ライフサイエンスコーパス: extramedullary

1 of patients had visually detectable FLs (2% extramedullary), 24% and 67.7% of them with an FS of 3 a

2 of patients had visually detectable FLs (2% extramedullary), 24% and 67.7% of them with an FS of 3 a

3 At baseline, 78% of patients had FLs (11% extramedullary), 80% with an FS >= 4.

4 At baseline, 78% of patients had FLs (11% extramedullary), 80% with an FS 4.

5 Myeloid sarcomas are extramedullary accumulations of immature myeloid cells t

6 mplete responses occurred in 4 patients with extramedullary acute myeloid leukemia and 1 patient with

7 tologic subtypes of these cancers, including extramedullary acute myeloid leukemia.

8 DNA from extramedullary AML relapse after HSCT was compared with

9 e loss of graft-versus-leukemia response and extramedullary AML relapse in tissue with reduced immuno

10 hypothesized that this mechanism applies to extramedullary AML relapse which occurs frequently after

11 iesis is best understood in mice where it is extramedullary and occurs primarily in the spleen.

12 best characterized in the mouse, where it is extramedullary and utilizes progenitors and signals that

13 herapeutic evaluation allowing medullary and extramedullary assessment.

14 review inflammation's effects on central and extramedullary B lymphopoiesis and discuss the potential

15 The patient with extramedullary blastic disease achieved complete respons

16 onic phase; and 1 had a complete response in extramedullary blastic disease).

17 cells into BM, an in vivo model of humanized extramedullary BM (EXM-BM) was developed in NOD/SCID/IL-

18 Here, we describe the development of extramedullary bone and bone marrow using human mesenchy

19 ulation of the bone marrow microenvironment: Extramedullary bone marrow in which hypoxia-inducible fa

20 al and leukemic cells engraft into the human extramedullary bone marrow.

21 ctively; P < .001), and higher likelihood of extramedullary disease (16% v 5%, respectively; P = .013

22 Purpose Extramedullary disease (EMD) at diagnosis in patients wi

23 Extramedullary disease (EMD) is a high-risk feature of m

24 east 5% blood or marrow blasts or measurable extramedullary disease (EMD) was required for enrollment

25 ved EFS (P = .02), whereas grade 4 aGVHD and extramedullary disease at diagnosis led to inferior OS.

26 Extramedullary disease at diagnosis was an independent p

27 ytogenetic abnormalities, or the presence of extramedullary disease at diagnosis.

28 al, reduced medullary disease, and increased extramedullary disease burden.

29 CD36 promotes blast migration and extramedullary disease in acute myeloid leukemia and rep

30 Extramedullary disease is associated with adverse progno

31 Extramedullary disease is typically an aggressive, poorl

32 well as transformation from myeloma to overt extramedullary disease such as sPCL.

33 ferritin levels, high-risk cytogenetics, and extramedullary disease were independently associated wit

34 bone marrow lymphoblasts, no CNS3, or other extramedullary disease), or undetectable disease, pretis

35 Low-risk criteria included no extramedullary disease, < 5% marrow blasts by day 15, en

36 riple-class-refractory disease, 55 (35%) had extramedullary disease, and 92 (59%) were refractory to

37 recurrent disease after therapy, especially extramedullary disease, is a poor prognostic factor.

38 of patients; 14% and 11% of them had PMD and extramedullary disease, respectively.

39 ty, with or without imaging-based absence of extramedullary disease, to allow uniform reporting withi

40 uding those with triple-class-refractory and extramedullary disease.

41 Another 4 (25%) of 16 patients had focal extramedullary disease.

42 ansplantation and pretransplant diagnosis of extramedullary disease.

43 d are akin to the transcriptional program of extramedullary disease.

44 ed and relapsed/refractory settings and with extramedullary disease.

45 how patchy bone marrow (BM) infiltration and extramedullary disease.

46 ion after >= 2 lines of prior therapy and no extramedullary disease.

47 ration, focal bone lesions, and soft-tissue (extramedullary) disease.

48 receptor CD36 was positively associated with extramedullary dissemination of leukemic blasts, increas

49 For bone marrow (BM) +/- extramedullary (EM) (BM +/- EM; n = 174) relapses, 4-yea

50 w-risk patients with bone marrow disease +/- extramedullary (EM) involvement (4-year DFS 72.7% +/- 5.

