ライフサイエンスコーパス: facile

1 fluoride from metabolic intermediates can be facile.

2 dition with N-methylmaleimide remains highly facile.

3 in live cells and animals, while permitting facile (18) F radionuclide incorporation required for PE

4 attention for ammonia synthesis due to their facile ability in activating N(2) under ambient pressure

5 ate these findings, we used our laboratory's Facile Accelerated Specific Therapeutic (FAST) platform

6 eaten exposure of the dental pulp, providing facile access for bacteria to cause severe infection bot

7 posed in the protein surface, which suggests facile access for IgE-binding to the structure of Pin p

8 pon treatment with isothiocyanates enables a facile access to a single regioisomer of N(1)-substitute

9 The method provides facile access to a wide range of previously unknown hete

10 ergent and step-economic approach provides a facile access to diverse indoloquinazoline structures in

11 Enabled by more facile access to molecular baskets of type 1 (syn), a ra

12 In addition, this method also provides facile access to N-methyliminodiacetyl (MIDA) acylborona

13 Facile access to various tetraarylethenes is provided.

14 The facile acid treatment is capable of weakening the bondin

15 bimetallic cooperativity that allows for the facile activation of strong C-F bonds across the gallium

16 e transition-metal complexes with respect to facile activation of such small molecules.

17 This process allows facile addition and segregation of chemical functionalit

18 l discovery pipeline presents a paradigm for facile and accelerated exploration of MMNCs for a broad

19 vely deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up sca

20 otoinitiators, and light sources that enable facile and cytocompatible photo-cross-linking.

21 This approach is remarkably facile and easily accessible compared to conventional va

22 This work provides a facile and effective method for preparing amorphous Pd n

23 ttering technique, suggesting that this is a facile and effective method of enhancing the performance

24 ne precipitation enrichment sequencing) as a facile and effective method to enrich A-to-I edited tran

25 Collectively, our findings identify a facile and effective route to directly synthesize 2D MWW

26 As a proof-of-concept strategy, this facile and effective strategy for biosensor fabrication

27 Here, we report a facile and efficient approach for a laser-induced 2D pat

28 Described herein is a facile and efficient approach for synthesizing well-defi

29 A facile and efficient method for the synthesis of 3-[(4-n

30 Herein, we report a facile and efficient redispersion process that enables u

31 A facile and efficient synthetic methodology for preparing

32 s and reaction solvents are investigated for facile and efficient transformation.

33 A facile and efficient two-step synthesis of p-substituted

34 A facile and general method for the controllable synthesis

35 hin common fluorophores, we have developed a facile and general strategy to obtain photoactivatable f

36 Protein-peptide epitope fusions represent a facile and generalizable strategy for enhancing the T-ce

37 ration of crotyl alcohol to 1,3-butadiene is facile and occurs over the mildly Bronsted acidic =Si-OH

38 Here, a facile and precise measurement method is reported for sc

39 It provides facile and rapid access to (11)C-labeled compounds with

40 Facile and reversible switching between glassy and cryst

41 The technique provides a facile and robust way of separating cells based on eleva

42 This facile and scalable growth method solves previously enco

43 he bulk hex-BSCF material synthesized by the facile and scalable sol-gel method achieves 10 mA cm(-2)

44 e BN heterocycle into a CPP scaffold enables facile and selective late-stage functionalizations that

45 lpha-amino C(sp3)-H bond of the substrate is facile and selective relative to activation of a beta-am

46 ogenation of thioesters with H(2) provides a facile and waste-free method to access alcohols and thio

47 The study demonstrates a novel, rapid, facile, and powerful approach for identification of magg

48 bles precise tumour treatment with flexible, facile, and spatiotemporal control.

