ライフサイエンスコーパス: extraocular muscle

1 ed to study the effect of Pitx2 depletion on extraocular muscle.

2 d receptor (PPAR)gamma were more abundant in extraocular muscle.

3 ase were only approximately 2-fold higher in extraocular muscle.

4 drug treatments to strengthen an underacting extraocular muscle.

5 as means of pharmacologically weakening the extraocular muscle.

6 gents that weaken and strengthen the treated extraocular muscle.

7 ated for patients with total paralysis of an extraocular muscle.

8 rhodamine-phalloidin, as does the zebrafish extraocular muscle.

9 system in association with the medial rectus extraocular muscle.

10 to all en plaque and en grappe endplates of extraocular muscle.

11 al extension of intramuscular haemangioma of extraocular muscle.

12 ismus, possibly by altering vergence tone in extraocular muscle.

13 ative image of the motor command sent to the extraocular muscles.

14 tly remodel the proximal segment of juvenile extraocular muscles.

15 f oculomotor axons to innervate their target extraocular muscles.

16 iation of the myogenic regulatory cascade in extraocular muscles.

17 phogenesis and gene expression in developing extraocular muscles.

18 by an outer mechanism driven by the oblique extraocular muscles.

19 imum [Ca2+]i and force significantly more in extraocular muscles.

20 sis that mitochondria serve as Ca2+ sinks in extraocular muscles.

21 educed muscle fiber diameters within treated extraocular muscles.

22 ic response of oculomotor nuclei to abnormal extraocular muscles.

23 issue biopsy for lesions not confined to the extraocular muscles.

24 motor nucleus, and contractility of isolated extraocular muscles.

25 related to the pattern of innervation of the extraocular muscles.

26 velopmental decision regions close to target extraocular muscles.

27 in patients with total paralysis of multiple extraocular muscles.

28 orbital inflammation primarily involving the extraocular muscles.

29 nd their corresponding alpha motoneurons and extraocular muscles.

30 lities result from myopathic fibrosis of the extraocular muscles.

31 omosome 12-linked congenital fibrosis of the extraocular muscles.

32 at they determine functional origins for the extraocular muscles.

33 luding dual or accessory muscle slips of the extraocular muscles.

34 ients (22/28 orbits) had enlargement of some extraocular muscles.

35 portion of slow fibers at birth, such as the extraocular muscles.

36 ar motor neurons and/or their innervation of extraocular muscles.

37 lmoplegia involving progressive paralysis of extraocular muscles.

38 plicating primary involvement of the oblique extraocular muscles.

39 ectivity between cranial motor axons and the extraocular muscles.

40 sessment of the pathophysiological status of extraocular muscles.

41 commonly affect the optic nerve, retina, and extraocular muscles.

42 GLUT1 and GLUT4 were detectable in extraocular muscles.

43 ated upstream activator of myogenesis in the extraocular muscles.

44 lability of substrate for energy pathways in extraocular muscles.

45 regulates [Ca2+]i and production of force in extraocular muscle; (2) mitochondrial content correlates

46 ed by afferent signals from receptors in the extraocular muscles [3,4].

47 ated or syndromic congenital fibrosis of the extraocular muscles, a form of complex congenital strabi

48 uired at several steps in the development of extraocular muscles, acting first as an anti-apoptotic f

49 er candidates, including pulleys that affect extraocular-muscle action and the role of nasally biased

50 ults are consistent with the hypothesis that extraocular muscle afferent signals provide a feedback s

51 common singly-innervated muscle fiber (SIF), extraocular muscles also contain multiply-innervated mus

52 genetic locus for congenital fibrosis of the extraocular muscle, an autosomal dominant muscular dystr

53 All three Pitx2 isoforms were expressed by extraocular muscle and at higher levels than in other st

54 , slow-tonic MyHC and EOM-MyHC expression in extraocular muscle and its absence leads to increased ex

55 disorders such as congenital fibrosis of the extraocular muscles and blepharophimosis.

