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1 ifferentiation was both T cell intrinsic and extrinsic.
2 2 in adipocytes, some features are adipocyte-extrinsic.
7 notypes of AD infants (intrinsic AD, iAD and extrinsic AD, eAD), and established ovalbumin (OVA) perc
9 (~50 ms), favoring reduction of Y(373)(*) by extrinsic agents and protonation of FAD(*-) to form the
12 W RV, uniquely triggers the cleavage of both extrinsic and intrinsic caspases (caspases 8, 9, and 3)
14 apies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms tha
17 Looking through the "lens" of intrinsic, extrinsic, and drug-induced resistance (also referred to
18 tion-number-dependent atom removal rates and extrinsic anisotropy induced by the graphene window.
19 1B light chain 3B-II] formation) followed by extrinsic apoptosis (cleaved CASP8/3 [caspase-8/3] and P
20 TRADD deficiency inhibits RIPK1-dependent extrinsic apoptosis and proteasomal stress-induced intri
21 on was correlated to increased intrinsic and extrinsic apoptosis pathway markers in a radical oxygen
22 acts by preferentially suppressing the cell-extrinsic apoptosis pathway, highlighting a previously u
23 e receptors (TLRs), caspase-8 initiates cell-extrinsic apoptosis while inhibiting RIPK3-dependent pro
25 3-kinase -> Akt pathway, upregulation of the extrinsic apoptotic pathway- tumor necrosis factor alpha
26 se-3 activation in response to intrinsic and extrinsic apoptotic stimuli are significantly reduced in
30 r sIgA deficiency, we examined intrinsic and extrinsic aspects of B-lymphocyte development and functi
32 ube, which has been proposed to be driven by extrinsic axial tension due to the activity of secondary
33 ance, is widely assumed to persist only when extrinsic barriers prevent niche divergence or selection
35 ical experiments demonstrating key roles for extrinsic biases by maternal factors and/or extraembryon
36 cobalt and intrinsic potassium ions), (iii) extrinsic bromine and intrinsic phosphorus SAD to solve
37 tes an electric field that serves to recruit extrinsic cationic proteins, can alter the disposition o
38 Caspase-8 (Casp-8), a key protease in the extrinsic cell death-signaling pathway, regulates cell d
40 tant role in understanding the intrinsic and extrinsic cellular processes in biological and biomedica
41 lia may partially explain this decline, cell-extrinsic changes in the systemic environment, mediated
42 nsic changes to protein structure as well as extrinsic changes to protein-protein and protein-metabol
43 y of predictive performance to intrinsic and extrinsic characteristics of the considered predictors.
46 ents integral to the crystallization buffer (extrinsic cobalt and intrinsic potassium ions), (iii) ex
47 he target article about distinctions between extrinsic coding (external references to known things, a
48 incidental finding of left common iliac vein extrinsic compression by right common iliac artery with
49 s in paramedian position, potentially due to extrinsic compression of the posterior branch of the rec
50 role in the diagnostic workup as it reveals extrinsic compression of the spinal cord and disruption
55 on cognate antigen challenge with major cell-extrinsic contributions responsible for the diminished m
59 e that eye formation is regulated in part by extrinsic control of extracellular matrix assembly.This
60 ing de novo artificial granules that provide extrinsic control of translation, we report a bottom-up
62 of Pole in DNA replication and the action of extrinsic correction systems that remove Pole errors.
