ライフサイエンスコーパス: extremely

1 Extracellular vesicles (EVs) are extremely abundant in semen, and because they play a key

2 The extremely active TC activity and northward shift of TC g

3 , lysosomes, mitochondria, and cytoplasm) is extremely advantageous in the search for a potential dru

4 on dialysis, even if the kidney came from an extremely aged donor.

5 brains of human EOfAD mutation carriers (and extremely aged fish), possibly contributing to EOfAD pat

6 switch II domain of NRAS from a patient with extremely aggressive colorectal carcinoma.

7 ed neuroendocrine prostate cancer (NEPC), an extremely aggressive variant of castration-resistant pro

8 of fertile monsoonal alluvial plains into an extremely arid margin.

9 Sixty percent of mRNAs from its extremely AT-rich (81%) genome harbor long polyadenosine

10 ld improve the response to cancer therapy is extremely attractive to many patients, who are highly mo

11 acoustic modulations required to do this are extremely brief, raising questions about how their audit

12 e separation methods utilized, and thus have extremely broad application space in the field of microf

13 The extremely broad infrared spectrum of water in the OH str

14 anion deintercalation or anion-exchange) is extremely challenging as these low-temperature conversio

15 Such a problem is extremely challenging because compound attributes includ

16 tion of the diversity of transition paths is extremely challenging because it requires measuring more

17 lization mechanisms at the nanoscale remains extremely challenging despite its fundamental interest a

18 kers from a physiological biosample is still extremely challenging due to the abundant variety and am

19 Sometimes, however, it can also be extremely challenging for various intrinsic reasons (e.g

20 Clinical diagnosis and management is extremely challenging in women due to phenotypic diversi

21 ing the radiocarbon dating method has proven extremely challenging owing to the limited survival of o

22 Technically, this remains an extremely challenging problem because of the size of the

23 It is extremely challenging to grow single-crystal halide pero

24 It remains extremely challenging to identify specific membrane prot

25 , and low signal to noise ratio (SNR), it is extremely challenging to recover such information with e

26 ectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically.

27 tem as a photocathode for H(2) production is extremely challenging with the majority of reports repre

28 natural selection within such communities is extremely challenging, and it is thus unclear how eco-ev

29 e transition-metal dichalcogenides, although extremely challenging, is crucial for activating the ine

30 reveal the underlying growth mechanisms, is extremely challenging, owing to the fragility and short

31 environment, and electronic systems, yet is extremely challenging.

32 the rational design of catalysts and is also extremely challenging.

33 dynamics and hence structural prediction is extremely challenging.

34 from carbon dioxide (CO(2)) fixation but is extremely challenging.

35 ening in schools, cafes, and busy workplaces extremely challenging.

36 fy the causative mechanisms of cell death is extremely challenging.

37 ases in complex quantum materials has proven extremely challenging.

38 However, this can be extremely challenging: crystallization can be influenced

39 Alterations in sleep are extremely common in patients with neuropsychiatric illne

40 Premature ventricular complexes (PVCs) are extremely common, found in the majority of individuals u

41 s in Mycobacterium tuberculosis, which shows extremely complex dynamic allostery: three distinct arom

42 Mastitis in dairy cattle is extremely costly both in economic and welfare terms and

43 ometimes nonconclusive, e.g., if spectra are extremely crowded, coupling patterns are not resolved, o

44 mplement appropriate control measures for an extremely damaging disease in terms of animal health, pr

45 Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor l

46 than 3% of vertebrate populations; if these extremely declining populations are excluded, the global

47 e effects of long-term active restoration of extremely degraded grassland on soil parameters have bee

48 ature enables the developed sensor to detect extremely delicate variations in the electromagnetic pro

49 identify the conformers responsible for the extremely dense rotational spectra observed, it was esse

50 he Andromeda Galaxy (M31), RBC EXT8, that is extremely depleted in heavy elements.