56 C are expressed in and around the developing extraocular muscles and cause growth cone collapse of oc

57 The very few exceptions are some extraocular muscles and facial muscles that normally att

58 trophic factors strengthen juvenile maturing extraocular muscles and gain insight into mechanisms of

59 onance imaging revealed marked hypoplasia of extraocular muscles and intraorbital cranial nerves.

60 increases the dynamic response range of the extraocular muscles and matches metabolic demand to supp

61 can now directly demonstrate innervation to extraocular muscles and quantify optic nerve size.

62 uria, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

63 amps, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

64 ere detected in the posterior regions of the extraocular muscles and the connective tissues of the ex

65 cts of ocular motility are properties of the extraocular muscles and their associated connective tiss

66 The study of the oculomotor periphery, the extraocular muscles and their orbital attachments, is un

67 ive anatomic sites: eye, orbit, optic nerve, extraocular muscle, and lacrimal drainage system.

68 tion, and survival, leading to craniofacial, extraocular muscle, and ocular developmental abnormaliti

69 Thus, the retinal image and functional extraocular muscles appeared nearly simultaneously with

70 Motoneurons of extraocular muscles are controlled by different premotor

71 Second, extraocular muscles are divided into two layers; the inn

72 ted muscle fibers (MIFs) are peculiar to the extraocular muscles as they are non-twitch but produce a

73 The extraocular muscles assumed their adult configuration be

74 fied five parameters of the superior oblique extraocular muscle at 2 weeks of age: contractile force,

75 This mechanism may not apply to extraocular muscles because their constant activity may

76 Extraocular muscle biopsy should be strongly considered

77 eries with a minimum 50 patients; evaluating extraocular muscle BTXA injection for initial or repeat

78 Morphogenesis of all extraocular muscle bundles correlated highly with Pitx2

79 sorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons.

80 reported to cause congenital fibrosis of the extraocular muscles, c.1228G>A results in a TUBB3 E410K

81 (CN3) and applied to congenital fibrosis of extraocular muscles (CFEOM) and congenital oculomotor pa

82 ing of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrom

83 egia, and include congenital fibrosis of the extraocular muscles (CFEOM) and Duane syndrome (DURS).

84 ly who segregates congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria.

85 e classic form of congenital fibrosis of the extraocular muscles (CFEOM1) are born with bilateral pto

86 all three age groups in the Pitx2-deficient extraocular muscle compared with littermate controls.

87 lternative subunit isoform expression in the extraocular muscles compared with limb muscles.

88 ar muscles and the connective tissues of the extraocular muscle cones in the normal mouse.

89 Mammalian extraocular muscles contain singly innervated twitch mus

90 Extraocular muscles contain two types of muscle fibers a

91 Imaging of the orbit and extraocular muscles continues to be recommended as helpf

92 Extraocular muscle contractility was impaired by dark re

93 Pitx2) is known to regulate the formation of extraocular muscle development and in this report we sho

94 comparable upstream factors required during extraocular muscle development have not been identified.

95 s, the ectopic nerves were seen to innervate extraocular muscle directly.

96 355 patients (81.1%, n = 355/438) had their extraocular muscles disinserted during surgery, with the

97 nd additional proteomic data, establish that extraocular muscle does not constitute a distinctive mus

98 Exogenous IGF1 and CT1 strengthen extraocular muscles during maturation.

99 Enophthalmos, diplopia resulting from extraocular muscle dysfunction, and infraorbital nerve h

100 e, especially in the presence of ipsilateral extraocular muscle enlargement, sinus disease, or focal

101 mably is the basis for the broad spectrum of extraocular muscle (EOM) contractile properties in drivi

102 branched to enter the LR and arborized among extraocular muscle (EOM) fibers.

