ライフサイエンスコーパス: extravasate

1 etween 7 and 100 nm (e.g., liposomes did not extravasate).

2 seemed to strongly vary in their ability to extravasate.

3 the walls through which fluid and cells can extravasate.

4 CF-7 cells are deficient in their ability to extravasate.

5 herical circulating T cells must polarize to extravasate.

6 Edema was estimated by measuring extravasated 125 I-labeled albumin in the various tissue

7 based contrast agent with high propensity to extravasate across a permeable capillary endothelial bar

8 locally increase vascular permeability, and extravasate across inflamed endothelium.

9 lial cells (VECs), leukocytes preferentially extravasate across junctional gaps in the endothelial mo

10 d survive the vascular system can eventually extravasate across the endothelium to metastasize at a s

11 cells contact blood vessels either when they extravasate across the walls of microvessels into inflam

12 The corresponding extravasated activity related to administered activity w

13 Extravasated activity was quantified relative to injecte

14 ity, such that submicron-sized particles can extravasate and accumulate within the islet microenviron

15 lls (CTCs) survive circulatory cytotoxicity, extravasate and colonise secondary sites effecting metas

16 ng the ability of circulating tumor cells to extravasate and colonize, leading to inhibition of metas

17 ould also assist the drug and/or carriers to extravasate and enter the tumor cells.

18 ting tumor cells to distant sites where they extravasate and establish metastatic lesions.

19 their way to distant organ sites where they extravasate and establish metastatic lesions.

20 , and those were more likely to successfully extravasate and form a macrometastasis.

21 lls lacking the integrin activator Kindlin-3 extravasate and induce experimental autoimmune encephalo

22 survive within the circulation, subsequently extravasate and metastasise.

23 tumor microenvironment, monocytes must first extravasate and migrate through the type-1 collagen rich

24 behavior of myeloid cells as they interact, extravasate and survey the mouse retina.

25 than 50% of all accumulated neutrophils were extravasated and colocalized with foci of oncotic hepato

26 (ii) liposome material in these tissues has extravasated and is found extracellularly near a variety

27 pothesis that, in addition to hyperglycemia, extravasated and oxidized LDL is an important insult to

28 nment, serum coagulation factors are readily extravasated and therefore lead to continuous TF-mediate

29 invade, intravasate, enter the circulation, extravasate, and colonize target organs.

30 lls migrate to the vasculature, intravasate, extravasate, and establish metastatic colonies.

31 e capacity of these cells to adhere, arrest, extravasate, and survive in the murine lung over a 24-h

32 er i.v. inoculation, both variants arrested, extravasated, and proliferated in host tissues with simi

33 aring mice, CRV selectively homes to tumors, extravasates, and preferentially binds to macrophages wi

34 this issue by examining the distribution of extravasated antibodies in islet cell tumors of RIP-Tag2

35 tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it invol

36 the primary tumor and then adhere to ECs and extravasate at the metastatic site.

37 ntally that cancer cells also preferentially extravasate at vertices, even when they first arrest on

38 Thrombin, an important clotting factor, extravasates at sites of blood-retina barrier breakdown

39 argeted CT could depict CEB as low as 111 HU extravasating at a rate of 0.3 mL/min.

40 r perfusion with lactated Ringer's solution, extravasated bBSA was detected with immunoprecipitation

41 PLN-formulated ICLs extravasated better than PEGylated liposomal doxorubicin

42 It relied on the quantitation of extravasated bovine serum albumin conjugated to Evans Bl

43 clodronate-ablated macrophages, neutrophils extravasate, but have limited ability to reach the perit

44 nd, as predicted by our hypothesis, ferritin extravasated by way of VVOs, just as in hyperpermeable t

45 ion, and crawling onto the EC surface before extravasating by breaching the EC barrier.

46 cyte activation in the immediate vicinity of extravasating cancer cells might support their progressi

47 Tracking single extravasating cancer cells using multimodal correlative

48 However, once extravasated, CD18(-/-) leukocytes transmigrated more ra

49 ed calcification in murine aortic rings, and extravasated CD235a-positive erythrocytes or Perl iron-p

50 is allowed quantification of the dilution of extravasated CEB as a function of time that was then mod

51 The extravasated cells had a near absence of neutrophil phag

52 ted with a significant delay in apoptosis of extravasated cells.

