ライフサイエンスコーパス: extraocular

1 some patients with coloboma had evidence of extraocular abnormalities, the majority of findings on r

2 th oMG had serum autoantibodies to the mouse extraocular AChR, pathologic deposits of IgG, C3, and C5

3 Recordings of extraocular and limb motor nerves during spontaneous "fi

4 gic deposits of IgG, C3, and C5b-C9 in their extraocular and limb neuromuscular junctions, and droopi

5 Thus, Porcn is required in both extraocular and neuroectodermal tissues to regulate dist

6 eleration signals to control the activity of extraocular and postural neurons, thus completing a fund

7 choroidal invasion (4/38) or trans-scleral, extraocular, and postlaminar optic nerve invasion (1/38)

8 he tumor but loss of the 3q arm only for the extraocular area.

9 8p was observed between the intraocular and extraocular areas of the tumor.

10 or screening of the entire body and directed extraocular biopsy.

11 The percentage of extraocular cases was also higher in counties with the f

12 n ciliary cells of eyes in the larva, and in extraocular cells around the brain in the adult.

13 These extraocular cells house hundreds of cilia in an intra-ce

14 itially resulted in the production of yellow extraocular color.

15 ndingly, the neural pathways mediating spino-extraocular coupling have switched from contralateral to

16 Hispanic children had a higher percentage of extraocular disease (86 of 261 [33.0%] vs. 102 of 510 no

17 emission: 4 with ocular disease only, 4 with extraocular disease only, and 5 with both.

18 al invasive procedures caused the subsequent extraocular disease or if growth of the tumor into the e

19 tive biopsies compared to those who also had extraocular disease.

20 ic and genomic analyses with minimal risk of extraocular dissemination.

21 to the fovea are essential for the design of extraocular drug delivery systems.

22 This study assessed the capability of extraocular (EO) and intraocular (IO) pressure transduce

23 led RPE-specific cre activity in the eye and extraocular expression limited to the testes.

24 tation (48%, 53%, 69%, 78%) (P < 0.001), and extraocular extension (0%, 1%, 11%, 22%) (P < 0.001).

25 mbrane (9%, 24%, 40%, and 40%; P<0.001), and extraocular extension (1%, <1%, 4%, and 12%; P<0.001).

26 esence of ciliary body involvement (CBI) and extraocular extension (EXE) was analyzed among 5,403 pat

27 51%), intratumoral cysts (n = 25, 61%), and extraocular extension (n = 4, 10%).

28 phatic signal between cases with and without extraocular extension (P > 0.05).

29 malignant melanomas of the ciliary body with extraocular extension (two of these developed a regional

30 ent-naive medium choroidal melanomas without extraocular extension from July 2012 through September 2

31 Four cases of extraocular extension of melanoma are documented followi

32 e aspiration biopsy (FNAB) or open biopsy is extraocular extension of the tumor.

33 globes with a ciliary body melanoma without extraocular extension regarding tumor size, cell type, m

34 Malignant melanomas of the ciliary body with extraocular extension show intraocular lymphatic vessels

35 malignant melanoma of the ciliary body with extraocular extension were matched with 10 globes with a

36 ary body in uveal melanomas with and without extraocular extension, and as such, the presence of peri

37 These results suggest that for UM with extraocular extension, both the intraocular and the extr

38 cidence of subretinal fluid, hemorrhage, and extraocular extension.

39 tic metastasis in ciliary body melanoma with extraocular extension.

40 avior such as intraocular tissue invasion or extraocular extension.

41 ed families differed in that one included no extraocular features and the other manifested with highl

42 Ocular and extraocular features were recorded using Human Phenotype

43 conjunctival erosion or dehiscence over the extraocular implant and was treated successfully in all

44 is of intraocular medulloepithelioma with no extraocular invasion was confirmed and conservative trea

45 ed visual acuity, Foster stages, presence of extraocular involvement, history of autoimmune disease,

46 ssive retinitis pigmentosa (RP), but without extraocular involvement.

