 ellular compartments and are released in the extracellular space.

10 s and facilitates import of the ion from the extracellular space.

11 e endoplasmic reticulum, the cytosol and the extracellular space.

12 of incorporated C3(H2O) was returned to the extracellular space.

13 osine nucleotide/nucleoside release into the extracellular space.

14 hat acidifies subcellular organelles and the extracellular space.

15 E cells, rather than being extruded into the extracellular space.

16 cell surface and releasing material into the extracellular space.

17 and deposition of EMILIN-1 and -2 within the extracellular space.

18 he cytoplasm and subsequent release into the extracellular space.

19 to maintain intracellular pH, acidifying the extracellular space.

20 tosis releases intracellular bacteria to the extracellular space.

21 clusions and their subsequent release to the extracellular space.

22 xcitability by controlling the volume of the extracellular space.

23 t its ATPase activity is not required in the extracellular space.

24 r than the extended diffusion throughout the extracellular space.

25 y Ca(2+), which is then extruded back to the extracellular space.

26 once it is released into the poorly perfused extracellular space.

27 s also secreted and modifies collagen in the extracellular space.

28 ain cells due to the entry of water from the extracellular space.

29 lular membrane to liberate exosomes into the extracellular space.

30 ls use motile cilia to generate force in the extracellular space.

31 chanism by which tau can transfer is via the extracellular space.

32 , a maximum of 10% may be extracted from the extracellular space.

33 sociated histones that are extruded into the extracellular space.

34 ma membrane and causing acidification of the extracellular space.

35 n during its simultaneous extrusion into the extracellular space.

36 y alter the concentrations of solutes in the extracellular space.

37 ccumulation of water-paralleled Na(+) in the extracellular space.

38 a negligible ambient glutamate level in the extracellular space.

39 are small vesicles released from cells into extracellular space.

40 s that allow metalloprotease cleavage in the extracellular space.

41 S proteins have never been identified in the extracellular space.

42 e question of the role of these sRNAs in the extracellular space.

43 ng protein during collagen maturation in the extracellular space.

44 make use of a similar mechanism to reach the extracellular space.

45 ssue distortion including a reduction in the extracellular space.

46 l accumulation of Eu-HPDO3A in the increased extracellular space.

47 tein isoform (sGP) that is secreted into the extracellular space.

48 various compartments of the cell or from the extracellular space.

49 s and causes prolonged ATP release into the extracellular space.

50 , but extending more than 30 microm into the extracellular space.

51 sition and identifying those secreted in the extracellular space.

52 hat are surrounded by large, open regions of extracellular space.

53 plasma membrane and is not uploaded from the extracellular space.

54 sense and respond to neuromodulators in the extracellular space.

55 minutes after calcein-AM is removed from the extracellular space.

56 aluronan (HA) directly into cell surface and extracellular space.

57 asma membrane and deliver their cargo to the extracellular space.

58 by mediating reuptake of serotonin from the extracellular space.

59 cilium that projects from the soma into the extracellular space.

60 of alpha-synuclein and growth factors in the extracellular space.

61 by deposition of various protein fibrills in extracellular space.

62 vation fragments C3a and C3b confined to the extracellular space.

63 onto higher redox potential acceptors in the extracellular space.

64 n reaching the neutral-pH environment of the extracellular space.

65 -to-cell communication and remodeling of the extracellular space.

66 s the release of protein aggregates into the extracellular space.

67 interior due to fluid phase uptake from the extracellular space.

68 nexons) of apposed cells dock head-on in the extracellular space.

69 esult of decreased ambient GABA level in the extracellular space.

70 ains unclear; only a minority comes from the extracellular space.

71 ne with the N-terminal LRR domain facing the extracellular space.

72 ction between the lumen of a vesicle and the extracellular space.

73 at fused to invaginations with access to the extracellular space.

74 and regulate growth factor signaling in the extracellular space.

75 s, with its accumulation most intense in the extracellular space.

76 , acts as an energy storage and donor in the extracellular space.

77 lly rupture, releasing their contents to the extracellular space.

78 hils, but a large portion may also enter the extracellular space.

79 elease of their intraluminal vesicles in the extracellular space.

80 n via reuptake of dopamine released into the extracellular space.

81 le, drives lower exosome levels in the brain extracellular space.

82 dence that Fpn can export Mn from cells into extracellular space.

83 lting in release of viable S aureus into the extracellular space.

84 pass a variety of vesicles secreted into the extracellular space.

