ライフサイエンスコーパス: exuberant

1 concentration of rhBMP-2, bone formation was exuberant.

2 f striatal inhibitory neurons were much more exuberant.

3 ay represent a mechanism to prevent the over-exuberant activation of macrophages during infection and

4 kin-6) induces systemic inflammation with an exuberant acute-phase response.

5 ls following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression an

6 uses increased mortality by promoting overly exuberant airway inflammation and cumulative lung damage

7 s, P2Y(6) receptors protect the lung against exuberant allergen-induced pulmonary inflammation by inh

8 nvironmental irritants but that also trigger exuberant allergic reactions in patients with allergies.

9 Exuberant and expansive myelination/remyelination is det

10 atients suffer from recurrent infections and exuberant and persistent tissue granuloma formation.

11 dysregulation of FasL could further enhance exuberant and prolonged cytokine production by DCs follo

12 lial-mesenchymal transition (EMT) along with exuberant angiogenesis that together changed the microen

13 ovenous identity but instead seem to feature exuberant angiogenic signaling.

14 microvilli, whereas high density cells have exuberant apical surface infolding and microvilli.

15 Electron microscopy revealed exuberant apoptosis and necrosis as the mechanisms of Pr

16 to dissociate PrV patterning anomalies from exuberant apoptosis in DRG11(-/-) mice.

17 e are not the result of refinement of richly exuberant arbors but rather the elaboration of arbors pr

18 The IRP in normal mice is also more exuberant at early ages, and the process of refinement m

19 Repeated AT1 cell killing elicited exuberant AT2 proliferation, generating aberrant daughte

20 y promoting either the corrective pruning of exuberant axon branches or the specific ingrowth and ela

21 in JNK-interacting protein 3 (JIP3) triggers exuberant axon branching and self-contact in primary gra

22 ate the cerebellar cortex, where they sprout exuberant axon collaterals.

23 pecific projections emerge by elimination of exuberant axonal branches and suggest that they may use

24 Axon pruning by degeneration remodels exuberant axonal connections and is widely required for

25 The widespread developmental phenomena of exuberant axonal projections and synaptic connections re

26 active ErbB2 (CAErbB2) led to synaptic loss, exuberant axonal sprouting, and lethality at birth.

27 There was no indication of exuberant bipolar cell projections.

28 We suggest that the exuberant blood clotting and immune hyper-reaction seen

29 osing dysostosis characterized by asymmetric exuberant bone formation.

30 l periods has revealed an important role for exuberant brain plasticity during early development, and

31 We hypothesize that exuberant branches and synapses are eliminated to achiev

32 lop precisely from the outset without making exuberant branches in incorrect cortical layers.

33 ns that are later refined through pruning of exuberant branches.

34 has been hypothesized that normal pruning of exuberant branching of afferent neurons in the developin

35 This phase includes a period of exuberant branching where arbors grow in number, complex

36 pment, dendrites acquire their morphology by exuberant branching.

37 n epithelial repair - both too little or too exuberant - can render mice susceptible to tumorigenesis

38 aorta, enhanced yolk sac hematopoiesis, and exuberant cardiac blood island formation.

39 Our preliminary results suggest an exuberant caspase response in COVID-19 that may facilita

40 versible cartilage and bone destruction, and exuberant coagulation system activity within joint tissu

41 global commons presents a systemic risk for exuberant competition for space goods and services, whic

42 We hypothesized that exuberant complement activity in PNH results in enhanced

43 sponsive neurons could be the consequence of exuberant connections formed during development that wer

44 ally restricted L4 connectivity emerges when exuberant contralateral axons are refined in an area- an

45 Exuberant corneal fibrin(ogen) deposition was noted in P

46 ulation of whole T cell subsets leads to the exuberant cytokine production that in turn causes the sh

47 A dysregulated innate immune response and exuberant cytokine/chemokine expression are believed to

48 s were enhanced, and this was accompanied by exuberant dendritogenesis of bSCs by 24 h.

49 pulmonary fibrosis (IPF) is characterized by exuberant deposition of extracellular matrix components,

50 ion increases connectivity by stabilizing an exuberant developmental projection, we examined the norm

51 erns do not result from anomalous pruning of exuberant distributions of 17-18a fibers in gray matter.

52 iacaran and earliest Cambrian, heralding the exuberant diversification of body forms that account for

53 the prepatterning of a biological system of exuberant diversity and illustrate how shifts in the dep

54 1) that are critical for PD-1 transcription, exuberant effector differentiation, and interferon respo

55 To study the dependence of exuberant endothelial cell proliferation on initial apop

56 The exuberant expression of GC-C by nonparenchymal cells and

57 ry sensory projections are established in an exuberant fashion.

