ライフサイエンスコーパス: fM

1 sDNA-T concentration over the range from 1.0 fM to 1.0nM, with a detection limit of 0.47 fM, can be o

2 eprotonated prior to Zn(II) binding, the 1.0 fM Zn(II)-GGG Kd value reflects a Zn(II) complexation re

3 tration of the target miRNA ranging from 2.0 fM to 8.0 pM, and the detection limit was 0.6 fM.

4 0 fM to 2.0 pM with a detection limit of 2.0 fM.

5 ing (~435 fold) the detection limit from 3.0 fM (without NSs labeling) to 6.9 aM (with NSs labeling).

6 administered GO (dissociation constant: 36.0 fM) and that the method's detection limit reached 9.3 ag

7 ation of target DNA in a wide range from 5.0 fM to 1.0 pM.

8 iling can be performed label-freely from 5.0 fM to 2.0 pM with a detection limit of 2.0 fM.

9 ing NanoLuc as reporter, with an LOD <= 50.0 fM HgCl(2) 30 min postinduction.

10 Assay linear range was from 50.0 fM to 1.0 nM, with a limit of detection of 1.72 fM.

11 A wide linear range from 5.0 to 500.0 fM was achieved and the detection limit was calculated a

12 se concentrations ranged from 0.76 fM to 6.0 fM showed that cluster number has a linear relationship

13 ing its detection at a concentration of 0.01 fM, five orders of magnitude lower than that detectable

14 e with the detection limit estimated as 0.03 fM (S/N=3.0) and 0.08 fM (S/N=3.0) for 20-mer ssDNA and

15 OD of 1300 bacteria per 50 muL sample (0.042 fM).

16 an average limit of detection (LOD) of 0.07 fM, or 2100 DNA molecules per 50 muL sample.

17 OD of 1100 bacteria per 25 muL sample (0.074 fM), and (b) water from the Charles River, with an LOD o

18 imit estimated as 0.03 fM (S/N=3.0) and 0.08 fM (S/N=3.0) for 20-mer ssDNA and for dsDNA (PCR product

19 at subfemtomolar levels ( approximately 0.08 fM).

20 n a sample of 100 muL (corresponding to ~0.1 fM analyte concentration) in less than 5 min.

21 ient of 0.999, a detection limit between 0.1 fM and 0.5 fM, and a linear dynamic range of over 500-fo

22 (ssDNA) concentrations in the range from 0.1 fM to 0.1 nM with a low detection limit of 62.41 aM, and

23 ch, the detection limit of miRNA-122 was 0.1 fM via direct readout, with a wide detection range from

24 +) (Site I K(a)=1.3 fM(-1), Site II K(a)=1.1 fM(-1)), in conjunction with reversible direct Cu(+) tra

25 cid complexes were determined to be 15 +/- 1 fM and 33 +/- 8 fM, respectively.

26 hese values for k(1) and k(-1), was 15 +/- 1 fM.

27 otein, reaching a detection limit of 4 +/- 1 fM in buffer and 10 +/- 2 fM in 10-fold diluted nasophar

28 n of the enzyme inhibitor, which is around 1 fM.

29 The Scano-miR system was able to detect 1 fM concentrations of miRNA in serum with single nucleoti

30 ors were able to detect glycoproteins from 1 fM (Con A), 10 fM (Ricinus communis agglutinin (RCA), or

31 reases upon hybridization (signal on) from 1 fM to 1 nM of target miRNA.

32 monstrates a very wide dynamic range (from 1 fM to 1 nM).

33 /- 2.1% for target DNA concentrations from 1 fM to 10 fM, while a capacitance increase was observed w

34 20s and exhibits a large linear range from 1 fM to 10 pM, with a limit of detection (LOD) of 152.93 a

35 n of 0.37 fM and a wide dynamic range from 1 fM to 100 nM along with clear distinction from mismatche

36 The limit of detection (LOD) is 1 fM, which is achieved with an analyte binding time of 1

37 5 +/- 0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330 +/- 70 a

38 to detect ssDNA down to a concentration of 1 fM in a volume of 25 muL (25 zeptomoles).

