ライフサイエンスコーパス: extravasation

1 mphatic drainage cannot compensate for fluid extravasation).

2 le for CD31 and CD54 in neonatal homeostatic extravasation.

3 on to endothelial cells and transendothelial extravasation.

4 elevating invadopodia formation and in vivo extravasation.

5 sepsis, associated with increased neutrophil extravasation.

6 e-expressed oxidase that regulates leukocyte extravasation.

7 uitment in mouse lung but delayed neutrophil extravasation.

8 ty treatments, with somewhat improved tissue extravasation.

9 adhesion molecule actively involved in cell extravasation.

10 acilitate tumor angiogenesis and cancer cell extravasation.

11 ssion of ICAM-1, intravascular crawling, and extravasation.

12 adherens junctions and a block in molecular extravasation.

13 at prevent vascular leakage during leukocyte extravasation.

14 grin, which facilitate neutrophil arrest and extravasation.

15 eutic interventions aimed at blocking cancer extravasation.

16 latures permit tumour cell intravasation and extravasation.

17 in endothelial cell activation and leukocyte extravasation.

18 rometastatic effects by enhancing tumor cell extravasation.

19 suggesting a role for adenosine in reducing extravasation.

20 to achieve particle adhesion and subsequent extravasation.

21 th endothelial cells (ECs) followed by their extravasation.

22 he joint diminished CXCL8-induced neutrophil extravasation.

23 ial for leakage prevention during neutrophil extravasation.

24 but had no effect on tumor cell invasion or extravasation.

25 ells can regulate permeability and leukocyte extravasation.

26 ading to their arrest on the endothelium and extravasation.

27 nisms of dissemination, including intra- and extravasation.

28 nse, be it platelet aggregation or leukocyte extravasation.

29 field of endogenous inhibitors of leukocyte extravasation.

30 because the former merely counteracts fluid extravasation.

31 elial cells to mediate vascular adhesion and extravasation.

32 min effects that are inhibitory to leukocyte extravasation.

33 g primary tumor invasion, intravasation, and extravasation.

34 signaling required for neutrophil arrest and extravasation.

35 parasites across the blood-brain barrier via extravasation.

36 ricyte contractility and enhances neutrophil extravasation.

37 ovascular permeability, in turn facilitating extravasation.

38 nflammation in colitis by limiting leukocyte extravasation.

39 t Myo1e is required for efficient neutrophil extravasation.

40 with the vascular endothelium and neutrophil extravasation.

41 anoparticles to visually assess nanoparticle extravasation.

42 rain barrier (BBB) integrity and tumor brain extravasation.

43 to cancer cell invasion, intravasation, and extravasation.

44 phil-endothelial interactions and neutrophil extravasation.

45 In areas of gadolinium extravasation, (123)I-CLINDE binding parameters were not

46 mechanisms have been suggested, including Hb extravasation across the blood vessel wall, scavenging o

47 To improve the management of urinary extravasation after high-grade renal trauma, large, mult

48 rounding tissues which mediates nucleic acid extravasation and cellular uptake.

49 tory response, cell proliferation, leukocyte extravasation and cholesterol biosynthesis.

50 ngiogenesis in these organs, allowing tumour extravasation and colonization.

51 lity and motility are likely selected during extravasation and colonization.

52 robubble oscillations, for enhanced OV tumor extravasation and delivery has not been previously repor

53 mputational modeling evaluates drug vascular extravasation and diffusive transport as key RF-modulate

54 ovessel walls while also initiating enhanced extravasation and drug delivery into target tissues.

55 in the metastatic process, platelets promote extravasation and establishment of metastatic cells in d

56 oro-Jade C staining, brain edema, Evans blue extravasation and fluorescence, western blot, RhoA activ

57 of the TRCs at the secondary sites show that extravasation and formation of micrometastases by TRCs a

58 portantly, also by sensitive fluorescent dye extravasation and immunohistochemistry.

59 rnalization was suggested, based on the fast extravasation and internalization rates of copolymer uni

60 A new mechanism of micelle extravasation and internalization was suggested, based o

61 and cannot effectively compensate for fluid extravasation and interstitial accumulation by commensur

62 tein suppresses chemokine-induced neutrophil extravasation and ischemia-induced reperfusion injury.

