ライフサイエンスコーパス: eye opening

1 x was unaffected by dark rearing from before eye opening.

2 -OFF RGCs, a process that also occurs before eye opening.

3 ye accelerates RGC laminar refinement before eye opening.

4 nd continues to change dramatically prior to eye opening.

5 gressive events initiated around the time of eye opening.

6 center to specific stratum of the IPL after eye opening.

7 e retinal ganglion cells from birth to after eye opening.

8 terned sensory activity over 4 days spanning eye opening.

9 shrews reared in the dark from before normal eye opening.

10 nt synapses known to appear in the sSC after eye opening.

11 e, direction selectivity was not detected at eye opening.

12 ansmission to layer 4 as well as the ear and eye opening.

13 visual cortex would differ before and after eye opening.

14 ring the course of wave development prior to eye opening.

15 d during a protracted postnatal period after eye opening.

16 eas exhibited strong responses shortly after eye opening.

17 es in central visual neurons that is tied to eye opening.

18 eady state in approximately 20 seconds after eye opening.

19 are eliminated over a 3-week period spanning eye opening.

20 ivity in the developing visual cortex before eye opening.

21 esent in cholinergic amacrine cells prior to eye opening.

22 sity, is transiently higher than just before eye opening.

23 uperficial collicular layers beginning after eye opening.

24 ncies of the spontaneous events increased at eye opening.

25 of the rod synaptic terminals just prior to eye opening.

26 cribrosa by P34, coincident with the time of eye opening.

27 s bursting disappears shortly after birth or eye opening.

28 arkedly increased levels were observed after eye opening.

29 d neurites on ipRGCs that sense light before eye opening.

30 ortex during the second postnatal week until eye opening.

31 ynchronous and slow-synchronous activity, by eye opening.

32 y patterns present before and at the time of eye opening.

33 onment to rod precursors via ipRGCs prior to eye opening.

34 ered synapses can already be observed before eye opening.

35 rcuitry and guides binocular plasticity from eye opening.

36 etinal space of CLC-2-KO mice at the time of eye opening.

37 neuronal cell types are established prior to eye opening.

38 eriod of retinogeniculate development before eye opening.

39 y 8, reaching the adult shape at P13, around eye opening.

40 liest age sampled (P12), several days before eye opening.

41 Directional tuning stabilized shortly after eye opening.

42 able to control HD responses within 24 hr of eye opening.

43 le the retina with time, and disappear after eye opening.

44 , which occurs rapidly over a few days after eye opening.

45 between visually nonresponsive neurons after eye opening.

46 2/3 cells remained as weakly tuned as before eye opening.

47 e throughout the entire visual system before eye opening.

48 ak direction selectivity just before natural eye opening.

49 more pronounced when daily testing began at eye opening.

50 corneal parameters unreliable directly after eye opening.

51 omotor responses in B6 mice at any age after eye opening.

52 or blue (585-660 nm) light beginning before eye-opening.

53 aked at P10-12, corresponding to the time of eye-opening.

54 ely-moving juvenile ferrets before and after eye-opening.

55 set of vision and by visual experience after eye-opening.

56 of Tyro3 led to RPE inflammation even before eye-opening.

57 synapse-associated protein enrichment after eye-opening.

58 o acquire sensitivity to visual inputs after eye-opening.

59 t the same age as wild-type, two days before eye-opening.

60 nt a substantial spatial rearrangement after eye-opening.

61 tely from birth and reached stable levels by eye-opening.

62 ater than those of the WT mouse, even before eye-opening.

63 At 6 hr after eye opening (AEO), a transient population of currents me

64 Here, they are a consequence of eye opening and are associated with a new wave of synapt

65 ns of molecular diversification occur before eye opening and are therefore experience independent.

66 Y were delayed relative to Sprague-Dawley in eye opening and beam walking.

67 atal day 16 (P16) in the rat pup, just after eye opening and coinciding with the first spontaneous ex

68 s of two forms of blindness initiated before eye opening and continuing through recording: (1) bilate

69 Eye opening and increased motor activity after the secon

70 tion to synaptic currents that occurs before eye opening and is closely associated with changes in NR

71 ing wakefulness finally emerges 1-2 d before eye opening and is statistically indistinguishable from

72 eratan sulfates in cornea is concurrent with eye opening and may contribute to corneal transparency.

