ライフサイエンスコーパス: fail

1 ematics while autistic individuals tended to fail.

2 ves when the assumptions of existing methods fail.

3 pants with imaging data, accounting for scan fails.

4 served for those in whom medical therapy had failed.

5 H&E-staining and serum transaminase profile failed.

6 the immunosuppressive pathways have largely failed.

7 until medical and endoscopic treatment have failed.

8 ation efforts after significant efforts have failed.

9 th the hope of treating tumors have thus far failed.

10 s standard-of-care preventive treatments had failed.

11 -time GDD implants in the study, of which 11 failed (50%), and increased risk for failure was associa

12 t-sided origin of the AP was suspected after failed ablation of the right inferior extension of atrio

13 threshold, while all commonly used operators fail above it.

14 ine 3D-Cu, planar rGO@Cu, and planar Cu foil fails after 5110, 3012, and 1410 min, respectively.

15 re to recognize and reluctance to manage the failed airway.

16 should be considered if those initial drugs fail and ablation has been declined, has been unsuccessf

17 However, some THRs fail and require revision surgery, which results in wors

18 of early endpoint responders that ultimately failed and early endpoint non-responders that ultimately

19 ocytes (CMs) and non-CMs (NCMs)-from normal, failed and partially recovered (left ventricular assist

20 Failing and nonfailing hMSCs from both sources exhibited

21 s until later stages, when ductal remodeling fails, and signs of acinar-to-ductal metaplasia appear.

22 The results are less favorable in women with failed annuloplasty rings.

23 ation in patients with HS naive to or having failed anti-TNF therapy.

24 (25/50) with CA (P=0.036) on/off previously failed antiarrhythmic drugs and in 53.5% (53/99) versus

25 y direct contact, whereas hydroxychloroquine failed as prophylaxis.

26 ear, equilibrium-based model assumptions may fail at predicting population dynamics across a wide ran

27 h inflammatory bowel disease (IBD), who have failed azathioprine (AZA) or mercaptopurine (MP) due to

28 monotherapy or to improve radiotherapy have failed because oxygenation protocols were not combined w

29 t, in young women, transseptal TMVI to treat failing bioprostheses may result in good short-term outc

30 successful parents divorced more often than failed breeders (Halimubieke et al. in Ecol Evol 9:10734

31 ractory mantle cell lymphoma following prior failed Bruton's tyrosine kinase inhibitor therapy, with

32 In failing cells, the loss of Ca(2+) release synchrony at t

33 aribavir for cytomegalovirus (CMV) infection failing conventional therapy (trial 202) and 119 receive

34 patients, 29 (3.8%) and 175 (22.8%) patients failed CS by strict and expanded definitions, respective

35 .15; 95% CI: 1.79-9.58) were associated with failed CS by the strict definition.

36 Various pass/fail cut-off scores were described.

37 ors (NAMs) that have reached clinical trials failed due to lack of efficacy.

38 An additional 455 (1.4%) observations failed due to low bead numbers (<20/analyte).

39 , attenuation, incorrect start codons, and a failed gate.

40 major contributors to cancer recurrence and failed GBM therapy.

41 = 111; bullous keratopathy [BK]: n = 24; and failed graft: n = 18).

42 The failing heart is characterized by changes in gene expres

43 Further, we found that the treated failing heart is more prone to sustain VF than the norma

44 the deleterious metabolic adaptations of the failing heart.

45 susceptible to sustained VF as the untreated failing heart.

46 Comparing promoter usage between healthy and failed hearts highlighted promoter shifts which altered

47 d protein levels (~1.5-2.5-fold increase) in failing hearts compared with nonfailing hearts using our

48 Failing hMSCs exhibited increased secretion of inflammat

49 Compared with nonfailing hMSCs, failing hMSCs prolonged action potential duration by 24%

50 Phenytoin inhibits RyR2 from failing human heart and not from healthy heart, indicati

51 Notably, phenytoin inhibits RyR2 from failing human heart but not from healthy heart, indicati

52 at define electrophysiological properties in failing human heart ventricles have not been examined fo

53 dian expression pattern in the ventricles of failing human hearts, which may underlie a circadian pat

54 However, even seemingly intelligent machines fail in strange and "unhumanlike" ways, threatening thei

55 Treatment failed in 37 eyes (23.7%), with a 5-year survival rate o

56 f intrinsic excitability and spontaneous MFR failed in hippocampal GABAergic inhibitory neurons, whic

57 esults in preclinical models but have so far failed in human clinical trials.