51 Management of ERPC is extremely difficult because available therapeutic regime

52 ent Protein) fusion microscopy approaches is extremely difficult because the GFP signal of the cytoso

53 Without the aid of automation, it is extremely difficult to avoid the development of kinetic

54 l presentations makes dietary FB perforation extremely difficult to diagnose, being a laparoscopic or

55 todorokite, a tunnel-structured Mn oxide, is extremely difficult while it is the dominant form over o

56 Here, we show how many details of this extremely distant interaction are explained by water wav

57 Viruses are extremely diverse and modulate important biological and

58 f Y. pestis infection of the lung is decided extremely early during infection and that Pla plays a du

59 ally a somewhat hydrophobic polymer that was extremely effective at inhibiting drug crystallization,

60 at lifetime endurance exercise appears to be extremely effective at preserving or even enhancing card

61 ened the door to forward genetics as well as extremely efficient and precise genome editing in P pate

62 With the help of an accurate yet extremely efficient DNN surrogate, we revealed the stati

63 y mechanical devices has the potential to be extremely efficient due to the large optomechanical resp

64 ompared to existing methods, our approach is extremely efficient, making it suitable for the analysis

65 gning adequate therapeutic strategies, it is extremely essential to diagnose the disease at the outse

66 We believe it is an extremely exciting time to be a neuroscientist, as we ha

67 ormous datasets, we have developed BBKNN, an extremely fast graph-based data integration algorithm.

68 sion is moderate, it nevertheless allows for extremely fast traversal times that overshadow known phy

69 sion of the possible trajectories that grows extremely fast.

70 lways inaccessible experimentally due to the extremely fine length and time scales over which it occu

71 c derivation was not possible because of the extremely fragile intestinal tissue perioperatively, and

72 train that consumes minimal footprint and is extremely frugal in its use of energy.

73 Here, we show that, in Arabidopsis, an extremely functionally redundant mitogen-activated prote

74 d compounds represent mechanistically novel, extremely G protein-biased agonists is in question, as i

75 As such, the algorithm is extremely general and has a wide range of applicability.

76 The ability to characterize such extremely heterogeneous mixtures of large particles with

77 ck young oceanic lithosphere (20-25 km), and extremely heterogeneous upper mantle.

78 a functional morphology, even in the face of extremely high and potentially damaging contact stresses

79 inetics toward F6P, as it appears to have an extremely high degree of cooperative binding, resulting

80 reate biased libraries - especially with the extremely high degrees of exponential amplification requ

81 mily of candidate materials with potentially extremely high EC performance.

82 rature topological insulation in bismuthene, extremely high electron mobilities in phosphorene and si

83 a narrow corridor, crossing the Himalayas at extremely high elevations (up to > 6500 m a.s.l.) by the

84 In particular, it achieves an extremely high energy density of 27.5 W h kg(-1), which

85 ents with eosinophilic esophagitis (EoE) and extremely high esophageal eosinophilia have a distinct e

86 y large l(T) (10-100 mm), resulting from the extremely high fiber/matrix modulus ratios (10(4) -10(5)

87 ntinites is a source of Si to the ocean with extremely high fluid delta(30)Si values, which can expla

88 ssemia is a subtype of beta-thalassemia with extremely high frequency in Asia.

89 trially relevant ethanologenic organism with extremely high glycolytic flux and low biomass yield.

90 Mutations in the BRCA1 gene cause an extremely high lifetime risk of breast and ovarian cance

91 m to the gallbladder, where it replicates to extremely high numbers.

92 (177)Lu-HTK03121 and (177)Lu-HTK03123 had extremely high peak uptake (104 +/- 20.3 and 70.8 +/- 23

93 Utilizing their extremely high pore density of 1 sub-nm channel nm(-2) ,

94 the subbands and their uniformity guarantees extremely high quality electronic transport in these sys

95 typically transfer energy to their young at extremely high rates while undergoing prolonged fasting,

96 ges, with dose-response assays demonstrating extremely high resistance intensity to the pyrethroid de

97 igh-performance broadband photodetector with extremely high sensitivity under zero bias; it can also

98 e on chronic liver failure (ACLF) results in extremely high short-term mortality in patients with und

99 over large distances of 150 nanometers with extremely high spatial precision of 0.1 angstrom across

100 thanks to its negligible signal drifting and extremely high stability.

