ライフサイエンスコーパス: failure of

1 ng the patients enrolled, 54.5% had previous failure of 1 or more tumor necrosis factor (TNF) antagon

2 he exemplar unit with an all-cause construct failure of 1.7% (95% CI 1.3-2.3) compared with 2.9% (95%

3 uccessful detection rates of excessive graft failures of 15%, 62%, and 73% and false alarm rates of 5

4 sent in the tumors and could not explain the failure of [(18)F]FDG-PET to detect treatment response.

5 tional study examines prevalence of fit test failure of 2 types of N95 mask (dome-shaped and duckbill

6 handover from ATR to MCM is revealed by the failure of 5'-deoxyadenosylcobinamide, lacking the tail,

7 Surprisingly, the failure of 5'-end maturation elicits increased polyadeny

8 ic and/or immunomodulator therapy only after failure of 5-aminosalicylates, and (4) role of continuin

9 results in a decrease in risk of transplant failure of 5.5%, 7.8%, and 13.3%, respectively.

10 ction selection can influence the success or failure of a candidate molecule to meet a functional obj

11 al death pathway and caspase activation, and failure of a caspase inhibitor or necrostatin-1s to prev

12 Interestingly, the success or failure of a given structure cannot be predicted by qual

13 reshold decrease, (iii) neuronal integration failure of a multilevel brain network will occur and aff

14 se (231INS)-in 6 patients at the virological failure of a raltegravir-based regimen.

15 fer below such a clay layer and the repeated failure of a structurally sound community well.

16 nnecessarily deplete resources and even risk failure of a study.

17 ified if it is defined as a general adaptive failure of a subjective intrapsychic system needed to fu

18 distinction urges us to consider whether the failure of a system to behave as ideally hypothesized, o

19 nsfer, and frequently defines the success or failure of a transformation.

20 Here we describe the successes and failures of a hybrid in-person/virtual conference model.

21 inhibition, providing an explanation for the failure of ABCB1 inhibitors in clinical trials.

22 development, coupled with repeated clinical failures of Abeta-directed drugs, suggests that molecule

23 The failure of AcCYP51 to fully refold upon inhibitor bindin

24 ipin-deficient preadipocytes exacerbated the failure of adipogenesis in these cells.

25 ect models and z score transformation showed failure of age-expected brain growth in patients.

26 RE exhibit significant brain volume loss and failure of age-expected brain growth.

27 ed degradation routes that contribute to the failure of aged cells.

28 Moreover, failure of alpha-cells to increase glucagon secretion in

29 leads to reduction of alveolar type 1 cells, failure of alveolar inflation and early postnatal lethal

30 The repeated failures of amyloid-targeting therapies have challenged

31 Failure of anti-amyloid-beta peptide (Abeta) therapies a

32 ge estimated in this study can result in the failure of antibiotic treatment of infections with bacte

33 ate whether containment strategies can delay failure of antibiotic treatment regimens.

34 Following the failure of antimicrobial therapy, she was diagnosed with

35 le dopamine D2 receptor (D2R) levels and the failure of antipsychotic drugs to rescue adult behaviora

36 Failure of antipsychotic medications to resolve symptoms

37 Failure of any aspect of this barrier can result in tran

38 are grouped together as the signalosome, and failure of any single member of this group leads to fail

39 PHA results from failure of apoptosis during gestation.

40 c castration-resistant prostate cancer after failure of approved therapy options remains challenging.

41 preclinical models of HCC with the clinical failure of AR antagonists in patients with advanced HCC

42 V-1-infected cells producing virus can cause failure of ART to suppress viremia.

43 on and fail to localize ste50p, suggesting a failure of association and function of Ste50 mutants in

44 sess factors contributing to the success and failure of ASSURED diagnostics, lessons learnt in the im

45 hronisation and dysconnectivity, whereas the failure of astrocytic differentiation results in abnorma

46 The failure of axonal regeneration in the damaged CNS limits

47 bbit infection could potentially explain the failure of B. burgdorferi to persist.