47 adult-fast MyHC-IIa and the specialized MyHC-Extraocular isoform, that was predicted to be the fastes

48 sthenia gravis clinically involving only the extraocular, levator palpebrae superioris, and orbicular

49 fibrillar PEX aggregates in both intra- and extraocular locations and to co-localize with various el

50 AQP1 expression was also studied in extraocular microvessels and in primary endothelial cell

51 choroidal and hyaloid vessels and in various extraocular microvessels in neonatal and prenatal mice.

52 tients requiring surgery had higher rates of extraocular motility (EOM) restriction (78.6% vs 38.8% P

53 l nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple site

54 We show that BT neurons, like extraocular motoneurons but different from the evoked ey

55 We propose that the temporal development of extraocular motoneurons plays a key role in assembling a

56 cologically distinct functional subgroups of extraocular motoneurons that act in concert to mediate t

57 nces that ensure a coactivation of bilateral extraocular motoneurons with synchronous left-right limb

58 showed, for the first time, that they, like extraocular motoneurons, are also immunoreactive for cal

59 ellar output into the sustained discharge of extraocular motoneurons.

60 locomotory CPG output that produce rhythmic extraocular motor activity appropriate for minimizing mo

61 ring metamorphosis enables spinal CPG-driven extraocular motor activity to match the changing require

62 oncert to mediate the large dynamic range of extraocular motor commands during gaze stabilization.SIG

63 ific CNS lesions, we have investigated spino-extraocular motor coupling in the juvenile frog and the

64 se amplitude and peak velocity revealed that extraocular motor function was unchanged, and immunohist

65 e timing yielded unique activity patterns in extraocular motor nerves, compatible with a spatially an

66 t of nontargeted effects at the level of the extraocular motor neurons and/or their innervation of ex

67 This study examined the development of two extraocular motor nuclei (nIII and nIV), structures in w

68 uron pools: SIF motoneurons found within the extraocular motor nuclei, and MIF motoneurons found alon

69 g change in spinal efference copy control of extraocular motor output.

70 Decrease in proptosis and improvement in extraocular movements were also significantly better wit

71 mably is the basis for the broad spectrum of extraocular muscle (EOM) contractile properties in drivi

72 branched to enter the LR and arborized among extraocular muscle (EOM) fibers.

73 Extraocular muscle (EOM) has a distinct skeletal muscle

74 graphy (AS-OCT) in measuring the distance of extraocular muscle (EOM) insertion to the limbus to impr

75 e quantitative measures of horizontal rectus extraocular muscle (EOM) morphology to determine the mag

76 t of recessions and resections on horizontal extraocular muscle (EOM) paths and globe position.

77 Surgical recession of an extraocular muscle (EOM) posterior to its original inser

78 ic resonance imaging (MRI) was used to study extraocular muscle (EOM) responses to head tilt in HTDHT

79 mutation and MRI findings that demonstrated extraocular muscle (EOM) size, location, contractility,

80 ated that prolonged exposure of adult rabbit extraocular muscle (EOM) to insulin-like growth factor-1

81 Extraocular muscle (EOM)-specific MyHC expressing fibres

82 r (IGF)-II in increasing force generation in extraocular muscle (EOM).

83 sex (P = .01) and inflammation extending to extraocular muscle (P = .01).

84 All three Pitx2 isoforms were expressed by extraocular muscle and at higher levels than in other st

85 , slow-tonic MyHC and EOM-MyHC expression in extraocular muscle and its absence leads to increased ex

86 fied five parameters of the superior oblique extraocular muscle at 2 weeks of age: contractile force,

87 Extraocular muscle biopsy should be strongly considered

88 Morphogenesis of all extraocular muscle bundles correlated highly with Pitx2

89 all three age groups in the Pitx2-deficient extraocular muscle compared with littermate controls.

90 ar muscles and the connective tissues of the extraocular muscle cones in the normal mouse.

91 Pitx2) is known to regulate the formation of extraocular muscle development and in this report we sho

92 comparable upstream factors required during extraocular muscle development have not been identified.

93 s, the ectopic nerves were seen to innervate extraocular muscle directly.