63 activity of iRGD in inducing macromolecular extravasation and leads to greater drug accumulation in

64 that intraplaque hemorrhage with erythrocyte extravasation and lysis promotes osteoblastic differenti

65 ty and adherens junctions disassembly during extravasation and may aid in identification of therapeut

66 hibition prevented VEGF-dependent tumor cell extravasation and melanoma dermal to lung metastasis wit

67 IL-35 has critical roles in PDAC cell extravasation and metastasis by facilitating the adhesio

68 Xenograft models showed that the lung extravasation and metastasis of FOXC1-overexpressing TNB

69 FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung.

70 eta/Smad pathway that promotes lung ADC cell extravasation and metastasis.

71 g in dramatically lower rates of cancer cell extravasation and metastatic colony formation compared t

72 Metastatic progression, including extravasation and micrometastatic outgrowth, is the main

73 act of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgr

74 rs (10-30 nm) to achieve sufficient vascular extravasation and pervasive tumor penetration.

75 re detailed understanding for the continuing extravasation and recruitment of Th1 lymphocytes into si

76 Blast injury resulted in increased extravasation and reduced levels of TJPs in tissues cons

77 on molecules resulting in impaired leukocyte extravasation and reduced MPO activity in lungs.

78 ntusion model of severe SCI, we demonstrated extravasation and retention of intravenously administere

79 djacent stroma, intravasation and ultimately extravasation and seeding.

80 , including genes involved in immune escape, extravasation and small GTPase signal transduction.

81 oduction to inhibit late-stage melanoma cell extravasation and subsequent metastasis development.

82 for metastasis in vivo through regulation of extravasation and suggest that it may represent a valid

83 cellular processes involved in driving fluid extravasation and the severe anaphylactic phenotype are

84 tion of monocytes that facilitate tumor cell extravasation and thereby metastasis.

85 We report a case of vasopressor extravasation and threatened limb perfusion related to i

86 in the processes of micelle and nanodroplet extravasation and tissue accumulation was possible.

87 eal an unexpected role for CtsB in leukocyte extravasation and transmigration, which advances our und

88 Intravital imaging of nanoparticle extravasation and tumor accumulation has revealed, for t

89 The extravasation and tumor cell internalization occurred mu

90 term high-fat-diet feeding decrease molecule extravasation and uptake rates in vivo in islets, indepe

91 Leukocyte extravasation and vascular leakage are both prominent bu

92 rule out a role for NO in bradykinin-induced extravasation and/or angioedema.

93 ation coefficient (measuring capillary fluid extravasation) and isovolumetric pressure (above which l

94 ocytes and perivascular edema, 4) Evans blue extravasation, and 5) appearance of parenchymal astrogli

95 Similarly, leukocyte adhesion, extravasation, and bacterial clearance were diminished.

96 processes, which include rolling, adhesion, extravasation, and chemotaxis.

97 , interactions with components of the blood, extravasation, and colonization of distant organs.

98 ic tumor vaccine model, inhibited neutrophil extravasation, and delayed the outgrowth of tumor xenogr

99 nt adhesion to endothelial cells, supporting extravasation, and directing specific intratissue locali

100 Evans blue (bound to macromolecule albumin) extravasation, and hematoxylin-eosin staining helped det

101 se effect of diabetes on SCI, reduced EB dye extravasation, and limited the loss of endothelial cells

102 s that enable efficient tumor cell survival, extravasation, and metastasis.

103 dimensional (3D) visualization of tumor cell extravasation, and mouse models of lung metastasis.

104 ils contained in these aggregates, leukocyte extravasation, and organ damage.

105 lymphocytes and neutrophils, red blood cell extravasation, and plumping endothelium were the main hi

106 that includes local invasion, intravasation, extravasation, and proliferation at distant sites.

107 he premetastatic niche, intravasation and/or extravasation, and resistance to apoptosis.

108 and histamine-induced VE dysfunction, fluid extravasation, and the severity of anaphylaxis through a

109 microenvironmental cues to guide cancer cell extravasation, and when PAK1 is depleted, brain tropism

110 al cells and astrocytes, blood-brain barrier extravasation, angiogenesis, and outgrow.