49 ome organization and regulation and offers a facile approach for DNA technology to control the assemb

50 etry (MS) coupled to chromatography offers a facile approach for such analyses by using fluorine as a

51 In this research, we demonstrated a facile approach for the simultaneous preparation of a bi

52 We demonstrate a facile approach for the synthesis of gem-disubstituted c

53 Importantly, this work demonstrates a facile approach to employ two-dimensional aromatic compo

54 In this study, we demonstrate a facile approach to improve the energy efficiency by fill

55 Our results present a facile approach to tailor hybrid layered metal halide pe

56 ndings ultimately contribute a synthetically facile approach toward highly emissive TADF emitters usi

57 re, techniques that are relatively rapid and facile are needed.

58 This protocol describes the facile assembly of APC-ms in ~4 h and rapid expansion or

59 ls are more 'addiction like', as well as the facile assignment of behaviors to a given brain region a

60 ), indicating that confinement leads to more facile association of reactants at active sites to form

61 This process is facile at room temperature and allows for the generation

62 ional) provide new architectural elements of facile atroposelective construction and broad conformati

63 Unfortunately, facile benzylic oxidation resulted in a short plasma hal

64 es not reveal a shared set of properties for facile bioinformatic identification of new anti-CRISPR f

65 the cyclization reaction mechanism suggests facile C-N bond formation in the radical cation leading

66 This represents a facile catalyst screening method, using replaceable glas

67 With facile cell fabrication, simplified battery structures,

68 ent conversion efficiencies of over 20 % and facile cell production have placed hybrid perovskites at

69 aces make them colloidally stable and ensure facile cellular entry.

70 e feature that most strongly correlated with facile cellular repair was the ability of the A analogue

71 Facile changes to the sensor enable sensor response tuni

72 ize the field of proteomics, allowing a more facile characterization of novel gene products and subce

73 This limits reliable and facile characterization; for example, when using common

74 clinically relevant small molecules with its facile, cheap, and highly sensitive nature.

75 Overall, this work provides new facile chemical approaches for tuning the degradability

76 lying this chemistry to bacteriophage allows facile chemical modification of phage libraries, which g

77 Presented here is a facile chemical modification to attenuate solvent-depend

78 dvantages, such as small size, low cost, and facile chemical modification.

79 velop methanol-storable solar H(2) fuel with facile chemical rebonding actualized by 2D single-layer

80 The high potency, low toxicity, facile chemical synthesis, and great opportunities for c

81 Facile chemical treatments provide a significant degree

82 n have filtration properties altered through facile chemical treatments.

83 Here, we report a facile chemical vapor deposition (CVD) strategy to synth

84 Modification of approved drugs, facile cleavage of the benzazole auxiliary, and toleranc

85 how that the artificial interface provided a facile CO(2) diffusion pathway.

86 s envisioned that libraries of synthetically facile composites will be broadly deployed as photosensi

87 The facile construction and mapping of the regulatory networ

88 This approach enables the facile construction of otherwise difficult to prepare al

89 Facile construction of the acyl azolium in situ followed

90 The facile control of disulfide formation in M88 will enable

91 -precious-metal catalysis and allows for the facile conversion of amides to chiral alcohols via a one

92 f ferric heme superoxo oxidants mediates the facile conversion of an array of indole substrates into

93 at are piezoelectric, i.e., that allow for a facile conversion of electrical energy into mechanical a

94 Here, we develop a facile, cost-effective and one-step approach to create a

95 a simple sample preparation technique and a facile coupling strategy for dNAAT.

96 ss steric hindrance during C-C coupling, and facile dearomatization.

97 e in the environment, scalability, rapid and facile decoding, and biocontainment.

98 Herein, we describe the facile degradation of P(4) mediated by two divalent sili

99 Facile derivatizations of the azidoamine group demonstra

100 e in multiple mutational steps is relatively facile despite the complexity of the underlying landscap

101 For example, the facile device integration was used to attach the well-kn

102 We demonstrate a method for facile differentiation of acidic, isomeric metabolites b

103 diffusion species in the ALD process due to facile diffusion of reactant species in nonideal ALD.

