ライフサイエンスコーパス: extravascular

1 sensitivity, and imaging space (vascular and extravascular).

2 blood vessel and significantly increases its extravascular accumulation.

3 Although extravascular actions of AngII have been suggested, a di

4 te subpopulations in the CP without inducing extravascular albumin leakage or major leukocyte infiltr

5 ionine gamma-lyase, activated caspase-3, and extravascular albumin), and immunoblotting (nuclear fact

6 =.003), backflow compartmental rate constant extravascular and extracellular to plasma (Kep) (-15% re

7 Currently, we compared the abilities of extravascular and intravascular cells to support fibrin

8 ional databases of ECs toward uncovering the extravascular and intrinsic signals that define EC heter

9 developed with a goal of inhibiting both the extravascular and the intravascular hemolysis of PNH.

10 e in regulating the biology of TF-expressing extravascular and vessel wall cells that are exposed to

11 therapeutic strategies aimed at controlling extravascular as well as intravascular hemolysis are als

12 mages the uptake of inhaled xenon gas to the extravascular brain tissue compartment across the intact

13 ession illness is caused by intravascular or extravascular bubbles that are formed as a result of red

14 ration either from the adventitia or from an extravascular, but nonhematopoietic source.

15 fragments were intravascular or immediately extravascular by using primarily endobronchial forceps f

16 Extravascular cells (fibroblasts, smooth muscle) support

17 This renders extravascular cells clearly distinct and allows tumor ce

18 Once TF on epithelial and other extravascular cells is exposed to plasma, sequential act

19 s acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture mo

20 ty, and instead have supported the idea that extravascular cells sense O2 .

21 vasation assays, robust and rapid scoring of extravascular cells, combined with high-resolution imagi

22 actors, effects of various intravascular and extravascular cells, hydrodynamic flow, and some functio

23 ells throughout the vascular bundle and into extravascular cells, revealing a radial movement of jasm

24 of integrin alpha6beta1-dependent neutrophil extravascular chemotactic function in vivo, effective th

25 odulating the size and density of intra- and extravascular clots and thrombi.

26 T cells into effector cells that form dense, extravascular clusters of immotile cells scattered throu

27 ravascular proliferation, extravasation, and extravascular colony formation.

28 ith staining for fibrin(ogen) present in the extravascular compartment of tumors, but not in other ti

29 s in vivo to target the tumor vasculature or extravascular compartment with high specificity.

30 150 IU/kg, where they appear to saturate an extravascular compartment, because there is no additiona

31 40 to 50 IU/kg will, because of FIX's large extravascular compartment, efficiently prolong prophylac

32 s from the capillary lumen to the peripheral extravascular compartment, in the absence of vascular di

33 y effect of complement may be present in the extravascular compartment, in which many malignant lymph

34 ill require understanding its biology in the extravascular compartment, within the interstitium and l

35 ggested the presence of nanoparticles in the extravascular compartment.

36 ein D (SP-D) become temporarily deposited in extravascular compartments after tissue injury and perfo

37 s are present both in the circulation and in extravascular compartments and are central players of th

38 at unbound Hb is oxidatively modified within extravascular compartments consistent with our in vitro

39 ype 1 (HIV-1) can replicate independently in extravascular compartments such as the central nervous s

40 As infected prMCs mature within extravascular compartments, they become both latently in

41 cal indices of coronary resistance (HMR) and extravascular compression (pressure at zero flow) obtain

42 repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix.

43 ated that alpha6beta1 integrins orchestrated extravascular directionality but not the speed of neutro

44 es neutrophil transendothelial migration and extravascular directionality without affecting the speed

45 e that the barrier layer effectively impedes extravascular drug loss.

