ライフサイエンスコーパス: extrahepatic

1 the site of insulin action to control EGP is extrahepatic.

2 ography in the detection and localization of extrahepatic (99m)Tc-MAA and to evaluate the typical and

3 All images were reviewed for hepatic and extrahepatic (99m)Tc-MAA deposition and compared with th

4 estimate the liver-to-lung shunt and exclude extrahepatic (99m)Tc-MAA deposition.

5 The extrahepatic activity was measured as the sum of all vox

6 on, new hepatic lesions) progression or (ii) extrahepatic (adrenal/bone/lung/lymph node) metastases.

7 craving and physical dependence, as well as extrahepatic alcohol-related diseases merge with the com

8 IVKA-II) were measured, inversely related to extrahepatic and hepatic vitamin K status, respectively.

9 holangiopathy that culminates in fibrosis of extrahepatic and intrahepatic bile ducts.

10 flammatory disorder of infants involving the extrahepatic and intrahepatic biliary tree.

11 ells, are found in peribiliary glands within extrahepatic and large intrahepatic bile ducts.

12 Here, we identify extrahepatic arginase-1(+) Id2(+) fetal ILC precursors t

13 median age 58 years; median AMA titer 1:160; extrahepatic autoimmune disorders 46%; normal serum alka

14 HCV) infection is frequently associated with extrahepatic autoimmune disorders while interferon (IFN)

15 ortant to continue to assess the hepatic and extrahepatic benefits of a DAA-induced sustained virolog

16 higher: 100% for gallbladder cancer, 97% of extrahepatic bile duct cancer, 91% of ampula of Vater ca

17 ary atresia is a neonatal liver disease with extrahepatic bile duct obstruction and progressive liver

18 ered or partially covered) for palliation of extrahepatic bile duct obstruction initially is more exp

19 doscopic stents are placed for palliation of extrahepatic bile duct obstruction.

20 ed by lymphadenectomy (67%) and sometimes by extrahepatic bile duct resection (23%).

21 Extrahepatic bile duct resection with hepaticoenterostom

22 gs, spleen, liver, lymph nodes, pancreas and extrahepatic bile duct with potential for recurrence and

23 ls residing in the submucosal compartment of extrahepatic bile ducts (EHBDs).

24 f cancers that arise in either the intra- or extrahepatic bile ducts or the gallbladder.

25 progressive fibroinflammatory obstruction of extrahepatic bile ducts that presents as neonatal choles

26 The density of lesions along extrahepatic bile ducts were measured and compared with

27 d cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to bil

28 flammation and fibrosis of the intra- and/or extrahepatic bile ducts.

29 Sar among blood, hepatocytes, and intra- and extrahepatic bile ducts.

30 sulting in dramatic and rapid enlargement of extrahepatic bile ducts.

31 pithelial malignant neoplasm of the liver or extrahepatic bile ducts.

32 ibro-obliteration of the intrahepatic and/or extrahepatic bile ducts.

33 en benign and malign lesions in intraluminal extrahepatic bile ducts.

34 Extrahepatic biliary atresia (BA) is a pediatric liver d

35 h affect these loops and are associated with extrahepatic biliary atresia, lead to a loss of membrane

36 ers, suggesting roles for Hippo signaling in extrahepatic biliary carcinomas.

37 ology and expansion of both intrahepatic and extrahepatic biliary cells, and ultimately larval lethal

38 months; P < 0.0001), as was the presence of extrahepatic biliary disease (HR = 1.45; P = 0.01).

39 phosphatase, albumin, platelets, presence of extrahepatic biliary disease, and variceal hemorrhage, w

40 naling in the maintenance of both intra- and extrahepatic biliary ducts.

41 Extrahepatic biliary obliteration was present in both WT

42 tire glandular stomach, rostral duodenum and extrahepatic biliary system to pancreas, with formation

43 resulting in inflammatory obstruction of the extrahepatic biliary tract and intrahepatic bile ducts.

44 e best test to evaluate the intrahepatic and extrahepatic biliary tract, and MRI also provides inform

45 that PBGs populate the entire length of the extrahepatic biliary tract, except the gallbladder.

46 Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been

47 at the upper, middle, and lower part of the extrahepatic biliary tree in 11, 4, and 4 patients (58%,

48 A) is a fibroinflammatory obstruction of the extrahepatic biliary tree in neonates.

49 propagation of human cholangiocytes from the extrahepatic biliary tree in the form of extrahepatic ch

50 ified on cholangiography as narrowing of the extrahepatic biliary tree to < 75% of the diameter of th

51 Associated resection of the extrahepatic biliary tree was required in 11 cases (58%)

52 ing in necroinflammatory obliteration of the extrahepatic biliary tree.

