ライフサイエンスコーパス: failing

1 munity, although fundamental, is fragile and failing.

2 nd preserved or reduced kidney function from failing.

3 e has to accumulate damage before ultimately failing.

4 l consequences of the underlying assumptions failing.

5 rotein was observed, with 659 (2.0%) samples failing.

6 continually blame contextual factors for its failings.

7 Predictors of failing a single FMT included inpatient status, severe a

8 ver failure (ACLF) with three or more organs failing (ACLF-3) portends low survival without transplan

9 moderate to severe hidradenitis suppurativa failing adalimumab therapy, or those ineligible to recei

10 To determine the role of SPEG in healthy and failing adult hearts.

11 The environment of the failing and infarcted myocardium drives resident and tra

12 We build failing and non-failing cardiac regulatory gene networks

13 Failing and nonfailing hMSCs from both sources exhibited

14 was directly related to the number of organs failing and to 28-day mortality (area under receiver ope

15 in patients in whom antiretroviral drugs are failing, and the appreciation of the role of testing, ar

16 ly treatment-experienced adults (>=18 years) failing antiretroviral therapy (HIV-1 RNA >=400 copies p

17 cents and young adults (aged 10 to 24 years) failing antiretroviral therapy (viral load, >1,000 copie

18 Ag screening should be considered in persons failing ART in Uganda with viral loads >=5000 copies/mL.

19 Ag screening should be considered in persons failing ART in Uganda with viral loads >=5000 copies/mL.

20 Participants on failing ART regimens had a high burden of HIVDR that pot

21 ycle was associated with an elevated odds of failing at IVF prior to live birth ([Formula: see text],

22 os (OR) and 95% confidence intervals (CI) of failing at IVF.

23 It is time to reappraise the concept of the failing atrium as a primary cause or aggravating factor

24 afety of low-dose TG therapy in IBD patients failing AZA and MP.

25 e mid-infrared and long-wavelength infrared, failing beyond, roughly 2.5 mum, our generalization of t

26 t, in young women, transseptal TMVI to treat failing bioprostheses may result in good short-term outc

27 e NaV1.5 proteins purified from adult WT and failing CaMKIIdeltac-overexpressing (CaMKIIdeltac-Tg) mo

28 We build failing and non-failing cardiac regulatory gene networks, revealing impo

29 Failing cardiomyocytes exhibit elevated viscosity and re

30 Thus, while immature and failing cardiomyocytes share similarities in subcellular

31 sion patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcri

32 ted an impaired ability to release Ca(2+) in failing cardiomyocytes.

33 ocytes, while markedly improving kinetics in failing cardiomyocytes.

34 ormed dyads, dyadic function was impaired in failing cells despite similar organization of Ca(2+) han

35 ganized arrangement of dyads in immature and failing cells promoted desynchronized and slowed Ca(2+)

36 l parallels; disorganization of t-tubules in failing cells was strikingly reminiscent of the late sta

37 In failing cells, the loss of Ca(2+) release synchrony at t

38 ply that facilitates their transition toward failing cells.

39 ealthy cells undergo while transforming into failing cells.

40 A strains lacking STK1 become susceptible to failing cephalosporins, such as Ceftriaxone and Cefotaxi

41 redictor correctly identified early and late failing circuits (86.2% and 93.6% specificity, respectiv

42 Hg (7.1-7.9 mm Hg) less negative than early failing circuits and pressures demonstrated lower variab

43 demonstrated lower variability in such late failing circuits.

44 aribavir for cytomegalovirus (CMV) infection failing conventional therapy (trial 202) and 119 receive

45 particularly urgent medical need in patients failing current first-line therapies, such as with eryth

46 asting fracture locations in a progressively failing disordered structure is of paramount importance

47 abnormal Ca(2+) wave activity in normal and failing dog atrial myocytes which occurs during the acti

48 n make the difference between succeeding and failing, even between life and death.

49 outcomes with a survival detriment for each failing factor.

50 Besides failing for the reasons Brette gives, codes fail to help

51 attendance by 12%, and reduced the number of failing grades by 18%.

52 clude the hemodynamic cross-talk between the failing heart and the response of the kidneys and vice v

53 GRK2 and GRK5 are overexpressed in the failing heart and thus have become therapeutic targets.

54 rial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in hear

55 he main features of VF dynamics in a treated failing heart are not affected by the level of electrica

56 This shift was also observed in human failing heart biopsies in comparison with nonfailing con

57 In failing heart cells, restoration of the action potential

58 afterdepolarizations (EADs) are triggered in failing heart cells.

59 ied to probe TATS electrical conductivity in failing heart cells.