51 Extramedullary (EM) manifestations of acute leukemia inc

52 after bone marrow (BM) relapse and isolated extramedullary (EM) relapse for 347 patients with SR-ALL

53 cellular bone marrow (BM), splenomegaly with extramedullary erythropoiesis and erythropoietin-indepen

54 tosis that was partially compensated by avid extramedullary erythropoiesis at all erythroid stages in

55 th elevated bacterial burdens, implying that extramedullary erythropoiesis benefits the host.

56 y, elevated erythropoietin (EPO) levels, and extramedullary erythropoiesis in a process independent o

57 a thrombospondin-1-dependent basal level of extramedullary erythropoiesis in adult mouse spleen.

58 ens of infected mice despite the presence of extramedullary erythropoiesis in this tissue.

59 ocytes in the peripheral blood and extensive extramedullary erythropoiesis indicated that the Rb-/- e

60 roid and erythroid tissues, including during extramedullary erythropoiesis induced by n-acetylphenylh

61 Extramedullary erythropoiesis is not expected in healthy

62 In an attempt to overcome this anemia, extramedullary erythropoiesis was activated.

63 emolytic anemia with compensatory marrow and extramedullary erythropoiesis, abundant circulating sick

64 fever with splenomegaly, microcytic anemia, extramedullary erythropoiesis, and increased hemophagocy

65 a, hemolytic anemia with reticulocytosis and extramedullary erythropoiesis, and, notably, the charact

66 R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thromb

67 ddition to defining a role for CD47 to limit extramedullary erythropoiesis, these studies reveal a th

68 vere anemia despite the presence of enhanced extramedullary erythropoiesis.

69 se in Hb, and diminished reticulocytosis and extramedullary erythropoiesis.

70 ases in hemoglobin (Hb) level and diminished extramedullary erythropoiesis.

71 This disease, which was characterized by extramedullary erythropoietin-independent erythropoiesis

72 10% in the blood or bone marrow, absence of extramedullary evidence of leukemia, basophils of less t

73 vis was requested to enable exclusion of any extramedullary extension of leukemia.

74 Extramedullary (extraosseus) PCT are rare spontaneous ne

75 d SCID mice developed osteomyelofibrosis and extramedullary/extrasplenal hemopoiesis.

76 rom the bone marrow to the spleen and induce extramedullary haematopoiesis (EMH).

77 a link between the IL17 cytokine family and extramedullary haematopoiesis, and suggests a previously

78 ple, in the case of lymphoma infiltration or extramedullary haematopoiesis, it might be caused by a t

79 This report describes an unusual extramedullary hematologic malignancy in an 18-month-old

80 ts and platelet counts, and markedly reduced extramedullary hematopoeisis and bone marrow fibrosis.

81 Extramedullary hematopoiesis (EMH) expands hematopoietic

82 characterized by splenomegaly, leukocytosis, extramedullary hematopoiesis (EMH) in spleen and liver w

83 Extramedullary hematopoiesis (EMH) is induced during pre

84 Extramedullary hematopoiesis (EMH) refers to the differe

85 Ineffective erythropoiesis and extramedullary hematopoiesis (EMH) regress, as reflected

86 ere anemia (2-4 g/dL), massive splenomegaly, extramedullary hematopoiesis (EMH), and hepatic iron ove

87 oplasms (MPNs), including varying degrees of extramedullary hematopoiesis (myeloid metaplasia) and sp

88 , an increase in splenic megakaryocytes, and extramedullary hematopoiesis accompany the hematologic c

89 -/-) mice was associated with an increase in extramedullary hematopoiesis and expansion of neutrophil

90 e capacity is sustained by expanded sites of extramedullary hematopoiesis and is accompanied by multi

91 Mechanistically, FTY720 enhanced extramedullary hematopoiesis and massive accumulation of

92 thalassemia, with the potential of reversing extramedullary hematopoiesis and preventing splenectomy.

93 K hyperplasia, myelofibrosis, and consequent extramedullary hematopoiesis and splenomegaly.

94 2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymph

95 Dysmegakaryopoiesis and extramedullary hematopoiesis characterize primary myelof

96 rease in myeloid progenitor populations, and extramedullary hematopoiesis composed of maturing myeloi

97 der steady-state conditions and mobilize for extramedullary hematopoiesis during periods of stress su

98 pment due to atypical growth trajectories or extramedullary hematopoiesis in anemias such as SCD.

99 aly, fibrotic and hypercellular bone marrow, extramedullary hematopoiesis in both spleen and liver, a

100 possibility of hemolytic anemia and splenic extramedullary hematopoiesis in Nrf2(-/-) mice.