53 ul imaging modality for the pancreas and the extrahepatic biliary tree.

54 provements to the IVIVE models are needed or extrahepatic biotransformation plays an underestimated r

55 al, f(U)); (iv) species differences; and (v) extrahepatic biotransformation.

56 ptoms of HCC and/or vascular invasion and/or extrahepatic cancer are considered to have advanced-stag

57 e need to reassess risk and risk factors for extrahepatic cancer, cardiovascular disease, and diabete

58 ral hepatitis, cause-specific mortality from extrahepatic cancers increased, whereas mortality from c

59 nfection, the age-standardized mortality for extrahepatic cancers was 2.6%, for cardiovascular diseas

60 ses in 48 (47%; bacterial infection: n = 13; extrahepatic cancers: n = 10; cardiovascular events: n =

61 r cancer: n = 18; miscellaneous, n = 30) and extrahepatic causes in 48 (47%; bacterial infection: n =

62 y its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA).

63 e present in the preponderance of intra- and extrahepatic CCA specimens.

64 50 human CCA samples (25 intrahepatic and 25 extrahepatic CCA) as well as human KMCH-1, Mz-CHA-1, and

65 e aspiration (FNA) for detection of MRLNs in extrahepatic CCA, but there are no data for its role in

66 utility of EUS-FNA for detection of MRLN in extrahepatic CCA, but there is no data for its role in i

67 We profiled 10 intrahepatic and 8 extrahepatic CCs in comparison to non-neoplastic biliary

68 nclude endocrine effects, HCV replication in extrahepatic cells, or a heightened immune reaction with

69 e measured in the following intrahepatic and extrahepatic cholangiocarcinoma (CCA) cell lines, Mz-ChA

70 er development and survival in patients with extrahepatic cholangiocarcinoma (ECC), including perihil

71 The role of postoperative therapy in extrahepatic cholangiocarcinoma (EHCC) or gallbladder ca

72 Patients with extrahepatic cholangiocarcinoma or gallbladder cancer an

73 ted with radiation therapy for patients with extrahepatic cholangiocarcinoma or gallbladder cancer.

74 frequency of genomic alterations typical of extrahepatic cholangiocarcinoma, such as TP53 (35.5%), K

75 r and histological characteristic similar to extrahepatic cholangiocarcinoma.

76 as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma.

77 = 3, intrahepatic cholangiocarcinoma: n = 2, extrahepatic cholangiocarcinoma: n = 2, malignant epithe

78 the extrahepatic biliary tree in the form of extrahepatic cholangiocyte organoids (ECOs) for regenera

79 Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs) in zebrafish larvae.

80 testinal FXR protected mice from obstructive extrahepatic cholestasis after bile duct ligation or adm

81 nt model of insulin kinetics and hepatic and extrahepatic clearance parameters were estimated.

82 Key extrahepatic comorbidities that are influenced by NAFLD

83 (n = 27) or absence (n = 14) of significant extrahepatic comorbidities.

84 zed mortality from hepatitis B virus-related extrahepatic complications increased by an average of 2.

85 om ALD continued to increase, mortality from extrahepatic complications of ALD did not change signifi

86 Trends of mortality associated with extrahepatic complications of chronic liver disease migh

87 ature that results in the development of the extrahepatic complications of chronic liver disease.

88 to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mort

89 Metabolic Bone disorders are well-recognized extrahepatic complications of cirrhosis.

90 tion and to reduce the burden of hepatic and extrahepatic complications of HCV that are observed in k

91 We studied trends in mortality from extrahepatic complications of viral hepatitis, alcoholic

92 s associated with hemorrhagic and thrombotic extrahepatic complications.

93 Extrahepatic conditions related to INCPH (P = 0.03) and

94 Twenty-five (57%) patients had one or more extrahepatic conditions related to INCPH, and 16 (36%) h

95 nsion-related complications when they harbor extrahepatic conditions related to INCPH, history of asc

96 ents and was associated with the presence of extrahepatic conditions related to INCPH, history of asc

97 normal kidney function or do not have severe extrahepatic conditions, TIPS is an excellent option to

98 mortality, however, persisted, attributed to extrahepatic conditions.

99 ults demonstrate that hepatic and, possibly, extrahepatic cytochrome P450 (P450) enzymes play a role

100 titis C virus (HCV) infection on hepatic and extrahepatic deaths.