39 ransducing system allowed the detection of 1 fM of DNA target in a 50-uL drop corresponding to 3 x 10

40 complementary strands at concentrations of 1 fM, 1 pM, and 1 microM, both separately and sequentially

41 sor displayed wide linear detection range (1 fM to 1 muM) with a detection limit of 4.8 fM in standar

42 tude and provided detection limits down to 1 fM (28.5 fg/mL).

43 ted within the dynamic range from 10 aM to 1 fM and detect as low as 2 aM of miR-122 ( approximately

44 235, 419, and 1613 nucleotides at 1 pM to 1 fM and found that the LOD decreased as DNA length increa

45 early discriminated and detection limit to 1 fM range is observed.

46 Detection sensitivity of up to 1 fM was demonstrated for the Raman labels chosen to clear

47 Sensor hybridization responses to 1 fM, 1 pM, and 1 microM complementary strand were nearly

48 ion sensitivity in sandwich assays down to 1 fM--a three-order-of-magnitude improvement over most rep

49 itivity allowed us to detect unprecedented 1 fM Hg ions in 20 min in field samples treated by simple

50 Detection of SNPs down to 0.10 fM is realized by measuring the conductance of the nanog

51 o detect glycoproteins from 1 fM (Con A), 10 fM (Ricinus communis agglutinin (RCA), or 100 fM (SNA) w

52 tection limit is investigated to be 1 and 10 fM for miR-204 and miR-210, respectively.

53 lowest limit of detection (LOD) as low as 10 fM.

54 Target DNA fragments at 10 fM concentration (approximately 6 x 10(5) molecules) wer

55 for this novel assay was determined to be 10 fM.

56 ine and a detection limit was found to be 10 fM/L (S/N=3).

57 gher-specificity and attained femtomolar (10 fM) sensitivity.

58 as enhanced the sensitivity to 100 folds (10 fM).

59 mic range spanning 6 orders of magnitude (10 fM-1 nM) with a limit of detection of less than 10 attom

60 n performed in the concentration range of 10 fM - 1 uM, whereas the detection of the other targets ha

61 bodies, we establish a detection limit of 10 fM for the protein IL-2, 150 times more sensitive than t

62 A detection limit of 10 fM in a 50-microL sample volume was achieved within 30 m

63 osited gold layer, the detection limit of 10 fM R6G solution concentration with uniform SERS effect a

64 nteractions were quantified in a range of 10 fM to 100nM.

65 voltammetry enabled a detection limit of 10 fM to be reached with good reproducibility.

66 tect unmodified DNA at a concentration of 10 fM.

67 y showed excellent detection sensitivity (10 fM) and specificity and was demonstrated for quantitativ

68 ssociation constant: biotin/streptavidin (10 fM) and HER2/HER2 antibody (0.44 +/- 0.07nM), respective

69 With this assay, detection limits down to 10 fM and 1 pM were achieved for proteins and target DNA, r

70 t insulin with limit of detection down to 10 fM in both buffer solution and diluted human serum witho

71 f 277aM with a linear range from 315aM to 10 fM starting DNA concentration and a sensitivity of 122 n

72 for concentration quantification down to 10 fM using SM detection events.

73 or target DNA concentrations from 1 fM to 10 fM, while a capacitance increase was observed when H5 ta

74 ction, lowers the detection limit down to 10 fM.

75 3 nucleotide oligomers detectable down to 10 fM.

76 mixture of analytes ranging from 1 nM to 10 fM.

77 orders of magnitude, from approximately 100 fM to 100 nM.

78 BP (FRB.rapamycin+FKBP, Kd approximately 100 fM; FKBP.rapamycin+FRB, Kd = 12 nM).

79 cted at initial concentrations as low as 100 fM by using a combination of field-amplified injection a

80 NA sequences at concentrations as low as 100 fM in 500 muL.

81 It permits detection of as low as 100 fM trigger oligonucleotide in under 10 min total assay t

82 ere detected at concentrations as low as 100 fM, corresponding to <1 muL of perfluorocarbon per liter

83 dic peptides at concentrations as low as 100 fM.