101 We found that G6 significantly reduced extramedullary hematopoiesis in the liver and splenomega

102 mplicate IL-25-elicited MPP(type2) cells and extramedullary hematopoiesis in the promotion of Th2 cyt

103 Moreover, AEP deficiency provokes extramedullary hematopoiesis in the spleen and abnormall

104 erative phenotype, which was associated with extramedullary hematopoiesis in the spleen and liver, wa

105 lls; myeloid hyperplasia in bone marrow; and extramedullary hematopoiesis in the spleen and liver.

106 y high white blood cell counts and extensive extramedullary hematopoiesis in the spleen, liver, bone

107 one mass, reduced medullary cavity space and extramedullary hematopoiesis in the spleen.

108 tipotential progenitor cell mobilization and extramedullary hematopoiesis in the spleen.

109 marrow, and spleen; significantly increased extramedullary hematopoiesis in the spleen; and a 2-fold

110 Splenic extramedullary hematopoiesis is an integral component of

111 In the orthotopic BALB/cJ model, extramedullary hematopoiesis occurred in the spleen, res

112 However, KRAS activation enhanced extramedullary hematopoiesis of MA4-expressing cell line

113 it, leukocytosis, megakaryocyte hyperplasia, extramedullary hematopoiesis resulting in splenomegaly,

114 Extramedullary hematopoiesis was also evident, and granu

115 Increased extramedullary hematopoiesis was associated with elevate

116 ecrease in bone marrow hematopoiesis, active extramedullary hematopoiesis was observed in the spleen

117 Marked splenomegaly caused by extramedullary hematopoiesis was observed.

118 Greater HSPC mobilization and extramedullary hematopoiesis were reversed by raising HD

119 Instead, these animals exhibit extensive extramedullary hematopoiesis with progressive splenomega

120 e blood cells, bone marrow hypercellularity, extramedullary hematopoiesis, a tendency for thrombosis,

121 f Hmga2 enhanced megakaryopoiesis, increased extramedullary hematopoiesis, and accelerated the develo

122 enlargement of the spleen, increased splenic extramedullary hematopoiesis, and altered clinicopatholo

123 mune manifestations, including splenomegaly, extramedullary hematopoiesis, and autoantibody productio

124 loproliferation, ineffective erythropoiesis, extramedullary hematopoiesis, and bone marrow fibrosis a

125 acterized by erythrocytosis, granulocytosis, extramedullary hematopoiesis, and bone marrow fibrosis,

126 1(+) granulocytes, splenomegaly, evidence of extramedullary hematopoiesis, and bone marrow fibrosis,

127 enlarged spleen due to lymphoid hyperplasia, extramedullary hematopoiesis, and bone marrow hypoplasia

128 atopoietic stem and progenitor cell cycling, extramedullary hematopoiesis, and differentiation defect

129 gh incidence of premature death, age-related extramedullary hematopoiesis, and lack of early degenera

130 ymph nodes, splenomegaly due to erythrocytic extramedullary hematopoiesis, and lymphoid hyperplasia w

131 ave important implications for understanding extramedullary hematopoiesis, and may be relevant to cur

132 icrovesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and portal hypercellularit

133 d Mk hyperplasia, BM fibrosis, IL-6 release, extramedullary hematopoiesis, and splenomegaly.

134 poietic defects develop without compensatory extramedullary hematopoiesis, and the loss of HSCs occur

135 osis, resulting in extreme levels of splenic extramedullary hematopoiesis, anemia, and leukopenia.

136 gic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34+ cells, s

137 e develop severe neutrophilia, splenomegaly, extramedullary hematopoiesis, decreased body weight, and

138 ient mice have a peripheral leukocytosis and extramedullary hematopoiesis, demonstrating that Lsc is

139 acterized by splenomegaly, neutrophilia, and extramedullary hematopoiesis, despite normal numbers of

140 sease phenotype-bone marrow stromal changes, extramedullary hematopoiesis, ineffective erythropoiesis

141 d circulating MIP-1alpha and ameliorated the extramedullary hematopoiesis, inflammation, and osteopen

142 tipotential progenitor cell mobilization and extramedullary hematopoiesis, leading to decreased produ

143 n Tet2(-/-) HSPCs reduces HSPC expansion/CH, extramedullary hematopoiesis, myeloid skewing, and genet

144 irect renal infiltration by monocytes, renal extramedullary hematopoiesis, myeloproliferative neoplas

145 cluding iron overload, bilirubin gallstones, extramedullary hematopoiesis, pulmonary hypertension, an

146 , lead to autoinflammatory disease involving extramedullary hematopoiesis, skin and bone lesions.