60 The failing heart consumed more ketones and lactate and had

61 A failing heart differs from healthy hearts by an array of

62 ocaine autoradiography to determine that the failing heart has 30% lower SCN5A levels - the first evi

63 Our findings indicate that the failing heart has a previously unrecognized reparative c

64 Thus, induction of Mg29 in the failing heart is a compensatory response that directly c

65 The failing heart is characterized by changes in gene expres

66 Further, we found that the treated failing heart is more prone to sustain VF than the norma

67 results suggest that IF1 upregulation in the failing heart may be a maladaptive response.

68 a 30% loss in levels of NAD(+) in the murine failing heart of both DCM and transverse aorta constrict

69 he pathophysiological progression of HF, the failing heart reduces fatty acid and glucose oxidation,

70 Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increase

71 ked to metabolic remodelling and whether the failing heart shares a common Na-mediated metabolic 'fin

72 METHODS AND Leukocytes infiltrating the failing heart were analyzed by a multistep enzymatic pro

73 (2) alterations in ketone metabolism in the failing heart, (3) effects of therapeutic ketosis in ani

74 amage and DDR activation are observed in the failing heart, however, the type of DNA damage and its r

75 s of contractile reserve in the stressed and failing heart, inhibition of overactive GRKs has been pr

76 In the failing heart, oxidative stress occurs in the myocardium

77 In a failing heart, the elevated diastolic Ca(2+) leak from t

78 d to diseased heart tissue and symptoms of a failing heart.

79 SCs) is an emerging therapy for treating the failing heart.

80 stabilizing myocardial NAD(+) levels in the failing heart.

81 red SSB is observed in cardiomyocytes of the failing heart.

82 significantly increases the function of the failing heart.

83 Mg29 to model this observed induction in the failing heart.

84 the deleterious metabolic adaptations of the failing heart.

85 susceptible to sustained VF as the untreated failing heart.

86 ence in regional work between nonfailing and failing hearts after MI and offer novel insight into the

87 kinase C (betaIIPKC) activity is elevated in failing hearts and contributes to this pathology.

88 molecular and biochemical ECM alterations in failing hearts are dependent on the type of underlying i

89 creatine, and ATP-mirror changes observed in failing hearts compared to healthy controls.

90 d protein levels (~1.5-2.5-fold increase) in failing hearts compared with nonfailing hearts using our

91 e first demonstration of reduced acyl CoA in failing hearts of humans and mice, and suggests possible

92 dial remodeling in altering the mechanics of failing hearts remains unclear.

93 Human failing hearts show higher HuR levels.

94 achidonic acid (AA) in mitochondria from non-failing hearts was calcium-dependent phospholipase A2zet

95 6A in individual transcripts, in healthy and failing hearts, and in myocytes.

96 Th1) and Th17 (versus Treg) predominance in failing hearts, and with expansion of memory T cells in

97 reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias

98 nnels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels A

99 transcriptional pathways are dysregulated in failing hearts, only recently has the idea of disrupting

100 l for SAN conduction, especially in fibrotic failing hearts.

101 een implicated in the aberrant Ca-cycling of failing hearts.

102 or lipoxygenases attenuated mPTP opening in failing hearts.

103 of JMCs underlies contractile dysfunction in failing hearts.

104 significantly upregulated in mouse and human failing hearts.

105 EHDs associate with Cx43 in human and murine failing hearts.

106 ization when comparing untreated and treated failing hearts.

107 PDE4B protein was decreased in human failing hearts.

108 bition of RyR2 channels from sheep and human failing hearts.

109 rected at improving myocardial energetics in failing hearts.

110 sequencing in 70 human control and end-stage failing hearts.

111 hematopoiesis, which may include support to failing hematopoiesis.

112 CLD)) to reduce effects of failing hepatic detoxification functions.

113 Failing hMSCs exhibited increased secretion of inflammat

114 Failing hMSCs or nonfailing hMSCs were cocultured with n

115 Compared with nonfailing hMSCs, failing hMSCs prolonged action potential duration by 24%

116 otent stem cells, replicating the effects of failing hMSCs.

117 rescued the arrhythmia substrates induced by failing hMSCs.

118 (insulin-like growth factor)-1 compared with failing hMSCs.

119 tly attenuated activation characteristics of failing human cardiac fibroblasts isolated from end-stag

120 hat VASH1 depletion reduces the stiffness of failing human cardiomyocytes.

121 Phenytoin inhibits RyR2 from failing human heart and not from healthy heart, indicati

122 Notably, phenytoin inhibits RyR2 from failing human heart but not from healthy heart, indicati

123 at define electrophysiological properties in failing human heart ventricles have not been examined fo

124 glycolysis induction during the recovery of failing human hearts after mechanical unloading.