101 cal engineering strategies for enhancing the extrahepatic delivery of lipophilic siRNAs.

102 e.g. docosanoic acid, DCA) to siRNA supports extrahepatic delivery, but tissue accumulation and gene

103 Extrahepatic deposition of a (166)Ho scout dose seems to

104 r, in contrast to (99m)Tc-MAA, an unintended extrahepatic deposition of this beta-emitting scout dose

105 Of 160 patients, 32 patients (34 cases) of extrahepatic deposition were identified.

106 used for lung shunt analysis, evaluation of extrahepatic deposition, and sometimes for treatment pla

107 Of the extrahepatic depositions of (99m)Tc-MAA on SPECT, the am

108 e (2.4), tumor burden (2.8), and presence of extrahepatic disease (3.5).

109 (P = .003), high modified CRS (P = .02), and extrahepatic disease (EHD) (P < .001).

110 progression: locally advanced disease (LAD), extrahepatic disease (EHD), and macrovascular invasion (

111 ectal liver metastases (CRLM) and concurrent extrahepatic disease (EHD), and to define prognostic fac

112 Patients with extrahepatic disease and positive lymph node primary tum

113 correlated with the severity of hepatic and extrahepatic disease and systemic inflammatory responses

114 onous presentation, primary node status, and extrahepatic disease as matching variables to compare ov

115 ereas positive surgical margins and resected extrahepatic disease determined prognosis thereafter.

116 Extrahepatic disease localization is reconfirmed not to

117 -related risk prediction between hepatic and extrahepatic disease might need to be accounted for in t

118 Extrahepatic disease was present at time of LT in 4 (19%

119 lar thrombosis (TVT) was present in 55%, and extrahepatic disease was present in 12%.

120 , absence of postoperative chemotherapy, and extrahepatic disease were predictive of recurrence (HR=2

121 variables (ie, surgical margin and resected extrahepatic disease) determined prognosis thereafter (d

122 performance status, macrovascular invasion, extrahepatic disease, and alpha-fetoprotein level to bes

123 or B, ECOG performance status of 0 to 2, no extrahepatic disease, and no prior radiation received 15

124 or and metastases, CRLM number and diameter, extrahepatic disease, and preoperative chemotherapy.

125 olization, hepatic tumor burden, presence of extrahepatic disease, and sex.

126 d KRAS mutations, R1 margin status, resected extrahepatic disease, patient age, primary tumor lymph n

127 nvasion (HR = 2.2; P = 0.03), but not pre-LT extrahepatic disease, were significant risk factors for

128 year, recurrence-free, liver-tumor-free, and extrahepatic disease-free survival was >=86%, >=50%, >=5

129 e than 3 liver metastases, R1 resection, and extrahepatic disease.

130 had 4 or more CRLM, and 22.5% had associated extrahepatic disease.

131 lly appraise key studies on NAFLD-associated extrahepatic disease.

132 evaluation because of accurate assessment of extrahepatic disease.

133 number of liver metastases, and preoperative extrahepatic disease.

134 rwent more major hepatectomies, but had less extrahepatic disease.

135 3 months to evaluate for tumor response and extrahepatic disease.

136 AFLD may be a new, and added risk factor for extrahepatic diseases such as CVD, chronic kidney diseas

137 nificantly higher mortality from hepatic and extrahepatic diseases than anti-HCV seropositives with u

138 s had higher mortality from both hepatic and extrahepatic diseases, showing multivariate-adjusted haz

139 ) for hepatic diseases; 1.35 (1.15-1.57) for extrahepatic diseases; 1.50 (1.10-2.03) for circulatory

140 otential of targeting KC for immune-mediated extrahepatic disorders.

141 Extrahepatic distributions included lungs (100%), the ga

142 were involved in 11 (24.4%) patients and the extrahepatic ducts were involved in 14 (31.1%), with 17

143 were analyzed using intrahepatic (iCCA) and extrahepatic (eCCA) biopsies (Copenhagen and Salamanca c

144 The mechanisms causing the extrahepatic effects of HCV infection are likely multifa

145 s of insulin on HGP and utilization, and (2) extrahepatic effects of insulin are sufficient to mainta

146 ribavirin was shown to improve some of these extrahepatic effects; sustained virological response is

147 -tuning siRNA chemical structure for optimal extrahepatic efficacy is a critical next step for the pr

148 tivates both hepatic coagulation factors and extrahepatic endothelial anticoagulant protein S, requir

149 After 3 years of follow-up, extrahepatic events still explained half of deaths in pa

150 FT505 concentrated in the liver with limited extrahepatic exposure and underwent extensive enterohepa

151 7 cm), and solitary (ISS) and those that had extrahepatic extension and were large (>/=7 cm) and mult

152 zards model demonstrated that multifocality, extrahepatic extension, grade, node positivity, and age

153 ithout metastatic disease, nodal metastasis, extrahepatic extension, or major vascular invasion).