111 the most critical events for limiting plasma extravasation are the stable accumulation of platelets,

112 ocesses, which are fundamental to tumor cell extravasation, are driven by DOCK4-mediated Rac1 activat

113 n monocytes demonstrated lower adherence and extravasation as compared to adults.

114 We found apocynin completely inhibited dye extravasation as well as restored TJP levels to that of

115 amed cremaster muscle at sites of neutrophil extravasation, as visualized by fluorescent microspheres

116 d invasion in vitro and in experimental lung extravasation assay in xenografted mice.

117 Contrary to most in vivo and in vitro extravasation assays, robust and rapid scoring of extrav

118 Extravasation at the injection site and accumulation in

119 Leakage was dependent on neutrophil extravasation, because it was absent upon neutrophil dep

120 eterogeneous, and in vitro analysis of their extravasation behavior is often impeded by the inability

121 re cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signal

122 myosin, or alpha-actinin, regulate leukocyte extravasation by controlling actin dynamics, biomechanic

123 an effective drug that restricts tumor cell extravasation by enhancing endothelial barrier stability

124 reen to identify drugs that block tumor cell extravasation by testing 3,520 compounds on a transendot

125 a sequence of steps, including circulation, extravasation by the enhanced permeability and retention

126 The leukocyte extravasation cascade is a complex multistep process tha

127 Ab before i.v. injection into mice inhibited extravasation/colonization of circulating tumor cells an

128 sion of LZTFL1 in lung tumor cells inhibited extravasation/colonization of circulating tumor cells to

129 Dysregulated neutrophil extravasation contributes to the pathogenesis of many in

130 ocess underlying both cancer and immune cell extravasation, contributing to the functioning of the im

131 al fluorescent microscopy, the extent of the extravasation, diffusion in the tissue, internalization

132 t MST1 is a critical regulator of neutrophil extravasation during inflammation.

133 rom an apolar state in circulation for their extravasation during inflammation.

134 C-A/cGMP signaling and facilitate neutrophil extravasation during the early phase after MI.

135 and alphabeta(+) T cells as well as enhanced extravasation during the later stages of inflammation.

136 deformability is a key factor in controlling extravasation dynamics during metastasis.

137 (SCID-bg) mice, should be attributed to the extravasation effect, leading to the lipoproteinated NC

138 d, after which the tumor can be perfused and extravasation events are easily tracked over 72 h via st

139 ation between separate doses implies dynamic extravasation events on the scale of microns.

140 capability for live tracking of single-cell extravasation events, allowing both tumor and endothelia

141 n a breast cancer xenograft model as well as extravasation following injection of carcinoma cells int

142 fier) was used to identify iodine markers of extravasation for risk of hematoma expansion.

143 analysis of mutant mouse eyes showed protein extravasation from dilated vessels into the anterior cha

144 r metastasis through promotion of tumor cell extravasation, growth, and angiogenesis.

145 atic seeding, including: tumor cell arrival; extravasation; growth and progression to micrometastases

146 of receptor-ligand interactions to leukocyte extravasation has been studied extensively, the contribu

147 Although the mechanisms of extravasation have been vastly studied in vitro and in v

148 Mechanisms controlling PMN extravasation have been well characterized, but the mole

149 th and metastasis, but its specific roles in extravasation have not yet been clearly elucidated.

150 nce of Coro1A impairs leukocyte adhesion and extravasation in inflamed cremaster muscle venules in co

151 s), specialized blood vessels for lymphocyte extravasation in lymphoid organs.

152 severely compromised leukocyte adhesion and extravasation in MK(-/-) mice compared with MK(+/+) anim

153 t a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional me

154 nts, and intraluminal haemorrhage and active extravasation in one patient.

155 ural hemorrhage characterized by erythrocyte extravasation in outer lamellar layers of the media.

156 Measurements of DBP-EGFP extravasation in plvapb mutants provided direct proof th

157 ctions and increased neutrophil crawling and extravasation in response to Ab-opsonized bacteria.