125 ase kinase kinase-4 (MAP4K4) is activated in failing human hearts and relevant rodent models.

126 Here, we harvest 1352 healthy and failing human hearts directly from transplant center ope

127 Ventricular tissue from failing human hearts display a circadian pattern of circ

128 Explants from healthy and failing human hearts were compared using radiocaine auto

129 ncer drugs, given its reported activation in failing human hearts with doxorubicin (DOX) cardiomyopat

130 Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels a

131 dian expression pattern in the ventricles of failing human hearts, which may underlie a circadian pat

132 ed the downregulation of SPEG mRNA levels in failing human hearts.

133 ning OM-induced modulation of XB behavior in failing human myocardium are unclear.

134 yocyte stiffness contributed to stiffness of failing human myocardium because of reduced titin disten

135 ed the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the highly selective pharm

136 half of difficult-to-treat and multi-therapy failing IBD patients.

137 ts in the kidney of diabetic mice but not in failing implants.

138 omising drugs based on work in rodent models failing in clinical trials.

139 a long and difficult course with 3 compounds failing in phase III clinical trials.

140 soybean cultivars, a strategy that has been failing in recent years.

141 publications illustrate a serious potential failing in this domain: inclusion of refuted science, la

142 Valdes et al contest our results, suggesting failings in our modeling approach as well as in our comp

143 tion and restoration of ER homeostasis; that failing, it drives apoptotic cell death.

144 regeneration of nephrons in situ to restore failing kidney function.

145 obstructive pulmonary disease, cancer, weak/failing kidneys, diabetes, hepatitis, depression, and he

146 nary disease: OR 1.65; cancer: OR 1.23; weak/failing kidneys: OR 2.29; diabetes: OR 1.56; hepatitis:

147 miRs) expression distinguish failing RV from failing LV.

148 In explanted failing LVs that were homozygous for PDE3A DEL and had b

149 covered that FTO has decreased expression in failing mammalian hearts and hypoxic cardiomyocytes, the

150 tension/inner unrest (37 [69%] vs 50 [88%]), failing memory (41 [76%] vs 44 [77%]), and weight gain (

151 Improving expression of FTO in failing mouse hearts attenuated the ischemia-induced inc

152 pathway was up-regulated in human and murine failing myocardia.

153 acorporeal membrane oxygenation alleviates a failing myocardial function.

154 NOD1 was examined in human failing myocardium and in a post-myocardial infarction (

155 hain acyl CoA was similarly reduced in human failing myocardium and restored to control levels by mec

156 ell therapy on the reverse remodeling of the failing myocardium and to discuss the rationale for usin

157 en structural and functional recovery of the failing myocardium, as only a small fraction of VAD-supp

158 In failing myocardium, confocal laser microscopy revealed a

159 In failing myocardium, microtubules elevate stiffness over

160 nt expansion of CD8(+) and CD4(+) T cells in failing myocardium, with increased Th1, Th2, Th17, and T

161 tential to augment reverse remodeling of the failing myocardium.

162 ontribute to the high diastolic stiffness of failing myocardium.

163 Wk-4 cardiomyocytes closely mimicked the non-failing (NF) adult human heart.

164 orial increase in possible sets of initially failing nodes.

165 ions are flawed as the result of a number of failings of both the modeling and the data comparison.

166 The project of justifying all the limits and failings of human cognition as inevitable consequences o

167 The failings of the guide-specific approach highlights the n

168 CA2-mutant tumours have a high likelihood of failing on conventional management after diagnosis.

169 CMV-infections in lung transplant recipients failing on currently available antiviral agents.

170 Quantifying the risk that failing onsite waste treatment systems (OWTS), such as s

171 -chronic liver failure (ACLF) with 3 or more failing organs (ACLF-3) is controversial.

172 urvival rate among patients with 2, 3, and 4 failing organs was 27%, 22%, and 8%, respectively.

173 utcome was not associated with the number of failing organs.

174 al model to data from 127 (85 healthy and 42 failing pregnancies) US women, aged 18-45, who were atte

175 iles are distinguishable between healthy and failing pregnancies.

176 1.32 (95% CI: 1.10, 1.59) times the odds of failing prior to ET.

177 1.23 (95% CI: 0.96, 1.59) times the odds of failing prior to oocyte retrieval, and 1.32 (95% CI: 1.1

178 The impact of remaining on failing protease inhibitor (PI)-containing regimens is u

179 ed the literature based on whether normal or failing rat heart models were used.

180 growth stimulation that was concealed due to failing regeneration in several species.