48 We propose this underlies the progressive failure of beta-cells in diabetes.

49 ver, the molecular mechanisms underlying the failure of beta-cells to respond to glucose in T2D remai

50 ecular mechanisms underlying the progressive failure of beta-cells to respond to glucose in type-2 di

51 in the neonatal period that can lead to the failure of body organs and thereby causing damage to the

52 croenvironment (TME) is a major cause of the failure of both nanomedicines and immunotherapies that n

53 Drug resistance is a major cause for the failure of cancer chemotherapy or targeted therapy.

54 re delivery, $44.4 billion to $93.3 billion; failure of care coordination, $29.6 billion to $38.2 bil

55 ick and Hackbarth: failure of care delivery, failure of care coordination, overtreatment or low-value

56 measures to eliminate waste were as follows: failure of care delivery, $44.4 billion to $93.3 billion

57 itute of Medicine and Berwick and Hackbarth: failure of care delivery, failure of care coordination,

58 Furthermore, we discuss the successes and failures of CCA-targeted therapies, emphasizing key less

59 s of a subset of splicing factors leads to a failure of centriole duplication.

60 Failure of CF closure results in colobomas.

61 BACKGROUNDThe recent failure of checkpoint-blockade therapies for glioblastom

62 ntial autophagy genes ATG5 and ATG7 leads to failure of CHK1 activation by 20A and subsequently incre

63 nd chromosome alignment defects are due to a failure of chromosome congression independent of kinetoc

64 vated KRAS and its downstream effectors, the failure of clinical trials to date indicates that the me

65 the resulting uncertainties can lead to the failure of clinical trials.

66 Failures of clinical trials investigating Abeta-targeted

67 , rebleeding from both adhesive and cohesive failure of clots decreases survival from hemorrhage in v

68 has not been specifically tested if adhesive failure of clots is a major contributor to rebleeding an

69 nd the detrimental mechanisms leading to the failure of CNS tissue regeneration during disease progre

70 rgery and induced strabismus, in addition to failure of collapse of AHP.

71 Failure of communication between female tissues of the p

72 at this transition occurs as a result of the failure of compensatory biological systems to cope with

73 g more energy than is expended may reflect a failure of control over eating behaviour in obesity.

74 r damage that typically lead to catastrophic failure of conventional dielectric electroadhesives.

75 y, accumulating reports showed the treatment failure of conventional Pt(II) drugs, which is likely du

76 eterogeneity is a major driving force behind failure of current therapies and development of resistan

77 One of the major reasons for the failure of currently available antiviral therapeutics to

78 gent on the presence of CD4 T cells and on a failure of DCs to activate CD4 T cells, trapping the cel

79 Perturbing Xist/Polycomb spreading causes failure of de novo Xi silencing, with partial compensato

80 Failure of dermal protection or repair mechanisms might

81 rombosis, 2 to arterial thrombosis, and 2 to failure of desensitization and development of antibody-m

82 l models of severe forms of the disease with failure of developmental myelination, and more recently,

83 ermally induced degradation directly lead to failure of device operation.

84 The failure of discharge diagnosis coding to identify DUA-IE

85 ectively trigger shear bands thereby causing failure of ductile solids.

86 02), and gamma-H2ax ( P < 0.001], suggesting failure of earlier compensatory responses.

87 The apparent failure of ecosystems to recover from increasingly wides

88 ly, (iv) an ultimate pathway might encounter failure of effective motor output and give rise to freez

89 Failure of eIF2B to sense eIF2 phosphorylation likely le

90 l catabolism and normal cell physiology, and failure of either system causes disease.

91 to understanding its role in the mechanical failures of electrodes.

92 d to lack of tissue integration and ultimate failure of engineered grafts.

93 lars, which essentially recapitulate primary failure of eruption in humans, a rare genetic disorder e

94 Failure of ESCRT-III/Vps4 to release Lem2-Nur1 from hete

95 e pill stem from a response to the perceived failure of expert advice, evidence-based guidelines and

96 nts with small-cell lung cancer (SCLC) after failure of first-line therapy.