104 This work provides tools for the facile discovery and development of high-accumulating co

105 Additionally, we demonstrate facile discrimination of several JWH-018 isomers via SER

106 DOSY NMR studies show the facile displacement of at least one of the counterions,

107 s are often decoupled, which can enable both facile dissociation of reactants and weak binding of int

108 Herein, a facile diversity-oriented approach to access functionali

109 Here, we designed a facile DNA/RNA nanoflower (NF) to perform the controlled

110 A facile efficient synthetic tool, Buchwald-Hartwig cross-

111 work establishes a structural basis for the facile electrochemical oxidation of Pd(II) to a M-M bond

112 e high-entropy carbide, (TiNbTaZrHf)C, via a facile electrochemical process.

113 In this paper, we developed a facile electrodeposition process for creating a redox-ac

114 sing more accessible active sites, providing facile electron conductivity, and facilitating the mass

115 ge coupling with the Cu(II) sites reflecting facile electron transfer (ET) pathways, which may be pro

116 tifying and optimizing antibodies, providing facile entry points for further applications.

117 A facile, environment-friendly, versatile and reproducible

118 ormation of [Mo(OtBu)(5)] to be particularly facile, even though the parent complex [MoCl(4)(THF)(2)]

119 This flexibility allows facile evolution of new activities, as shown by reinvent

120 uenza virus hemagglutinin (HA) is enabled by facile evolvability.

121 ese and other mechanistic data indicate that facile exchange between MPAAs and anionic ligands coordi

122 s, e.g., for easy tailoring of conditions or facile exchange of catalysts and reactions.

123 -van der Merwe regime growth, while allowing facile exfoliation due to the absence of interfacial for

124 t seen in random-sequence pools, providing a facile experimental approach to isolation of highly acti

125 In vitro cancer cell cultures are facile experimental models used widely for research and

126 In this study, we developed a facile extraction process employing water as the primary

127 Ultra-long metal nanowires and their facile fabrication have been long sought after as they p

128 The resultant superior printability enables facile fabrication of conducting polymers into high reso

129 The facile fabrication of the hybrid membranes shed light on

130 Renewable production of Mfp proteins and the facile fabrication process described provides a new aven

131 The underlying mechanism is the facile formation of Li-transition metal antisite defects

132 This route allowed for facile formation of the crucial depsi bond.

133 ey selectivity challenge, resulting from the facile formation of undesired fully-oxidized CO(2).

134 These bowed PDIs were synthesized through a facile fourfold Suzuki macrocyclization with aromatic li

135 sity is reported, which are synthesized by a facile free-radical polymerization using branched and am

136 onal electron-deficient alkynes allowing for facile functionalization of payload molecules.

137 timizes long-wavelength variants and enables facile functionalization with different chemical groups.

138 Here, we develop a facile, general, and high throughput solvent-free self-a

139 [1-LH](+), from which ligand dissociation is facile, generating [2-LH](+).

140 ed nitriles, namely cyanamides, leads to the facile generation of difficult-to-obtain 2,5-diaminooxaz

141 Here, we leverage the facile genetics of the metabolically versatile bacterium

142 ffers unique attributes for live imaging and facile genetics.

143 omic repeats (CRISPR) technologies allow for facile genomic modification in a site-specific manner.

144 Through a facile Gly to Pro substitution, we have altered backbone

145 We also report the development of a facile high-throughput screen to interrogate their activ

146 glutamic acid and lysine (EK) peptides as a facile, highly effective and low-immunogenicity approach

147 aging this sensing mechanism, we demonstrate facile, highly sensitive, fast-response detection of Gsp

148 A facile hydrothermal approach was employed to grow highly

149 and copper (II) chloride as precursors via a facile hydrothermal method.