101 concentration of proteins consistent with an extremely high-resolution separation and concentration s

102 talization for a sickle cell crisis (SCC) is extremely high.

103 Sarcomeres are extremely highly ordered macromolecular assemblies where

104 most important factor mediating responses to extremely hot or dry weeks; residents and short-distance

105 methyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized

106 away from predators, this desert insect has extremely impact-resistant and crush-resistant elytra, p

107 cially between benign and malignant ones, is extremely important and can often be particularly challe

108 Identification of opportunistic viruses is extremely important as they are associated with co-morbi

109 Due to PTMs' extremely important roles, many major PTMs have been stu

110 chemical composition and sensory quality is extremely important since these data may contribute to t

111 Carbohydrate-active enzymes (CAZymes) are extremely important to bioenergy, human gut microbiome,

112 the mechanisms that control PD-1 expression extremely important to increase the response to the ther

113 ng the class of prior genotype distributions extremely important.

114 al tools to enable such developments becomes extremely important.

115 18 core competencies as "very important" or "extremely important." More than 80% of the programs curr

116 Overall, the extremely inactive TC activity during SO of 2018 is due

117 We showed that bortezomib and carfilzomib extremely increased the ubiquitinated OAT1, which correl

118 aterials in the last 5-10 years due to their extremely interesting layer dependent properties.

119 Imaging is an extremely intriguing tool since it assumes a follow up t

120 An extremely isotopically depleted carbon source, such as m

121 ar field and is electrically tunable over an extremely large broadband spectrum.

122 tructure features a previously unattainable, extremely large cage.

123 The N-glycome of human lung contains extremely large complex-type N-glycans with linear poly-

124 ormal mode computations and visualization of extremely large complexes more manageable.

125 ioning remain unclear within the confines of extremely large embryonic cells, such as the early divis

126 While we found that 1 displays an extremely large g(max) value of 3.99, the binding of an

127 ntually fails when they reach adulthood with extremely large myonuclear domains.

128 proton conductivity, fast response time, and extremely large on/off ratio upon visible-light irradiat

129 ed the issue of whether specific cities with extremely large population sizes, known as dragon-kings,

130 This catalyst exhibits an extremely large turnover frequency (TOF) up to 12500 h(-

131 o have case-control (binary) response and an extremely large-scale categorical features.

132 rds the sensing layer is random and might be extremely lengthy, especially in case of low concentrati

133 of MCPyV in Merkel cell carcinoma (MCC), an extremely lethal form of skin cancer.

134 ing plaque inflammation between the sexes is extremely limited relative to the vast literature explor

135 leotides that insert opposite DNA adducts is extremely limited, and furthermore, there has been no re

136 elow 100 millikelvin, where cooling power is extremely limited, and this severely affects the prospec

137 ries but comparative, multi-country data are extremely limited.

138 nd killing of Gram-positive pathogens remain extremely limited.

139 uring heat changes in small open systems are extremely limited.

140 on of advanced multiplex techniques has been extremely limited.

141 he PIN rewired by curcumin was a scale-free, extremely linked biological system.

142 However, extremely little is known about the importance of social

143 more accurate than composite AL in eyes with extremely long AL and can improve post-operative hyperop

144 silica-derived signal, benefitting from the extremely long T(2) relaxation time of quartz in (29)Si

145 isolate circulating rare cells due to their extremely low abundance compared to hematologic cells.

146 es to enable isolation and identification of extremely low abundance endogenous analytes present with

147 ing capacity fade when fade rates are low or extremely low and recommend refining methods to include

148 ly low gestational age neonates (ELGAN) with extremely low birth weight (ELBW; <1000 g) participating

149 The complexity of blood matrixes along with extremely low concentration of pathogens in blood poses

150 el analytical technique for the detection of extremely low concentrations of amino acids using ORIGIN

151 ), which humans and various animals sense at extremely low concentrations(5,6).