85 invade plant tissues and proliferate in the extracellular space.

86 of oxygen with high resolution in the brain extracellular space.

87 protease-2 (MMP-2) and MMP-9 activity in the extracellular space.

88 omas and it exists in both intracellular and extracellular spaces.

89 permeation in the context of such restricted extracellular spaces.

90 this: (1) the presence of melanocores in the extracellular space; (2) within keratinocytes, melanin w

91 een placed on limiting Ca(2+) entry from the extracellular space across cell membranes, and emphasize

92 tic transmitters need to be cleared from the extracellular space after release, and transporters are

93 A moves Na(+) ions from the cytoplasm to the extracellular space against their gradient by utilizing

94 ing synaptically released glutamate from the extracellular space, allowing repeated rounds of signall

95 passenger domain") that is secreted into the extracellular space and a C-terminal beta-barrel domain

96 esmosomal remodeling, seen as an increase in extracellular space and a loss of the desmosomal interce

97 the amino and carboxyl termini reside in the extracellular space and are initially linked by two tran

98 MPs function in tissue remodeling within the extracellular space and are therefore involved in many h

99 denosine triphosphate (ATP) is released into extracellular space and contributes to purinergic chemot

100 The other pool is released into the extracellular space and contributes to the propagation o

101 and C-terminus of the protein located at the extracellular space and cytosol, respectively.

102 cytoplasmic structures were secreted to the extracellular space and endocytosed by neighboring cells

103 In vivo, amyloid deposits are found in the extracellular space and involve a variety of accessory m

104 plasmic membrane material protrudes into the extracellular space and is released as MVs.

105 These analyses demonstrate the importance of extracellular space and lipid metabolism in atopic skin

106 -regulated genes known to have impact in the extracellular space and on the supporting stroma and wit

107 -soluble proteins that are secreted into the extracellular space and presented in the context of MHC

108 P binding opens the transport pathway to the extracellular space and reconfigures the substrate-bindi

109 orting cells that dramatically increased the extracellular space and speed of K(+) redistribution.

110 Given that p-tau can be released to the extracellular space and that the astroglial water transp

111 chanisms: the diffusion of morphogen through extracellular space and the direct transport of morphoge

112 nt trafficking of lysosomal proteases to the extracellular space and the nucleus.

113 ulating ion mobility, the volume fraction of extracellular space and the viscosity of matrix componen

114 In the first case, virions exit into the extracellular space and then infect another cell from th

115 osed of Connexin (Cx) hexamers paired across extracellular space and typically form large rafts of cl

116 nt promising reagents for imaging ATP in the extracellular space and within cells during a variety of

117 Aberrant remodeling of the extracellular space and/or defects in properly respondin

118 lular tissue structures (vacuole, cytoplasm, extracellular spaces and cell wall) was investigated by

119 res occur in both physiologic and pathologic extracellular spaces and often involve interactions betw

120 Gene ontology terms for "extracellular space" and "defense response" were enriche

121 m (ER) and mitochondria, (ii) the ER and the extracellular space, and (iii) the ER and cytoplasmic Ca

122 nt (100 kDa, s100), which is released in the extracellular space, and a residual C-terminal part (130

123 ionic polysaccharides, are ubiquitous in the extracellular space, and important extrinsic regulators

124 iation with serum albumin in circulatory and extracellular spaces, and association with intracellular

125 The extracellular space (apoplast) of plant tissue represent

126 on of Hyal1 and concurrent reuptake from the extracellular space are critical for rapid HA internaliz

127 r mechanisms regulating tau release into the extracellular space are not well understood.

128 Determining the electrical properties of the extracellular space around neurons is important for unde

129 We identify the extracellular space as an important compartment for mali

130 culating miRNAs using the gene ontology term extracellular space as part of blood plasma.

131 lactate followed by lactate release into the extracellular space, as detected by a lactate-sniffer.

132 umulation in AD, tau is also released in the extracellular space, as revealed by its increased presen

133 s a balance between Fickian diffusion in the extracellular spaces at the brain surface and convective

134 In the extracellular space between photoreceptors, Muller glial

135 ectric field inside cells, and in the narrow extracellular spaces between cells in the lens.

136 tivation and function is not confined to the extracellular space but also occurs within cells.