103 Extraocular muscle (EOM) has a distinct skeletal muscle

104 graphy (AS-OCT) in measuring the distance of extraocular muscle (EOM) insertion to the limbus to impr

105 The orbital layer of each rectus extraocular muscle (EOM) inserts on connective tissue, a

106 Although extraocular muscle (EOM) is skeletal muscle, aspects of

107 Extraocular muscle (EOM) is spared in Duchenne muscular

108 e quantitative measures of horizontal rectus extraocular muscle (EOM) morphology to determine the mag

109 t of recessions and resections on horizontal extraocular muscle (EOM) paths and globe position.

110 Extraocular muscle (EOM) paths are constrained by connec

111 Surgical recession of an extraocular muscle (EOM) posterior to its original inser

112 ic resonance imaging (MRI) was used to study extraocular muscle (EOM) responses to head tilt in HTDHT

113 direct injection of ricin-mAb 35 into rabbit extraocular muscle (EOM) results in significant muscle l

114 re correlated with MRI studies demonstrating extraocular muscle (EOM) size, location, contractility,

115 mutation and MRI findings that demonstrated extraocular muscle (EOM) size, location, contractility,

116 ated that prolonged exposure of adult rabbit extraocular muscle (EOM) to insulin-like growth factor-1

117 es were analyzed quantitatively to determine extraocular muscle (EOM) volume, maximum diameter, and l

118 In myasthenia gravis (MG), extraocular muscle (EOM) weakness is often an initial an

119 ative muscle classes, limb, masticatory, and extraocular muscle (EOM), in adult mice by high-density

120 Extraocular muscle (EOM)-specific MyHC expressing fibres

121 r (IGF)-II in increasing force generation in extraocular muscle (EOM).

122 Because the extraocular muscles (EOM) are preferentially affected in

123 Human extraocular muscles (EOM) are preferentially susceptible

124 Extraocular muscles (EOM) represent a unique muscle grou

125 le, only 56 genes were altered in the spared extraocular muscles (EOM).

126 erve as functional mechanical origins of the extraocular muscles (EOMs) and are normally stable relat

127 onance imaging (MRI) was used to demonstrate extraocular muscles (EOMs) and associated motor nerves i

128 ed magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ra

129 Connective tissue pulleys inflect the extraocular muscles (EOMs) and receive insertions from s

130 n freshly dissected and cryosectioned rectus extraocular muscles (EOMs) and tibialis anterior (TA) mu

131 Orbital and global layers of rectus extraocular muscles (EOMs) are believed to serve differe

132 Mammalian extraocular muscles (EOMs) are both physiologically and

133 ness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared.

134 The paths of the rectus extraocular muscles (EOMs) are constrained by pulleys, c

135 Extraocular muscles (EOMs) are highly specialized skelet

136 Extraocular muscles (EOMs) are specialized skeletal musc

137 ial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals co

138 Rectus extraocular muscles (EOMs) consist of orbital (OL) and g

139 Rectus and the inferior oblique extraocular muscles (EOMs) consist of orbital layers (OL

140 Strabismic extraocular muscles (EOMs) differ from normal EOMs in st

141 hy after intramuscular injection with Botox, extraocular muscles (EOMs) do not.

142 The phenotypically novel extraocular muscles (EOMs) exhibit fundamental differenc

143 e lateral rectus (LR) and medial rectus (MR) extraocular muscles (EOMs) have largely nonoverlapping s

144 mmon treatment for motility disorders of the extraocular muscles (EOMs) is a resection procedure in w

145 tramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior a

146 nective tissues that surround the horizontal extraocular muscles (EOMs) of humans.

147 dings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primate

148 Structural abnormalities of extraocular muscles (EOMs) or their pulleys are associat

149 toxin-treated normal adult rabbit and monkey extraocular muscles (EOMs) were analyzed.

150 studies have shown that direct injection of extraocular muscles (EOMs) with insulin growth factor or

151 ry nerve terminal elimination at synapses in extraocular muscles (EOMs), a specialized set of muscles

152 sue structures constrain paths of the rectus extraocular muscles (EOMs), acting as pulleys and servin

153 Here, we investigated the morphogenesis of extraocular muscles (EOMs), an evolutionary conserved cr

154 l of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possi

155 inear viscoelastic stress-strain behavior of extraocular muscles (EOMs).