154 etween systemic insulin appearance and total extrahepatic extraction was linear.CONCLUSIONHyperinsuli

155 However, higher ELF scores may reflect extrahepatic fibrosis in HIV-infected patients with a hi

156 Interestingly, hepatic and extrahepatic Hh-pathway was enhanced in PPVL rats, which

157 ex vivo model using precision-cut slices of extrahepatic human bile ducts obtained from discarded do

158 to the liver in 1 patient (4%), exclusively extrahepatic in 18 patients (72%), and were both intra a

159 n 18 patients (72%), and were both intra and extrahepatic in 6 patients (24%).

160 ssion pattern was divided into: intrahepatic/extrahepatic increase in tumor size, new intrahepatic le

161 ype 2 diabetes by altering either hepatic or extrahepatic insulin action.

162 ce test (FSIGT), we estimated hepatic versus extrahepatic insulin clearance in 29 EA and 18 AA health

163 el-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and

164 epatic extraction was 25.8% [32.7%], and for extrahepatic insulin clearance was 20.7 mL/kg/min [11.7

165 In contrast, extrahepatic insulin clearance was not lower in AAs than

166 cterizes the contributions of hepatic versus extrahepatic insulin degradation related to ethnic diffe

167 n appearance in the systemic circulation and extrahepatic insulin extraction progressively increased

168 tion, without a decrease in total hepatic or extrahepatic insulin extraction.

169 The results regarding density of extrahepatic intraductal lesions that were studied at BT

170 din insufficiency, hepatic iron loading, and extrahepatic iron accumulation in males.

171 ice exhibited reduced hepcidin and increased extrahepatic iron loading compared to single Hfe or endo

172 ochromatosis models, hepcidin deficiency and extrahepatic iron loading were similarly severe in Smad1

173 tain hepcidin to a level sufficient to avoid extrahepatic iron loading.

174 We evaluated the preperitoneal space as an extrahepatic islet transplant site to deliver high tissu

175 tumor size, new intrahepatic lesion, and new extrahepatic lesion (NEH).

176 PET/CT showed uptake in 18 extrahepatic lesions and no uptake in 3 lesions affirmed

177 umor diameter, number of nodules, intra- and extrahepatic macroscopic vascular invasion, extrahepatic

178 ents at risk for HCC but without established extrahepatic malignancy from August 2012 through August

179 The risk of hepatic and extrahepatic malignancy was significantly increased in A

180 xed cryoglobulinemia (MC) is the most common extrahepatic manifestation of chronic hepatitis C virus

181 h clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize derm

182 Few data regarding genotype 3 HEV extrahepatic manifestations exist.

183 meta-analysis to determine the prevalence of extrahepatic manifestations in patients with HCV infecti

184 However, important extrahepatic manifestations include immune complex glome

185 d the aberrant Ab production are the leading extrahepatic manifestations of cholestatic liver disease

186 Extrahepatic manifestations of HCV in this high-risk pop

187 h condition to determine prevalence rates of extrahepatic manifestations of HCV infection and their e

188 Total direct medical costs of extrahepatic manifestations of HCV infection, in 2014 US

189 prevalence, risks, and costs associated with extrahepatic manifestations of HCV infection.

190 t, outpatient, and pharmacy) associated with extrahepatic manifestations of HCV infection.

191 r 2014, to identify studies of the following extrahepatic manifestations of HCV infection: mixed cryo

192 f cirrhosis and hepatocellular carcinoma and extrahepatic manifestations of HCV infection; there are

193 ic conditions associated with HCV infection, extrahepatic manifestations of HCV may become a major in

194 Extrahepatic manifestations of HCV, including myocardial

195 likely result in greater improvements in the extrahepatic manifestations of HCV.

196 a from 102 studies, we found the most common extrahepatic manifestations to be diabetes (in 15% of pa

197 itis C virus (HCV) infection has hepatic and extrahepatic manifestations with various costs and impai

198 s (HCV) infection is associated with several extrahepatic manifestations.