137 rich N-terminal domain is not exposed to the extracellular space but is localized intracellularly, an

138 ctivates EGFR only when it is present in the extracellular space, but that PEPD is released from inju

139 measurements also allow for an estimation of extracellular space by calculation of extracellular volu

140 ere metabolites are removed from the brain's extracellular space by convective exchange between inter

141 CKB is released into the extracellular space by metastatic cells encountering hep

142 ed by various cell types and degraded in the extracellular space by secreted adenosine deaminase.

143 ncreases the persistence of glutamate in the extracellular space by slowing its clearance by astrocyt

144 leavable to mature bioactive IL-1beta in the extracellular space by the protease caspase-1.

145 properties that allow them to survive in the extracellular space, bypass biological barriers and deli

146 ls to starve intracellular pathogens; in the extracellular space, calprotectin chelates Mn and Zn.

147 aracteristics and cellular biomarkers of the extracellular space can provide significant information

148 The transport of calcium to the extracellular space carried out by plasma membrane Ca(2+

149 he finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2

150 d access to the LPA1 binding pocket from the extracellular space contrasting with the proposed access

151 axonal cytoskeletal protein tau in the brain extracellular space correlated well with diffusion tenso

152 ) four structural parameters: fibre numbers, extracellular spaces, cross section area, and connective

153 As well as preserving a physiological extracellular space, cryo fixation reveals larger number

154 OLZ was then exocytosed to the extracellular space due to a high calcium ion (Ca(2+)) c

155 fraction decrease could reflect expansion of extracellular space due to tissue loss, intracellular so

156 nery to export electrons from the cytosol to extracellular space during extracellular respiration.

157 causing non-vesicular GABA release into the extracellular space during intense network activity.

158 hway to rapidly recover Ca(2+) ions from the extracellular space during repetitive muscle activity.

159 heir ability to recapture glutamate from the extracellular space, EAATs exhibit a sodium- and glutama

160 FICANCE STATEMENT The volume fraction of the extracellular space (ECS alpha), that portion of CNS tis

161 We explored preserving extracellular space (ECS) during chemical tissue fixatio

162 Extracellular space (ECS) is a major channel transportin

163 IgG diffusion within brain extracellular space (ECS) may also play a role in limiti

164 The extracellular space (ECS) plays an important role in the

165 re greatly and significantly enriched in the extracellular space (even in non-mammary cell lines), wh

166 yte edema secondary to vacuolization without extracellular space expansion.

167 sites that influence neurotransmission: the extracellular space, fine astrocytic processes, and neur

168 cultures to different flow conditions in the extracellular space (for example, expression of atherosc

169 ase chromatin and granular proteins into the extracellular space, forming DNA traps.

170 etween blood plasma and tissue extravascular extracellular space, fractional volume of the extracellu

171 acts as an effective DAMP when released into extracellular space from damaged cells.

172 irst differentiated membranes exposed to the extracellular space from intracellular membranes; the se

173 lasmalemmal monoamine transporters clear the extracellular space from their cognate substrates and su

174 at is able to separate changes affecting the extracellular space from those that reflect changes in n

175 n also release transmitter directly into the extracellular space, from 'ectopic' release sites.

176 superoxide produced within cells and in the extracellular space, generating peroxynitrite.

177 Chloride is the major free anion in the extracellular space (>100 mM) and within the cytoplasm i

178 AAT expression, glutamate clearance from the extracellular space has been thought to have invariant k

179 that allows recovery of Ca(2+) ions from the extracellular space, has been proposed to limit fatigue

180 With release into the extracellular space, hCP encounters elevated Ca(2+) conc

181 ached to the cell surface and exposed to the extracellular space, hereafter called membrane-associate

182 The reservoir was released to the extracellular space immediately after exposure of astroc

183 red the coordinated release of zinc into the extracellular space in a prominent "zinc spark." The abi

184 agments of the protein are released into the extracellular space in active form.

185 ion translocation between intracellular and extracellular space in association with recurrent transi

186 H2 co-localized with collagen fibrils in the extracellular space in human lung cancer specimens and i

187 urfaceome, is the interface for engaging the extracellular space in normal and cancer cells.

188 microglia continuously scan the surrounding extracellular space in order to respond to damage or inf

189 r organelles in all eukaryotic cells and the extracellular space in some tissues.

190 ignal-to-noise ratios, assumptions regarding extracellular space in the brain, and estimates of heat

191 to the cell surface and its release into the extracellular space in the form of exosomes.

192 Although the extracellular space in the neuropil of the brain is an i

193 tical model of ion movement in the intra and extracellular space in the presence of ionic, potential

194 RNA emphasizes the implication of the plant extracellular space in viral infection.

195 g eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs.