73 ncreases rapidly in the first few days after eye opening and more slowly thereafter, reaching adult l

74 ate dynamic changes in gene expression after eye opening and provide new probes for exploring corneal

75 We found that between eye opening and puberty, release changes from an immatur

76 Pase isoform expression was completed before eye opening and the onset of electroretinographic respon

77 ally occurs in defined steps: it begins with eye opening and unresponsiveness in a vegetative state,

78 iRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing.

79 the mouse cornea in vivo within 1-2 days of eye opening and were elevated in a lens cell line expose

80 d cone pathway function rapidly reduced from eye-opening and by P21 became undetectable.

81 We find that in animals 7 to 14 d prior to eye-opening and ear canal opening, spontaneous activity

82 f axon guidance-associated proteins prior to eye-opening and synapse-associated protein enrichment af

83 Coma Scale (GCS) eye response score of 1 (no eye opening) and a GCS motor response score of at least

84 ective neurons are unspecific at the time of eye opening, and become to some degree functionally spec

85 s in deep cortical layers (5 and 6) prior to eye opening, and in both deep and superficial layers (2

86 sion in the visual cortex is coincident with eye opening, and it increases until the peak of the crit

87 te neurons at the base of layer 4 (4c) after eye opening, and levels decrease near the end of the cri

88 ioral maturation in SHR, body weight, age at eye opening, and performance in several behavioral tasks

89 t of the critical period, about a week after eye opening, and that plasticity of visual responses is

90 ndritic arbors is already established before eye opening, and that these arbors primarily grow throug

91 at ON [2] and ON-OFF DSGCs are well tuned at eye-opening, and even a few days prior to eye-opening, i

92 t, ectopic contacts appear in the days after eye opening, appearing progressively farther into the ON

93 ay of novel phenotypes, which present around eye opening, are linked to glutamatergic neurotransmissi

94 (P) 9 and begin to break down shortly after eye opening, around P15.

95 cal activity and implicate the period before eye opening as a critical checkpoint.

96 rhythmically hyperactive around the time of eye opening as a result of increased spontaneous glutama

97 mpal neurons starting on the first day after eye opening as naive rats navigated linear environments

98 how they have no photoreceptor function from eye opening, as demonstrated by a lack of electroretinog

99 ion of retinal wave input ends just prior to eye-opening, as cortex begins to inhibit LGN.

100 ues from Europe and North America provide an eye-opening assessment of long-term neurocognitive, orga

101 Around the time of eye opening at 4 weeks postnatal, the retinotopic arrang

102 Delayed awakening (no eye opening at 72 hours after cessation of sedatives and

103 Around eye opening at P12, cholinergic neurons were mature-like

104 However, after eye opening at P14, Fam151b mutant eyes exhibit signs of

105 es persisting from embryonic day 16 (E16) to eye opening at postnatal day 14 (P14).

106 irection-selective responses are detected at eye opening, before which spontaneous correlated activit

107 eveloping visual cortex several weeks before eye opening; both transmitters have been implicated in p

108 ilar neurochemistry to control retina before eye opening but a subsequent decline.

109 both normal and e,nNOS knockout mice before eye opening but is significantly delayed in the double k

110 Visual experience begins at eye opening, but current models consider cortical circui

111 Grid cell responses develop gradually after eye opening, but little is known about the rules that go

112 time in young RGS7(-/-) mice is prolonged at eye opening, but the phenotype disappears at 2 months of

113 at distinct FF and FB circuits develop after eye opening by rearranging the distribution of excitator

114 lready exhibit highly selective responses at eye opening, can develop feature-specific connectivity i

115 Beyond the first hours after eye opening, corneal thickness measurements are unlikely

116 ws started monocular lens wear 24 days after eye opening (days of visual experience [VE]).

117 nd of the second postnatal week, just before eye opening, dendrites are almost entirely covered by do

118 At eye-opening, dorsal RGCs of all types were more responsi

119 PHR, head-direction cells are present before eye-opening, earliest detected in postnatal day (P)11 an

120 perience and as such does not exist prior to eye opening (EO).