46 During intrabronchial or intraperitoneal (extravascular) E. coli challenge, the pattern of effecti

47 erythropoiesis, with specific injury to the extravascular erythron, expansion and maturation of EPO-

48 ate between blood and tissue (K(trans)), and extravascular extracellular fractional volume values for

49 ADC (P = .021) and fractional volume of the extravascular extracellular space (v(e)) (P = .025) of o

50 : transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tis

51 presents transfer of contrast agent from the extravascular extracellular space to the blood plasma),

52 nt (K(trans)), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractiona

53 the transfer coefficient from blood to brain extravascular extracellular space) when comparing the FU

54 trast agent from the arterial blood into the extravascular extracellular space), K(ep) (the rate cons

55 r gadolinium between blood plasma and tissue extravascular extracellular space, fractional volume of

56 y-surface area product, extraction fraction, extravascular extracellular volume (v(e)), and volume tr

57 e constant (P = .003), 15.0% in the backflow extravascular- extracellular rate constant (P = .0007) a

58 lular rate constant (P = .0007) and 14.3% in extravascular-extracellular volume fraction (P = .002) w

59 = 2), idiopathic T-cell lymphopenia (n = 2), extravascular extravasation of lymphocytes (n = 3), and

60 Extravascular factor activity and joint-directed gene tr

61 a novel fibrin endocytic pathway engaged in extravascular fibrin clearance and shows that interstiti

62 revealing a novel intracellular pathway for extravascular fibrin degradation.

63 Extravascular fibrin deposition accompanies many human d

64 ion of the blood clotting system, leading to extravascular fibrin deposition to limit the spread of i

65 work, immunohistochemical studies identified extravascular fibrin deposits within white adipose tissu

66 In tumors, extravascular fibrin forms provisional scaffolds for end

67 el and unexpected mechanism for clearance of extravascular fibrin that is accomplished by a specific

68 Using extravascular fibrinogen as a marker of vascular disrupt

69 al interventions to modify intravascular and extravascular fibrinogenesis, neutrophil activation and

70 A robust pool of extravascular FIX is clearly observed surrounding blood

71 There is also credible evidence of extravascular FIX.

72 days postinfusion, presumably because of the extravascular FIX.

73 If diuresis occurs at a rate greater than extravascular fluid can refill the intravascular space,

74 n has renal effects that could contribute to extravascular fluid collection characterizing anthrax in

75 n this early would not indicate euvolemia if extravascular fluid has not yet equilibrated.

76 of nanoparticles from tumor vessels into the extravascular fluid space.

77 867), but there was greater expansion of the extravascular fluid volume after saline (P = 0.029).

78 Changes in body water, blood volume, and extravascular fluid volume were calculated.

79 ays of least resistance for the transport of extravascular fluid, as well as tumor cells.

80 malignant ascites was used as surrogates for extravascular fluid, suggesting the inhibitory effect of

81 Because extravascular fragments are not readily accessible for r

82 All extravascular fragments except one were retained.

83 afts and selectively disseminated throughout extravascular glioma parenchyma, causing reduced tumor b

84 Extravascular granulomatous inflammation may be initiate

85 Extravascular hemolysis after transfusion progressively

86 e, we provide experimental evidence for such extravascular hemolysis and demonstrate that PNH erythro

87 nt on the surface of red cells, resulting in extravascular hemolysis by the reticuloendothelial syste

88 NH treatment in which both intravascular and extravascular hemolysis can be inhibited while preservin

89 deposition of complement opsonins that drive extravascular hemolysis in the liver.

90 y prevent both intravascular and C3-mediated extravascular hemolysis of PNH erythrocytes and warrants

91 e disease appears to be more associated with extravascular hemolysis than with intravascular hemolysi

92 uding disruption in iron handling, increased extravascular hemolysis, and the formation of circulatin

93 Sutimlimab rapidly abrogated extravascular hemolysis, normalizing bilirubin levels wi

94 cells to healthy human volunteers increased extravascular hemolysis, saturated serum transferrin, an

95 RBC destruction in these patients occurs via extravascular hemolysis.

96 s, possibly leading to clinically meaningful extravascular hemolysis.