158 with Cy5-Fab-PAS200 confirmed better tracer extravasation in the Granta-519 tumors.

159 y 1 (ABL1)-mediated VE dysfunction and fluid extravasation in the severity of IgE-mediated anaphylact

160 mors shared the similar systemic PK, but DOX extravasation in the tumor extravascular tissue was subs

161 ma cell-induced gap formation, melanoma cell extravasation in vitro and subsequent lung metastasis de

162 enhanced NSC viability, and facilitated NSC extravasation in vitro, as compared to NSC encapsulated

163 cient to induce EMT, stimulate migration and extravasation in vitro.

164 bly, transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR

165 n in vitro and metastasis via attenuation of extravasation in vivo.

166 d forskolin significantly reduced tumor cell extravasation in zebrafish, and niclosamide drastically

167 lyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvir

168 ood brain barrier (BBB) and dampen leukocyte extravasation into CNS during AHI.

169 erivascular basement membrane for successful extravasation into inflamed tissue, but this process is

170 ir arrest at the endothelium, supporting CTC extravasation into secondary sites.

171 y ultrastructure, significantly decreased EB extravasation into spinal cord parenchyma, meaningfully

172 DTC extravasation into the bone marrow may be encouraged by

173 stically, Src activation promoted tumor cell extravasation into the brain parenchyma via permeabiliza

174 sing peripheral inflammatory cells and their extravasation into the brain.

175 om the skin via dermal lymphatic vessels and extravasation into the LN parenchyma from lymph in the s

176 over, Ccl5-triggered neutrophil and monocyte extravasation into the peritoneal cavity was severely re

177 mor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic co

178 Neutrophil extravasation is a migratory event in response to inflam

179 Tumor cell extravasation is a multistep process preceded by cell ro

180 Extravasation is observed for 38.8% of the tumor cells i

181 ole of the tumor extravascular tissue in the extravasation kinetics of doxorubicin (DOX), delivered b

182 The extravasation kinetics were different for nanodroplets a

183 aves the diagnosis and management of urinary extravasation largely dependent upon physicians' experie

184 a several targeting mechanisms, particularly extravasation (leakage into tumour).

185 Zebrafish imaging demonstrates that after extravasation, melanoma cells become pigmented and enact

186 ely, our findings in this novel model of the extravasation microenvironment revealed a critical requi

187 plasma neither improved newborn homeostatic extravasation nor shaped age-specific differences in end

188 Neutrophil extravasation occurs across postcapillary venules, struc

189 astinal drainage is important if significant extravasation occurs and should be instituted from the s

190 cytotoxic NK cells into the sciatic nerve by extravasation occurs within 3 days following crush injur

191 on, predictors of complications when urinary extravasation occurs, protocols for obtaining and interp

192 for studying with intravital microscopy the extravasation of 0.58 kDa rhodamine and 153 kDa anti-VEG

193 ced by two distinct methods caused increased extravasation of 40-kDa dextran from capillaries and pos

194 d postcapillary venules but had no effect on extravasation of 70-kDa dextran or albumin.

195 R3 in stabilizing intravascular adhesion and extravasation of adoptively transferred CD8(+) effectors

196 a physical barrier that may hinder vascular extravasation of agents through transvascular fluid flux

197 causing blood-brain barrier (BBB) breakdown, extravasation of autoantibodies into the CNS, and loss o

198 ure, loss of vascular integrity resulting in extravasation of blood cells, stromal inflammation, and

199 ensin II-infused rats, minocycline prevented extravasation of BM-derived cells to the hypothalamic pa

200 cells after injection into the yolk sac and extravasation of cancer cells into tissues from the vasc

201 nd extracellular matrix invasion, as well as extravasation of cancer cells into tissues in zebrafish

202 Intravasation and extravasation of cancer cells through blood/lymph vessel

203 44 mimics CNL-induced anoikis and diminished extravasation of cancer cells.

204 s play an essential part in the adhesion and extravasation of circulating leukocytes into inflamed ti

205 transport pathway and facilitating the local extravasation of circulating substances.