152 tches; under weak electric fields, they show extremely low conductivity, whereas under strong fields,

153 The patient has extremely low counts of circulating Mycobacterium-reacti

154 hirality in a crystal for a helicene with an extremely low enantiomerization barrier, and nanometer s

155 ersist by slow population turnover rates and extremely low energy requirements.

156 We point out the chemistries with low or extremely low established fade rates that also exhibit o

157 r annotation errors, and tend to be found at extremely low frequencies, so their analysis requires ca

158 magnetic nanoparticles (MNPs) by non-heating extremely low frequency magnetic field (ELF MF) is explo

159 ral conventional T cell compartment of human extremely low gestational age neonates (ELGAN) with extr

160 uggesting that it may be advantageous to set extremely low IOP targets for some patients with TBK1-as

161 adual reduction of an Ab concentration to an extremely low level.

162 o achieve sequence error correction, we show extremely low levels of cross-contamination by tracking

163 nted polymerization rates were achieved with extremely low light intensities (<1 mW/cm(2)) and cataly

164 candidate for super-resolution imaging with extremely low luminescence background and high photoblea

165 NE = tetracyanoethylene; x ~ 2] has shown an extremely low magnetic damping comparable to, for exampl

166 channels within the plates, enabled by their extremely low mass and thermal conductivity.

167 As these extremely low mechanical forces are physiologically rele

168 eq to prokaryotes has been hindered by their extremely low mRNA abundance(14-16), lack of mRNA polyad

169 Therefore, under conditions of extremely low or absent antigen levels, memory virus-spe

170 ds of individual cells in parallel, but with extremely low sequencing coverage (<0.05x) per cell.

171 to the diversity of particle shapes and the extremely low signal-to-noise ratio of micrographs.

172 proteomics remains challenging owing to the extremely low solubility of the ECM.

173 em from the use of a graphene monolayer with extremely low specific heat(14) as the active material.

174 After 6 months of extremely low sporadic DUX4 expression, dystrophic muscl

175 sis remain operational and efficient down to extremely low temperatures, and natural photosystems exh

176 in which low momentum is engineered through extremely low temperatures.

177 The increase in shelf-life was due to the extremely low water vapor transmission rate of the films

178 ting with acute gastrointestinal symptoms is extremely low with an additional detection rate of aroun

179 ption associated with the non-thermal IMT is extremely low, rivaling that of state-of-the-art electro

180 that retain their metabolic potential under extremely low-energy conditions for up to 101.5 Ma.

181 The human threshold for TCA is extremely low.

182 nical or tumour predictors is expected to be extremely low.

183 may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia.

184 In extremely-low-birth-weight infants, a higher hemoglobin

185 ce originates in the foveal cones, which are extremely narrow and long to form a high-resolution pixe

186 aracterize the exciton and to demonstrate an extremely narrow excitonic linewidth below 50 kelvin.

187 This extremely nonequilibrium condition, not found in nature,

188 molecule devices must be designed to exhibit extremely nonlinear current-voltage (I-V) characteristic

189 High harmonic generation (HHG) is an extremely nonlinear effect generating coherent broadband

190 ailure (including those receiving dialysis), extremely old patients (such as those aged >80 years wit

191 respondents reported being satisfied (either extremely or somewhat) with telemedicine encounters.

192 ioritized in each round, and those noted as "extremely" or "very important" by >= 50% of respondents

193 not able to escape out until emulsions were extremely oxidized.

194 pecialized on a single pollinator taxon were extremely pollen limited across land use types.

195 PEL is an aggressive disease with extremely poor prognosis when treated with conventional

196 ggressive and lethal human malignancies with extremely poor prognosis, there is an urgent demand of m

197 ansparent front contact, however, results in extremely poor solar cell performance.