97 d fix complement, resulting in predominantly extravascular hemolysis.

98 y observed in iron parameters and markers of extravascular hemolysis.

99 to be susceptible to AP complement-mediated extravascular hemolysis.

100 an arbovirus-infected mosquito can inoculate extravascular host tissues with virus-infected saliva du

101 for intravascular infection and downward for extravascular infection.

102 ir emigration from the circulation toward an extravascular inflammatory insult.

103 y has demonstrated the application of MEs as extravascular injectable drug delivery systems for susta

104 e through in-situ phase transition following extravascular injection.

105 date, published research has used presession extravascular injections to examine nicotine as a contex

106 These results suggest a novel, critical extravascular iNKT cell immune surveillance in joints th

107 e joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pa

108 Increases in cortical tissue damage, extravascular iron and glial activation assessed by hist

109 We report multiple extravascular lipoprotein localization patterns, as well

110 s in the disease course in intravascular and extravascular locations.

111 s despite their respective intravascular and extravascular locations.

112 these enzymes are dispensable for neutrophil extravascular locomotion.

113 tep 2-bypass pathway' of cell migration, and extravascular lodgment, in absence of chemokine receptor

114 atio were lower in patients with a change in extravascular lung water >/= 10% than in patients with a

115 A change in extravascular lung water >/= 10% was predicted by baseli

116 Predictive values for change in extravascular lung water >/= 10% were evaluated.

117 lly contributed to prediction of a change in extravascular lung water >/= 10%, independent of the pre

118 ung water <10% and patients with a change in extravascular lung water >/= 10%.

119 e compared between patients with a change in extravascular lung water <10% and patients with a change

120 er >/= 10% than in patients with a change in extravascular lung water <10%.

121 ding upper limits for fluid resuscitation of extravascular lung water (<10 mL/kg) and global end-dias

122 erval, 0.65-0.94) was larger than for actual extravascular lung water (0.72; confidence interval, 0.5

123 hough the area under the curve for predicted extravascular lung water (0.8; confidence interval, 0.65

124 l showed a pattern consistent with increased extravascular lung water (diffuse, bilateral, symmetrica

125 Measurements of extravascular lung water (EVLW) correlate to the degree

126 hypothesized that it could be improved using extravascular lung water (EVLWi) and plasma biomarkers o

127 ve analysis indicated that EVLWp, Vd/Vt, and extravascular lung water (p = .0005, .009, and .013, res

128 for lung edema and has been shown to reduce extravascular lung water and improve lung function in mo

129 Extravascular lung water and other markers of lung injur

130 drome, to determine the relationship between extravascular lung water and other markers of lung injur

131 respiratory distress syndrome (ARDS) reduced extravascular lung water and plateau airway pressure.

132 iple logistic regression analysis, predicted extravascular lung water but not actual extravascular lu

133 The change in extravascular lung water correlated to baseline cardiac

134 predicted or actual body weight for indexing extravascular lung water does not lead to independence o

135 ody weight, improves the predictive value of extravascular lung water for survival and correlation wi

136 Traditionally, extravascular lung water has been indexed to actual body

137 Extravascular lung water increase during fluid loading i

138 Extravascular lung water increased in 17 of 22 liberally

139 Extravascular lung water increased with positive periope

140 was 70% in patients with a maximum value of extravascular lung water index >21 mL/kg and 43% in the

141 A maximum value of extravascular lung water index >21 mL/kg predicted day-2

142 distress syndrome episode (maximum value of extravascular lung water index and maximum value of pulm

143 ght, p < 0.001 [t-test] for maximum value of extravascular lung water index and median [interquartile

144 rome might be associated with an increase in extravascular lung water index and pulmonary vascular pe