97 immunotherapy may be considered in cases of failure of first-line treatments or to modify the natura

98 intracellular H. pylori (aiHp) on treatment failure of first-line triple therapies.

99 rpus biopsies proved to be a risk factor for failure of first-line triple therapies; occurrence of ai

100 planned Fontan procedure was associated with failure of Fontan completion and longer postoperative st

101 The rate of failure of Fontan completion was higher in patients with

102 s at this neuronal compartment rather than a failure of forward trafficking to the AIS.

103 Detailed analyses attribute the failure of gap laws to the exceedingly strong intermolec

104 Different mutations caused failure of glycoproteins to function in a virus-specific

105 ds to enhanced type I IFN signaling due to a failure of Golgi-to-ER STING retrieval.

106 Renal failure of grade III or IV was seen in 5 patients with b

107 Patients with refractory IBS, defined as failure of >=3 conventional therapies, were randomly ass

108 shows that CLA resistance is associated with failure of H. pylori eradication.

109 d genotype 4-infected individuals with prior failure of HCV treatment received 16 weeks of grazoprevi

110 acterised by a natural history of consistent failure of healing was chosen to assess the biological p

111 HLA-B27 allotypes to form homodimers and the failure of HLA-B*27:03 to form homodimers challenge the

112 l response of the regulation mechanism and a failure of homeostasis.

113 Failure of homologous chromosomes to recombine is arguab

114 on of ecdysone by glycosylation results in a failure of host larvae to molt, and probably a reduced a

115 ents are deleterious at many levels, and the failure of host surveillance systems for these elements

116 ween animals and humans contributed to prior failures of human clinical trials.

117 much has been learned from the successes and failures of hundreds of high-quality clinical trials.

118 to IAV, observing new features, including a failure of IAV-treated MDMs to induce feedback inhibitor

119 AV, observing many new features, including a failure of IAV-treated MDMs to induce feedback inhibitor

120 immune privilege may be responsible for the failure of immune-therapeutic strategies in CLL and may

121 at may be simultaneously responsible for the failure of immuno-surveillance.

122 ment, either because of thin buccal plate or failure of implant stability.

123 crypt base columnar stem cell markers, and a failure of in vitro crypt organoid growth.

124 absence of membrane budding correlates with failure of in vivo platelet production.

125 ppointing in treating UTI, likely due to the failure of infused antibiotics to penetrate the bladder

126 s led to the concept that tics result from a failure of inhibition.

127 flect on recent controversies, including the failure of initial lineage-tracing experiments to confir

128 The failure of initial pharmacological therapy might not be

129 and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and sugges

130 or InSTI resistance mutations, for treatment failure of InSTI-based regimens.

131 ard-seeking and Pavlovian fear, and due to a failure of instrumental control.

132 mia, sustained hyperinsulinemia without late failure of insulin production, and lipodystrophy leading

133 haracterized by insulin resistance with late failure of insulin production, severe hyperglycemia/diab

134 or to treatment is associated with long-term failure of integrase inhibitor-containing first-line reg

135 n days 3 and 5 of hospital admission predict failure of intravenous steroids.

136 A failure of iron to appropriately regulate liver hepcidin

137 None of the constructs were related to a failure of large incentives to boost model-based control

138 tor ZFPM1 in mice results in a developmental failure of laterally located dorsal raphe serotonergic n

139 ng a complex immune dysregulation leading to failure of local immune surveillance.

140 The failure of lung cancer treatments has been attributed mo

141 the role of stochasticity in the success or failure of management because there is almost always no

142 The failure of many new, mostly biologic, drugs to meet thei

143 This may explain, in part, the failure of many successful preclinical therapies upon th

144 has undoubtedly been a major reason for the failure of many therapeutic trials.

145 ation of meiosis-related genes, which causes failure of maturation-promoting factor (MPF) activation.

