ライフサイエンスコーパス: familial Alzheimer disease

1 yloid precursor protein (APP) gene can cause familial Alzheimer disease.

2 2 (PS1 and PS2) are the most common cause of familial Alzheimer disease.

3 ause the most aggressive form of early-onset familial Alzheimer disease.

4 that shows evidence of linkage to late-onset familial Alzheimer disease.

5 ciated with approximately 50% of early-onset familial Alzheimer disease.

6 n the gene STM2 result in autosomal dominant familial Alzheimer disease.

7 myloid precursor protein (APP) identified in familial Alzheimer disease.

8 enilin 2 (PS2) proteins are a major cause of familial Alzheimer disease.

9 that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onse

10 Most early-onset familial Alzheimer disease (AD) cases are caused by muta

11 Linkage to chromosome 12p for familial Alzheimer disease (AD) has been inconsistent.

12 red PS1 gene are responsible for early-onset familial Alzheimer disease (AD), and PS1 is abnormally a

13 e brains of patients with autosomal dominant familial Alzheimer disease (AD).

14 e have been described as causing early onset familial Alzheimer disease (AD).

15 Further studies of familial Alzheimer diseases and diabetes show that the a

16 homodimerization, or of the presence of the familial Alzheimer disease Arctic mutation (APP E693G).

17 S1 in two affected siblings with early-onset familial Alzheimer disease characterized by deposition o

18 erved in individuals affected by early-onset familial Alzheimer disease (FAD) associated with mutatio

19 ble for approximately 40% of all early-onset familial Alzheimer disease (FAD) cases in which a geneti

20 eta and in particular Abeta42 is enhanced by familial Alzheimer disease (FAD) causing mutations in AP

21 Familial Alzheimer disease (FAD) is linked to mutations

22 Familial Alzheimer disease (FAD) mutations suppress the

23 hiN cells from familial Alzheimer disease (FAD) patients with presenili

24 Furthermore, in contrast to WT PS1, familial Alzheimer disease (FAD) PS1 mutants expressed i

25 lead to dominant inheritance of early onset familial Alzheimer disease (FAD).

26 in 1 gene on chromosome 14 cause early onset familial Alzheimer disease (FAD).

27 cretase, and mutations in this protein cause familial Alzheimer Disease (FAD).

28 (PS1) and -2 (PS2), which when mutated cause familial Alzheimer disease, have been localized to numer

29 sing an inherited form of Alzheimer disease (familial Alzheimer disease) in the PS1 motif suggested t

30 1, a protein involved in the development of familial Alzheimer disease, is an important functional c

31 In addition, six familial Alzheimer disease-linked mutant human presenili

32 Late-onset familial Alzheimer disease (LOFAD) is a genetically hete

33 Remarkably, PS1 familial Alzheimer disease mutant DeltaE9 increased neit

34 e to Abetao as well as chronic expression of familial Alzheimer disease mutant transgenes in model mi

35 s nor cell aggregation, suggesting that this familial Alzheimer disease mutation interferes with cadh

36 Early onset familial Alzheimer disease mutations in presenilin (PS),

37 d that PS1 positively regulates, whereas PS1 familial Alzheimer disease mutations suppress, phosphati

38 This cleavage is inhibited by presenilin 1 familial Alzheimer disease mutations.

39 ic function associated with the presenilin-1 familial Alzheimer disease mutations.

40 mic reticulum Ca(2+) leak function, and many familial Alzheimer disease presenilin mutations impair t

41 senilin-1 (PS1), the major causative gene of familial Alzheimer disease, regulates neuronal different

42 hologic changes in the retina of carriers of familial Alzheimer disease who are cognitively unimpaire