66 ction is the stem cell 'niche'-a set of cell-extrinsic cues that include chemical and mechanical sign
67 n by temporally regulated intrinsic and cell-extrinsic cues that organize neurogenesis, migration, an
69 (plastic phenotypes driven by intrinsic and extrinsic cues) can be identified, associated to specifi
70 ation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poo
75 s constantly being attacked by intrinsic and extrinsic damaging agents, such as reactive oxygen speci
76 after CI+Txp requires inhibition of both the extrinsic death receptor pathway via TNFR1 and caspase-8
78 defect in antibody production as well as an extrinsic defect in IgA transport in the EdnrB(NCC-/-) m
81 iscuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice between th
82 These findings identify cell intrinsic and extrinsic determinants of B cell fate during ontogeny an
83 MoS(2) polarity control is realized without extrinsic doping by employing a 1D elemental metal conta
84 onal dilute magnetic semiconductors utilized extrinsic doping techniques or bulk crystal growth, detr
85 ion was not cell intrinsic, revealing a cell-extrinsic downregulation of the antiviral NK cell respon
86 nd ultimately induces both the intrinsic and extrinsic drug-induced apoptotic pathways in MM cells.
87 how that the interplay of both intrinsic and extrinsic dynamics is required to explain the intermitte
90 es a complex interaction of factors that are extrinsic (eg, neurohumoral factors) and intrinsic (eg,
91 neuronal intrinsic signalling, the neuronal extrinsic environment, the capacity to reconnect the sev
92 n in 46 African lakes and reported that both extrinsic environmental factors and intrinsic lineage-sp
93 operate at an organismal level, integrating extrinsic environmental signals to orchestrate ILC3 resp
94 ies, indicating that intrinsic (host) and/or extrinsic (environmental) ecological factors may influen
95 s influenced by both intrinsic (genetic) and extrinsic (environmental) factors, but little is known o
96 on strategies to improve both intrinsic and extrinsic (environmental) stabilities of high-efficiency
100 ion tasks and 8 million instances from three extrinsic evaluation tasks), which is, by far, the most
101 rug-gene and gene-gene interactions) and two extrinsic evaluations (protein-protein interaction predi
105 malian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated sig
106 essments of edoxaban included endogenous and extrinsic factor Xa activity and edoxaban concentration.
107 iological catch bonds because it requires an extrinsic factor-competitor proteins-rather than a speci
109 nary history) play more important roles than extrinsic factors (experimental treatment and environmen
111 e that anthropophagy was better explained by extrinsic factors (namely, local host availability and i
112 ark Service units and examined intrinsic and extrinsic factors associated with the variation in Hg co
114 between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and disse
115 etween genotype and phenotype indicates that extrinsic factors frequently impact the severity of gene
117 We examine the extent to which intrinsic and extrinsic factors influence reproductive phenology in ma
119 in the identification of dynein subunits and extrinsic factors required for preassembly of dynein com
120 ium was swapped between cultures showed that extrinsic factors secreted by activated fibroblasts unde
123 requirements by incorporating intrinsic and extrinsic factors that affect susceptibility, adequately
125 availability, which additionally depends on extrinsic factors that may be rare or widespread at the
126 requires scrutiny of tumours' intrinsic and extrinsic factors that may impact host antitumour immuni
128 out evolution, whether it can be affected by extrinsic factors, and its role in regulating dynein fun
130 R) stress, whether triggered by intrinsic or extrinsic factors, can be resolved by the unfolded prote
131 ned by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the envir
132 nce of such a pattern, albeit insensitive to extrinsic factors, requires a balance between intrinsic
133 abolic programmes and also describe how cell-extrinsic factors, such as nutrients and regulatory T ce
134 rtex differentiation depends on intrinsic or extrinsic factors, we generated models of gonadal inters
137 n and expression of Ly49 receptors in a cell-extrinsic fashion from both nonhematopoietic and hematop
138 y quantifying the effect of wrist posture on extrinsic finger EMG activity in able-bodied subjects, t
139 sought to quantify the posture-dependence of extrinsic finger muscle activity using bipolar fine-wire
140 polar fine-wire electrodes inserted into the extrinsic finger muscles of able-bodied subjects during
142 Based on the responses analyzed against extrinsic fish catch and human development index data, p
145 c forces generated by molecular motors(1-3), extrinsic forces exerted by adjacent cells(4-7) and mech
146 otopic ossification (HO) to examine how cell-extrinsic forces impact mesenchymal progenitor cell (MPC
147 result, cells were susceptible to rupture by extrinsic forces, such as shear stress or compression.