147 by bone marrow fibrosis, myeloproliferation, extramedullary hematopoiesis, splenomegaly and leukemic

148 opoietic stem cell function, contributing to extramedullary hematopoiesis, splenomegaly, BM failure,

149 n the P-loop of Gimap5, lymphopenia, hepatic extramedullary hematopoiesis, weight loss, and intestina

150 -old IRP1(-/-) mice exhibit splenomegaly and extramedullary hematopoiesis, which is corrected in olde

151 a dramatic increase in HSPC mobilization and extramedullary hematopoiesis.

152 a, they have macrocytic anemia and increased extramedullary hematopoiesis.

153 chitecture, bone marrow hypocellularity, and extramedullary hematopoiesis.

154 d splenomegaly with altered architecture and extramedullary hematopoiesis.

155 cture, and infected mice exhibited extensive extramedullary hematopoiesis.

156 us animals are anaemic with splenomegaly and extramedullary hematopoiesis.

157 at was accompanied by splenomegaly caused by extramedullary hematopoiesis.

158 mph nodes were enlarged and exhibited marked extramedullary hematopoiesis.

159 fibrosis, osteosclerosis, angiogenesis, and extramedullary hematopoiesis.

160 with a recovery of medullary and decrease in extramedullary hematopoiesis.

161 ive hematopoiesis, bone marrow fibrosis, and extramedullary hematopoiesis.

162 nto RBCs via formation of blood islands with extramedullary hematopoiesis.

163 tes, varying degrees of marrow fibrosis, and extramedullary hematopoiesis.

164 defect correlated with disease duration and extramedullary hematopoiesis.

165 rial infection, resulting in a transition to extramedullary hematopoiesis.

166 ls for growing in LEC-1 domains during liver extramedullary hematopoiesis.

167 and a pathological reduction in red pulp and extramedullary hematopoiesis.

168 s) are recruited to tissue sites and undergo extramedullary hematopoiesis.

169 itlg expression, and the presence of splenic extramedullary hematopoiesis.

170 Cs in the spleen, where we observed enhanced extramedullary hematopoiesis.

171 hetic nervous system, expanded medullary and extramedullary hematopoiesis.

172 showed transient bone marrow depression and extramedullary hematopoiesis.

173 enitor cells in the bone marrow, and splenic extramedullary hematopoiesis.

174 R/Hedgehog-related genes in spleen, reducing extramedullary hematopoiesis.

175 rythroid differentiation and greatly reduced extramedullary hematopoiesis.

176 pler, albeit functional and more accessible, extramedullary hematopoietic niches.

177 EdnrB, ET-1, ET-3) expression in developing extramedullary hematopoietic organs and that some spleni

178 on in the splenic red pulp of typically rare extramedullary hematopoietic stem and progenitor cells,

179 expansion of macrophages, granulocytes, and extramedullary hematopoietic tissue.

180 ype I IFN signaling resulted in compensatory extramedullary hemopoiesis in the liver and spleen.

181 myeloid hyperplasia, and splenomegaly due to extramedullary hemopoiesis.

182 myeloid hyperplasia, and splenomegaly due to extramedullary hemopoiesis.

183 We also reported that extramedullary hepatic hematopoiesis occurs only in clos

184 ating factor (G-CSF), which was required for extramedullary HSC accumulation.

185 reased BAALC expression (P = .004), and less extramedullary involvement (P = .01).

186 MRD </= 1 x 10(-4) at weeks 5 and 12 and no extramedullary involvement or high-risk features.

187 romosome 13 deletion, advanced bone disease, extramedullary involvement, and patients with renal impa

188 tiple myeloma, pPCL presents more often with extramedullary involvement, anemia, thrombocytopenia, hy

189 bsorbed doses calculated for bone marrow and extramedullary lesions are sufficient to be effective as

190 Dose estimates for tumors and extramedullary lesions ranged from 1.5 to 18.2 Gy/GBq of

191 D56 expression has been associated with both extramedullary leukemia and multidrug resistance, we sou

192 hite blood cell count of <50 x109/L, lack of extramedullary leukemia, and minimal residual disease le

193 g the same hydrogels to a xenograft model of extramedullary leukemias, we confirm the pathological re

194 d to be associated with an increased risk of extramedullary leukemic involvement.