198 OCCC thus lack effective therapies and face extremely poor survival rates.

199 nosis for patients with pancreatic cancer is extremely poor, as they are resistant to first line chem

200 Trametinib is an extremely potent allosteric inhibitor of mitogen-activat

201 This agent was found to be extremely potent with an in vitro IC50 ~ 100x lower than

202 ratified was 4.04 (95% CI: 2.69 to 6.08) for extremely pre-term (22 to 27 weeks), 2.62 (95% CI: 2.09

203 pproximately 2 months premature to affecting extremely premature infants.

204 mproves BPD risk assessment, particularly in extremely premature infants.

205 Children born extremely preterm (< 28 weeks gestation, EPT) are at inc

206 ose erythropoietin treatment administered to extremely preterm infants from 24 hours after birth thro

207 , the benefits and safety of this therapy in extremely preterm infants have not been established.

208 PUFA is especially challenging for immature, extremely preterm infants who are typically supported by

209 to elucidate the mechanisms at play in this extremely prevalent DP disorder and provide further supp

210 ma, the most lethal primary brain cancer, is extremely proliferative and invasive.

211 Preliminary data are extremely promising and solid evidence is being gathered

212 the Bi(2)X(3) family (X = O, S, Se, Te), are extremely promising for beyond Moore's Law computing app

213 have finally allowed the synthesis of these extremely promising heterocycles in amounts of more than

214 ugh lone-pair delocalization, which leads to extremely rapid intermolecular enolate equilibration.

215 tudies have shown that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles a

216 nal organization of cells, thus facilitating extremely rapid reorganization in response to internal a

217 Loss of (129)I from solution was extremely rapid; the average half-lives of (129)I(-) and

218 y efficient C-H functionalization methods is extremely rare and challenging.

219 st ubiquitous and studied class of LLCs, are extremely rare and report only the ratios of elastic con

220 ge ordered structures at the atomic level is extremely rare and so far has only been reported for sol

221 Nodal and/or bone marrow involvement is extremely rare and, if present, suggests an alternative

222 Improving our knowledge about these extremely rare autosomal recessive forms of LGMD was hel

223 l/histiocytoid carcinoma of the eyelid is an extremely rare but aggressive neoplasm diagnosed primari

224 tra-large scRNA-Seq datasets, without losing extremely rare or transcriptionally similar yet distinct

225 of dinitrogen to an f-block metal cation is extremely rare.

226 nificant development during childhood and is extremely reactive to stress.

227 Metastatic breast cancer (MBC) is an extremely recalcitrant disease capable of bypassing curr

228 their strong C-F bonds, these molecules are extremely recalcitrant, requiring advanced treatment met

229 ere, we demonstrate 3D/2D hybrid PeLEDs with extremely reduced luminance overshoot and 21 times longe

230 The extremely reduced transcriptional activity of the two pr

231 N people are uniquely challenging due to the extremely remote locations of many residents.

232 -systems under homogeneous gold catalysis is extremely rich and varied.

233 The proposed approach provided extremely satisfactory results (in external validation,

234 ) memory B cells and IgE(+) plasma cells are extremely scarce and short-lived, respectively.

235 ion is essential; however, these studies are extremely scarce in cetaceans.

236 The detection assays need to be extremely sensitive and selective in small value of intr

237 a critical role in fear conditioning and is extremely sensitive to ELS.

238 m and at high temperatures, where it becomes extremely sensitive to hydrostatic pressure.

239 that Nile red's (NR) orientation spectra are extremely sensitive to membrane chemical composition.

240 ellent choice for trace gas detection, being extremely sensitive while having fast response times.

241 s based on a clinical case of a patient with extremely severe anaphylaxis to paper wasp venom.

242 ting BCR tonic signaling, resulting in their extremely short lifespan.

243 se express unfolded protein response and are extremely short lived.

244 hat purchase prediction is reliable even for extremely short observation windows.