196 dominantly on the plasma membrane/within the extracellular space/in or on astrocytes.

197 distinct Y RNA fragments are abundant in the extracellular space, including in biofluids.

198 microdomains, and probe the complex neuronal-extracellular space interactions that regulate neural ex

199 Fluorescently labeled dsRNA is imported from extracellular space into oocytes along with yolk and acc

200 The extracellular space is an exciting area for research tha

201 by which morphogens are proposed to traverse extracellular space is by traveling along specialized fi

202 In contrast, their function in the extracellular space is different.

203 l imaging illustrated that Zn(2+) entry from extracellular space is essential for translocation of MG

204 by diffusion of unbleached dextran from the extracellular space is monitored.

205 The effect of spreading depression on extracellular space is much larger than previously estim

206 Activation of MMP gelatinase in the extracellular space is necessary for and potentiates cue

207 of astrocytes in releasing lactate into the extracellular space is not affected by MeCP2 deficiency,

208 ogical significance of miRNAs present in the extracellular space is not currently well understood.

209 metazoan chaperone whose secretion into the extracellular space is regulated by the UPR, revealing a

210 et al. has claimed that the impedance of the extracellular space is some three orders of magnitude gr

211 Brain extracellular space is the narrow microenvironment that

212 The release of nucleotides into extracellular space is triggered by insults like woundin

213 phobic lipoprotein can spread in the aqueous extracellular space is unknown.

214 he increased persistence of glutamate in the extracellular space, is reflected by increased decay tim

215 GAPDH protofibrils could be assembled in the extracellular space kidnapping alpha-synuclein toxic oli

216 ysin and ATP interact with each other in the extracellular space leading to reduced neutrophil activa

217 stribution of phosphatidylserine (PS) to the extracellular space, leading to a disruption of plasma m

218 r resorption by supporting cells reduced the extracellular space, leading to K(+) accumulation.

219 e imaging (MRI) as passive intravascular and extracellular space markers.

220 rnalization and/or micro-vesicle loss to the extracellular space may also contribute.

221 dicate that activity-dependent regulation of extracellular space may contribute to visual processing

222 ii) transport of dextrans in the parenchymal extracellular space, measured by 2-photon fluorescence r

223 nitially uniform polysaccharide layer in the extracellular space, mechanically coupled to the cell me

224 and loss of water from vacuole and cytoplasm/extracellular space, more pronounced in cut and blanched

225 ier radiotracer methods, have shown that the extracellular space occupies approximately 20% of brain

226 accumulation of product in the much greater extracellular space of fermentors.

227 iral replication complexes, localized in the extracellular space of infected Nicotiana benthamiana le

228 tracellular concentrations of solutes in the extracellular space of mammalian tissue, e.g., brain.

229 ysteamine, homocysteine, and cysteine in the extracellular space of OHSCs are 10.6 +/- 1.0 nM (n = 70

230 lism of cystamine, pantethine and CoA in the extracellular space of organotypic hippocampal slice cul

231 However, it is also found in the extracellular space of the brain at appreciable concentr

232 rm for multisite O2 recording in vivo in the extracellular space of the brain, demonstrated in anaest

233 Despite GABA being present throughout the extracellular space of the brain, previous work has show

234 2D patients IAPP is found aggregating in the extracellular space of the islets of Langerhans.

235 Vmax and Km for an enzymatic reaction in the extracellular space of the tissue.

236 higher EV levels were observed in the brain extracellular space of transgenic mice expressing human

237 tin within and between the intracellular and extracellular spaces of a tumor, as well as clearance of

238 oxyproline-rich glycoproteins present in the extracellular spaces of plant cells.

239 kidney, epithelia in general, and the narrow extracellular spaces of the central nervous system, the

240 dy effects of oscillatory convective flow in extracellular space on the velocity of chemical signal p

241 lasmic Zn balance by exporting Zn out to the extracellular space or by sequestering cytoplasmic Zn in

242 er large molecules out of the cytosol to the extracellular space or even across membranes of neighbor

243 IDUA can be released directly into extracellular space or within microparticles during mega

244 SLC4A4 is involved in brain extracellular space pH regulation.

245 ventually rupture, releasing material to the extracellular space prior to catastrophic axon degenerat

246 nd escape of the cytosolic bacteria into the extracellular space, providing a potential mechanism of

247 of the formation and release of ROL into the extracellular space quantitatively describes this novel

248 es are segregated for their release into the extracellular space remains a challenge.