150 Moreover, development of a facile in vitro method for Hsp70:CHIP-mediated ubiquitin

151 ogeneity among basal cells and establishes a facile in vitro organoid model of human distal lung infe

152 poration rates and high-error rates allowing facile insertion of Favipiravir into viral RNA, provokin

153 ic hydroxamic acid as a key step that allows facile installation of the embedded nitrogen-oxygen (N-O

154 s show that lipid sponge droplets permit the facile integration of membrane-rich environments and sel

155 Finally, facile integration of the bottom-up templated crystalliz

156 pen-source software ConfBuster, which allows facile integration with CPMG and ready parallelization f

157 ion of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidati

158 This method also allowed for facile introduction of an affinity tag or fluorescent pr

159 contributing to outstanding HER activity and facile kinetics.

160 e sequential adsorption of oxygen atoms with facile kinetics.

161 er models in livers and lungs of mice though facile knockout of multiple genes.

162 In this work, a facile, label-free, and ultrasensitive electrochemical D

163 We report a high-pressure approach to facile late-stage functionalization of unclosed cryptand

164 es of each oxide and contributes to the more facile Li(+) transport.

165 erpinski pyramids; assembly is driven by the facile lipophilic-lipophilic association of the alkyl mo

166 k of a biomaterial platform which allows the facile manipulation of spheroid cultures on a large scal

167 scopy and, furthermore, can be achieved in a facile manner utilizing a graded neutral density filter,

168 te important factors associated with ET in a facile manner, such as the type of the cofactor and its

169 Ru and Pt catalysts supported on carbon in a facile manner.

170 natural amino acid derivatives by exploiting facile Mannich-type reactions between readily available

171 light-emitting diodes (LEDs) owing to their facile manufacture and excellent optoelectronic performa

172 akes this approach a promising route for the facile manufacturing of high-performance electrodes at l

173 We report a mild and facile means to generate the parent 3,4-oxacyclic allene

174 e graphene protective skin is prepared via a facile mechanical method followed by Li stripping, which

175 This new, facile mechanism has not previously been considered.

176 nal diversity, efficient polymerization, and facile mechanoactivation.

177 Our studies support a facile method for affinity-ranking hits.

178 to bundles of SERS spectra yields a robust, facile method for concentration quantification down to 1

179 These analyses provide a facile method for distinguishing ctDNA from other cfDNA

180 Herein, we present a facile method implementing a deoxyribozyme, VMC10, which

181 e digitally and repeatedly reprogrammed by a facile method of direct laser writing.

182 Herein, we present a facile method of enhancing the cell penetrating and anti

183 In this work, we present a facile method termed high-salt molecular rheotaxis (HiSM

184 apability is uniquely achieved by a fast and facile method that was used to fabricate a smart actuato

185 These results raise the possibility for a facile method to carry out enantioselective separation.

186 Here, we report a facile method to disassemble vdW single crystals layer b

187 A facile method to oxidatively trimerize phenols using a c

188 tational approaches provides an improved and facile method to predict the severity of an amino acid s

189 We report a facile methodology for rapid epitope mapping of neutrali

190 a unique cysteine residue is among the most facile methods for site-specific labeling of proteins.

191 utilisation of renewable resource along with facile microwave treatment paves the way to sustainable,

192 ron-rich barbituric acid with melamine via a facile microwave-assisted heating, thereby eliminating t

193 Herein we report a facile, mild reaction protocol to form carbon-carbon bon

194 and exquisite selectivity, thereby enabling facile modification of NCys-bearing proteins in complex

195 f these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible

196 ructural versatility which permits scalable, facile modulations of structural and functional elements

197 iplexed insertions in three genomic loci and facile, multi-loci deletions by combining orthogonal int

198 ion reveals a tripeptide tag CIS that allows facile N, S-double labeling of a protein of interest wit

199 t were prebiotically abundant and capable of facile oligomerization and self-assembly.

200 ivity would be highly valuable for rapid and facile on site screening.