53 This suggests that extravasating cells, rather than initially signaling to

54 study of cancer cells, neutrophils, or other extravasating cells.

55 ce of signaling molecules that can influence extravasating cells.

56 Although plasma fluids and proteins extravasate continuously from tissue microvasculature (c

57 in the diagnosis of vascular versus enteric extravasated contrast material.

58 mmunogens expressing PF3 elicited activated, extravasating CS-specific T cells that protected against

59 P = 0.3), with a significantly higher median extravasated dose (0.14 Gy [range, 0.03-0.67 Gy] vs. 0.0

60 Extravasated dye was detected at 620 nm and was normaliz

61 inal muscularis identified the phagocytes as extravasating ED1+ monocytes.

62 Notably, the extravasated erythrocytes following SAH are significantl

63 nstrates that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH,

64 Extravasated erythrocytes in cerebrospinal fluid (CSF) c

65 eningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH remains uncle

66 The extravasated erythrocytes that surround the brain contai

67 cular and interstitial spindle-shaped cells, extravasated erythrocytes, and an inflammatory mononucle

68 had, in addition, tumor cell-lined lakes of extravasated erythrocytes.

69 y was determined by fluorescent detection of extravasated Evans blue.

70 forts to define the physiologic functions of extravasated fibrin(ogen) have led to the discovery, rep

71 city of the surrounding tissue to absorb the extravasated fluid, edema (with its associated increased

72 Plasma fibronectin (pFN) extravasates for days from intact hyperpermeable vessels

73 g, suggesting that memory cells can directly extravasate from blood into Peyer's Patches and lymph no

74 rious extracellular matrix molecules as they extravasate from blood vessels and accumulate within can

75 Mst1-/- neutrophils also failed to extravasate from gastric submucosal vessels in a murine

76 avital microscopy we showed that neutrophils extravasate from inflamed dermal venules in close proxim

77 s "shrink" to 10-nm nanoparticles after they extravasate from leaky regions of the tumor vasculature

78 Leukocytes extravasate from the blood in response to physiologic or

79 Leukocytes extravasate from the blood into inflammatory sites throu

80 by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tiss

81 lymphoid haematopoietic cells must not only extravasate from the bloodstream into the tumour tissue

82 Platelets extravasate from the circulation into tumor microenviron

83 ve the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to

84 in nanomedicine depends on their ability to extravasate from vasculature towards the target tissue.

85 nstrate that soluble and particulate tracers extravasate from venules by apparently different transce

86 gents, particulates circulating in the blood extravasate from venules through endothelial cell openin

87 Circulating leukocytes are thought to extravasate from venules through open interendothelial j

88 Wild-type (WT) leukocytes extravasated from limbal vessels, angiogenic stalks, and

89 enous particulates (erythrocytes, platelets) extravasated from plasma through transendothelial openin

90 lood circulation interstitial fluid that has extravasated from the blood capillaries.

91 Circulating ICs extravasated from these PV1(+) capillaries, and nocicept

92 Both tracers extravasated from venules in response to all three perme

93 cleic acid cargo from enzymatic degradation, extravasates from the vasculature, traverses the cell me

94 Chyle extravasates from these plexuses and enters the thoracic

95 t-TBI is decompartmentalization of iron from extravasated hemoglobin (Hb).

96 The overall area density of extravasated IgG/antibodies decreased after treatment bu

97 ow) neutrophil population that was unable to extravasate in response to inflammatory challenges but f

98 Long-circulating liposomes extravasate in tumors such as the rat 9L gliosarcoma and

99 mmunodetection confirmed that TTR was indeed extravasated in its monomeric form when CNS barriers wer

100 ibutes to homeostatic mechanisms by draining extravasated interstitial fluid and facilitating the tra

101 circulation, arrest in the microcirculation, extravasate into a tissue compartment, and grow.

102 nto the lymphatic system or vasculature, and extravasate into and colonize secondary sites.

103 ar matrix, to survive in circulation, and to extravasate into distant vital organs all depend on spec

104 lation, indicating an inherent propensity to extravasate into inflamed and barrier sites.

105 While classical monocytes extravasate into inflamed tissue and give rise to macrop

106 a critical role in stimulation of T cells to extravasate into inflammatory tissue.