249 Most proteins destined for the extracellular space require disulfide bonds for folding

250 nic drift and diffusion within the intra and extracellular space, respectively, which contributed to

251 ntents through the glial syncytia and to the extracellular space, respectively.

252 accounted for resistive heterogeneity in the extracellular space showed similar HS distributions to t

253 vestigate the effects of modulating multiple extracellular spaces, specifically the intercellular cle

254 ons suggest that these local enlargements in extracellular space speed transmitter clearance and redu

255 Nucleotides released to the extracellular space stimulate purinergic receptors, and

256 creted ERdj3 binds misfolded proteins in the extracellular space, substoichiometrically inhibits prot

257 phenotypes uncommon for glycoproteins in the extracellular space, such as a high abundance of phospho

258 ses when levels of glutamate are high in the extracellular space, such as following demyelination.

259 r glycoproteins with unique functions in the extracellular space, such as modulation of pro-transform

260 on are examined in other tissues with narrow extracellular spaces, such as cardiac and skeletal muscl

261 eater proportion of intracellular water into extracellular spaces than US.

262 tant for protein-protein interactions in the extracellular space that are instrumental in cell adhesi

263 n control of protein distribution within the extracellular space that serves to regulate the protein-

264 In the EMI model, the extracellular space, the cell membrane, the intracellula

265 Further, tau protein transference via the extracellular space, the compartment that is cleared by

266 Although continuous with the extracellular space, the narrow lumen and the tortuous s

267 on pore as initial aqueous connection to the extracellular space, through which small transmitter mol

268 fate groups from heparan sulfate (HS) in the extracellular space, thus eliminating docking sites for

269 t neurons and release of seeded tau into the extracellular space to complete the cycle.

270 hallenging to localize existing GEZIs to the extracellular space to detect secreted Zn(2+).

271 tents <=10 kDa between the intracellular and extracellular space to drive death receptor 6 and calpai

272 Both routes deliver AGs from the extracellular space to lysosomes, and structural differe

273 lly rupture, releasing their contents to the extracellular space to promote degeneration.

274 ly participating in their transport from the extracellular space to the photoreceptors.

275 ms a unidirectional transit pathway from the extracellular space to the venous system.

276 bosis, particularly when accumulating in the extracellular space under tissue-damaging or pathologica

277 phages remove modified lipoproteins from the extracellular space until the cholesterol overload leads

278 mpts to reveal the size and structure of the extracellular space using electron microscopy have had l

279 egates and their subsequent release into the extracellular space via exosomes.

280 ng the release of intracellular ATP into the extracellular space via regulation of as-yet unidentifie

281 arenchyma and subsequently secreted into the extracellular space via SWEET9, where sucrose is hydroly

282 hannel GOF isolated heart model and modulate extracellular spaces via osmotic agents.

283 reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractional plasma volum

284 For a long time, protein transport into the extracellular space was believed to strictly depend on s

285 The presence of TuMV proteins in the extracellular space was confirmed by proteomic analysis

286 oefficient from blood to brain extravascular extracellular space) when comparing the FUS-sonicated br

287 ffinity transition metal ion chelator in the extracellular space where it inhibits microbial growth.

288 seases leads to redistribution of MPO to the extracellular space, where it can mediate tissue damage

289 compartments, including the nucleus and the extracellular space, where the normal WT enzymes also ap

290 Cells release adenine nucleotides into the extracellular space, where these mediators are converted

291 er pyroptosis, ASC specks accumulated in the extracellular space, where they promoted further maturat

292 ted in decreased secretion of alpha-syn into extracellular space, whereas overexpressed PARK9 promote

293 tion, lysosomal enzymes are missorted to the extracellular space, which results in lysosomal dysfunct

294 umulation or depletion, respectively, in the extracellular space, which we attributed to a residual c

295 itate the transport of molecules through the extracellular space while also regulating interstitial h

296 olesterylated HH ligand is secreted into the extracellular space with help of the Dispatched-1 (DISP1

297 control over the chemical composition of the extracellular space with high spatiotemporal resolution.

298 s acts to clear this harmful enzyme from the extracellular space, with lysosomal-delivered MPO exhibi

299 nuously produce and release protons into the extracellular space, with the rate of acid production co

300 Macrophages are motile cells that roam the extracellular spaces within organs or the body cavity an