199 To understand the role of hepatic vs extrahepatic metabolism in the disposition of chiral PCB

200 ents followed until death, only 50 developed extrahepatic metastases (24%).

201 The presence of extrahepatic metastases (mean survival in both groups, 4

202 01), macrovascular invasion (P < 0.001), and extrahepatic metastases (P < 0.002).

203 ever, there were more patients with resected extrahepatic metastases in the no-HAI group.

204 LSF did not correlate with the presence of extrahepatic metastases or prior administration of bevac

205 Histologic examination demonstrated that no extrahepatic metastases were detectable during primary t

206 with liver metastases plus or minus limited extrahepatic metastases were randomly assigned to receiv

207 extrahepatic macroscopic vascular invasion, extrahepatic metastases).

208 ce status, no more than 25% tumor burden, no extrahepatic metastases, albumin greater than 3 g/dL, an

209 ts in the absence of macrovascular invasion, extrahepatic metastases, and deteriorated PS predicts th

210 ocoregional therapies die without developing extrahepatic metastases, the notion of HCC as a systemic

211 minimisation with four factors: presence of extrahepatic metastases, tumour involvement of the liver

212 l, and does not correlate to the presence of extrahepatic metastases.

213 % of patients with HCC in NCL presented with extrahepatic metastases.

214 ognosis as a result of widespread intra- and extrahepatic metastases.

215 Furthermore, LOXL2 facilitated extrahepatic metastasis by enhancing recruitment of bone

216 ence in clinical outcome between hepatic and extrahepatic metastatic disease.

217 Mice with loss-of-function mutation in the extrahepatic mitochondrial enzyme CoA transferase (succi

218 Cytochrome P450 (CYP) 1A1 is an extrahepatic monooxygenase involved in the metabolism of

219 Notably, PSC-BTC shows a distinct extrahepatic morpho-molecular phenotype, independent of

220 the main factor associated with hepatic and extrahepatic nADEs in HIV controllers.

221 Extrahepatic nonmalignant partial PVT improved spontaneo

222 ACLF was defined as two or more extrahepatic organ failures in patients with cirrhosis.

223 isting chronic liver disease and hepatic and extrahepatic organ failures, and is associated with subs

224 ay survival worsened with a higher number of extrahepatic organ failures, none (92%), one (72.6%), tw

225 e likely to reflect epithelial cell death in extrahepatic organs.

226 most common being the presence of intra- or extrahepatic portal abnormalities.

227 tosis-mediated islet death within portal and extrahepatic portal sites in mice.

228 ding indications for MesoRex bypass (MRB) in extrahepatic portal vein obstruction and the role of pri

229 Therefore, children with extrahepatic portal vein obstruction should be offered M

230 The vast majority of children with extrahepatic portal vein obstruction will experience com

231 etric features of the liver in children with extrahepatic portal vein thrombosis (EHPVT), with surgic

232 Congenital extrahepatic portosystemic shunt (CEPS) or Abernethy mal

233 Two patients had an extrahepatic portosystemic shunt, 17 had a portacaval sh

234 All extrahepatic portosystemic shunts, H-type portal-caval,

235 95% CI: 1.544-2.975; P < 0.001), concomitant extrahepatic procedures (HR: 1.742, 95% CI: 1.103-2.750;

236 oss of ketone body oxidation, an exclusively extrahepatic process, disrupts hepatic intermediary meta

237 Thus, MCs are considered as extrahepatic producers of complement proteins.

238 nt factors are preferentially activated over extrahepatic proteins.

239 treated with exogenous PP-IX (mimicking XLP extrahepatic protoporphyria) or with the iron chelator d

240 37.7%) patients having both intrahepatic and extrahepatic PSC.

241 event involving coordinated intrahepatic and extrahepatic regulation.

242 nsmitted infection that has both hepatic and extrahepatic repercussions.

243 CRBP1, and CD36 in retinoid mobilization and extrahepatic retinoid uptake, as well as a role for CYP2

244 lformation and gives a working algorithm for extrahepatic shunts.

245 he different hepatic cell types and multiple extrahepatic signals.

246 s regulated by nutrient- and clock-dependent extrahepatic signals.

247 It can also serve as an extrahepatic site for transplanting large volume of isle

248 (eg, xenogeneic tissue or human stem cells), extrahepatic sites of implantation (eg, omental, subcuta

249 Several extrahepatic sites were tested in experimental animals,

250 in amino acid metabolism in the liver and at extrahepatic sites.

251 ahepatic inflammation, vasoconstriction, and extrahepatic splanchnic vasodilation.