145 The maximum values of extravascular lung water index and pulmonary vascular pe

146 Extravascular lung water index and pulmonary vascular pe

147 Extravascular lung water index and pulmonary vascular pe

148 We tested whether extravascular lung water index and pulmonary vascular pe

149 There was no difference in extravascular lung water index between those who progres

150 An extravascular lung water index cutoff value on day 1 of

151 Extravascular lung water index had a moderate sensitivit

152 Elevated extravascular lung water index is a feature of early acu

153 The mean extravascular lung water index on day 1 for patients who

154 In multivariate analyses, maximum value of extravascular lung water index or maximum value of pulmo

155 Furthermore, extravascular lung water index predicts progression to a

156 Global end-diastolic index, extravascular lung water index, and stroke volume index

157 f cardiac index, global end-diastolic index, extravascular lung water index, and stroke volume index,

158 Extravascular lung water index, dead space fraction, PaO

159 We tested whether the changes in extravascular lung water indexed for ideal body weight c

160 An increase in extravascular lung water indexed for ideal body weight g

161 During spontaneous breathing trial, extravascular lung water indexed for ideal body weight i

162 taneous breathing trial-induced increases in extravascular lung water indexed for ideal body weight,

163 nary edema were 0.89 (95% CI, 0.78-0.99) for extravascular lung water indexed for ideal body weight,

164 ded pulmonary artery occlusion pressure, the extravascular lung water indexed for ideal body weight,

165 Associations between extravascular lung water indexed to predicted body weigh

166 50 eligible patients, 132 patients (88%) had extravascular lung water indexed to predicted body weigh

167 Peak values for extravascular lung water indexed to predicted body weigh

168 Extravascular lung water indexed to predicted body weigh

169 Perioperative extravascular lung water indexed to predicted body weigh

170 We assessed the accuracy of peak extravascular lung water indexed to predicted body weigh

171 Extravascular lung water indexed to predicted body weigh

172 Extravascular lung water indexed to predicted body weigh

173 Extravascular lung water indexed to predicted body weigh

174 We aimed to evaluate whether extravascular lung water indexed to predicted body weigh

175 Early measurement of predicted extravascular lung water is a better predictor than actu

176 Increased extravascular lung water is a feature of early acute res

177 Extravascular lung water is a quantitative marker of the

178 Increasing extravascular lung water is further reflected by a decre

179 It is largely unknown why extravascular lung water may increase during fluid loadi

180 Extravascular lung water may prove valuable for diagnosi

181 Here, we tested the prognostic value of extravascular lung water measured by a simple, well vali

182 We explored extravascular lung water measured by single-indicator tr

183 Extravascular lung water measurement may be valuable for

184 Accurate extravascular lung water measurements were obtained afte

185 to predicted body weight, females had a mean extravascular lung water of 9.1 (SD=3.1, range: 5-23) mL

186 To determine whether extravascular lung water predicts survival in patients w

187 o detect small short-term changes of indexed extravascular lung water secondary to bronchoalveolar la

188 iately after bronchoalveolar lavage, indexed extravascular lung water significantly increased from 12

189 ol, providing semiquantitative assessment of extravascular lung water through B-lines.

190 Our data suggest that indexing extravascular lung water to height is superior to weight

191 lung water is a better predictor than actual extravascular lung water to identify patients at risk fo

192 Indexing extravascular lung water to predicted body weight, inste

193 A baseline predicted extravascular lung water value of 16 mL/kg predicted int

194 Extravascular lung water values were significantly highe

195 ribe and assess the clinical significance of extravascular lung water variations after pulmonary enda

196 cted extravascular lung water but not actual extravascular lung water was a predictor of mortality wi

197 Extravascular lung water was indexed to predicted body w

198 Extravascular lung water was measured using the PiCCO sy

199 bronchoalveolar lavage, the value of indexed extravascular lung water was significantly different fro

200 s of lung injury, and to examine if indexing extravascular lung water with predicted body weight (EVL

201 , PaO2/Fio2 ratio, oxygenation index, actual extravascular lung water, and predicted extravascular lu

202 lowing endotoxin-induced lung injury reduced extravascular lung water, improved lung endothelial barr

203 ting a 169 +/- 166 mL increase in nonindexed extravascular lung water.