58 soybean cultivars, a strategy that has been failing in recent years.

59 publications illustrate a serious potential failing in this domain: inclusion of refuted science, la

60 onal-theory-based first-principles framework fails in the cuprate superconductors.

61 When conservative treatment fails or worrisome clinical findings are present, magnet

62 F-DMEK is a safe and effective procedure in failed PK patients, with outcomes comparable to M-DMEK,

63 iles are distinguishable between healthy and failing pregnancies.

64 those findings were recently challenged by a failed putative direct replication attempt [M.

65 ributing taxa as potentially responsible for failed recovery.

66 e of 600 mg twice daily) or placebo to their failing regimen for 8 days, followed by open-label foste

67 A 10-predictor BN accurately predicted failed revascularization: area under the receiver operat

68 next-generation lithium-metal batteries, a "fail safe" mechanism for internal short is highly desira

69 n has been that alternative nitrogenases are fail-safe enzymes that are used in situations where moly

70 data reveal the workings of an evolutionary fail-safe, a duplicate enhancer mechanism that is hard-w

71 ersus those for which no association is made fails should reveal electrophysiological patterns in the

72 ical disorder; (4) cognitive impairment; (5) failed social reconstruction; and (6) persistent impaire

73 g/kg, 6x, monthly) from 12 cAMR patients who failed standard of care treatment with intravenous immun

74 iant tear, chronic RD, or RD with previously failed surgery.

75 ients with degenerated mitral bioprostheses, failed surgical repairs with annuloplasty rings or sever

76 regulation of rpl10a splicing contributes to failing T cell development in upf1 deficiency.

77 Patients were less likely to fail the chemoprophylaxis process measure if treated at

78 The IV push group was less likely to fail the goal of beta-lactam antibiotics within 1 hour (

79 for loss-of-license actions for surgeons who failed their first recertification exam were significant

80 The models may also fail to account for intra-tumoral spatial and microenvir

81 However, existing references fail to account for racial/ethnic differences in body co

82 We first determined that pax2a(-/-) embryos fail to accumulate F-actin in the OF prior to basement m

83 not capture the varied reasons why vaccines fail to advance to regulatory approval.

84 While RB1-mutant cells fail to arrest at G(1)-S in response to cell-cycle restr

85 Retained TMDs that fail to assemble with their cognate TMDs are slowly tran

86 r actin filaments, many clathrin-coated pits fail to be severed from the membrane, causing accumulati

87 Escape variants with such extended CP fail to be transmitted by nematodes linking Nb-mediated

88 We report that HIFs fail to bind CpG dinucleotides that are methylated in th

89 As such conventional optimization methods fail to capture the global optimum within the feasible s

90 nderlying diseases while the other 9 methods fail to capture the key phenomena.

91 However, in vitro measurements fail to capture the viscoelastic modulation of nuclear s

92 Mutants in the tol-pal locus fail to complete division and form cell chains.

93 However, double-mutant cells fail to complete HR, as excessive shieldin activity also

94 We now report that we fail to confirm the association of rs1047552 with AD in

95 Results fail to confirm the null hypothesis of no association be

96 focus primarily on nitrogen or protein, and fail to consider carbohydrates, this study has important

97 tive, but uncoordinated responses frequently fail to control disease, with a connection between aging

98 Mutant axons from R-neurons fail to cross the midline, which is indicative of an abe

99 , in their majority, diffraction-limited and fail to deliver matching resolution.

100 The authors fail to demonstrate that bees can access the concealed n

101 hat are more powerful than distal inputs and fail to depress with repeated stimulation.

102 re the main diagnostic tools for malaria but fail to detect low-density parasitemias that are importa

103 ecommendations are either silent about HF or fail to differentiate between the prevention of HF in th

104 f Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced defici

105 ons where isotropic tension is elevated, but fail to do so in elongated cells within the crowded midl

106 Here, we show that macrophages not only fail to efficiently kill phagocytosed S. aureus, but als

107 e spermatocytes arrest in prometaphase I and fail to either progress to anaphase or attempt spermatid

108 approaches for protein-based vaccines often fail to elicit potent and long-lasting immune responses.