156 ayer (OL) and global layer (GL) of adult rat extraocular muscles (EOMs).

157 as the functional mechanical origins of the extraocular muscles (EOMs).

158 aths and determine pulling directions of the extraocular muscles (EOMs).

159 tal pulleys proposed to be positioned by the extraocular muscles (EOMs).

160 rbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

161 Extraocular muscles express a number of characteristics

162 Populations of mature myofibers from all six extraocular muscles express N-CAM homogeneously on their

163 reported to have congenital fibrosis of the extraocular muscles, facial weakness, developmental dela

164 pothesis that there is greater complexity to extraocular muscle fiber types than the traditional desc

165 Fine control of extraocular muscle fibers derives from two subpopulation

166 Patients with extraocular muscle fibrosis or paralysis were excluded.

167 ous trophic factors regulate and/or maintain extraocular muscle force through a rapid mechanism that

168 fibers may either provide resistance against extraocular muscle forces or limit globe axial elongatio

169 We show Pax7 is dispensable for extraocular muscle formation, whereas Pitx2 is cell-auto

170 Extraocular muscles from adult male Sprague-Dawley rats

171 h sensory-induced strabismus, innervation to extraocular muscles from motor nuclei produce the inappr

172 Extraocular muscles from rabbits, monkeys, and humans we

173 Magnetic resonance imaging (MRI) of extraocular muscle function was used to evaluate the rol

174 Modulation of Pitx2 expression can influence extraocular muscle function with long-term therapeutic i

175 nd in the multiply innervated slow fibers of extraocular muscle, gamma subunit expression persists in

176 The mutant extraocular muscle had no obvious pathology but had alte

177 ture; to date there are no reported cases of extraocular muscle haemangiomas extending into the brain

178 When involving the extraocular muscles, haemangiomas are extremely rare, wi

179 stablished several years ago that the rectus extraocular muscles have connective tissue pulleys, rece

180 al nerves grow toward, and connect with, six extraocular muscles in a stereotyped pattern, to control

181 (CT1) are known to increase the strength of extraocular muscles in adult and embryonic animals, but

182 Because of the exclusive involvement of the extraocular muscles in Graves' ophthalmopathy, the absen

183 elation was found between IS and T2-time for extraocular muscles in healthy volunteers.

184 lity of the rectus and superior oblique (SO) extraocular muscles in hypertropic and hypotropic eyes w

185 s established the normal paths of the rectus extraocular muscles in primary gaze.

186 s in estimation of inflammatory processes of extraocular muscles in the clinical practice.

187 ng group in whom greater manipulation of the extraocular muscles inevitably occurs, are consistent wi

188 Extraocular muscle injection of BTXA achieves a high rat

189 Extraocular muscle inner mitochondrial membrane density

190 ubtypes, suggesting a potential link between extraocular muscle innervation, co-contraction, and corn

191 re calculated as distances between published extraocular muscle insertions and rotational axes.

192 thorough clinical examination and imaging of extraocular muscle insertions on the Swept Source Anteri

193 eoperations based on preoperative imaging of extraocular muscle insertions, and whether the Anterior

194 Compartmentalization of the extraocular muscles into well-defined orbital and global

195 alterations in the dynamic properties of the extraocular muscles involved in eye torsion.

196 are likely to underlie the low threshold for extraocular muscle involvement in this disease?

197 7 patients with orbital metastasis, 5 showed extraocular muscle involvement with restricted ocular mo

198 mage, and ptosis and ocular dysmotility from extraocular muscle involvement.

199 mal positioning of the eyeball suggested the extraocular muscles involvement.

200 in retinal pigment epithelium, optic nerve, extraocular muscle, iris, ciliary body, cornea, and seve

201 Ca2+ sinks; and (3) mitochondrial content in extraocular muscle is determined by the transcription fa

202 Extraocular muscle is fundamentally distinct from other

203 pmental disorder in which the lateral rectus extraocular muscle is not properly innervated.