201 following oxidation to Ru(III), they undergo facile, on-surface dimerization to give surface-bound, o

202 n of a stable Fe(VI) complex (3) prepared by facile one-electron oxidation of an Fe(V) bis(imido) (2)

203 Herein, we demonstrate a facile one-pot synthetic strategy to incorporate multipl

204 trategy used for this novel synthesis is the facile one-step construction of a spiroketal trimer inte

205 a hierarchical bio-composite sensing film by facile one-step electro-deposition of 0D enzyme-polymer

206 imilarity between their environments and the facile overoxidation of the initially formed hydroxylati

207 By the facile oxidation of yttrium (A-site) and ruthenium (B-si

208 A facile oxidative dearomatization of N-(p-methoxyaryl)pro

209 gh HOMO energy of TANG-COF (-4.8 eV) enables facile p doping, resulting in electrical conductivity of

210 e with the activated P(4) complex results in facile P-atom transfer.

211 nent reaction provides a straightforward and facile pathway for the synthesis of alpha-((4-hydroxy/me

212 he SO(4) tetrahedra, which, in turn, provide facile pathways for proton locomotion.

213 ults indicate (64)Cu-Macrin could serve as a facile PET nanotracer to survey spatiotemporal macrophag

214 MQ-ADN complex ((Fe)MQ-ADN) mostly favors a facile PET.

215 A mild and facile Peterson olefination has been developed employing

216 We demonstrate that this facile platform facilitates complete separation of small

217 ens generated in situ may broadly serve as a facile platform to modulate the suppressive TME, and ena

218 th ester groups could be achieved, providing facile preparation of an indolizidine framework commonly

219 from a synthetic pathway that allows for the facile preparation of asymmetric redox-active Au(I) bis-

220 The facile preparation of three regioisomeric thienopyrrolo[

221 The high stability, facile preparation, and high performance of the TBPCExBo

222 We demonstrate facile probe loading, and subsequent interaction- and li

223 A facile process for fabricating 3D-architected metal oxid

224 If the facile process of radical racemization could be effectiv

225 The new and facile protocol presented here allows to synthesize GeH

226 ocatalysts have band structures that promote facile PT concerted with electron transfer (ET), known a

227 applicable to nucleic acids, enabling their facile, rapid and accurate detection and quantification

228 nutes of analyte addition, making sensor use facile, rapid, and instrument-free.

229 substrate directivity is demonstrated by the facile reactivity of the beta-gamma alkene of the starti

230 nly in red-shifted absorptions but also more facile reductions.

231 lated switchgrass and poplar samples allowed facile relative quantitative analysis of their polysacch

232 th the superior leaving group promoting more facile release from the tether.

233 he best methods for efficient capture impede facile release.

234 In this study, we report a facile, reusable, and highly sensitive label-free impeda

235 tics of PCs, such as exceptional plasticity, facile reversible switching of order-to-disorder states

236 bon materials has also been revealed to be a facile, reversible process at high redox potentials.

237 high strain of the AlCP ring of 3 allows for facile ring enlargement in reactions with CyNC, bis(diis

238 olypropylene polymers (Jeffamines) through a facile room-temperature synthesis with no byproducts.

239 H-Phosphaallenes are accessible on a new and facile route and show a fascinating chemical behavior.

240 logical activity, our methodology provides a facile route to reproducibly obtain samples containing m

241 In this work, we developed a facile route to synthesize cobalt single atoms/nitrogen-

242 The facile route to two of the simplest organosulfur molecul

243 Here, we report a facile route, based on electro-spraying/netting, to self

244 have been formed that exhibit floppiness and facile routes for transformation into more rigid structu

245 The COFs via the facile, scalable, and mild chemical exfoliation method a

246 Rapid and facile screening of this disease is in high demand.

247 We demonstrate the utility of this facile, selective post-processing method on DNA structur

248 Here, we report a facile sensitive, portable, user-friendly, cost-effectiv

249 ion, this signal-on nanobiosensor provides a facile, sensitive and reliable assay for clinical monito

250 urgent need for diagnostic methods that are facile, sensitive, rapid and inexpensive.