84 e to enable human CDK2 to be detected at 100 fM or 5 pg/mL, well within the clinically relevant range

85 evels of circulating TF, whole blood (+/-100 fM added TF) was tested under static and flow conditions

86 stimulated with a high (100 muM) or low (100 fM) dose of cognate antigen.

87 limits were demonstrated down to nearly 100 fM, which may be low enough to identify certain genetic

88 itive response in broad dynamic range of 100 fM -10 nM with limits of detection of 16.7 pM and 48.6 p

89 We demonstrated detection of trace of 100 fM Alexa Fluor 488 (signal-to-noise ratio of 11) with a

90 10 successive, 1-microL applications of 100 fM IgE.

91 After 5 minutes, the addition of 100 fM TF to whole blood had negligible effect under static

92 eotides (nt) and a limit of detection of 100 fM with a dynamic range of 5 decades.

93 al system, with a low detection limit of 100 fM, which is approximately 5 orders of magnitude lower t

94 ulting in an improved detection limit of 100 fM.

95 M (Ricinus communis agglutinin (RCA), or 100 fM (SNA) with a linear range spanning 6 (SNA), 7 (RCA),

96 ntration of model target miRNA-21 in the 100 fM to 25.0 pM range.

97 10,000 ssDNA molecules corresponding to 100 fM thrombin in solution) by a subsequent surface RNA tra

98 of eight transistors--is achieved with a 100-fM sensitivity, on par with optical DNA microarrays and

99 or amperometry); IgG was detected down to 12 fM (CL) and 120 fM (amperometry), while glucose down to

100 IgG was detected down to 12 fM (CL) and 120 fM (amperometry), while glucose down to 17 muM (CL) and

101 probes; the insulin detection limit was 128 fM with a dynamic range of over 4 orders of magnitude in

102 idly and reliably detected up to 1 pg/mL (13 fM) concentration on PNA electrode but, as expected, yie

103 ter Hg(0) concentrations ( approximately 130 fM) observed in the Pacific intertropical convergence zo

104 imated at 100%, the limit of detection is 15 fM.

105 out additional operation steps, an LOD of 15 fM target DNA is achieved with a total assay time of ca.

106 unambiguously detectable up to 10 pg/mL (150 fM) on PNA and SNA electrodes, respectively.

107 Sea and found low concentrations (39 +/- 16 fM) above the halocline and high concentrations in anoxi

108 35.4 nl assay volume) for target DNA and 16 fM (338 molecules) for target RNA after 1h on-chip hybri

109 oassays but, with the detection limit of 180 fM, it is to-date the most sensitive NAzyme-mediated, be

110 We observe a limit of detection of 19 fM for a proof-of-concept synthetic DNA analyte in a 12-

111 with LOD values of 650 fM (160 amol) and 190 fM (50 amol) for the event-specific and the taxon-specif

112 t the biosensor could detect PSA down to 1.2 fM and at the same time to glycoprofile such low PSA con

113 ear dynamic range of concentrations from 1.2 fM to 1.8 pM).

114 to attain ultra-low sensitivities (LOD = 1.2 fM; linear dynamic range of concentrations from 1.2 fM t

115 n limit of 4 +/- 1 fM in buffer and 10 +/- 2 fM in 10-fold diluted nasopharyngeal swabs, which is com

116 he device is able to selectively detect 36.2 fM of EGFR in the total protein solution of 0.1 ng/ml ex

117 ection of DNA, with a detection limit of 5.2 fM (a linear range of from 0.1 pM to 10 nM), as well as

118 t the amperometric detection of glucose at 2 fM concentration in a physiological buffer solution at 1

119 the mixture nor the individual congeners (2 fM to 2 muM) exhibited agonistic or antagonistic activit

120 A detection limit of 2 fM was achieved with a total assay time of ca. 70 min.

121 coma cells are also sensitive to fM-GAi; (2) fM-GAi drugs only display inhibitory activity against HG

122 The detection limit is ca. 20 fM, corresponding to 6pgL(-1) diclofenac, which is compe

123 tokine interleukin-2 concentrations from <20 fM to >200 pM were demonstrated, surpassing the conventi

124 blood at a concentration as low as 16 to 20 fM results in pronounced acceleration of clot formation.