204 Extraocular muscle is unusually fast with a far weaker K

205 Extraocular muscle is very responsive to direct injectio

206 Congenital fibrosis of the extraocular muscles is an autosomal dominant congenital

207 amount of residual function of the affected extraocular muscles is essential to determine which surg

208 tested the hypothesis that glucose uptake by extraocular muscles is not regulated by insulin or contr

209 Glucose uptake in extraocular muscles is regulated by insulin and contract

210 y-induced strabismus, central innervation to extraocular muscles is responsible for setting the state

211 The constant activity of the extraocular muscles is supported by abundant mitochondri

212 specific isoform alpha, and the specialized extraocular muscle isoform).

213 th the different loads and usage patterns of extraocular muscle layers, as proposed in the active pul

214 of the structure-function characteristics of extraocular muscle layers.

215 transcripts) was identified between the two extraocular muscle layers.

216 (AL) on globe rotational axis and horizontal extraocular muscle leverage during horizontal duction.

217 rom an abnormality in the development of the extraocular muscle lower motor neuron system.

218 nversus syndrome, congenital fibrosis of the extraocular muscles, lymphedema-distichiasis syndrome, n

219 nition of the regulation of MyHC isoforms in extraocular muscle may allow their rational manipulation

220 The presence of N-CAM in normal mature extraocular muscles may play a role in the etiology and

221 risk factors for congenital fibrosis of the extraocular muscles, may play a role in SOP and conseque

222 Activity of complexes I and IV was lower in extraocular muscle mitochondria (approximately 50% the a

223 The results demonstrate that extraocular muscle mitochondria respire at slower rates

224 The authors tested the hypothesis that extraocular muscle mitochondria respire faster than do m

225 States 3, 4, and 5 respiration rates in extraocular muscle mitochondria were 40% to 60% lower th

226 Finally, complex V was less abundant in extraocular muscle mitochondria.

227 of insulin-like growth factor II (IGF-II) on extraocular muscle morphometry and force generation were

228 ntains premotor neurons supplying horizontal extraocular muscle motoneurons.

229 demonstrated the presence of Pitx2 mainly in extraocular muscle myonuclei.

230 The ultrafast extraocular muscles necessitate tight regulation of free

231 t animals' (16 and 20 to 21 days) RPE and in extraocular muscle of a 16-day-old untreated mutant.

232 nalysis of triceps surae (a limb muscle) and extraocular muscles of adult male Sprague-Dawley rats.

233 Mouse extraocular muscles of different ages were examined for

234 Direct injection of ricin-mAb 35 into the extraocular muscles of rabbits results in a dose-related

235 M, was assessed immunohistochemically in the extraocular muscles of rabbits, monkeys, and humans to e

236 rough the oculomotor nucleus that innervates extraocular muscles of the eye.

237 CAM-positive myofibers were found in all six extraocular muscles of the three species examined.

238 which the plant responds to neural drive to extraocular muscles on exclusively short, subsecond time

239 Although polyNCAM was present in the extraocular muscles, only a few small diameter cells wer

240 brachytherapy, type of strabismus developed, extraocular muscles operated, and modality of treatment

241 Reductions in extraocular muscle, orbital fat volume, or both were obs

242 ll musculature, as well as the diaphragm and extraocular muscles, originate from MyoD+ progenitors.

243 sex (P = .01) and inflammation extending to extraocular muscle (P = .01).

244 HZO may cause extraocular muscle palsies, with the third nerve being t

245 Alan Scott initially investigated extraocular muscle paralysis by botulinum injection in 1

246 bulbar anesthesia for cataract extraction is extraocular muscle paresis/restriction and is unique to

247 The rectus extraocular muscles pass through fibromuscular connectiv

248 Pitx2 is important in maintaining the mature extraocular muscle phenotype and regulating the expressi

249 Data show that the extraocular muscle phenotype results from the combinatio

250 Three congenital fibrosis of the extraocular muscles phenotypes (CFEOM1-3) have been iden

251 omously required to prevent apoptosis of the extraocular muscle primordia.