206 permeability, leading to a locally enhanced extravasation of components from the vascular compartmen

207 r phenotype, collagen content determined the extravasation of DOX-PLD to different tumor phenotypes.

208 pression of CCL24 from endothelial cells and extravasation of eosinophils into the ear pinna.

209 observed that diabetic rats showed increased extravasation of Evans Blue (EB) dye, and loss of endoth

210 80 kPa and the BBB integrity was assessed by extravasation of Evans blue and changes in tight junctio

211 nces in microvascular leakage (determined by extravasation of Evans Blue Dye) and in renal relative b

212 (TUNEL+ / NeuN+ cells) and BBB permeability (extravasation of Evans blue) at D1.

213 Moreover, intraspinal extravasation of fibrinogen and immunoglobulins was decr

214 which likely contributes to hypoxia-induced extravasation of fluid and leukocytes.

215 te-phase responses to histamine with reduced extravasation of fluid, SK-1 activity, proinflammatory c

216 time in mouse models using the differential extravasation of fluorescent tracers as a biomarker.

217 oach helped demonstrate in a dynamic fashion extravasation of fluorescently-tagged antibodies and the

218 amic multi-scale imaging of OBBBO as well as extravasation of IA injected therapeutic agents are esse

219 s inhibitor, the optimized compounds reduced extravasation of invasive breast cancer cells in a zebra

220 ing peripheral lymph node addressin, and the extravasation of lymphocytes to the omental and mesenter

221 n binding, rolling, integrin activation, and extravasation of mature neutrophils, but only the combin

222 t junctions (TJ) between them, regulates the extravasation of molecules and cells into and out of the

223 The extravasation of monocytes across the brain endothelium

224 ue construct enabled age-specific autonomous extravasation of monocytes through a confluent human end

225 tochastic eruptions may explain the enhanced extravasation of nanoparticles from the tumour blood ves

226 leukocytes and endothelial cells, leading to extravasation of neutrophils and monocytes.

227 with cytoskeletal dysfunction and defective extravasation of neutrophils as the most prominent featu

228 or GDF-15 gene-deficient mice, we found that extravasation of neutrophils deficient for ALK-5 or TGF-

229 direct the vascular recruitment, arrest, and extravasation of neutrophils in a sterile inflammation m

230 l and orchestrate the subsequent arrival and extravasation of neutrophils through the production of p

231 jury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airsp

232 -eosin staining helped detect only scattered extravasation of red blood cells.

233 to drug delivery by only allowing selective extravasation of solutes and small molecules.

234 the sub-nanometre regime also slows down the extravasation of sub-nanometre AuNCs from normal blood v

235 In mice, loss of miR-155 reduced CNS extravasation of systemic tracers, both in EAE and in an

236 Extravasation of the contrast agent was defined as anast

237 The transfer coefficient Ktrans describing extravasation of the MRI contrast agent Gd-DTPA was sign

238 Remarkably, efficient extravasation of TRCs in vivo and transmigration in vitr

239 more, IQGAP1 knockout significantly inhibits extravasation of tumor cells from circulation, possibly

240 ation of CTCs from the primary tumor and the extravasation of tumor cells from the vasculature.

241 aling components in platelets and favors the extravasation of tumor cells.

242 We also show extravasation of tumour cells and the close association

243 Vascular permeability measured by Evans blue extravasation on days 1, 3, and 7 correlated with the T1

244 st that, although CD18 facilitates efficient extravasation, outside of the vessel CD18 interaction wi

245 which activate mast cells leading to plasma extravasation, pain, and itching.

246 en content may offer a biophysical marker of extravasation potential of liposomal drug formulations.

247 cell proliferation, migration, intravasation/extravasation potential, favors cell death, and suppress

248 s, and decreased migration and intravasation/extravasation potential, with a corresponding drastic su

249 ponses to CSD and the ensuing plasma protein extravasation (PPE).