109 4 double knockout mouse embryonic stem cells fail to exit pluripotency and differentiate efficiently.

110 refers to elusive orbital interactions that fail to explain short interatomic contact distances.

111 ficient values of D(b) > 10(-10) cm(2) s(-1) fail to explain the growth of the Aitken mode.

112 elations and ignore inter-sentential ones or fail to extract inter-sentential relations accurately an

113 into wild-type recipient, Cosmc-null B cells fail to home to lymph nodes as well as non-lymphoid orga

114 Standard microbiological culture may fail to identify unusual or fastidious organisms and can

115 at, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer.

116 arginally effective against HDV because they fail to inhibit HBsAg production/secretion.

117 DA projections are misguided and fail to innervate the striatum in both constitutive and

118 s that disrupt its association with Swi6/HP1 fail to localize to heterochromatin, lead to accumulatio

119 d cell death (RCD) when homeostatic programs fail to maintain viability.

120 iant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate l

121 Using these models in vivo and in vitro, we fail to observe a requirement for phosphorylation in NLR

122 In contrast, loci that fail to produce siRNA may be targeted for demethylation

123 d transcriptome misregulation, as cht7 cells fail to properly arrest growth, nuclear replication, and

124 Mice deficient in C1q, which fail to properly refine retinogeniculate connections, ha

125 levels, current therapies for these cancers fail to provide long-term cures.

126 A late first IPTp-SP dose fail to provide optimal protection against P. falciparum

127 f traditional cell culture techniques, which fail to recapitulate mechanobiologic stimuli known to af

128 -infected immunological non-responders (INR) fail to reconstitute their CD4 + T cell pool after initi

129 oring a macrophage-specific deletion of BCAP fail to recover from and succumb to dextran sulfate sodi

130 h injury, centrally-projecting sensory axons fail to regenerate across the dorsal root entry zone (DR

131 ulate myelin-associated genes and completely fail to remyelinate regenerated axons.

132 iants identified in the affected individuals fail to rescue the loss of Cdk8 and behave as null allel

133 erapeutics remains limited, as many patients fail to respond for reasons that still largely evade und

134 Human fungal infections may fail to respond to contemporary antifungal therapies in

135 aces and related anomalies in data which may fail to satisfy the manifold hypothesis.

136 Patients with type 2 diabetes (T2D) fail to secrete insulin in response to increased glucose

137 he absence of the fork remodeler HLTF, forks fail to slow following replication stress, but underlyin

138 SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an intermolecular beta-sheet around a

139 drenaline) when ventilation and compressions fail to stabilize the newborn infant, appropriate routes

140 n LSCs, then antiproliferative therapies may fail to target self-renewal, allowing for relapse.

141 ent is retarded, and the embryos potentially fail to thrive due to lack of luteal support.

142 margin can maintain RPE fate ectopically and fail to transition from neuroepithelial to cuboidal shap

143 More often than not, action potentials fail to trigger neurotransmitter release.

144 Exl1 inactive mutants fail to trigger such responses.

145 nternalized through endocytosis, but capsids fail to uncoat and accumulate within LAMP1(+) endolysoso

146 re, we demonstrate that HLTF-deficient cells fail to undergo fork reversal in vivo and rely on the pr

147 nf2h are infertile and oocytes lacking Snf2h fail to undergo meiotic resumption.

148 isation and early fixation of fractures that fail to unite in adults with scaphoid waist fractures di

149 SCs lacking YAP/TAZ, however, fail to upregulate myelin-associated genes and completel

150 -Ser754 STAT3 relative to phospho-Ser727 and fail to upregulate the STAT3 target Socs3, which is requ

151 tants can be subject to compensation, or may fail to yield a null phenotype due to leakiness (e.g. us

152 ional on prior achievement, polygenic scores failed to accurately predict later achievement.

153 owever, to date, pharmacological agents have failed to achieve significant target engagement in vivo,

154 nectivity, which condensed-phase separations failed to achieve.