125 cids, with limits of detection as low as 200 fM, were achieved using a capillary format with a total

126 wed a lower limit of detection (LLOD) of 200 fM and 460 fM respectively.

127 etection of 63 fM and a dynamic range of 200 fM-8 pM was observed for the assay.

128 0.40 fM and a dynamic range from 1.0 to 200 fM.

129 d the detection limit was calculated as 0.21 fM.

130 30-300 pM, and the limit of detection was 22 fM.

131 st detection limit (DL) of 0.5 pg mL(-1) (25 fM) for IL-6 in 10 microL of calf serum.

132 ith a detection limit of 2.5 microg/mL (1.25 fM) by adopting well-designed DNA probes.

133 concentration detection limits of 270 +/- 25 fM and mass detection limits of 150 +/- 15 zmol for Chro

134 nsor provided a very low detection limit (25 fM, 0.25 attomol in 10muL sample) for miRNA-21 without a

135 he case of SPR-PI, the detection limit of 25 fM for nanoparticle-enhanced SPR-PI is approximately 20

136 eously detected at concentrations down to 25 fM using a three-sequence hybridization format that empl

137 Parathion concentrations as low as 4.26 fM are easily detected.

138 of clinically relevant concentrations (73.26 fM) of ctDNA from human plasma.

139 ation, with a limit of detection down to 260 fM (260 x 10(-15) M), two orders of magnitude higher tha

140 highest known engineered affinity (K(d)=270 fM) to its high affinity wild-type (K(d)=700 pM) through

141 e a limit of detection (LOD) of 10 fg/ml (28 fM) and are able to detect catalytic activity of thrombi

142 0.16 to 1.20 pM with a detection limit of 28 fM.

143 on binds AP with a calculated K(d) of </=290 fM.

144 t of ZIKV RNA detection of 1.11 fg/muL (~0.3 fM) and high selectivity that allows for reliable discri

145 l of ferrocene with a detection limit of 0.3 fM.

146 The lowest sensitivity corresponds to 1.3 fM in a 75 microL sample.

147 ty of these sites for Cu(+) (Site I K(a)=1.3 fM(-1), Site II K(a)=1.1 fM(-1)), in conjunction with re

148 values were calculated and found to be 26.3 fM and 62.04 m degrees , respectively, for the immobiliz

149 mely low limit of detection of 95 fg/mL (7.3 fM) for PCT.

150 ith a relatively low detection limit of 84.3 fM.

151 of prostate specific antigen in buffer and 3 fM in 10% serum.

152 st limit of detection (LOD) at 100 fg/mL (~3 fM) of f-PSA in PBS solutions.

153 NA detection with a low detection limit of 3 fM.

154 A limit of detection < 30 fM was obtained for HIV-1 synthetic target with just a s

155 its of detection [LODs] ranging from 1 to 30 fM) and high specificity (distinguishing miRNAs with a s

156 ation just above the CAC ranged from 5 to 30 fM.

157 N concentration within the range of 0.01-300 fM.

158 y and specificity to tau ( approximately 300 fM) and synuclein ( approximately 300 pM) fibrils.

159 and multiplexing capabilities, detecting 326-fM concentrations of SERS nanoparticles and unmixing 10

160 the limit of detection (LOD) was 5 pg/mL (33 fM), 1,000 times better than that of ELISA.

161 hibitor of AChE, TZ2PIQ-A6 with a K(d) of 33 fM, did not distinguish between the active and OP-inhibi

162 tight (bovine Kd = 0.69 fM; human Kd = 0.34 fM).

163 ic range of EV concentration ranging from 35 fM to 35 pM, which matches the typical range of EV conce

164 ay achieved a limit of detection (LOD) of 35 fM and signals were detectable with analyte concentratio

165 the limit of detection was approximately 350 fM at the 99% confidence level.

166 oncentrations in anoxic waters (1249 +/- 369 fM).