94 e, especially in the presence of ipsilateral extraocular muscle enlargement, sinus disease, or focal

95 Patients with extraocular muscle fibrosis or paralysis were excluded.

96 fibers may either provide resistance against extraocular muscle forces or limit globe axial elongatio

97 We show Pax7 is dispensable for extraocular muscle formation, whereas Pitx2 is cell-auto

98 Magnetic resonance imaging (MRI) of extraocular muscle function was used to evaluate the rol

99 Modulation of Pitx2 expression can influence extraocular muscle function with long-term therapeutic i

100 The mutant extraocular muscle had no obvious pathology but had alte

101 Extraocular muscle inner mitochondrial membrane density

102 re calculated as distances between published extraocular muscle insertions and rotational axes.

103 mage, and ptosis and ocular dysmotility from extraocular muscle involvement.

104 Ca2+ sinks; and (3) mitochondrial content in extraocular muscle is determined by the transcription fa

105 Extraocular muscle is fundamentally distinct from other

106 pmental disorder in which the lateral rectus extraocular muscle is not properly innervated.

107 Extraocular muscle is unusually fast with a far weaker K

108 specific isoform alpha, and the specialized extraocular muscle isoform).

109 (AL) on globe rotational axis and horizontal extraocular muscle leverage during horizontal duction.

110 nition of the regulation of MyHC isoforms in extraocular muscle may allow their rational manipulation

111 Activity of complexes I and IV was lower in extraocular muscle mitochondria (approximately 50% the a

112 The results demonstrate that extraocular muscle mitochondria respire at slower rates

113 The authors tested the hypothesis that extraocular muscle mitochondria respire faster than do m

114 States 3, 4, and 5 respiration rates in extraocular muscle mitochondria were 40% to 60% lower th

115 Finally, complex V was less abundant in extraocular muscle mitochondria.

116 ntains premotor neurons supplying horizontal extraocular muscle motoneurons.

117 demonstrated the presence of Pitx2 mainly in extraocular muscle myonuclei.

118 Alan Scott initially investigated extraocular muscle paralysis by botulinum injection in 1

119 bulbar anesthesia for cataract extraction is extraocular muscle paresis/restriction and is unique to

120 Pitx2 is important in maintaining the mature extraocular muscle phenotype and regulating the expressi

121 omously required to prevent apoptosis of the extraocular muscle primordia.

122 iplopia, enophthalmos, orbital dystopia, and extraocular muscle restriction.

123 Extraocular muscle strengthening is a common treatment f

124 Extraocular muscle surgery frequently is required for pl

125 ing may provide an adjunct or alternative to extraocular muscle surgery in selected cases.

126 ium 103 plaque brachytherapy with or without extraocular muscle surgery.

127 Imaging studies disclosed extraocular muscle swelling (8 cases), most frequently o

128 expression in adulthood also defines certain extraocular muscle traits.

129 e ability of sustained treatment of a single extraocular muscle with glial cell line-derived neurotro

130 ive anatomic sites: eye, orbit, optic nerve, extraocular muscle, and lacrimal drainage system.

131 tion, and survival, leading to craniofacial, extraocular muscle, and ocular developmental abnormaliti

132 Reductions in extraocular muscle, orbital fat volume, or both were obs

133 identified in the Pitx2(Deltaflox/Deltaflox) extraocular muscle, suggesting that altered innervation

134 ismus, possibly by altering vergence tone in extraocular muscle.

135 ed to study the effect of Pitx2 depletion on extraocular muscle.

136 d receptor (PPAR)gamma were more abundant in extraocular muscle.

137 ase were only approximately 2-fold higher in extraocular muscle.

138 regulates [Ca2+]i and production of force in extraocular muscle; (2) mitochondrial content correlates

139 (CN3) and applied to congenital fibrosis of extraocular muscles (CFEOM) and congenital oculomotor pa

140 ing of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrom

141 ly who segregates congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria.