195 Extramedullary lympho-hematopoietic expansion was also o

196 We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized me

197 nulocytic responses and consequently promote extramedullary lymphopoiesis.

198 Myeloid sarcoma is an extramedullary malignancy of myeloblasts.

199 ll infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia

200 d patients with intramedullary and extensive extramedullary manifestations of multiple myeloma underg

201 ated in 15, and blastic in 8 (7 medullary, 1 extramedullary); median time from transplantation to rel

202 , a defect in clot retraction, and increased extramedullary megakaryocytes.

203 stly, KO animals exhibited excessive splenic extramedullary megakaryocytopoiesis, which likely compen

204 hyperdiploid D1 group is virtually absent in extramedullary MM and MM cell lines, suggesting a partic

205 GUS, 60-65% in intramedullarly MM, 70-80% in extramedullary MM, and >90% in MM cell lines.

206 rves as the primary niche for hematopoiesis, extramedullary mobilization and differentiation of HSPCs

207 Our data implicate inflammation-induced extramedullary monocytopoiesis as a peripheral source of

208 tained need of newly made Mo was fostered by extramedullary monocytopoiesis in the spleen; d) splenic

209 Abrogation of extramedullary monocytopoiesis proved deleterious for in

210 megaly, myeloid bone marrow hyperplasia, and extramedullary myeloid cell infiltration of multiple org

211 th, but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cache

212 dependent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with

213 revealed a partial loss of chromosome 6p in extramedullary myeloid sarcoma relapse of AML after sust

214 Extramedullary myeloma (EMM) is defined by the presence

215 R T cells led to resolution of medullary and extramedullary myeloma manifestations in a murine xenogr

216 on B cells or plasma cells, more than 90% of extramedullary myelomas (a late stage B-cell neoplasm) e

217 e 1 (VCAM-1)(+) macrophages are essential to extramedullary myelopoiesis because these macrophages us

218 3(+) T cells can negatively regulate splenic extramedullary myelopoiesis by suppressing the naive T c

219 e demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansi

220 nstrate that NLRP3 activation causes chronic extramedullary myelopoiesis marked by myeloid progenitor

221 Extramedullary myelopoiesis occurs in peripheral organs

222 Furthermore, we show that GM-CSF promotes extramedullary myelopoiesis, tissue-toxic neutrophil acc

223 gulated metabolism stimulate bone marrow and extramedullary myelopoiesis, which increases immune cell

224 arrow myeloblasts and myelocytes, as well as extramedullary myelopoiesis.

225 ich FoxP3(+) regulatory T cells regulate the extramedullary myelopoiesis.

226 ults provide new insights into regulation of extramedullary myelopoiesis.

227 However, extramedullary neurons originating from ventral epidermi

228 ar pathway that regulates myeloid bias in an extramedullary niche.

229 Monocytes born in such extramedullary niches intravasate, circulate, and accumu

230 ssociated with worse prognosis than isolated extramedullary or late relapse (> 30 months from diagnos

231 ant tumor proliferation and dissemination to extramedullary organs, leading to disease progression an

232 stem and progenitor cells have been found in extramedullary organs.

233 , reduced fitness, short t1/2, and potential extramedullary origin.

234 These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treat

235 A subset of PCT, designated extramedullary PCT, is distinguished from multiple myelo

236 Extramedullary plasmacytoma (EMP) is a plasma cell neopl

237 solitary bone plasmacytoma (SBP; n = 35) and extramedullary plasmacytoma (EMP; n = 29) through multip

238 Extramedullary plasmacytomas are highly radiosensitive a

239 ring the blood, in a process that gauges the extramedullary pool size.

240 otherapy (36 hematologic, 4 molecular, and 1 extramedullary) proceeded to allogeneic HCT.

241 ic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+)

242 and less likely to have combined marrow and extramedullary relapse (19% versus 30%).

243 8 patients transplanted in CR2 for isolated extramedullary relapse (all MRD-), MRD was detected at h

244 erall survival of patients who experience an extramedullary relapse is <6 months.

245 with B-precursor ALL, in first marrow and/or extramedullary relapse were eligible.

246 We use both systemic and local treatment for extramedullary relapse, mainly represented by radiothera

247 posed to marrow involvement only or isolated extramedullary relapse, was associated with impaired out

248 and asparaginase, and have increased risk of extramedullary relapse.