245 Here, we use extremely short optical pulses to non-resonantly excite

246 Extremely short X-ray pulses from a free-electron laser

247 ts catalytic rate per molecule of protein is extremely slow and the binding of the primary substrate,

248 ostructure of 3D cell cultures still remains extremely slow because of the manual, laborious, and tim

249 n, we generated a genetic variant exhibiting extremely slow phototransduction kinetics, yet normal se

250 mic, the deployment of RT-PCR tests has been extremely slow, and key reagents such as PCR primers and

251 The coalescence is extremely slow, decelerating process, resulting in a rar

252 formed relatively quickly, G-hairpins folded extremely slowly, indicating that short G-overhangs, whi

253 for transition metal dichalcogenides use an extremely small amount of precursor to render large sing

254 ospheric pressure resulted from fractures of extremely small aperture that are essentially invisible.

255 en evolution reaction (HER), resulting in an extremely small overpotential (18 mV), an ultralow Tafel

256 length scale of rock matrix diffusion may be extremely small, on the order of centimetres, even over

257 yr68, and Asp141 to the transition vector is extremely small.

258 ripartite construction, protein-MOFs possess extremely sparse lattice connectivity, suggesting that t

259 ination of complex molecular structures from extremely sparse NMR data.

260 GCN for SL prediction as SL interactions are extremely sparse, which is more likely to cause overfitt

261 viruses in this part of the biosphere being extremely sparse.

262 h stereochemical activity of Pb(2+) with the extremely strained [Zn(2)Ga(2)O(7)](4-) framework along

263 After finding evidence for extremely strong selection at both hybrid zones, we use

264 Extremely suitable voltammetric performance was demonstr

265 channels make membrane conductance of cells extremely temperature dependent, allowing the detection

266 ventional analysis of structural features is extremely time-consuming and subject to observer bias.

267 nship provides guidance toward the design of extremely tough soft composites.

268 Yet, excess copper is extremely toxic, and is exploited as a bacteriocide in m

269 comere mutations independent of age, and was extremely uncommon in older patients.

270 environmental component of human disease is extremely underrepresented in these linked data sets.

271 Rupture of RAA is an extremely unusual cause of acute flank pain and haemodyn

272 that higher-order correlation functions are extremely useful for forming a general model for predict

273 radioactively labelled tracer compounds) are extremely useful for in vivo characterization of central

274 Our results indicated WGS was extremely useful for monitoring trends for specific ESBL

275 immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune resp

276 investigations, the 3DI observations will be extremely useful in identifying ionosphere composition,

277 modulate perforin activity in vivo could be extremely useful, especially in the context of bone marr

278 identify proteins from their surface shapes extremely useful.

279 Heart rate (HR) is extremely valuable in the study of complex behaviours an

280 riants, and small molecule modulators can be extremely valuable tools.

281 molecular mechanisms of nanotoxicity across extremely variable data sets.

282 The neurological outcome is extremely variable depending on the type, extent and sev

283 This toxic activity of silica dusts is extremely variable depending on their source and prepara

284 difficulty of identifying sequences of this extremely variable gene.

285 ingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse,

286 diting sites in Selaginella plastomes can be extremely variable, to a degree that is currently unpara

287 find that the structure of these networks is extremely variable, where species constantly change how

288 conclusions regarding cost-effectiveness are extremely variable.

289 s, despite their limited bioavailability and extremely varied chemical structures.

290 The algorithm behind particle methods is extremely versatile and used in a variety of application

291 Broadband optical frequency combs are extremely versatile tools for precision spectroscopy, ul

292 Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector protein

293 rful tool for deepening our understanding of extremely weak protein-cosolute interactions.

294 -up out to day 360.RESULTSMIC infusions were extremely well tolerated.

295 (-) oxidative current was found to correlate extremely well with the predicted pH-dependent [OCl(-)]

296 metallic or coordination complexes are often extremely well-defined, with errors in the positions on

297 Hybrid integration of such biosensors with extremely well-established silicon-based microcircuit ch

298 nal image-sensing characteristics such as an extremely wide field of view, high resolution and sensit

299 ow that the error loss function presents few extremely wide flat minima (WFM) which coexist with narr

300 We found extremely wide variation in complexity of country level