142 Human extraocular muscles (EOM) are preferentially susceptible

143 Extraocular muscles (EOM) represent a unique muscle grou

144 onance imaging (MRI) was used to demonstrate extraocular muscles (EOMs) and associated motor nerves i

145 ed magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ra

146 Connective tissue pulleys inflect the extraocular muscles (EOMs) and receive insertions from s

147 n freshly dissected and cryosectioned rectus extraocular muscles (EOMs) and tibialis anterior (TA) mu

148 Extraocular muscles (EOMs) are highly specialized skelet

149 ial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals co

150 Rectus and the inferior oblique extraocular muscles (EOMs) consist of orbital layers (OL

151 Strabismic extraocular muscles (EOMs) differ from normal EOMs in st

152 e lateral rectus (LR) and medial rectus (MR) extraocular muscles (EOMs) have largely nonoverlapping s

153 mmon treatment for motility disorders of the extraocular muscles (EOMs) is a resection procedure in w

154 tramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior a

155 nective tissues that surround the horizontal extraocular muscles (EOMs) of humans.

156 dings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primate

157 Structural abnormalities of extraocular muscles (EOMs) or their pulleys are associat

158 toxin-treated normal adult rabbit and monkey extraocular muscles (EOMs) were analyzed.

159 studies have shown that direct injection of extraocular muscles (EOMs) with insulin growth factor or

160 ry nerve terminal elimination at synapses in extraocular muscles (EOMs), a specialized set of muscles

161 Here, we investigated the morphogenesis of extraocular muscles (EOMs), an evolutionary conserved cr

162 l of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possi

163 inear viscoelastic stress-strain behavior of extraocular muscles (EOMs).

164 ayer (OL) and global layer (GL) of adult rat extraocular muscles (EOMs).

165 rst time that neuromuscular junctions of the extraocular muscles (responsible for the control of eye

166 C are expressed in and around the developing extraocular muscles and cause growth cone collapse of oc

167 The very few exceptions are some extraocular muscles and facial muscles that normally att

168 trophic factors strengthen juvenile maturing extraocular muscles and gain insight into mechanisms of

169 onance imaging revealed marked hypoplasia of extraocular muscles and intraorbital cranial nerves.

170 increases the dynamic response range of the extraocular muscles and matches metabolic demand to supp

171 can now directly demonstrate innervation to extraocular muscles and quantify optic nerve size.

172 uria, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

173 amps, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

174 ere detected in the posterior regions of the extraocular muscles and the connective tissues of the ex

175 cts of ocular motility are properties of the extraocular muscles and their associated connective tiss

176 Motoneurons of extraocular muscles are controlled by different premotor

177 Second, extraocular muscles are divided into two layers; the inn

178 This mechanism may not apply to extraocular muscles because their constant activity may

179 sorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons.

180 lternative subunit isoform expression in the extraocular muscles compared with limb muscles.

181 Mammalian extraocular muscles contain singly innervated twitch mus

182 Extraocular muscles contain two types of muscle fibers a

183 Imaging of the orbit and extraocular muscles continues to be recommended as helpf

184 Exogenous IGF1 and CT1 strengthen extraocular muscles during maturation.

185 Extraocular muscles from adult male Sprague-Dawley rats

186 h sensory-induced strabismus, innervation to extraocular muscles from motor nuclei produce the inappr

187 stablished several years ago that the rectus extraocular muscles have connective tissue pulleys, rece

188 (CT1) are known to increase the strength of extraocular muscles in adult and embryonic animals, but

189 elation was found between IS and T2-time for extraocular muscles in healthy volunteers.

190 lity of the rectus and superior oblique (SO) extraocular muscles in hypertropic and hypotropic eyes w

191 s in estimation of inflammatory processes of extraocular muscles in the clinical practice.

192 alterations in the dynamic properties of the extraocular muscles involved in eye torsion.

193 mal positioning of the eyeball suggested the extraocular muscles involvement.

194 tested the hypothesis that glucose uptake by extraocular muscles is not regulated by insulin or contr

195 Glucose uptake in extraocular muscles is regulated by insulin and contract

196 y-induced strabismus, central innervation to extraocular muscles is responsible for setting the state

197 The constant activity of the extraocular muscles is supported by abundant mitochondri

198 nalysis of triceps surae (a limb muscle) and extraocular muscles of adult male Sprague-Dawley rats.