167 n of miRNA with a limit of detection of 0.37 fM and a wide dynamic range from 1 fM to 100 nM along wi

168 le detection yielded a detection limit of 39 fM (831 molecules in 35.4 nl assay volume) for target DN

169 ed 55 fM BoNT/A (1 LD50/ml) in 5 min and 0.4 fM (0.01 LD50/ml) in 5h.

170 could detect a minimum concentration of 0.4 fM DNA.

171 sequence, achieving a detection limit of 0.4 fM with a dynamic detection range of 3 orders of magnitu

172 my at concentrations as low as 14 fg/ml (0.4 fM).

173 , the limit of detection of RNA is about 0.4 fM, which is 10 000-fold more sensitive than conventiona

174 riation (CV) across a range from nearly 27.4 fM to 1.7 pM using the described collection method.

175 of less than 10 attomoles ( approximately 4 fM).

176 ss produced a detection limit as low as 0.40 fM and a dynamic range from 1.0 to 200 fM.

177 ncentration detection limits were 520 +/- 40 fM and mass detection limits were 310 +/- 30 zmol with p

178 ) to approximately 7 pg/mL (approximately 40 fM analyte antibody concentration), and also expands the

179 A ~400 fM streptavidin limit of detection is expected with a 0.

180 ed (not extrapolated) detection limit of 400 fM, which is among the best reported for single-step ele

181 es a limit of detection of 1.2 pg mL(-1) (42 fM) PSA in 25% blood serum, which is about ten times mor

182 ection limit of 1.30 x 10(12) nm/M and 79.43 fM respectively have been achieved.

183 ited triplet state concentrations of </=0.45 fM produced by UVA and visible light irradiation of natu

184 and EHI_182030 (10 pg/mL, corresponding 453 fM) with high specificity has been achieved, employing t

185 limit of detection (LLOD) of 200 fM and 460 fM respectively.

186 fM to 1.0nM, with a detection limit of 0.47 fM, can be obtained.

187 A sensitivity of 0.5 fM in 10% serum (0.1 LD50/ml serum) was attained when SN

188 providing minimum detection limits below 0.5 fM of targeted nucleic acids and requiring only 5 muL of

189 99, a detection limit between 0.1 fM and 0.5 fM, and a linear dynamic range of over 500-fold.

190 biosensor achieved a limit detection of 1.5 fM in 80 min with a linear detection range of approximat

191 s found to be linear within the range of 2.5 fM to 3.2 nM.

192 tion for this assay was determined to be 2.5 fM, and this is the first demonstration of a bar code-ty

193 Detection of concentrations as low as 5 fM proteins was obtained.

194 ngle molecules at concentrations as low as 5 fM, which is approximately a 10(3) reduction in the limi

195 The limit of quantification is ca. 5 fM.

196 amma9/Vdelta2 T-cells (EC(50) ranging from 5 fM to 73 nM), which translated into sub-nanomolar gammad

197 of MP-Ab(2) from the SPR sensor surface is 5 fM, compared to 3-8 nM for the free antibodies.

198 red on a mAb-coated chip, a sensitivity of 5 fM (0.1LD50/ml serum) was obtained.

199 with a detection limit that corresponds to 5 fM.

200 nder optimized experimental conditions, 0.50 fM target miRNA is successfully detected.

201 magnitude by direct molecule counting; a 50 fM dual-labeled model sample can be detected with 99.5%

202 pecific detection of as little as 5 amol (50 fM in 100 muL) of target DNA.

203 er than surrounding areas ( approximately 50 fM).

204 Proteins with concentrations as low as 50 fM were detectable with 30 min of preconcentration time.

205 M and a detected concentration as low as 50 fM.

206 and had a limit of detection (LOD) of ca. 50 fM (equivalent to single molecule detection).

207 n optimized to offer a detection limit of 50 fM (0.2 amol) DNA target.

208 At present, the sensitivity limit of 50 fM is determined by the encounter rate of the labeled an

209 nstants ranging from 700 nM for Mn(II) to 50 fM for Cu(II)).

210 e quantitation of two DNA targets down to 50 fM level.

211 antification down to a level of 0.5% and 500 fM duplex DNA.