204 was performed to record the value of indexed extravascular lung water.

205 iac index, pulmonary blood volume index, and extravascular lung water.

206 ema, which can be assessed by measurement of extravascular lung water.

207 tual extravascular lung water, and predicted extravascular lung water.

208 By contrast, the extravascular migration of T cells was insensitive to th

209 ration along abluminal vascular surfaces, or extravascular migratory metastasis (EVMM).

210 ng of cancer through imaging of vascular and extravascular molecular targets.

211 ese proteins not only drive the formation of extravascular networks but also ensure their perfusion b

212 y be initiated by ANCA-induced activation of extravascular neutrophils, causing tissue necrosis and f

213 nstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mammary tumors grow

214 Importantly, we demonstrate the presence of extravascular parasites in human skin biopsies from undi

215 stration only" (CM1) and "sequestration with extravascular pathology" (CM2), CM1 was associated with

216 onstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in

217 ion, but supported optimal intravascular and extravascular phagocytosis of zymosan particles.

218 olyps from subjects with AERD contained many extravascular platelets that colocalized with leukocytes

219 se activity may benefit from evaluating this extravascular pool.

220 topenia caused by both formation of aberrant extravascular PPs and defective intravascular PP sheddin

221 Furthermore, the extravascular presence of platelets in lungs of patients

222 udy clearly indicate that acute increases in extravascular pressure (200 mmHg for 2 s) elicit a signi

223 lation was found between graded increases in extravascular pressure and both the immediate and peak r

224 forearm blood vessels via acute increases in extravascular pressure elicits rapid vasodilatation in h

225 tagonist delays vessel sealing and increases extravascular protein accumulation, as does either inhib

226 ute fibrinolysis, is a critical component of extravascular proteolytic damage in immature brains, rep

227 n of whole-plant hydraulics, in general, and extravascular, radial hydraulic conductance in leaves (K

228 Extravascular RBCs were found to associate with placenta

229 % within 2 hr, but reduction rates slowed as extravascular re-equilibration occurred.

230 oxide (NO), inflammation, and vascular- and extravascular remodeling coexist in asthma and other dis

231 major inflammatory stimulus occurs in local extravascular sites of infection and circulating bacteri

232 r cells that traffic from the circulation to extravascular sites of inflammation.

233 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue dama

234 SP-D) are regulated by tissue fibroblasts at extravascular sites via an endocytic mechanism governed

235 a critical role in fibrin clot formation at extravascular sites, the expression and role of coagulat

236 to accumulate in allergic airways and other extravascular sites.

237 aRIIIB-mediated neutrophil interactions with extravascular soluble ICs results in the formation of ne

238 pace, fractional volume of the extracellular extravascular space (v(e)), and initial area under the g

239 Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonc

240 of plasma proteins that have leaked into the extravascular space in tumors and other lesions.

241 hat contribute to neutrophil swarming in the extravascular space of a damaged tissue.

242 The ratio of bacteria found in the extravascular space to those in the intravascular space

243 polarity, extend filopodia and migrate into extravascular space where they take up residence, in the

244 llular water, (b) water in the extracellular extravascular space, and (c) water in the microvasculatu

245 tant, or K(trans), fraction of extracellular extravascular space, or ve, and blood normalized initial

246 r Hb, translocation of the molecule into the extravascular space, oxidative and nitric oxide reaction

247 intraluminal crawling and diapedesis to the extravascular space, remains elusive.

248 ssels, and to a lesser extent throughout the extravascular space.

249 escaped from the intravascular space to the extravascular space.

250 py to investigate how fibrin is removed from extravascular space.

251 s migrated through the endothelium into the "extravascular" space (mean migration, 1.37% +/- 2.14%; n

252 along with haematopoietic progenitors in the extravascular spaces of the lungs.