121 ticocollicular terminals form 1-2 days after eye-opening (EO), accompanied by VC-dependent filopodia

122 ually-elicited LFP power was increased after eye-opening, especially in higher frequency bands (>30 H

123 increased and waves abnormally persist past eye opening, eye-specific projections to the LGN desegre

124 We found that in mice, following eye opening, fast-spiking, parvalbumin-positive GABAergi

125 st the rapid maturation of neurochemistry by eye opening followed by functional maturation by P30 in

126 ith the strongest ON responses shortly after eye-opening, followed by an increase in the strength of

127 Before eye opening, GABA(A)a3 gives way to GABA(A)a1 at individ

128 an open spatial environment, only days after eye opening, grid cells mature more slowly, over a 1-to-

129 ibitory responses did not emerge until after eye opening (>P14), when optic tract stimulation routine

130 Spontaneous retinal activity prior to eye opening guides the refinement of retinotopy and eye-

131 hat all of the starburst cells tested before eye opening had conspicuous tetrodotoxin-sensitive Na cu

132 hyper-excitability, visual responses before eye-opening had reduced spike rates and an absence of ea

133 Vision soon after eye opening improves the tuning properties of binocular

134 t stage, before birth in primates and before eye opening in altricial mammals, spontaneous activity g

135 participants were assessed immediately upon eye opening in hospital the morning of surgery.

136 vivo and identified a critical period before eye opening in mice when specific binocular features of

137 orsal pre-subiculum (PrSd), before and after eye opening in pre-weanling rats.

138 Outcome was defined by both early eye opening in the 1st week after arrest (either spontan

139 beginning at post-natal day 12 (P12) before eye opening in the absence of PROM1 with no apparent los

140 s of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this

141 layers of the primary visual cortex (V1) at eye opening in the awake mouse and identify the features

142 examined using Scheimpflug tomography after eye opening in the morning.

143 ures of mouse retinal waves from birth until eye opening in unprecedented detail using a large-scale,

144 monosynaptic excitatory synapses even before eye opening in young ferrets, suggesting that visual sig

145 In the few days prior to eye-opening in mice, the excitatory drive underlying wav

146 eased presynaptic protein abundance pre/post eye-opening in the SCN reflects a developmental increase

147 ray to demonstrate that DSGCs are present at eye opening, in mice that have been reared in darkness a

148 lasticity that commences in infant rats from eye opening, in which daily threshold testing of optokin

149 at eye-opening, and even a few days prior to eye-opening, in rabbits [3], rats [4], and mice [5-8], s

150 Six hours after eye opening, increased dendritic PSD-95 coimmunoprecipit

151 input to CRH(+) ACs is weak or absent before eye opening, indicating a primary role for this input in

152 ment arm and 622 um in the placebo arm after eye opening, indicating an early morning edema compared

153 Experiments discriminated between eye opening-induced and age-dependent changes in synapti

154 ) in mouse V1 are not visually responsive at eye opening, instead developing visual sensitivity durin

155 Their development after eye opening is greatly impeded by visual deprivation.

156 he development of cholinergic neurons before eye opening is independent of the lighting conditions.

157 n, we find that several days of vision after eye opening is necessary for triggering experience-depen

158 neurons for oriented stimuli at the time of eye opening is poor and increases dramatically after the

159 we show that normal visual experience after eye opening is required for V1 neurons to develop a sens

160 Both were eliminated by eye opening, leaving only the mature, short-latency resp

161 y of visual cortical neurons during the post-eye-opening life of an animal.

162 After eye opening, local connectivity reorganized extensively:

163 constant for approximately 10 seconds after eye opening (mean PO2 = 3.9 +/- 0.7) before increasing t

164 Prior to eye opening, modular patterns of spontaneous activity fo

165 Four days after eye opening, monocular neurons respond to a full range o

166 At eye opening, neurons in primary visual cortex (V1) are s

167 ready highly selective for visual stimuli at eye opening, neurons responding to similar visual featur

168 At eye opening, Nphp5(-/-) mice exhibited absence of scotop

169 Before eye opening, NR2A is encountered infrequently at postsyn

170 In mice, natural eye opening occurs at the end of the second postnatal we

171 At eye opening, ON directional tuning is mature, whereas OF

172 examination as (1) comatose, (2) arousable (eye opening or attending toward a stimulus), and (3) awa

173 degrees C, neurologic examination showed no eye opening or response to pain, spontaneous myoclonic m

174 was increased, by either a natural stimulus (eye opening) or pharmacological treatment.

175 in membrane excitability occurred just after eye opening (P10), such that all of the starburst cells

176 ojections did not fully innervate dLGN until eye opening (P12), well after the time when retinal inpu

177 apse formation, beginning around the time of eye-opening (P12-P14) and extending through the first po

178 postnatal stages (P3-P7) but increases after eye opening (P14).

179 ps of rats, or daily in groups that began at eye-opening (P15) or 10 days later (P25).