249 activity, prolonging survival and preventing extramedullary relapses in mouse models.

250 p (P < .0001), showing the largest effect on extramedullary relapses.

251 bone marrow B lineage cells is dependent on extramedullary signals.

252 eukemic blasts in blood, bone marrow, or any extramedullary site after 4 to 6 weeks of remission-indu

253 for early versus late relapse, marrow versus extramedullary site, adolescent versus younger age and T

254 Ns, and positions the spleen as an important extramedullary site, which can continuously supply growi

255 were lost from the BM due to mobilization to extramedullary sites and differentiation.

256 ematopoiesis in marrow, and hematopoiesis in extramedullary sites and is associated with abnormal meg

257 ection work-up revealing increased uptake at extramedullary sites and/or bones and joints that would

258 duced primarily through the establishment of extramedullary sites of eosinophilopoiesis.

259 igh sensitivity and specificity, and detects extramedullary sites of proliferating clonal plasma cell

260 as decreased in bone marrow and increased in extramedullary sites of Prx1-Cre;Has2(flox/flox);Has1(-/

261 occurring not only in the marrow but also in extramedullary sites such as the spleen.

262 Our findings indicate that extramedullary sites supplement the hematopoietic functi

263 tic plasma cells in the bone marrow or other extramedullary sites, along with evidence of disease-rel

264 in the skeleton significantly differed from extramedullary sites, showing similar numbers but differ

265 ively in marrow, and subsequent reseeding of extramedullary sites.

266 cking to the bone marrow, the skin and other extramedullary sites.

267 emination of tumor to other bones but not to extramedullary sites.

268 onment for establishment of hematopoiesis in extramedullary sites.

269 ts on infiltrating lymphocytes in marrow and extramedullary sites.

270 t and unlike PCs, are primarily localized at extramedullary sites.

271 ulate in the BM in SpA and, unexpectedly, at extramedullary sites: in the inflamed joints and spleen.

272 onstrated a role for ST6Gal-1, possibly from extramedullary sources (eg, produced in liver) in regula

273 mours can be divided into intramedullary and extramedullary spinal-cord tumours on the basis of their

274 bers of primitive hematopoietic cells in the extramedullary spleen site.

275 In phenylhydrazine-treated Lyn-/- mice, extramedullary splenic erythropoiesis was hyperactivated

276 /-), and PU.1(+/-) Spi-B(-/-) mice displayed extramedullary splenic hematopoiesis.

277 CD26 expression may explain the abnormal extramedullary spread of CML LSC, and inhibition of CD26

278 contributing to malignant expansion and the extramedullary spread of leukemic SC (LSC) in CML.

279 esses within the bone marrow, and then to an extramedullary stage from which MM cell lines are genera

280 vironment until progressing to very advanced extramedullary stages of the disease such as plasma cell

281 MK hyperplasia and a significantly increased extramedullary thrombopoiesis.

282 ic leukemia [BCP-ALL]) or are less common in extramedullary tissue (BCP lymphoblastic lymphoma [BCP-L

283 epended on S1P(1) signaling, and allowed the extramedullary tissue to supply new tumor-associated mac

284 Migratory HSPCs proliferate within extramedullary tissues and give rise to tissue-resident

285 egulate hematopoietic stem cell migration to extramedullary tissues and the metastasis of cancer stem

286 HSPC egress from extramedullary tissues into lymph depends on sphingosine

287 The frequency of extramedullary toxicities was comparable.

288 retazine has significant activity and modest extramedullary toxicity in elderly patients with AML or

289 In these nine patients, extramedullary toxicity was absent, neutropenia did not

290 No significant extramedullary toxicity was seen.

291 es of MK-0457 associated with no significant extramedullary toxicity, is very encouraging.

292 2 per course were administered without major extramedullary toxicity.

293 se, frequency at relapse, and progression to extramedullary tumor.

294 In patients with NF2 and spinal tumors, extramedullary tumors (predominantly NSTs) were present

295 h intramedullary tumors versus 16 (59%) with extramedullary tumors had undergone surgery for the resp

296 Intramedullary and intradural extramedullary tumors were counted, and imaging features

297 tramedullary tumors, 27 (55%) had intradural extramedullary tumors, and 22 (45%) had at least one tum

298 This phenotype manifested further with extramedullary tumors, hepatic macrophage infiltration,

299 Extramedullary uptake also occurred in 6 (23%) of 26 pat

300 This extramedullary uptake was a very poor prognostic factor