253 ing this process, neutrophils migrate in the extravascular spaces, directed to the site of injury by

254 e, whereas targeted nanoparticle delivery to extravascular structures is often limited and difficult

255 in intravascular and transvascular, but not extravascular, T-cell migration in LNs.

256 induced BBB opening technology for potential extravascular targeted drug delivery in the brain, exten

257 ar imaging can be extended to the imaging of extravascular targets through use of nanoscale, phase-ch

258 actor II (HCII) has been proposed to inhibit extravascular thrombin.

259 Here, we have studied the role of the tumor extravascular tissue in the extravasation kinetics of do

260 ar functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anasto

261 f concentration levels and exposure times in extravascular tissue of tumors.

262 te inflammation, neutrophil recruitment into extravascular tissue requires neutrophil tethering and r

263 We hypothesized that VEGF-induces extravascular tissue responses via NO-dependent mechanis

264 temic PK, but DOX extravasation in the tumor extravascular tissue was substantially different.

265 g was detected by HPLC/MS/MS in any examined extravascular tissue whereas high levels of drug were de

266 of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this re

267 nitude more efficient drug delivery into the extravascular tissue, compared to non-internalized local

268 of network geometry, endothelialization and extravascular tissue, it is compatible with a wide varie

269 es within the same lobe was used to identify extravascular tissue-resident mononuclear phagocytes and

270 ugs to both the vascular wall and non-target extravascular tissue.

271 up to the nanoparticle size scale deep into extravascular tissue.

272 regulate several biological functions in the extravascular tissue.

273 rect high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities

274 argeted nanoparticles that can interact with extravascular tissues at the receptor level.

275 of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal ex

276 he trafficking of leukocytes into and out of extravascular tissues.

277 ylaxis due to rapid clearance, bleeding, and extravascular toxicity.

278 a FUS) consistently inducing BBB opening and extravascular transfection.

279 Extravascular translocation of cell-free Hb into interst

280 However, how targeting ligands affect extravascular transport of nanoparticles in solid tumors

281 mechanical and chemical stimuli; intra- and extravascular transport of nutrients, growth factors and

282 Significant differences in vascular and extravascular transport variables as well as in lymphati

283 Intravascular and extravascular triggers may warrant different approaches

284 by the intact quantum dots remaining in the extravascular tumor cells and fibroblasts.

285 Such extravascular tumor spread may represent another form of

286 Poor penetration of antitumor drugs into the extravascular tumor tissue is often a major factor limit

287 The accessibility of extravascular tumor tissue to drugs is critical for ther

288 owing coadministered drugs to penetrate into extravascular tumor tissue.

289 rs by promoting transport of the drug to the extravascular tumour tissue, but the number of available

290 vascular VCD (0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2.0 minutes [IQR, 1.0-2.0]; P <.001)

291 ntly lower among those with intravascular vs extravascular VCD (80 patients [5.3%], vs 184 patients [

292 received intravascular VCD and 1506 received extravascular VCD) and 1509 patients were randomly assig

293 zed to hemostasis with an intravascular VCD, extravascular VCD, or manual compression in a 1:1:1 rati

294 4.2 +/- 2 mL/kg; p < 0.001), plasma volume, extravascular volume (bolus resuscitation: 17 +/- 4 mL/k

295 ansfer constant (P < .001) and extracellular extravascular volume (P < .001).

296 e transfer constant, K(trans); extracellular extravascular volume fraction, v(e); and blood plasma fr

297 fer constant [K(trans)], v(e) [extracellular extravascular volume fraction], k(ep)[K(trans)/v(e)], an

298 ther important features include papilledema, extravascular volume overload, sclerotic bone lesions, t

299 n the primary vein, the results suggest that extravascular water fluxes accompany the SWP.

300 Extravascular zeta-globin(+) primitive erythroid cells w