148 er tumor initiation and progression via cell extrinsic functions by creating a tumor-supporting envir
149 CD19-STAT3KO) and investigated intrinsic and extrinsic functions of STAT3 in B cells and its potentia
151 hrough positive or negative cooperativity by extrinsic G3BP1-binding factors that strengthen or weake
152 analyses identified germ-cell intrinsic and extrinsic genes responsive to Sertoli-cell androgen sign
154 as a late-acting temporal factor integrating extrinsic hormonal cues linked to developmental timing w
155 highlight key studies testing intrinsic and extrinsic hypotheses about geographic range size under c
156 ts, children versus adults, intrinsic versus extrinsic (IgE status) disease, and patients with and wi
158 ted with a new variant of CHIKV with shorter extrinsic incubation period in contaminated mosquitoes,
160 miR-146a affects HSC function via both cell-extrinsic inflammatory signals and increased cell-intrin
163 differences in density and centrality, with extrinsic input-output connectivity playing a greater ro
167 cope with both tumor cell-intrinsic and cell-extrinsic insults and develop acquired resistance to the
168 ch into Irf5(-/-) mice, we found that T cell-extrinsic IRF5 regulated T cell outcomes at multiple cri
169 ctions and grain boundaries (GBs) provide an extrinsic knob for manipulating the properties of nano-
170 f plasma DNA, which appears to act in a cell-extrinsic manner to regulate plasma DNA size and motif f
171 lley Hall effects have been achieved only by extrinsic means, such as substrate coupling, dual gating
172 s to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and c
175 ty is established through cell-intrinsic or -extrinsic mechanisms and how polarity is coupled to grow
176 se results show that both HSC-intrinsic and -extrinsic mechanisms are involved in age-associated hema
178 l evolution in MPNs, the cell-intrinsic and -extrinsic mechanisms driving leukemic transformation at
179 is Review, we discuss vascular intrinsic and extrinsic mechanisms of how ageing influences the pathol
182 is predisposition via multiple intrinsic and extrinsic mechanisms, and future studies could consider
186 1 interacts with and phosphorylates PsbO, an extrinsic member of photosystem II (PSII), to reduce pho
188 Other than intrinsic silica phytoliths, extrinsic mineral dust/grit adhering to plants causes to
192 le size and Fe doping is critical to control extrinsic morphological factors of FeN(4) sites for opti
193 ic positive density dependence often reduces extrinsic mortality (e.g. reduced predation), which favo
195 ROMM) of four macaque monkeys, we tested the extrinsic muscle shortening hypothesis, which posits tha
197 erials to distinguish intrinsic defects from extrinsic nanocrystals, and the findings pave the way fo
198 TNX was present in calretinin-immunoreactive extrinsic nerve endings in mouse and human stomach.
201 The colon is innervated by intrinsic and extrinsic neurons that coordinate functions necessary fo
202 n in the olfactory system, and reveals novel extrinsic neurons that provide strong input to this sero
203 ing, response variability is consistent with extrinsic noise (cell-to-cell variability in protein lev
204 dent activation of Akt and ERK by decreasing extrinsic noise (preexisting cell-to-cell differences in
205 n the same environment, and has two sources: extrinsic noise arising from the disparity of the cell s
206 e the mean number of molecules, overestimate extrinsic noise but underestimate intrinsic noise and ha
207 lized framework to approximate intrinsic and extrinsic noise in a population of cells expressing an u
208 gle-cell model predicted how combinations of extrinsic noise in PI3K, Ras, and mTORC1 superimposed on
209 lative history of cell density, predicted by extrinsic noise in transcription factor expression, and
210 uantify mean molecule numbers, intrinsic and extrinsic noise statistics in two-colour experiments.