199 Mouse extraocular muscles of different ages were examined for

200 Topographic relationships of the extraocular muscles relative to the fovea are essential

201 Extraocular muscles show specific adaptations to fulfill

202 In vitro, Pitx2 loss made the extraocular muscles stronger, faster, and more fatigable

203 All 6 patients had enlarged extraocular muscles that caused restrictive strabismus.

204 opharyngeal myotomy or corrective surgery of extraocular muscles to ease ptosis.

205 ve been linked to congenital fibrosis of the extraocular muscles type 1 (CFEOM1), a dominant disorder

206 otility disorder "Congenital fibrosis of the extraocular muscles type 1" (CFEOM1) results from hetero

207 abnormalities in congenital fibrosis of the extraocular muscles type 3 (CFEOM3), a disorder resultin

208 s consistent with congenital fibrosis of the extraocular muscles type 3 (CFEOM3); 1 patient harbored

209 ated or syndromic congenital fibrosis of the extraocular muscles, a form of complex congenital strabi

210 uired at several steps in the development of extraocular muscles, acting first as an anti-apoptotic f

211 reported to cause congenital fibrosis of the extraocular muscles, c.1228G>A results in a TUBB3 E410K

212 reported to have congenital fibrosis of the extraocular muscles, facial weakness, developmental dela

213 nversus syndrome, congenital fibrosis of the extraocular muscles, lymphedema-distichiasis syndrome, n

214 risk factors for congenital fibrosis of the extraocular muscles, may play a role in SOP and conseque

215 ll musculature, as well as the diaphragm and extraocular muscles, originate from MyoD+ progenitors.

216 or movements, and Congenital fibrosis of the extraocular muscles, Type III.

217 rbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

218 lmoplegia involving progressive paralysis of extraocular muscles.

219 plicating primary involvement of the oblique extraocular muscles.

220 ectivity between cranial motor axons and the extraocular muscles.

221 sessment of the pathophysiological status of extraocular muscles.

222 commonly affect the optic nerve, retina, and extraocular muscles.

223 GLUT1 and GLUT4 were detectable in extraocular muscles.

224 ated upstream activator of myogenesis in the extraocular muscles.

225 lability of substrate for energy pathways in extraocular muscles.

226 ative image of the motor command sent to the extraocular muscles.

227 tly remodel the proximal segment of juvenile extraocular muscles.

228 f oculomotor axons to innervate their target extraocular muscles.

229 iation of the myogenic regulatory cascade in extraocular muscles.

230 phogenesis and gene expression in developing extraocular muscles.

231 by an outer mechanism driven by the oblique extraocular muscles.

232 imum [Ca2+]i and force significantly more in extraocular muscles.

233 issue biopsy for lesions not confined to the extraocular muscles.

234 related to the pattern of innervation of the extraocular muscles.

235 velopmental decision regions close to target extraocular muscles.

236 ients (22/28 orbits) had enlargement of some extraocular muscles.

237 portion of slow fibers at birth, such as the extraocular muscles.

238 ar motor neurons and/or their innervation of extraocular muscles.

239 There are two muscle fiber types in extraocular muscles: those receiving a single motor endp

240 s occur in bilateral antagonistic horizontal extraocular nerves, during adult fictive limb-kicking, t

241 s a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle eva

242 However, neither extraocular nor cardiac muscle was affected in double-kn

243 MIF motoneurons are located outside the extraocular nuclei in primates, but are intermixed with

244 otor nuclei but not in the relatively spared extraocular nuclei.

245 e intermixed with SIF motoneurons within rat extraocular nuclei.

246 known pathways of cholesterol elimination in extraocular organs are operative in the retina and that

247 ular extension, both the intraocular and the extraocular parts of the tumor should be sampled for acc

248 The intraocular and extraocular parts of the tumor were microdissected and a

249 most motor neurons die but those innervating extraocular, pelvic sphincter, and slow limb muscles exh

250 using siRNA in primary mouse myoblasts from extraocular, pharyngeal and limb muscles.

251 ly dominant optic neuropathy with or without extraocular phenotypes.

252 Extraocular photoreception, the ability to detect and re

253 Before, extraocular photoreceptors of the lamina organ were sugg

254 antiphase via the largest PDFME entrained by extraocular photoreceptors of the lamina organ.