146 IFIs were observed, most often representing failures of micafungin (n = 16) and aerosolized amphoter

147 aditionally, the determination of success or failure of migraine surgery is based on whether there is

148 ng pathways and our experiments suggest that failure of mitochondrial redox regulation can contribute

149 n contemplating pregnancy and suffering from failure of mitral bioprosthesis or annuloplasty.

150 The failure of most standard therapies in PDA, as well as pr

151 that parC G248T/S83I mutations contribute to failure of moxifloxacin and sitafloxacin, and the findin

152 y significantly contribute to the success or failure of MSC-based virotherapy as well as generate new

153 Impaired function of motile cilia causes failure of mucociliary clearance.

154 e state at a young age, causing regenerative failure of muscle, as occurs in geriatric mice.

155 still face progressive disability because of failure of myelin regeneration and loss of neurons, sugg

156 encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in t

157 a subset also cause loss of function through failure of myofilament incorporation and rapid degradati

158 ice of NAD biosynthetic pathway, explain the failure of NAMPT inhibitors, and pave the way for more e

159 phenomenon hypothesized to arise due to the failure of nascent lineages to persist.

160 severe congenital malformations caused by a failure of neural tube closure during early embryonic de

161 Failure of neural tube closure during embryonic developm

162 Mechanistically, the failure of neurovascular coupling involves a tau-induced

163 ression of SMAD3 in SCC-TAFs in the clinical failure of nintedanib in SCC and supports that patients

164 ppressions over an extended time, leading to failure of nitrite shunt or PN/A.

165 These findings may explain the persistent failure of NK cell therapy in patients with solid tumors

166 of the main CT predictors of the success or failure of nonoperative management in adhesive SBO.

167 due to loss of nuclease activity, as well as failure of nuclear localization.

168 This was accompanied by a failure of numerous PSCs to upregulate galectin-3 (MAC-2

169 Postnatal failure of oligodendrocyte maturation has been proposed

170 l subcellular mechanism for the maturational failure of oligodendrocytes and offers a potential thera

171 em to behave as ideally hypothesized, or the failure of one creature to behave like another, arises n

172 -based targeting of SHP2 was hampered by the failure of orthosteric active-site inhibitors to achieve

173 be managed similarly to hypoxic respiratory failure of other etiologies.

174 ith not only the severity of HE but also the failure of other organs and is an independent risk facto

175 matically reduced mandible size and complete failure of palatal shelf elevation, whereas Has2(f/f);Os

176 Success or failure of pancreatic beta cell adaptation to ER stress

177 ype 2 diabetes (T2D) is marked by exhaustive failure of pancreatic beta-cell functional mass to compe

178 ral decisions in the lab have been linked to failures of patience ranging from insufficient saving to

179 of the possible factors contributing to the failure of PfHRP2-based RDTs in detecting malaria.

180 Failure of phosphorylation leads to an increased number

181 of lurbinectedin in patients with SCLC after failure of platinum-based chemotherapy.

182 The failure of polypeptides to achieve conformational matura

183 ing than using a single RGC, demonstrating a failure of population codes when correlated noise is sub

184 el to determine what conditions dictate this failure of population processing.

185 ALPPS is effective reliably even after failure of portal vein embolization.

186 ls between humans and mice, and explains the failure of potent biotin biosynthesis inhibitors in stan

187 perhaps most apparent in recent high-profile failures of potential Alzheimer's disease therapies, hav

188 an be attributed in the main to two factors: failure of preclinical research findings translating int

189 re the age of 50 years, who had a documented failure of preventive medications from two to four drug

190 uses on endovascular treatment options after failure of previous treatment such as "stent in stent" t

191 alistic in planning, learn from the planning failures of previous elimination and eradication efforts

192 Failure of procedure invariance has led to the widesprea

193 ly predicts preference in choice, overcoming failures of procedure invariance; (2) preference is not

194 An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in pancreati

195 ociated with reduced induction of AP-1 and a failure of proper chromatin remodeling.