211 sic variability, the framework also predicts extrinsic noise without the need to introduce fluctuatin
212 while most promoters show a common level of extrinsic noise, some insertions show higher noise level
214 and biological consequences of intrinsic and extrinsic noises and can aid the construction of desired
215 A-box and microRNA targeting on intrinsic or extrinsic noises and reveal gene function-associated noi
216 sed by other physiological circumstances and extrinsic obstacles, including other transcribing polyme
220 pathway involving caspase-9 and AIF, and the extrinsic pathway involving caspase-8 are significant fo
223 the effects of a combined deficiency of Fas (extrinsic pathway) and Bim (intrinsic pathway) on early
224 gle cell-intrinsic factor represses multiple extrinsic pathways that favor self-renewal, thereby ensu
226 Proper colon function requires signals from extrinsic primary afferent neurons (ExPANs) located in s
228 Poldelta proofreading defect, demonstrating extrinsic proofreading of Polepsilon errors by Poldelta.
229 en sequences of the drug targets and several extrinsic properties of the input drug structures, drug
231 ical tension at their apex, thereby allowing extrinsic pulling forces from neighboring interphasic bl
232 ical damage from cellular metabolism and (2) extrinsic rather than intrinsic sources of mortality are
233 f the peripheral stalk, part of the membrane extrinsic region of the stator, and how the action of th
235 These findings establish key features of the extrinsic regulation of IgE production by cytokines.
237 havior, and molecular identity via a complex extrinsic regulation that is far from being fully elucid
240 the B-ALL immune microenvironment identifies extrinsic regulators of B-ALL survival supporting new im
245 mbryonic enteric neurogenesis occurs via gut-extrinsic Schwann cell precursors during development and
247 proprioceptor subtypes depends, in part, on extrinsic sensory receptor organ-derived signals.SIGNIFI
251 th dependent on precise interactions between extrinsic signals and transcriptional and epigenetic reg
252 ated effector genes, cellular processes, and extrinsic signals are required to understand how transcr
253 ly limited to the neck, where head-dependent extrinsic signals create a permissive microenvironment f
254 Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control
256 aracterizing cellular responses to different extrinsic signals is an active area of research, and cur
259 entiation-inducing hematopoietic TFs by cell extrinsic signals remains surprisingly difficult to esta
261 dritic cells (DCs) are highly susceptible to extrinsic signals that modify the functions of these cru
262 y is tightly regulated by both intrinsic and extrinsic signals, such as mechanical force, cell-cell c
263 ration of transcription factor activity with extrinsic signals, while non-native paralogs enforced di
267 drocyte development is tightly controlled by extrinsic signals; however, mechanisms that modulate cel
268 h host genotype; resource satiation, whereby extrinsic sources of nutrients relax host control; and v
273 ing of E93 expression in MB neuroblasts, and extrinsic steroid hormone receptor (EcR) activation boos
274 the precise cellular mechanisms linking the extrinsic stimulus to the intrinsic RNA modification pat
277 s reveal microbiota-dependent control of gut-extrinsic sympathetic activation through a gut-brain cir
278 e find that the gut microbiome modulates gut-extrinsic sympathetic neurons: microbiota depletion lead
279 , which combine the integration of local and extrinsic synaptic input in a nuanced, region-specific m
281 nging because they are often not amenable to extrinsic tags, are diverse in nature, and are present w
283 activation via the intrinsic (FVIII-FIX) and extrinsic (tissue factor [TF]-FVII) coagulation pathways
288 at it requires inclusion of a protein factor extrinsic to the minimal in vitro transcription reaction
289 change is regulated by signals intrinsic and extrinsic to the SAM, but the relative importance of the
291 hat CHD4 suppression, even in the absence of extrinsic treatment, cumulatively increases DNA damage.
292 lling pathways (referred to as intrinsic and extrinsic) triggered by multiple factors, including cell
299 phomagenesis, and characterize intrinsic and extrinsic vulnerabilities of cancer cells that can be th
300 ry and T(FH) cells was largely CD4(+) T-cell extrinsic, whereas changes in cytokine production and T(