181 a day) or placebo in combination with their failing regimen for 8 days, followed by fostemsavir plus

182 e of 600 mg twice daily) or placebo to their failing regimen for 8 days, followed by open-label foste

183 Acutely failing respiratory mechanics can be caused by central a

184 The failing right ventricle (RV) does not respond like the l

185 artial sensory (less pain responsiveness and failing righting reflex) deficits that coincided with gl

186 s in microRNAs (miRs) expression distinguish failing RV from failing LV.

187 Risk factors for failing SBC and post-ERCP complications were analyzed by

188 es are not well defined among individuals on failing second-line antiretroviral therapy (ART) in low-

189 es are not well-defined among individuals on failing second-line ART in low- and middle-income countr

190 xin rapidly localizes via its LIM domains to failing SFs in cells, known as strain sites, to initiate

191 regulation of rpl10a splicing contributes to failing T cell development in upf1 deficiency.

192 rol group compared with only 18% of students failing the course if they participated in the emotion r

193 Failing the first recertification exam attempt was assoc

194 examination, participants were classified as failing the randomized management regimen if distance VA

195 M184V/I impacts virus load (VL) in patients failing therapy on a TDF/XTC plus nonnucleoside reverse-

196 M184V/I impacts virus load (VL) in patients failing therapy on a TDF/XTC plus nonnucleoside RT inhib

197 unique program of GSC cytokinesis, with GSCs failing to abscise from their daughter cells.

198 tributed to [Formula: see text] dislocations failing to accommodate plastic strain.

199 We show that failing to account for acclimation to antecedent environ

200 rweight risk paradox may result in part from failing to account for central adiposity, rather than re

201 Failing to account for denitrification products, especia

202 DLW calculations failing to account for diet-specific energy imbalance ef

203 Our results demonstrate that failing to account for nonbreeders in population studies

204 Failing to account for opioid strength would substantial

205 story justifying our fitness measures, while failing to account for our behavioral data.

206 Failing to account for repeated measurements when analyz

207 aspect such as loneliness or insecurity, but failing to account for the impact of co-occurring psycho

208 We show that failing to account for these factors leads to an underes

209 Failing to account for these sex-specific patterns (e.g.

210 e subject to high levels of uncertainty, and failing to account for this uncertainty is liable to lea

211 ially correlated with human vulnerabilities, failing to accurately capture physical exposure in an ec

212 ersity and/or multi-strain infections, often failing to accurately infer the transmission history.

213 not require MS/MS, yet they were constantly failing to achieve a meaningful depth of quantitative pr

214 85; P < .001) were independent predictors of failing to achieve complete dosing; private insurance st

215 ng performance, with almost half (n = 13/28) failing to acquire the reversed contingency, while the o

216 Failing to adjust a test's difficulty level to individua

217 phid (Rhopalosiphum padi), with high [CO(2)] failing to alleviate the aphid-induced decline in plant

218 erebral arteries, present devices still risk failing to arrive at target lesions.

219 show that lone proteins and complex subunits failing to assemble in the ER access the INM for Asi-med

220 kF is monomeric are Muk-, with the complexes failing to associate with chromosomes.

221 sing the resulting analyses, and in general, failing to capture sequences novel to a given genome.

222 erall amount of greenspace alone is probably failing to capture significant variance in local health

223 Donald Trump's 2016 win despite failing to carry the popular vote has raised concern tha

224 difference as significant) and power (i.e., failing to classify a true difference as significant) as

225 This study demonstrates that failing to climate-proof infrastructure investments can

226 Failing to complete chemotherapy adversely affects survi

227 Failing to consider COVID-19 due to false-positive dengu

228 Investigations failing to consider downstream migrating parr and pre-sm

229 Traditional control strategies are failing to contain Aedes albopictus as an emerging major

230 Neurotechnological devices are failing to deliver on their therapeutic promise because

231 + evidence context (eg, reports on 3 trials failing to demonstrate cardiovascular benefit of other t

232 Assessments which ignore this risk failing to detect change, identify its direction or gaug

233 s further complicated by monitoring programs failing to detect species.

234 /NZZ), as demonstrated by the spl/nzz mutant failing to develop an MMC.

235 se are eventually removed by apoptosis after failing to differentiate properly.

236 attachment by continuing to proliferate and failing to differentiate.

237 arning strategies than younger adults, while failing to disengage their default-mode network during l

238 fashion, with 40% of homozygous progenitors failing to divide.

239 ent, this could help identify people who are failing to engage in usual patterns of digital social in

240 of SVR12 (90% confidence interval, 36%-78%), failing to establish noninferiority.