107 Furthermore, CTLs were able to extravasate into islets in vivo, and no evidence for ind

108 when defects in angiogenesis permit blood to extravasate into many tissues.

109 Leukocytes migrate through the blood and extravasate into organs to surveil the host for infectio

110 w cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, y

111 ls must dock at the bone marrow endothelium, extravasate into the bone microenvironment, and destroy

112 Since serum proteins are known to extravasate into the brain parenchyma in AD due to blood

113 e vessel lumina, survive in the circulation, extravasate into the brain parenchyma, and then de-diffe

114 after naive T cells are activated they must extravasate into the ECM to function effectively.

115 We tested whether NDs extravasate into the immune-infiltrated islet microenvir

116 Neutrophils did not extravasate into the lungs of tryptase alpha-treated mic

117 microbes and other threats from the blood to extravasate into the meninges, potentially reaching the

118 istics in vitro and for tumorigenic cells to extravasate into the mouse lung.

119 cells from Kindlin-3-deficient mice fail to extravasate into the naive CNS.

120 pidly recruited to injured lungs, where they extravasate into the parenchyma.

121 ed to the endothelium of venules but did not extravasate into the tissue.

122 t 39 degrees C, nanoparticles were unable to extravasate into the tumor interstitium.

123 (at 34 degrees C), no liposomes were able to extravasate into the tumor interstitium.

124 nzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment.

125 tors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimula

126 somes to escape from the blood stream and to extravasate into tissues that have appropriate receptors

127 reted by HIV-infected cells, causing them to extravasate into underlying tissues and ultimately contr

128 ype lymphocyte counterparts and successfully extravasated into inflamed lymph nodes.

129 usly injected into mice and followed as they extravasated into lung tissue.

130 ere complication (18 mL of contrast material extravasated into the arm, causing brachial plexopathy).

131 large agglomerates composed of myeloid cells extravasated into the gut lumen.

132 ere complication (75 mL of contrast material extravasated into the hand, causing compartment syndrome

133 e vessels but was not detectable on PMN that extravasated into the infected cornea.

134 About 60% of these neutrophils had extravasated into the parenchyma.

135 plex class I expression on PMN that recently extravasated into the peritoneal cavity when compared wi

136 have marginated on activated endothelium or extravasated into the tissue.

137 Platelets extravasated into the tumor microenvironment and interac

138 ally recognizes angiogenic blood vessels and extravasates into sites of injury, fused with a therapeu

139 thelial cells of the tumour blood vessels or extravasates into the tumour interstitium, the overexpre

140 tatic cancer cells cease proliferating after extravasating into the parenchyma of the lungs; this res

141 Diffusible molecules extravasate, intravasate, are removed from the healthy t

142 CD18(-/-) leukocytes extravasated later than WT leukocytes.

143 h refers to the ability of macromolecules to extravasate leaky tumor vessels and accumulate in the tu

144 n a higher number in angiogenic vessels, but extravasated less toward the implanted cytokine.

145 out of corneal stroma, we showed reentry of extravasated leukocytes from angiogenic vessels into new

146 on in the retinal vessels, and the number of extravasated leukocytes into the vitreous.

147 ewly developed knockin mouse, we report that extravasating leukocytes (neutrophils, monocytes, and T

148 euronal nuclei, diminished the appearance of extravasated macrophages, and diminished the loss of dop

149 e among the first brain cells encountered by extravasating melanoma cells, they may play important ro

150 nly a few ventral ARH neurons perceive these extravasating metabolic signals due to a poorly understo

151 Recently extravasated metastatic cancer cells use the Rif/mDia2 a

152 tumor, intravasate, survive in circulation, extravasate, migrate to, and proliferate at a distal sit

153 ngs suggest a potentially important role for extravasated, modified LDL in promoting DR by promoting

154 We previously showed that extravasated, modified LDL is implicated in pericyte los

155 Our data suggest that extravasated, modified lipoproteins may be implicated in

156 e, and intravascularly injected cancer cells extravasate more easily in lphn2a null animals.