155 Interestingly, L1a and L5a failed to activate cellular DNA damage response.

156 CA4P failed to activate RhoA/ROCK/pMLC but its activity was r

157 Whereas homodimeric IL-22Ralpha1 SyCyRs failed to activate signaling, homodimerization of the se

158 re (the proportion of women in which surgery failed to adequately resolve midline pain) and the frequ

159 ad altered expression of angiogenic factors, failed to adopt tip cell properties, and displayed reduc

160 B2, or GPR55 receptors in gene-knockout mice failed to alter BCP's action against cocaine self-admini

161 AcanR3990 qPCR failed to amplify genomic DNA from the other related Ang

162 R, 0.18; 95% CI, 0.02-1.61), although the HR failed to attain statistical significance.

163 ed countermeasures against such attacks have failed to be effective, as they do not consider the util

164 These cellular mechanisms failed to be executed in regeneration-incompetent tadpol

165 egrees of severity in morbidity or mortality failed to be statistically significant because of survey

166 ies with promising outcomes in animal models failed to be translated to human disease, our platform a

167 acy in rodent Alzheimer's disease models yet failed to benefit human patients.

168 e to bind Cul5 and some mutants additionally failed to bind A3G, ruling out competitive binding to A3

169 ed (n=9356, 92.0%) their mask while using it failed to consistently wash their hands afterward.

170 Thus far, the regulators have failed to create policies that would assist to inform th

171 l therapies, imaging of myocardial viability failed to deliver effective guidance of coronary bypass

172 ts who received intraarterial administration failed to demonstrate higher uptake by hepatic metastase

173 e showed the least benefit and in some cases failed to demonstrate significant weight gain despite nu

174 exponential and-more notably-logistic models failed to describe the experimental data whereas the Gom

175 though initial genome analysis of crAssphage failed to detect related phages, or functionally annotat

176 eloped Chlamydia-specific intestinal IgA yet failed to develop IgA in the FRT, indicating that IgA re

177 tation defects, but only p.R33Q convincingly failed to dimerize.

178 However, lesion of VTA GABA neurons failed to disrupt this effect.

179 Unlike wild-type cells, the psr1 mutant failed to downregulate LST8 abundance and TORC1 activity

180 ogenes mutant impaired in c-di-AMP secretion failed to elicit a protective response, whereas a mutant

181 pletion of local fumarate, the DeltahemB SCV failed to elicit trained immunity and protection from a

182 Mice failed to eliminate S. aureus deficient in vWbp, but cle

183 host T(conv) and host T(regs), donor T(regs) failed to engraft even with interleukin-2 (IL-2) support

184 s, eszopiclone increased spindle density but failed to enhance sleep-dependent procedural memory cons

185 Consequently, EDA-KO pigs failed to eradicate a bacterial challenge in lung region

186 Gentamicin alone failed to eradicate Neisseria gonorrhoeae from the phary

187 ndependent mechanism of host cell death that failed to eradicate S. aureus and instead promoted Delta

188 Studies have failed to establish a clear link between high-density li

189 hat PLP(ECD)-immunized B cell-deficient mice failed to exhibit EAE.

190 We failed to find a difference between treatment training w

191 less, analyses based on tens of neurons have failed to find evidence of saturation.

192 This study failed to find evidence that medical POHS replaced denta

193 ension produced regular CLPs in bacteria but failed to form stable nucleocapsids in hepatoma cells.

194 defects during development, they strikingly failed to form the caudal vein plexus (CVP).

195 d with the inhibitors of the Arp2/3 complex, failed to form ZLSs.

196 of a C(32-)A(38) cross-loop interaction but failed to fully explain the means by which s(2)C(32) res

197 lted in suppression of virus replication but failed to fully restore T-cell function and eliminate HB

198 chronically exposed cells for up to 1 month failed to fully reverse the transcriptional and phenotyp

199 oxo1 actively repressed CD127 expression and failed to generate memory precursors and long-lived memo

200 uenced by the primes, participants typically failed to give the reason for their choice.