251 nd poor fragmentation characteristics hinder facile simultaneous quantification by liquid chromatogra

252 P(2))MnBr(4)), which can be prepared using a facile solution growth method at room temperature to for

253 Through a facile solvothermal procedure, a CdS/WO(x) nanocomposite

254 and provides a sufficient driving force for facile (stepwise) cycloaddition.

255 However, facile strategies for autonomously self-resettable DSD c

256 Here, we report a facile strategy for creating a DNA nanochamber (DNC), a

257 indings not only highlight an innovative and facile strategy for prion detection and strain different

258 A facile strategy is also presented for large-scale produc

259 Here a facile strategy is reported to control the hydration of

260 rt kinetics from the carbonate systems, this facile strategy provides cells with the additional benef

261 In this work, we present a facile strategy to construct polymeric molecular framewo

262 Herein, we present a facile strategy to engineer a polymersome nanoreactor wi

263 electronic environments, providing access to facile substitution chemistry at both electron-rich and

264 r nanozymes because of their easy synthesis, facile surface modifications, stability, and possessing

265 he-art stimuli-responsive systems capable of facile switching between catalytic pathways and provide

266 could provide functional advantages in Zur's facile switching between repression and derepression.

267 Notably, facile switching of the ion source to atmospheric-pressu

268 We report on facile synthesis and characterization of phosphate-funct

269 e vinyl chloride, and here we show that this facile synthesis method can produce effective catalysts

270 Here, we report the facile synthesis of a copolymer containing quinine and 2

271 The facile synthesis of a series of benzodithiophene (BDT)-

272 (2)H(2) + C(3)H(3) cascade could represent a facile synthesis of a substituted five-membered ring in

273 esent approach provides a new method for the facile synthesis of alpha,alpha-disubstituted ketones an

274 in bioactive molecules, but the scalable and facile synthesis of complex bioactive molecules carrying

275 Herein, we report a facile synthesis of cyclobutanones based on the C(sp(3)

276 However, the facile synthesis of effective DDSs remains a challenge.

277 sor for rapid detection of bacteria based on facile synthesis of silver wire across electrodes was co

278 ation is significantly hindered by a lack of facile synthetic methods.

279 A facile synthetic procedure to prepare pai-extended seven

280 3) solid-solution nanotubes synthesized by a facile synthetic route that contain 56 % less iridium th

281 itate exfoliation of the layers, providing a facile synthetic route to a new class of 2D chalcogenide

282 A facile synthetic strategy for casting ordered, nanoporou

283 locks and synthetic conditions, allowing for facile tailoring and optimisation of the structure and p

284 Here, we present a facile technique, which uses a thin film contact thermom

285 This facile three-component reaction delivered a mixture (17:

286 10) (Egyptian Blue, EB) via ball milling and facile tip sonication into NIR fluorescent nanosheets (E

287 It is more flexible and facile to adapt to the dwell time of ICP-qMS owing to th

288 Conveniently, rr-P3AT-based OHMs are facile to fabricate, flexible, and biocompatible, which

289 ke transgenic approaches, however, it is not facile to forensically detect gene-editing events at the

290 lvent-exposed conformation, AdoCbl undergoes facile transfer to MCM.

291 and well-stitched grain boundaries, enabling facile transfer to various target substrates without deg

292 A broad range of substrates tolerate this facile transformation, in which the bridgehead nitrones

293 es the three binding hot-spots and suggest a facile transition to an open state that can accommodate

294 ron energy-loss spectroscopy, we reveal that facile transport in Li(4+) (x) Ti(5)O(12) is enabled by

295 -organic frameworks (MOFs) together with the facile tunability of their properties makes these materi

296 y interface via electropolymerization allows facile tuning of the surface coverage and redox (capacit

297 ha,beta-unsaturated carbonyl scaffold allows facile variation of the functional groups, enabling labe

298 Our platform also allows facile visualization of drug effects in vivo at single-c

299 f photoelectrode as an air electrode opens a facile way for developing integrated single-unit zinc-ai

300 V O layers, offering expediting channels for facile Zn(2+) diffusion.