58 n tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas

59 Exuberant fibroproliferation is a common complication af

60 stimulated microvascular rarefaction with an exuberant fibrotic response.

61 ing of only the 3' end of the transcript, an exuberant fraction of reads mapping to ribosomal RNA, an

62 In contrast, the exuberant functional connectivity between extrastriate a

63 circuit maturation culminates in a period of exuberant GABAergic transmission.

64 Exuberant generation of nitric oxide (NO) by inducible n

65 These results suggest that exuberant granulomatous inflammation in CGD is probably

66 ncreases in non-SMC aortic cell mass induced exuberant growth and dilation of the aorta, calcificatio

67 lling branches during a subsequent period of exuberant growth and refinement.

68 endritic growth, having an initial period of exuberant growth followed by a period of retraction to m

69 than littermate controls but exhibited more exuberant growth in response to chronic phenylephrine in

70 ull base are more variably affected, showing exuberant growth in some animals, suggesting they are co

71 onversely, Dscam gain of function results in exuberant growth into the dorsal thalamus.

72 Exuberant growth of connective tissue within the periodo

73 A pyogenic granuloma is an exuberant growth of granulation tissue secondary to irri

74 The exuberant growth of neurites during development becomes

75 ic development is characterized by stages of exuberant growth, pruning, and stabilization during adul

76 Remarkably, despite this exuberant growth, stable neurotransmission is maintained

77 In development, 'exuberant' growth of neurons is often followed by prunin

78 ll aim to restore perfusion while inhibiting exuberant healing.

79 , vascular ectasia, intravascular hemolysis, exuberant hematopoiesis, cardiomegaly, glomerulosclerosi

80 ttention (lower levels of modesty) and being exuberant (higher activity levels).

81 Lungs of control mice manifested exuberant histiocytic inflammation with visible C. neofo

82 "anterior upper lobe," "straight-edge," and "exuberant honeycombing" signs), as well as two other mor

83 s of the organism on the lung parenchyma and exuberant host immune responses.

84 f parasites, suggesting three possibilities: exuberant host reactions to the few remaining parasites,

85 A major hallmark is the exuberant host response comprising the tumor microenviro

86 An exuberant host response contributes to influenza A virus

87 oresolving agent, possibly in the context of exuberant host responses to damaging respirable agents s

88 dy that ectopic FGF-3 expression resulted in exuberant hyperplasia of all bigenic prostatic lobes typ

89 is achieved by first establishing an initial exuberant immature pattern of connectivity that is then

90 e intensity of an immune response; an overly exuberant immune response can cause collateral damage th

91 mechanisms that limit damage from an overly exuberant immune response have evolved.

92 t phenotypic outcomes, an aberrant or overly exuberant immune response may be an additional requireme

93 st defense mechanisms against pathogens, the exuberant immune response resulting from inflammasome ac

94 une reconstitution inflammatory syndrome, an exuberant immune response that can contribute to morbidi

95 nknown, the vulvar ulcers may result from an exuberant immune response to infection.

96 ntributor to influenza pathology is the over-exuberant immune response to the virus, particularly whe

97 A dysregulated overly exuberant immune response, termed a "cytokine storm," ac

98 argeted to opposite effect: to curb the over-exuberant immune response.

99 despite aggressive antibiotic therapy and an exuberant immune response.

100 discuss how microglial participation in over-exuberant immune responses can drive immunopathology tha

101 ify a mechanism by which Treg cells suppress exuberant immune responses, highlighting a key role for

102 T (T(reg)) cells capable of suppressing over-exuberant immune responses.

103 lf-tolerance and function to suppress overly exuberant immune responses.

104 Despite providing the interface between an exuberant immune system and a highly antigenic lumenal e

105 observed at P15, with the pathway being more exuberant in CCKO mice.

106 , and somatostatin-immunoreactive axons were exuberant in the dentate gyrus despite loss of immunopos

107 owed hemophagocytic lymphohistiocytosis with exuberant infiltrates of CD8+ T cells that lacked perfor

108 asthma/chronic sinusitis in large part by an exuberant infiltration of eosinophils that are character

109 In conjunction, there was exuberant inflammasome-mediated caspase-1 activation in

110 nin-angiotensin system, which contributes to exuberant inflammation after bacterial infection.