201 Further imaging failed to identify a distant primary malignancy or metas

202 rm of the translocon of inner membrane, they failed to identify any outer-membrane translocon homolog

203 In contrast, neuroimaging investigations failed to identify cerebral features associated with fat

204 ic institutions and departments have largely failed to implement these recommendations, which has exa

205 These interventions failed to increase carpool sign-up or usage.

206 These agonists also failed to increase endothelial permeability in MYLK-L-de

207 a2delta-1 gene KO mice, treatment with FK506 failed to increase the frequency of NMDAR-mediated mEPSC

208 VTA or substantia nigra dopamine cell bodies failed to induce food approach or eating.

209 necrosis factor alpha (TNF-alpha) and vgRNA failed to induce NF-kappaB-dependent gene expression in

210 Expression of Akt3 in p47 (phox-/-) MEFs failed to induce ROS and to inhibit cell proliferation.

211 n-1(S714A) mutant and found that this mutant failed to infect mice, suggesting that the proteolytic a

212 GABA transaminase inhibitor vigabatrin also failed to influence glucagon secretion at 1 mm glucose a

213 in-resistant animals, portal vagal afferents failed to inhibit their spiking activity during glucose

214 organized processes from denervated NMJs and failed to initiate or guide nerve terminal sprouts at di

215 MLAV VP24 differed from MARV VP24 in that it failed to interact with Keap1 or activate an antioxidant

216 +/- 7.2% for IVF and 73.3 +/- 8.1% for ICSI) failed to litter after embryo transfer compared to embry

217 These differences failed to meet established thresholds for a clinically m

218 ultured with FFA, whereas female macrophages failed to migrate.

219 Meanwhile, leptin stimulation alone failed to mobilize Ca(2+) even in cells overexpressing l

220 ided competence stimulating peptide 1 (CSP1) failed to modulate the onset kinetics of competence deve

221 t cGAS sensing pathway, human CD4(+) T cells failed to mount a reverse transcriptase (RT) inhibitor-s

222 st extreme case, almost a third of observers failed to notice when less than 5% of the visual display

223 ng catabolic pathways have, however, largely failed to preserve muscle mass in cachexia, suggesting t

224 to our surprise, plasmid-deficient Chlamydia failed to produce infectious progenies in small intestin

225 However, our study showed that these cells failed to proliferate in the presence of rigosertib at c

226 ces synthesis of membrane proteins that have failed to properly assemble in the endoplasmic reticulum

227 sponses against the SIV envelope protein and failed to protect macaques from viral infection.

228 have worked in rodent models of stroke have failed to provide protection in clinical trials.

229 p than in the ODRH group (8% vs. 3%), but it failed to reach statistical significance (P = 0.167).

230 mall intestinal pGP3-deficient Chlamydia sp. failed to reach the large intestine, explaining the lack

231 -interact and that the rod-shaped structures failed to recognize glycoprotein E, the well-known bindi

232 The avirulent strain failed to reduce CD40 relocation to the detergent-resist

233 51-isavuconazole complex, the protein target failed to refold 74 N-terminal residues, suggesting a fu

234 nomer structure, isavuconazole-bound AcCYP51 failed to refold 74 N-terminal residues.

235 to regular inhaled corticosteroid inhalation failed to relieve symptoms.

236 to near baseline, LSD1-deficient CD8 T cells failed to remethylate the Pdcd1 locus to the levels of w

237 aA-Akt1WT/flx embryos, the capillary network failed to remodel.

238 258Arg mutant was enzymatically inactive and failed to rescue growth of ACO2-deficient cells.

239 YM2 proteins, based on individual mutations, failed to rescue renal and craniofacial defects.

240 sive to psychotherapy treatment for PTSD and failed to respond to an antidepressant medication for MD

241 Exploratory analyses of the microbiome failed to reveal possible responder compared with nonres

242 Compared to B6 BMMs, TLR4(-/-) BMMs failed to secrete a significant level of IL-1beta and ha

243 (anti-CTLA-4) or anti-PD-1/PD-L1 monotherapy failed to show a significant benefit.

244 Level I and II studies also failed to show a significant improvement over baseline i

245 However, Smoothened (SMO) inhibitors have failed to show clinical benefit in patients with cancers

246 ticipants with obesity, the patients with AN failed to show functional connectivity between the hypot

247 In contrast, the Is terminal failed to show functional or structural changes followin

248 Concordantly, mitochondrial DNA failed to show meaningful CpG methylation.

249 cytes or recombination-activating gene (Rag) failed to show rescue of mutant colonization.