252 core (ECOG PS; 0 or 1), vascular invasion or extrahepatic spread (yes or no), and hepatitis B virus (

253 S 0, 65.2%; HBV, 49.1%; vascular invasion or extrahepatic spread, 70.1%).

254 geographical region; macrovascular invasion, extrahepatic spread, or both; and baseline alpha-fetopro

255 itions, indication and extent of hepatic (or extrahepatic) surgery and the hospital type, location, a

256 disease and is associated with a variety of extrahepatic syndromes, including central nervous system

257 But extrahepatic synthesis also occurs, and mounting evidenc

258 rculating complement protein synthesis site, extrahepatic synthesis is known to optimize local tissue

259 the targeting ligand, have the potential for extrahepatic targeting.

260 CD8(+) T cells generated by infection at an extrahepatic, that is, subcutaneous, site.

261 othyroidism-induced NAFLD is both intra- and extrahepatic; they also reveal key metabolic differences

262 .e. hydrophobicity), predicted the degree of extrahepatic tissue accumulation necessary for productiv

263 Serum amyloid A3 (Saa3) derives mainly from extrahepatic tissue and is not detected in plasma from m

264 ntigen-specific T cells are also awakened by extrahepatic tissue damage and that the corresponding TR

265 gration of insulin secretion and hepatic and extrahepatic tissue extraction are not clear.METHODSA hy

266 expression, Bmp/Smad signaling, hepatic and extrahepatic tissue iron accumulation) with that of sing

267 ontent was mobilized from the liver, causing extrahepatic tissue retinoid levels to increase.

268 f Foxo1, insulin signals via an intermediary extrahepatic tissue to regulate liver glucose production

269 de novo lipogenesis, whereas its actions on extrahepatic tissues are mediated by IGF-1.

270 The characterization of VKOR activity in extrahepatic tissues demonstrated that a part of the VKO

271 ining the supply of energy from the liver to extrahepatic tissues during periods of prolonged food de

272 by an initial phase of rapid mobilization to extrahepatic tissues followed by extensive catabolism wi

273 iched plasma HDL may serve to deliver S1P to extrahepatic tissues for atheroprotection and may have o

274 ncrease in insulin delivery to the liver and extrahepatic tissues in obese-NAFLD is unable to compens

275 evelopment and expression of EPO and ERFE in extrahepatic tissues independent of TFR's role in the li

276 Circulating retinol may be taken up by extrahepatic tissues or recycled back to liver multiple

277 the vitamin K-dependent protein produced by extrahepatic tissues such as matrix Gla protein or osteo

278 studies indicated that As3MT is required in extrahepatic tissues to promote atherosclerosis.

279 aling molecules that act at both hepatic and extrahepatic tissues to regulate lipid and carbohydrate

280 rtly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists and the la

281 ystematically engineered to exclusively edit extrahepatic tissues via addition of a supplemental SORT

282 1) and secretes it into the plasma to supply extrahepatic tissues with selenium.

283 In extrahepatic tissues, MondoA, the paralog of ChREBP, par

284 ) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand

285 nt oligonucleotide delivery, particularly to extrahepatic tissues, remains a major translational limi

286 sulin sensitivity and glucose utilization in extrahepatic tissues.

287 more recently explored functions of PCSK9 in extrahepatic tissues.

288 a principal factor for enhancing activity in extrahepatic tissues.

289 ability thereby minimizing distribution into extrahepatic tissues; concurrently, they were also optim

290 eloping a clinically applicable protocol for extrahepatic transplantation of pancreatic islets.

291 A retrievable, extrahepatic transplantation site that mimics the pancre

292 pendently predicted by PS, prothrombin time, extrahepatic tumor spread, macrovascular invasion, and r

293 macroscopic vascular invasion, and 38% with extrahepatic tumor spread.

294 ns (V) or portal bifurcation (P), contiguous extrahepatic tumour (E), multifocal tumour (F), and spon

295 ions for the assessment of lung shunting and extrahepatic uptake.

296 The energy-intense nature of hepatic and extrahepatic urea osmolyte production for renal water co

297 the imbalance between hepatic production and extrahepatic utilization of ketone bodies.

298 ahepatic vascular invasion), and presence of extrahepatic vascular invasion or metastasis were includ

299 ata suggest a mechanism of pneumonia-induced extrahepatic vitamin K depletion leading to accelerated

300 y increased in COVID-19 patients, indicating extrahepatic vitamin K insufficiency, which was related