250 , patterns of clinically significant urinary extravasation, predictors of complications when urinary

251 ls have been reported thus far regarding the extravasation process or re-entry of circulating tumor c

252 of mature TAMs due to impaired recruitment, extravasation, proliferation, and maturation of their Ly

253 ent (interleukin-8 pathway, P = 1.41E-5) and extravasation proteins (P = 5.62E-4) were elevated durin

254 al requirement for beta1 in several steps of extravasation, providing new insights into the mechanism

255 Extravasation rates and microvasculature permeabilities

256 ll A3 adenosine receptors resulted in higher extravasation rates of cancer cells into the myoblast-co

257 cess are relatively efficient, with the post-extravasation regulation of tumour growth ('colonization

258 ors that induce invadopodia formation during extravasation remain unclear.

259 Neutrophil extravasation requires opening of the endothelial barrie

260 complementary mechanism by which LTB4 relays extravasation signals in neutrophils during early inflam

261 asthma, presumably due to greater eosinophil extravasation, specifically of activated or pre-activate

262 that they express molecular effectors of BM extravasation, such as the chemokine receptor CXCR4 and

263 rain-injured animals worsened Evans Blue dye extravasation, suggesting that systemic inflammation con

264 lex steps including transit, initial arrest, extravasation, survival and proliferation.

265 he premetastatic site and promote tumor cell extravasation, survival, and persistent growth.

266 ture to recapitulate the environment wherein extravasation takes place and assess the consequences of

267 RA-exposed mice increased TC1 migration and extravasation, TAMs from IH-exposed mice markedly enhanc

268 tissue is characterized by more intense drug extravasation than in contralateral mammary fat pad tiss

269 is a key evolutionary force driving parasite extravasation that could further result in tissue invasi

270 knowledge gaps in the management of urinary extravasation that need to be addressed include the timi

271 Our findings provide insights on how albumin extravasation that occurs upon BBB dysfunction in variou

272 We report an event of vasopressor extravasation that was potentially limb threatening.

273 nd location of interest in the brain without extravasation through a minimally invasive ultrasound in

274 dothelial barrier is critical for tumor cell extravasation through blood vessel walls and is mediated

275 ses in intraepithelial lymphocytes and fluid extravasation through epithelial leaks.

276 an effective drug that restricts tumor cell extravasation through modulation of signaling pathways,

277 born monocytes are intrinsically impaired in extravasation through quiescent endothelia, a phenomenon

278 prevented direct insight into the process of extravasation through the skull window.

279 subsets of NK and T lymphocytes, suggesting extravasation to affected tissues.

280 bloodstream, arrest within capillaries, and extravasation to invade distant tissues.

281 , endothelial-tumor cell interactions govern extravasation to the bone and potentially represent one

282 CT images identified two features of iodine extravasation: total iodine concentration within the hem

283 In a separate step in leukocyte extravasation, transendothelial migration is regulated b

284 cytes to undergo autonomous transendothelial extravasation under biologically accurate circumstances

285 creases anoikis while preventing cancer cell extravasation under both static and physiological fluid

286 t renal artery 6 x 6 cm, with signs of blood extravasation visible in colour and power Doppler.

287 astomotic insufficiency was suspected but no extravasation was present, a computed tomography (CT) sc

288 The case of vasopressor extravasation was successfully treated with pharmacologi

289 s of rhodamine-6G-labeled leukocyte adhesion/extravasation, was used.

290 Using sodium fluorescein extravasation, we found that CD2AP(-/-) mice had reduced

291 tive T-lymphocyte clustering, and fibrinogen extravasation were demonstrated in the core of FCD-II le

292 s factor alpha (TNF-alpha), PMN adhesion and extravasation were severely compromised in HPK1-deficien

293 itro as well as increased BM trafficking and extravasation when transplanted into mice.

294 igration, indicating that the final steps of extravasation, where actin polymerization plays an impor

295 may be important in processes like cellular extravasation, which are accompanied by significant norm

296 by pulmonary venous vasodilatation and fluid extravasation, which are thought to lead to the life-thr

297 diagnosis and optimal management of urinary extravasation, which complicates ~30% of high-grade rena

298 ze of the Hb:haptoglobin complex prevents Hb extravasation, which uncouples NO/Hb interaction and vas

299 f TREM1 signaling, complement, and leukocyte extravasation with stress were reversed by nIL-1R1(-/-).

300 treated tumors have detected red blood cell extravasation within tumors treated with temperature-sen