196 d in Sprouty2 morphants is attributed to the failure of proper movement of retinal progenitors into t

197 These results suggest that a failure of protein confinement at the connecting cilium

198 Recent studies have revealed that the failure of proteostasis with age is triggered by develop

199 imate, many are understandably distraught by failures of public policy to rise to the magnitude of th

200 s in a deterioration of these functions, and failure of RA signaling is perhaps associated with norma

201 Our investigation revealed the failure of rapid testing and genome-based prediction too

202 Delays or failure of rDNA double-strand break (DSB) repair are del

203 The failure of recent clinical trials in Alzheimer's disease

204 We also discuss the successes and failures of recent preclinical and clinical studies of T

205 of a mutation in the RdRP (D484Y) following failure of remdesivir in a 76-year-old woman with a post

206 Because BMPs may be involved in the failure of remyelination in multiple sclerosis (MS), we

207 diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal

208 Failure of remyelination underlies the progressive natur

209 More generally, given the recent failure of research institutions around the world to str

210 Our hypothesis was that failure of resolution programs may lead to unremitting i

211 mechanical stress using laser dissection and failures of retraction when amnioserosa cells are remove

212 The failure of RNA polymerase to read through the mutation a

213 nd developmental defects associated with the failure of RNA surveillance mechanisms, further highligh

214 mplicated in serious systemic infections and failure of root canal treatment, is a persistent inhabit

215 pectrum including clinical risk, linked to a failure of safety processing.

216 insertion in AtPAT21 results in the complete failure of seed production.

217 apilla morphology could be a risk factor for failure of selective biliary cannulation (SBC) and post

218 gical HDAC3 inhibition overcame regenerative failure of sensory axons following spinal cord injury.

219 DT-CMR demonstrated that failure of sheetlet relaxation in diastole correlated wi

220 of any single member of this group leads to failure of signaling via this classical pathway.

221 Failure of SLT was defined as any further glaucoma proce

222 uch like in ecological systems, catastrophic failures of SM networks are difficult to predict due to

223 We consider failure of social approach in autism as a special case o

224 ng to harness the deformation, buckling, and failure of soft materials for functionality.

225 dependent bioenergetic units, preventing the failure of specific cristae from spreading dysfunction t

226 ne to the DRG, thus pinpointing intermittent failure of spike propagation as the basis for integer-mu

227 demonstrated that transition from success to failure of SRT in adults could, in fact, have a fluid me

228 ngs raise concerns regarding the operational failure of standard LLINs and support the urgent deploym

229 The failure of such activity might contribute to the observe

230 cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in

231 tside of their approved label, successes and failures of targeted therapy are not systematically coll

232 A failure of ternary blends with PC(71) BM is likely due t

233 Furthermore, the failure of TERT promoter mutations to consistently corre

234 outflow tract and aortic arch arteries with failure of the 3rd and 4th pharyngeal arch arteries to f

235 The cumulative failure of the AADI was defined as intraocular pressure

236 ambient conditions, causing low temperature failure of the commercial Cu/SAPO-34 catalysts.

237 As these are risk-factors for fibrosis and failure of the conjunctival bleb, further studies are re

238 is hypermethylated state correlates with the failure of the corresponding genes to become transcripti

239 en radiation and ICI does exist - before the failure of the current, single-site approach leads to th

240 c materials, and ultimately, to catastrophic failure of the devices(3-5).

241 We propose that weakening and mechanical failure of the edifice was driven by changes in pore pre

242 underscoring the methodical limitations and failure of the findings of MRFIT compared to the potenti

243 erscoring the methodological limitations and failure of the findings of MRFIT compared with the poten

244 It is defined by failure of the heart to pump (HF with reduced ejection f

245 HF with reduced ejection fraction) or by the failure of the heart to relax, resulting in reduced fill

246 n the intestinal epithelium and a subsequent failure of the intestinal epithelial barrier have been s

247 he distribution of transition rates due to a failure of the local equilibrium approximation.