250 In Experiment 2, while chicks failed to spontaneously use a striped wall in a square a

251 Further, infection failed to stimulate the memory B cell compartment in pre

252 d dendritic cell-induced proliferation, they failed to sufficiently regulate T cells stimulated by an

253 US failed to suggest metastases in 10 patients.

254 excluded from the nucleus of CD8 T cells and failed to transactivate these genes.

255 MSU failed to trigger neutrophil and monocyte recruitment in

256 xpressed during pneumonia-derived sepsis but failed to turn off the competent state in mice.

257 tead a remnant effector cell population that failed to undergo initial contraction has remained uncle

258 story justifying our fitness measures, while failing to account for our behavioral data.

259 ed is the presence of non-detects: reactions failing to exceed the quantification threshold and there

260 omparison of peaks across different samples, failing to fully exploit the information available from

261 nonetheless it should be underlined that by failing to provide characteristics of the particles, an

262 Failing to sustain intensive surveillance during the lat

263 the rational planner, and it seems to us he fails to accommodate many of the interpersonal aspects o

264 This separation fails to account for the rich diversity of clinically an

265 genes, the pivotal transcription factor PIF4 fails to accumulate, indicating a role of SPAs in regula

266 In addition, CDK1 fails to activate, possibly due to persistent WEE1 activ

267 ects slow-evolving hemodynamic activity that fails to capture the faster timescale of normal physiolo

268 Transition state theory fails to capture the reaction kinetics and explain the o

269 f HCC development, even if antiviral therapy fails to completely eliminate HCC risk.

270 rtcoming of the proposed approach is that it fails to constrain what counts as a constraint.

271 he hypothesis that an innate immune response fails to develop following prostate infection with these

272 l to cumulative technological culture but it fails to discuss the implications for the emergence of c

273 We argue that the manuscript fails to do so convincingly.

274 nic phospholipids alone, exposure to agonist fails to elicit ion-flux activity.

275 1, its phenotypic variant, termed as F-type, fails to form spores, does not confer plant growth-promo

276 e will develop FXTAS, as clinical assessment fails to identify carriers at risk before significant ne

277 analyzing physical and biological variables fails to identify the significant association for walley

278 cal arteriovenous fistula (AVF) creation but fails to improve AVF maturation rates.

279 ctive photoreceptors, even though the mutant fails to induce the expression of photosynthesis-associa

280 ts multiple configurations in the pocket and fails to make an interaction critical for activation by

281 expression of FoxO3a and liver kinase B1 but fails to normalize impaired PPAR-alpha expression or met

282 ick mesoderm layer; later, paraxial mesoderm fails to organize into somites.

283 arranged to enable high information transfer fails to predict auditory pathway organization and has s

284 ed an ORF66-null virus and confirmed that it fails to produce late genes and infectious virions.

285 While standard linear interpolation mostly fails to produce realistic transitions, our method yield

286 the accumulation of bile acids in the liver, fails to promote liver injury in the absence of the micr

287 f a stimulus, but disappears when a stimulus fails to reach awareness.

288 e six remaining PubMLST loci (0.897, 79 STs) fails to reach the benchmark recommended for a reference

289 trimester improves maternal oral health but fails to reduce the risk of preterm birth.

290 s arteriosus (PTA), which trunk neural crest fails to rescue.

291 y reinvigorates exhausted CD8(+) T cells, it fails to restore T cell repertoire diversity.IMPORTANCE

292 shown to have rapid antidepressant effects, fails to reverse elevated arousal to distal threat contr

293 When these mechanisms fail, toxicity due to the nutrient surplus ensues, leadi

294 After accounting for the costs of failed trials, the median capitalized research and devel

295 reocontrol that invoke thermodynamic control fail when two or more potential products are energetical

296 alternative explanation behind some methods failing when in the QC laboratories.

297 -2 mA cm(-2) , while baseline Cu prematurely fails when the current reaches 0.5 mA cm(-2) .

298 cifically, like H-NS dimers, are expected to fail with this respect.

299 ity and resulting 'head-drop' had previously failed, with associated progressive deterioration in the

300 initially responded to SLT, but the majority failed within 1 year.