212 e to femtomolar concentrations of miRNA (500 fM), has a three-log linear dynamic range and is capable

213 of human thrombin at a concentration of 500 fM; the appropriate thrombin aptamer for the sandwich as

214 ection of thrombin and factor Xa at only 500 fM concentration.

215 was toxin serotype-specific and detected 55 fM BoNT/A (1 LD50/ml) in 5 min and 0.4 fM (0.01 LD50/ml)

216 ow limit of detection (LOD) (< 5 pg/mL or 56 fM), a wide dynamic range (> 6 orders of magnitude), hig

217 the limit of detection (LOD) at 1 pg/ml (57 fM) and a linear relationship between increasing TNF-alp

218 ) to date for PCB-based DNA biosensors of 57 fM is reported.

219 M to 8.0 pM, and the detection limit was 0.6 fM.

220 The assay provides 22.6 fM sensitivity over a three log range, demonstrates mult

221 sensor demonstrates a detection limit of 6.6 fM and high selectivity when compared to other non-speci

222 f detection of 4 x 10(5) copy numbers or 6.6 fM.

223 .1 pM to 0.10 mM) with detection limit of 60 fM.

224 lculated detection limit for this dye was 60 fM.

225 ng 365 nm excitation was determined to be 63 fM, which is 3 times lower than with the DELFIA solution

226 A limit of detection of 63 fM and a dynamic range of 200 fM-8 pM was observed for t

227 pM for both targets, with LOD values of 650 fM (160 amol) and 190 fM (50 amol) for the event-specifi

228 its) and an ultralow detection limit of 0.67 fM (0.012 pg/mL).

229 and the detection limit reached (0.24-1.67) fM for four highly-toxic OPs, with good specificity.

230 ound to be extremely tight (bovine Kd = 0.69 fM; human Kd = 0.34 fM).

231 es, within 15 min, with a sensitivity of 1.7 fM and without the need for amplification, a significant

232 M, with a detection limit of as low as 11.7 fM.

233 level by simple spectroscopic analysis (40.7 fM and 2.45fM as measured by UV-vis and dynamic light sc

234 emely high distal heme-NO affinity (K(d) ~70 fM).

235 nd a lower limit of detection of 1 pg/mL (70 fM).

236 his approach, a detection sensitivity of 700 fM (20 pg/mL) was achieved.

237 to 1.0 nM, with a limit of detection of 1.72 fM.

238 nning 7 orders of magnitude and LOD of 13.75 fM.

239 Rhodamine 6G (R6G) down to approximately 75 fM level (10(-15) molL(-1)).

240 lecules at concentrations c ranging from 750 fM (p > 90%) down to 75 aM (10(-18) molL(-1)) levels (p

241 amples whose concentrations ranged from 0.76 fM to 6.0 fM showed that cluster number has a linear rel

242 put and detects concentrations as low as 767 fM.

243 sperm can register a minimal gradient of 0.8 fM/microm and be attracted from as far away as 4.7 mm.

244 ions of 3'-MAP excited triplet states of 1.8 fM and above resulted in significant human rotavirus ina

245 with a calculated limit of detection of 22.8 fM.

246 re determined to be 15 +/- 1 fM and 33 +/- 8 fM, respectively.

247 1 fM to 1 muM) with a detection limit of 4.8 fM in standard.

248 kground noise at concentrations down to 58.8 fM with an interassay reproducibility (%RSD of n = 3) <

249 f detection = 1 pg/mL, corresponding to 58.8 fM) and EHI_182030 (10 pg/mL, corresponding 453 fM) with

250 A very low detection limit of ca. 8 fM is achieved with this sensor.

251 sence of miRNA, down to a concentration of 8 fM.

252 lytical technique with detection limit of 80 fM at concentration range up to 0.1mM.

253 with a limit of detection (LOD) of 26 and 81 fM in buffer and human plasma, respectively, confirming

254 s of endoglin at concentrations as low as 83 fM with high detection specificity and has a three-order

255 on limit for mediated-impact voltammetry (83 fM).

256 10(-8) M and limit of detection down to 0.84 fM.