248 brogates the PGC program, as demonstrated by failure of the maintenance and/or activation of germ cel

249 He attributes the failure of the Multiple Risk Factor Intervention Trial t

250 Neural tube defects (NTDs) represent a failure of the neural plate to complete the developmenta

251 lieve these deviations indicate the point of failure of the placenta to support a developing cub.

252 etuses, abnormal placental development and a failure of the placenta to transport sufficient nutrient

253 ariant, showing that the change results in a failure of the polymerisation of alpha/beta/gamma lamini

254 Failure of the postsynaptic site, rather than hyperexcit

255 ent success (defined as freedom from initial failure of the procedure or atrial arrhythmia recurrence

256 sed by loss of pancreatic beta-cell mass and failure of the remaining beta-cells to deliver sufficien

257 etal-semiconductor interface noise and early failure of the spectroscopic detection capabilities of t

258 A failure of the stem cells to respond to this demand can

259 The primary efficacy end point was time to failure of the strategy (TFS).

260 h behavioral deviations are interpreted as a failure of the subject; however, here we instead suggest

261 l and nonbiological dyes and complements the failure of the two-form model for donor-acceptor systems

262 in older female mice can be attributed to a failure of the uterus to decidualise in response to ster

263 asodilatory shock in sepsis is caused by the failure of the vasculature to respond to vasopressors, w

264 Given the failure of the world's governments to improve the status

265 embly, and focus on human diseases caused by failures of the biogenesis pathway.

266 otal, only 5 patients (4.4%) were considered failures of the primary endpoint.

267 t health and scientific investigation is the failure of these cells to achieve full functional maturi

268 Due to the failure of these strategies to provide accurate diagnost

269 The failure of these well-powered experiments designed to nu

270 Failures of these processes are suggested to play a role

271 Failure of this corrective mechanism impacts tissue arch

272 Failure of this event leads to congenital vision impairm

273 Failure of this phenomenon provides a parsimonious expla

274 ation of Pol II and nascent transcripts, and failure of this process dramatically alters mitotic gene

275 ry-persistent RNAPII depletion underlies the failure of this process in Cockayne syndrome B cells.

276 Failure of this relationship was suggested to contribute

277 Chick cardiac crest ablation results in failure of this septation, phenocopying the human heart

278 s bacteriocin limitations, the successes and failures of this technology thus far, the challenges tha

279 y of using ibrutinib in the third-line after failure of time-limited bendamustine and venetoclax-base

280 ioned rats perform worse, in part due to the failure of timely directional action plans to emerge in

281 Failure of TLS polymerases to overcome this barrier lead

282 ntly, recipient MerTK deficiency resulted in failure of tolerance by donor apoptotic cells, and this

283 ment apparatus, tooth root malformation, and failure of tooth eruption in molars, which essentially r

284 nt cells to enact feather formation, causing failure of tract formation, and instead the entire skin

285 lating burden of infections and the relative failure of traditional control methods, the development

286 of doxycycline resistance in contributing to failure of treatment or prophylaxis.

287 iodine therapy is generally considered after failure of treatment with antithyroid drugs, or when sur

288 all, eyes treated with biologic agents after failure of treatment with corticosteroids and a second-l

289 patients (156 eyes) with active NIPPU after failure of treatment with corticosteroids and a second-l

290 Failure of treatment with linezolid in 2 cases led to a

291 onspecific and often result in misdiagnosis, failure of treatment, and poor clinical outcome.

292 However, we noticed the failures of tumorigenesis in mice with the mutation, and

293 Recurrent pregnancy loss is defined as the failure of two or more clinically recognized pregnancies

294 ilure; multiple organ failure was defined as failure of two or more organs.

295 neuronal lineage commitment largely due to a failure of up-regulation of specific genes critical for

296 l functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may b

297 Mice deficient in Rdh10 exhibit failure of utricle-saccule separation, otoconial formati

298 ent (mE) in PCa might be responsible for the failures of various therapies.

299 -2 hospital-level quality measure identified failures of VTE chemoprophylaxis in 0% to 3% of patients

300 ynamic and precisely programmed process, the failure of which can bring devastating consequences to t