111 ircadian neutrophil checkpoint protects from exuberant inflammation and can be activated to protect t

112 c kidney disease (ADPKD) is characterized by exuberant inflammation and fibrosis, a process believed

113 sepsis, this response is dysregulated, with exuberant inflammation being followed by a state of prof

114 nflammatory response and its causes can fuel exuberant inflammation characteristic of many human dise

115 ought to be predominantly a syndrome of over exuberant inflammation, sepsis is now recognized as a sy

116 en present with chronicity and corresponding exuberant inflammation, which leads to loss of tooth sup

117 unoregulatory circuits will help to mitigate exuberant inflammation.

118 duced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defin

119 adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response.

120 Adult wound healing is characterized by an exuberant inflammatory response and scar formation.

121 te balance between a strong antiviral and an exuberant inflammatory response.

122 cterial replication while preventing an over-exuberant inflammatory response.

123 pified by impaired induction of interferons, exuberant inflammatory responses and delayed adaptive im

124 cause acute lethal disease characterized by exuberant inflammatory responses and lung damage.

125 Filarial infections evoke exuberant inflammatory responses in the peritoneal cavit

126 Moreover, we identify an exuberant innate immune response as key player in pathog

127 erve as an important checkpoint against over-exuberant innate immune responses.

128 An exuberant innate response, postulated to diminish as the

129 , neural circuits are initially generated by exuberant innervation and are rapidly refined by selecti

130 of neural circuit development include early exuberant innervation followed by competition and prunin

131 During the development of other systems, exuberant innervation is followed by activity-dependent

132 lack of IL-1alpha and not IL-1beta led to an exuberant intracellular pathogen replication and progres

133 ns alpha(v)beta(3)/alpha(v)beta(5) exhibited exuberant ISC expansion and enhanced differentiation int

134 cytogenetic abnormalities in lymphocytes are exuberant: juxtacentromeric heterochromatin is greatly e

135 We have tested the functional impact of exuberant leading process branching by expressing a domi

136 ve shown that pregnant women with CL develop exuberant lesions.

137 The exuberant liver injury phenotypes in syndecan-1 null (Sd

138 efects in neural patterning and wiring, with exuberant local and short-distance cortical interactions

139 vely active v-abl construct (CA-Abl) show an exuberant microtubule-associated protein 2-positive (MAP

140 ts show expression of stress response genes, exuberant mitochondrial gene transcription, and increase

141 of alveolar walls and spaces, followed by an exuberant mononuclear cell infiltration that correlated

142 inhibition may be a strategy for modulating exuberant mucosal airway inflammation.

143 rcholesterolemia, vascular injury induced an exuberant myointimal lesion that was augmented by the ac

144 der such inflammatory conditions, can induce exuberant NETs, thus making inhibition of NETs desirable

145 APP expression is required for exuberant neurite outgrowth and hippocampal axonal sprou

146 ollowed by refinement through elimination of exuberant neurons and synapses.

147 ve in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing.

148 ies P. aeruginosa infections is caused by an exuberant neutrophil response stimulated by 3-O-C12-HSL-

149 bally NADPH oxidase-deficient mice developed exuberant neutrophilic lung inflammation and proinflamma

150 by Jag1) in PCECs, which in turn stimulates exuberant Notch signaling in perivascular fibroblasts an

151 cal work suggests that the evolution of such exuberant offspring behavior reflects parent-offspring c

152 at human diseases characterized by an overly exuberant or chronic immune response to LPS.

153 To avoid damaging exuberant or chronic inflammation, the inflammatory proc

154 Regressive events that refine exuberant or inaccurate connections are critical in neur

155 Indeed, bone particles cause exuberant osteoclastogenesis in the presence of RANKL, a

156 L signaling as K270A substitution results in exuberant osteoclastogenesis in vitro and murine inflamm

157 posure to high-dose cytokine ex vivo induces exuberant osteoclastogenesis irrespective of in vivo TNF

158 w bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossificati

159 that, during early postnatal life, there is exuberant outgrowth of local CA3 recurrent axons, and wi

160 Previous studies have shown that an exuberant outgrowth of local recurrent excitatory axons

161 lular migration, amacrine cells exhibited an exuberant outgrowth of neurites that was undirected.

162 es reminiscent of a mature retina, including exuberant outgrowth of outer segment-like structures and

163 during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in l

164 Immunofluorescence revealed exuberant overgrowth of auditory afferent neurites in th

165 oping more severe acute pancreatitis with an exuberant pancreatic inflammatory response.

166 iol by 95% and induced the development of an exuberant papillomatous enlargement of the gingiva by ge

167 ding domain protein-2-deficient mice exhibit exuberant patterns of cytokine expression despite approp

168 Most clearly, exuberant placodal fibers grew in 10-day OPE cocultures,

169 emia and high-grade inflammation also induce exuberant plasmablast responses.