257 f n = 3) < 17.2%, and in buffer down to 5.88 fM with an interassay reproducibility (% RSD, n = 3) of

258 chemiresistive detection of DENVCP to be 1.9 fM.

259 thod enables detection of miRNAs as low as 9 fM and allows the discrimination of one base mismatched

260 res just 30 min, with a detection limit of 9 fM (0.17 amol).

261 ommercial products with a LOD (3sigma) of 90 fM.

262 ion limit for direct-impact voltammetry (900 fM), and is more than 30 times smaller than the previous

263 re successful in detecting as little as 2.94 fM of pathogen DNA, and using crude extractions of a pat

264 The limit of detection was 6.96 fM.

265 -cone signals of opposite polarity (-sM and +fM) cancel at low frequencies, but then constructively i

266 input signals of the same polarity (+sM and +fM) sum at low frequencies, but then destructively inter

267 spite their high avidity (K(d) approximately fM, lifetime approximately 4 days), immunity protein rel

268 inhibition of HGF/SF-induced uPA activity by fM-GAi is not uncommon, in that several human tumor glio

269 min activation at femtomolar concentrations (fM-GAi) in canine MDCK cells.

270 5 mug (time-independent) of dead carbon (DC, fM approximately 0).

271 imes basal uPA activity; and (3) not only do fM-GAi derivatives strongly inhibit uPA activity but the

272 Thus, we show that certain GA drugs (fM-GAi) in an HGF/SF-dependent manner block uPA-plasmin

273 its of 100 attomolar (aM) and 10 femtomolar (fM) in pure samples for two ELISA assays with low and hi

274 vity for uranyl with a Kd of 7.4 femtomolar (fM) and >10,000-fold selectivity over other metal ions.

275 This sensor allowed femtomolar (fM) detection of FAP, a detection limit well adapted and

276 nanofiber-based system realizes femtomolar (fM) sensitivity toward complementary target DNA, and dem

277 th the limit of detection in the femtomolar (fM) range for synthetic targets as well as viral RNAs.

278 NA targets in microwells down to femtomolar (fM) concentrations, without the need for any target ampl

279 lar calcium release channel (RyR) with high (fM) potency and provides a functional link between DDH a

280 o achieve detection of HIV-1 p24 antigens in fM range, suitable for early diagnosis.

281 romatic, and the fast, non-opponent inputs (+fM and +fL) as achromatic, both contribute to flicker ph

282 he analytic sensitivity extends into the low fM concentration range.

283 cy, inducing full channel openings at lower (fM) toxin concentrations whereas at higher pM concentrat

284 4 mug (time-dependent) of modern carbon (MC, fM approximately 1) and 4.1 +/- 5.5 mug (time-independen

285 d for the non-opponent luminance mechanism (+fM and +fL) may still generate spectrally opponent signa

286 at successfully detected BPA at femto molar (fM) levels, which is an improvement over prior work by a

287 ely 5 s) and ultrahigh sensitivity (1.38 muA/fM).

288 e biosensor showed a sensitivity of 0.62 muA/fM, with a response time of 14s.

289 These effects of fM-GAi drugs on the Met-activated signaling pathway occu

290 This aptasensor had a wide linear range of (fM ~ nM), and the detection limit reached (0.24-1.67) fM

291 annel has fast M- and L-cone input signals (+fM and +fL), and slow, spectrally opponent cone input si

292 eadout, with a wide detection range from sub fM to nM.

293 theory, the assay could be sensitive to sub-fM analyte because beads attached via single-immune comp

294 ve determination of targeted proteins at the fM concentration level.

295 in biomarkers, down to concentrations in the fM range, from unprocessed whole blood minuscule samples

296 or ultrasensitive protein detection into the fM and aM range.

297 ons, indicating that HSP90 is not likely the fM-GAi molecular target.

298 ed reactions allows for the detection of the fM concentration of analyte and can respond with the rel

299 ion by three orders of magnitude towards the fM regime.

300 n leiomyosarcoma cells are also sensitive to fM-GAi; (2) fM-GAi drugs only display inhibitory activit