180 Border cells have been recorded around eye-opening (P16), while grid cells do not obtain adult-

181 utput operates within its normal range after eye opening, perhaps to regain proper visual processing

182 es revealed that RF development following an eye-opening period is marked by an increased proportion

183 citatory and inhibitory inputs during a post-eye-opening period when OS of their spiking responses be

184 Before natural eye opening (postnatal day 14), the excitatory synaptic

185 s in mice, we found that several days before eye-opening, retinal and callosal activities drive massi

186 leus (LGN) of awake behaving ferrets, before eye opening, revealed patterns of spontaneous activity t

187 During week 1 after eye opening, running increases responsiveness in layers

188 ly stimulated LTP, in the juvenile sSC after eye opening, selectively involves the addition or stabil

189 predictor of poor outcome as measured by no eye opening (specificity, 100% [95% confidence interval

190 Following eye-opening, spontaneous activity and visual experience

191 But, around eye-opening, spontaneous and visually evoked activity in

192 late emergence of many cell types during the eye-opening stage and the onset of critical period, sugg

193 re is major synchronous reorganization after eye opening, suggesting a crucial role for visual experi

194 However, here we show that at eye-opening the preferred directions of both ON and ON-O

195 Here we show in ferrets that at eye opening, the cortical response to visual stimulation

196 Upon eye opening, the firing direction of these cells is anch

197 Following eye opening, the HD system matures rapidly, as more cell

198 In rodents, eye opening, the onset of pattern vision, triggers a rap

199 Before eye opening, the pattern of amino acid immunoreactivity

200 After eye opening, the space between the two cholinergic bands

201 After eye opening, the spatiotemporal structure of neural acti

202 We also find that 1 to 2 weeks after eye opening, there is a surge (>4-fold) in the frequency

203 of cortical feedback to V1 is present before eye opening, there is major synchronous reorganization a

204 es from the onset of responsiveness prior to eye-opening, through age equivalents of human juveniles.

205 of direction selectivity around the time of eye opening to identify the locations within the cortica

206 ake, freely viewing ferrets from the time of eye opening to maturity.

207 either eye in awake mice of either sex from eye opening to the closure of the critical period.

208 ticity, mice underwent MD during the pre-CP [eye-opening to postnatal day (p)17] or CP (p22-p25), and

209 MD of ipsilateral inputs from before eye opening (to reduce competitive interactions) did not

210 extended period of development, starting at eye opening, to measure receptive field properties and b

211 o improve binocular tuning and matching from eye opening until critical period closure.

212 l ERG responses improved simultaneously from eye-opening until adult levels were achieved at approxim

213 inocular deprivation from before the time of eye-opening up-regulated spine motility during the peak

214 n postmitotic mouse cones, between birth and eye opening, using serial block-face electron microscopy

215 vity emerges in the days and weeks following eye opening via a process that requires visual experienc

216 At the time of eye opening, visual cortical neurons in the ferret exhib

217 At eye opening, visual stimulation evokes robust patterns o

218 Third, between P11 and P14 (eye opening) we observed propagating activity that was a

219 ogenetics in juvenile ferret cortex prior to eye opening, we directly test several critical predictio

220 At eye opening, we find an adult-like fraction of neurons r

221 mals that were dark-reared until the time of eye opening, we found that individual neurons exhibited

222 alyzing their transcriptomic profiles before eye-opening, we identified the Type I membrane protein s

223 d abnormal ocular phenotypes such as delayed eye opening, weeping eyes, crusty eyelids, eyelid edema,

224 The changes occurring following eye opening were retarded by visual deprivation.

225 l a distinct period in development, prior to eye opening, when high levels of SNAP-25-IR are selectiv

226 After eye opening, when inhibitory responses are fully develop

227 ntation, direction, and spatial frequency at eye opening, which are similar across cortical layers.

228 This effect peaks after eye opening, which indicates a function for serotonergic

229 pressed at low levels in the cornea prior to eye opening, while markedly increased levels were observ

230 lk of synaptic refinement around the time of eye opening, while sensory experience is important for t

231 alleviate") and 3 ES signs ("abrupt onset," "eye-opening/widening," and postictal "confusion/sleep")

232 ression increases dramatically just prior to eye opening with a time course closely correlated with t

233 Combined gp120+Tat effects were noted for eye opening with potential interactive effects of gp120

234 lly thought to be fully established prior to eye-opening, with subsequent experience-dependent refine