170 S), and overexpression of Kv2.1 induces more exuberant PM:ER MCS in neurons and in certain heterologo

171 this regulation of Dscam translation lead to exuberant presynaptic arbor growth in Drosophila somatos

172 At rest, however, these exuberant process movements do not result in overt cellu

173 influenza A viruses is characterized by the exuberant production of cytokines and chemokines and the

174 Deaths were due to exuberant proinflammatory responses, not increased bacte

175 Initially diffuse and exuberant projections in the VPM at P1 coalesce into row

176 misperception that their collaterals extend exuberant projections into pain-specific regions of the

177 der the control of the NT-3 promoter develop exuberant projections of vestibular sensory neurons to t

178 crossing of axon projections, elimination of exuberant projections, and myelination of established tr

179 ice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required

180 specificity by the elimination of initially exuberant projections.

181 The exuberant proliferation of cortical precursors during fe

182 These deranged processes culminate in an exuberant proliferative response that occludes the pulmo

183 tration, loss of capillary barrier function, exuberant pulmonary inflammation, and extensive microthr

184 sponses: pathologies that are elicited by an exuberant reaction to antigens that do not pose any inhe

185 siological range (10-50 Hz), in spite of the exuberant recurrent excitation.

186 ator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while p

187 logy owing to self-reactivity or potentially exuberant responses to pathogens, but it may also limit

188 in the fresh JRA tissues correlated with the exuberant revascularization of JRA minced tissue fragmen

189 fibroblasts whose contractile properties and exuberant secretion of collagens promote tissue stiffnes

190 ng a secretory phenotype characterized by an exuberant secretion of inflammatory mediators and cytoki

191 By 8 weeks after SmT challenge, exuberant splenic granulomata developed in p47(phox-/-)

192 d induction of ATF4 and BiP, and (c) exhibit exuberant splice activation of XBP1 and robust cleavage

193 An exuberant spray of fine telodendria extends from each co

194 These connections undergo rapid and exuberant sprouting and pruning in response to removal o

195 tissues, fibrillin-2 antibodies demonstrated exuberant staining in only one location: peripheral nerv

196 pletion, while protecting the host from over-exuberant stem-cell proliferation.

197 on is a noncell autonomous defect, caused by exuberant stimulation of osteoclastogenesis by Cx43-defi

198 However, gut inflammation induced exuberant STING activation, which resulted in the cell d

199 eptor previously implicated in hunger-driven exuberant sugar intake.

200 This exuberant synaptic connectivity was lost over time in th

201 development is characterized by a period of exuberant synaptic growth that is well studied.

202 which, in turn, was explainable by an overly exuberant systemic hypotensive response.

203 This is associated with an exuberant systemic IFN-gamma response.

204 ugmented disease are thought to be caused by exuberant T cell activation, attention has focused on th

205 perates primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens.

206 wever, there has been emerging evidence that exuberant T(RM) -cell responses contribute to the develo

207 (IFN-alpha2b), All biopsy samples showed an exuberant T-cell infiltrate with scattered atypical larg

208 egate into patches, and instead they develop exuberant terminal arbors spanning most of the PrV.

209 could be important to control the otherwise exuberant Th17 response.

210 he onset of hearing or whether refinement of exuberant thalamocortical connections occurs following h

211 roblast-specific Egr-1 overexpression showed exuberant tissue repair, with enhanced collagen accumula

212 ve-regulatory mechanism that prevents overly exuberant TLR2- and TLR4-driven inflammatory responses.

213 this hypothesis, arthritic disease driven by exuberant TNF-alpha expression was not impeded by fibrin

214 Our data suggest that exuberant TNF-induced osteoclastogensis is the result of

215 d by CD103 expression, programmed to prevent exuberant type 2 inflammation and keep homeostasis in th

216 ed by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithel

217 capacity in proliferative endothelium causes exuberant vascular permeability, a cardinal feature of m

218 High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and signifi

219 BRD4 inhibition may be a strategy to reduce exuberant virus-induced mucosal airway inflammation.IMPO

220 tension and atherosclerosis characterized by exuberant VSM cell proliferation and vascular inflammati

221 , we show that increased activity results in exuberant VSN axonal projections and a delay in axonal c

222 e that olfactory sensory axons develop in an exuberant way, both in terms of branch growth and synapt

223 arge-scale overproduction and elimination of exuberant widespread axonal branches outside the target

224 oth tighter adhesion to wound matrix and the exuberant wound contraction observed in pathogenic scars

225 ficant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with