241 With most studies failing to establish their structural identity and exami

242 ed is the presence of non-detects: reactions failing to exceed the quantification threshold and there

243 , but their activity is typically transient, failing to explain the long-term, stable epigenomic prog

244 considerably more inducible in GD-OF, cells failing to express IL-23.

245 ents and had normal A11 localization despite failing to form immature virions.

246 ely after viral entry, with incoming virions failing to form replication complexes.

247 pted spindles, producing dead spores or even failing to form spores.

248 e midbody, but they are highly disorganized, failing to form symmetric rings and to expand laterally

249 Failing to fulfill IDSA criteria was not a risk factor f

250 omparison of peaks across different samples, failing to fully exploit the information available from

251 criticized for being overly reductionist and failing to generate suitable evidence for public health

252 d to testing only a few compounds at a time, failing to identify general molecular descriptors or che

253 erpredict historical significance while also failing to identify many documents that will later be de

254 sly applied dsRNAs, either degrading them or failing to import them into the cytoplasm.

255 There is significant risk of a fellow failing to meet case minimums in the ACGME system and th

256 butions, probabilities of individual fellows failing to meet minimum case numbers were calculated.

257 mark-capture-recapture, can generate bias by failing to meet sampling assumptions, or by incurring to

258 abilities of survival and reduce the risk of failing to meet the minimum needs for survival.

259 weeks and 4 prednisolone-treated eyes (5.4%) failing to meet the primary end point because of rebound

260 low- and middle-income countries (LMICs) are failing to meet their developmental potential.

261 was slower, which is reassuring, given that failing to notice one's own effort is dangerous in ecolo

262 nsidering alternative causes of symptoms, or failing to obtain complete psychiatric histories.

263 five clades, three spreading widely and two failing to persist.

264 rations in BAP1 outside the UCH domain, each failing to productively recruit ASXH to the wild-type BA

265 Failing to progress through the cell cycle, Muller glia

266 nonetheless it should be underlined that by failing to provide characteristics of the particles, an

267 nts of controversial receptor localizations, failing to provide support for CRF1 expression in centra

268 od, largely due to the conventional analysis failing to quantify it directly.

269 g experimental and technical structure while failing to quantify uncertainty in the statistical model

270 reveal that memory B cells, while failing to re-enter the germinal center, create an affin

271 At present, energy interventions are failing to reach optimal levels of adoption in buildings

272 Failing to reach such subpopulations with high coverage

273 d alertness in nonstressful conditions while failing to react adequately to stressors.

274 olvents inside the pores of frameworks, thus failing to realize solid-state single lithium-ion conduc

275 = 0.75), appropriateness and precision, thus failing to recognise the non-binary nature of food-plant

276 However, failing to recognize the additional role of environmenta

277 m a policy perspective as it suggests we are failing to recognize the importance of wasting simply be

278 Failing to recognize this possibility may lead to incorr

279 m, as participants in SSB suffer the cost of failing to reproduce after expending the time and energy

280 e-BII cells transdifferentiating rapidly but failing to reprogram.

281 c preconditioning groups, in the 15 patients failing to respond to the lowest dose, nine (60%) respon

282 Moreover, induction chemotherapy failing to restore normal vasculature was associated wit

283 o revealed that current IVM protocols may be failing to satisfy the metabolic demands of the equine C

284 responsible for effective active treatments failing to separate from placebo.

285 nical trials assessing anti-PD-1 monotherapy failing to show efficacy in newly diagnosed and recurren

286 d with proper object identification, such as failing to signal that a cow mug is a mug.

287 ar mixed model-I explore the consequences of failing to statistically operationalize verbal hypothese

288 ular weight biologically relevant scavengers failing to strip the metal from the peptide.

289 g truncation of actin microfilament, thereby failing to support the Sertoli cell morphology and adhes

290 Failing to sustain intensive surveillance during the lat

291 or hunting initiation but resulted in larvae failing to sustain prey-tracking sequences and aborting

292 noise has proven elusive, with most methods failing to transfer to untrained tasks.

293 nd defect in lung development with lung buds failing to undergo branching morphogenesis and progressi

294 aa-tRNAs failing to undergo peptide bond formation at the end of

295 focus on global topological measures, often failing to unveil hidden mechanisms behind vulnerability

296 standard ICBT, and it decreased the risk of failing treatment (odds ratio=0.33).

297 esistance rates continue to rise, leading to failing treatment regimens.

298 gain was associated with pocket closure, and failing when either clinically relevant CAL gain and poc

299 alternative explanation behind some methods failing when in the QC laboratories.

300 Failing would reveal challenging limits for cognitive ne