157 d be avoided as it may result in the flow of extravasated nanoparticles from the tumor to normal orga

158 14-fold, and the median penetration depth of extravasated nanoparticles was increased from 1.3-fold t

159 After accounting for tumor blood volume, the extravasated nanoparticles were quantified from the PET

160 Taken together, our data suggest that extravasated neutrophils acquire APC function within the

161 Although it had been assumed that extravasated neutrophils disintegrated (undergo necrosis

162 neutrophils at inflammatory sites, but that extravasated neutrophils displayed decreased surface exp

163 In addition, the presence of activated/extravasated neutrophils in intact intestines was determ

164 Because the host response of extravasated neutrophils to mycotic infections within ti

165 uropod detachment and effective migration of extravasated neutrophils to sites of inflammation in viv

166 In addition, a substantial number of extravasated neutrophils were found in the portal tract.

167 y accelerating the programmed elimination of extravasated neutrophils.

168 ulocytes significantly reduced the number of extravasating neutrophils and improved survival in septi

169 Extravasated nonspecific immunoglobulin G (IgG) and anti

170 d intravascular tumor cells rather than from extravasated ones.

171 The ability of antibodies to extravasate out of blood vessels is critical for therape

172 oth polymers and liposomes were less able to extravasate out of the vasculature and penetrate the int

173 netrate nearby blood vessels, and attach and extravasate out of the vessels to form secondary tumors

174 trast, leukocytes expressing active MMPs and extravasating parenchymal vessels were not observed unti

175 cles can drastically affect their ability to extravasate past cellular and biological barriers and ac

176 age, catheter gauge, injection site, volume extravasated, patient symptoms, severity of injury, trea

177 d trafficking were most severe in regions of extravasated perivascular inflammatory cells.

178 several MMPs were identified in immune cells extravasating pial vessels as early as 1 day post infect

179 Immunohistochemical analyses revealed extravasated plasma components, including Abeta42 in 19

180 Extensive extravasated plasma, platelets, and macrophages at sites

181 that interstitial flow, such as produced by extravasating plasma, directs endothelial morphogenesis

182 Secondary to epithelial abrasion, extravasated PMNs within the paralimbus developed close

183 The soluble plasma protein ferritin extravasated primarily by way of vesiculo-vacuolar organ

184 extremely high levels of vascular slits and extravasated red blood cells, making neoangiogenesis a k

185 The percent of tumor cells extravasated remained nearly constant from1 to 3 days af

186 welling), extent of the cellular infiltrate, extravasated serum albumin labeled by immunogold (for bl

187 mphatics to act as exchange vessels, able to extravasate solute and filter fluid.

188 ndings imply that activation of LFA-1 on the extravasating T cell will decrease the binding to VCAM-1

189 mammary duct) through the blood vessels and extravasating they initiate metastasis.

190 sues during development and is not simply an extravasated thrombin clearance mechanism as previously

191 In latter stages, myeloma cells extravasate through blood vessels and may seed a variety

192 h monocytes leave the circulatory system and extravasate through the endothelial lining of the blood

193 rculation time and made them small enough to extravasate through the openings of the bone's sinusoida

194 rne exposure to lipid antigen, they promptly extravasate to orchestrate the formation of peribronchio

195 ically, neutrophils in 24p3(-/-) mice do not extravasate to sites of infection and are defective for

196 irculating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate i

197 t the ability of circulating cancer cells to extravasate to surrounding lung tissues was linked to th

198 ls or will migrate to tight junctions before extravasating to the site of injury or infection.

199 f both tissues, less than 15% of neutrophils extravasated transcellularly in WT mice.

200 at the interface of blood and skin, ready to extravasate upon induction of inflammation, and we showe

201 tes preserved in hard tissues derive from an extravasated vasculature serum filtrate that becomes ent

202 rventions, which reversed the effects of the extravasated vasopressors: intraosseous phentolamine, to

203 (iii) An intravascular clot evolved when an extravasated vessel was further irradiated.

204 l clearance model and accounting for varying extravasate volumes, with infiltration depths ranging fr

205 Extravasated volumes ranged from 3 to 150 mL.

206 nd perivascular spaces while albumin and IgG extravasates were parenchymal.

207 tically, autoreactive Kindlin-3-null T cells extravasate when the CNS is inflamed and the brain micro

208 ion in blood of brain-specific proteins that extravasate when these endothelial junctions are breache

209 In long pulse samples, however, T cells did extravasate when using the two higher acoustic pressures

210 phocytes bound at endothelial cell junctions extravasate within minutes.