252 al eye position information (efference copy, extraocular muscle proprioception, or both) that is used

253 onsequence of modified efference copy and/or extraocular muscle proprioception.

254 Topographic relationships of the extraocular muscles relative to the fovea are essential

255 1130, 753, and 967 proteins EDL, soleus and extraocular muscles, respectively.

256 rst time that neuromuscular junctions of the extraocular muscles (responsible for the control of eye

257 iplopia, enophthalmos, orbital dystopia, and extraocular muscle restriction.

258 nts evidence that congenital fibrosis of the extraocular muscles results from an abnormality in the d

259 Extraocular muscles show specific adaptations to fulfill

260 disorder is genetically distinct from other extraocular muscle-specific disorders such as congenital

261 endogenous and exogenous trophic factors on extraocular muscle strength and mass were examined in th

262 Extraocular muscle strengthening is a common treatment f

263 In vitro, Pitx2 loss made the extraocular muscles stronger, faster, and more fatigable

264 identified in the Pitx2(Deltaflox/Deltaflox) extraocular muscle, suggesting that altered innervation

265 al mitochondrial clumping are found in other extraocular muscles, suggesting that the muscle patholog

266 We report 28 patients who underwent extraocular muscle surgery for strabismic diplopia after

267 Extraocular muscle surgery frequently is required for pl

268 ing may provide an adjunct or alternative to extraocular muscle surgery in selected cases.

269 Patients confirmed to have a history of extraocular muscle surgery targeting AHP and complete se

270 ates long-term motor and sensory outcomes of extraocular muscle surgery targeting AHP in patients wit

271 ium 103 plaque brachytherapy with or without extraocular muscle surgery.

272 ouplings facilitate implementation by rectus extraocular muscle suspensions of a commutative ocular m

273 Imaging studies disclosed extraocular muscle swelling (8 cases), most frequently o

274 rengthening of eye muscles in the developing extraocular muscle system.

275 oscopic study of the enthesis site-where the extraocular muscle tendon inserts onto the sclera-in nor

276 All 6 patients had enlarged extraocular muscles that caused restrictive strabismus.

277 xistence of a common tendinous origin of the extraocular muscles, that is continuous with the skull b

278 There are two muscle fiber types in extraocular muscles: those receiving a single motor endp

279 opharyngeal myotomy or corrective surgery of extraocular muscles to ease ptosis.

280 , from the genetics of disorders that affect extraocular muscles to the way in which the cerebral cor

281 fugal projection, the retinal image, and the extraocular muscles, to obtain an integrated picture of

282 expression in adulthood also defines certain extraocular muscle traits.

283 Current concepts regarding extraocular muscle transposition and the use of autogeno

284 es in humans with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) due to missense muta

285 ve been linked to congenital fibrosis of the extraocular muscles type 1 (CFEOM1), a dominant disorder

286 Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an

287 otility disorder "Congenital fibrosis of the extraocular muscles type 1" (CFEOM1) results from hetero

288 abnormalities in congenital fibrosis of the extraocular muscles type 3 (CFEOM3), a disorder resultin

289 s consistent with congenital fibrosis of the extraocular muscles type 3 (CFEOM3); 1 patient harbored

290 or movements, and Congenital fibrosis of the extraocular muscles, Type III.

291 ng-term myopathic effects of ricin-mAb 35 on extraocular muscle were investigated.

292 In all cadavers, extraocular muscles were observed to have a common tendi

293 We also analyzed the expression profile of extraocular muscle, which is divergent from other skelet

294 Peak tetanic [Ca2+]i increased in extraocular muscle with caffeine and CEP.

295 e ability of sustained treatment of a single extraocular muscle with glial cell line-derived neurotro

296 are effective for patients who have paretic extraocular muscles with residual function.

297 position and pulling direction of the recti extraocular muscles within the orbit.