255 atial vision due to a distributed network of extraocular photoreceptors whose fields of view are rest

256 gan tissues harboring the symbionts serve as extraocular photoreceptors, with the potential to percei

257 ts show that TRPA1 is essential for a unique extraocular phototransduction pathway in human melanocyt

258 ge series of FNAB for uveal melanoma with no extraocular recurrence have been reported by multiple ex

259 relapse, no further episodes of intraocular/extraocular recurrence were recorded, and all patients w

260 hree groups on the basis of risk factors for extraocular relapse and metastasis assessed on centraliz

261 isease-free survival (DFS), considering only extraocular relapse as an event.

262 tion are at risk of developing late solitary extraocular relapse even more than 30 years after surger

263 e strongly suggestive of a diagnosis of late extraocular relapse from previously resected iris melano

264 To report on cases of late extraocular relapse of previously resected iris melanoma

265 grouping of patients with increasing risk of extraocular relapse.

266 The number of aqueous shunts to the extraocular reservoir increased 231% from 2356 in 1994 t

267 shunts (external approach), aqueous shunt to extraocular reservoir, and ECP.

268 Different staging systems for extraocular retinoblastoma have been published, but to d

269 en any particular uveitis characteristic and extraocular sarcoidosis progression.

270 e during needle withdrawal for prevention of extraocular seeding.

271 at induction of dorsal fate would require an extraocular signal arising from a neighboring tissue to

272 work has identified the nature and source of extraocular signals required to pattern the dorsal retin

273 ate of relapse of MMP at any site (ocular or extraocular site) was 0.029/PY (95% CI 0.015-0.050/PY).

274 inimal dissemination [MD]) of tumor cells in extraocular sites might be a tool for designing appropri

275 , conjunctival, uveal, or remote melanoma at extraocular sites.

276 mRNA is a novel marker for retinoblastoma at extraocular sites.

277 r disease or if growth of the tumor into the extraocular space occurred independent of or prior to th

278 alous communications between intraocular and extraocular spaces.

279 alous communications between intraocular and extraocular spaces.

280 ated with a significant risk for recurrence, extraocular spread, and systemic metastases.

281 nt correlated with ciliary body involvement, extraocular spread, largest basal tumor diameter, tumor

282 ckness, TNM stage, ciliary body involvement, extraocular spread, melanoma cytomorphological findings,

283 al tumor diameter, ciliary body involvement, extraocular spread, TNM stage, closed loops, and mitotic

284 gnosed as LCA who presented with RAH with no extraocular symptoms or signs of phakomatosis were image

285 ts showed a classic form of RP with variable extraocular symptoms, such as history of recurrent child

286 stem cell transplantation, conjunctival and extraocular tissue transplantation, multiagent immunosup

287 en recruited during embryogenesis in various extraocular tissues including antennae and legs.

288 ys of enzymatic cholesterol removal exist in extraocular tissues.

289 T (P=0.019), tumor recurrence (P=0.002), and extraocular tumor extension (P=0.017) were predictive of

290 Biopsy of an extraocular tumor extension may not be representative of

291 The only factor predictive of extraocular tumor extension was intraocular tumor recurr

292 There was no case of extraocular tumor extension, hypotony, or phthisis bulbi

293 reased (18)F-FDG uptake was noted in primary extraocular tumor in all patients, except 5 with bilater

294 udies reporting treatment of benign tumours, extraocular tumours, or other forms of stereotactic radi

295 The implant consisted of an extraocular unit containing electronics for wireless dat

296 nd genetic analysis supported a diagnosis of extraocular uveal tumor spread rather than a primary con

297 neural tube and the branchial arches specify extraocular versus branchiomeric muscles.

298 ossessing discrete visual organs (eyes), but extraocular vision could facilitate vision without eyes.

299 Echinoderms form the focus of extraocular vision research [1-7], and the brittle star

300 ents one of the most detailed mechanisms for extraocular vision yet proposed and draws interesting pa

301 ting parallels with the only other confirmed extraocular visual system, that of some sea urchins, whi