ライフサイエンスコーパス: family member

1 y by forming a heterodimer with another bZIP family member.

2 umour and metastasis suppressor TAp63, a p53 family member.

3 served upon the loss or mutation of this PAX family member.

4 on coupling of opioid receptors to Galphai/o family members.

5 ld, leaving many grieving the sudden loss of family members.

6 ting the correlations between the genomes of family members.

7 ttle is known about DNA repair and other E2F family members.

8 l arrangement of this receptor or any of its family members.

9 ations for glaucoma patients and their close family members.

10 increase support for their parents and other family members.

11 aled that a Viking expedition included close family members.

12 mechanisms of action observed in other MORC family members.

13 arned distinct sequence preferences of DNMT3 family members.

14 transcription-factor-binding motifs of AP-1 family members.

15 in breast cancer patients, and in unaffected family members.

16 ture, substrate recognition, or catalysis by family members.

17 ed on sensory nerve biopsies from 2 affected family members.

18 cluding transcription factors and cytochrome family members.

19 function is likely conserved in other DUF328 family members.

20 are not only about physical contacts between family members.

21 orming more extended interactions than other family members.

22 he selective targeting of SHP2 and other PTP family members.

23 , a nanomolar potent inhibitor for the PLAAT family members.

24 s in patients with advanced cancer and their family members.

25 the inherent correlations between genomes of family members.

26 n targeting hSOAT1 and other mammalian MBOAT family members.

27 porate international partners, patients, and family members.

28 0.001) increased hazard in genotype-positive family members.

29 s have been identified by genotyping related family members.

30 rst symptoms were usually discordant between family members.

31 the mean age at onset and at death of their family members.

32 ial DNA (mtDNA) was performed for 6 affected family members.

33 her C1q/TNF-related proteins (CTRPs) and C1q family members.

34 bited by knockout mice lacking all three APP family members.

35 ted new roles for Rho GTPases, filled by new family members.

36 used to predict the specificity of other FOX family members.

37 28 consanguineous marriages and 59 genotyped family members.

38 ription factors including AP1, GRHL, and KLF family members.

39 for the patient but especially for affected family members.

40 is impossible to offer predictive testing of family members.

41 ty, need for surgery, and number of affected family members.

42 CUG-BP, Elav-like family member 1 (CELF1, also called CUGBP1) is an RBP, t

43 nnel, transient receptor potential vanilloid family member 1 (TRPV1), and the latency of TRPV1-mediat

44 usly reported the aberrant expression of Zic family member 1 (Zic1) in GC.

45 WNT10A (Wingless-type MMTV integration site family, member 10A) plays a crucial role in tooth develo

46 en phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) and specifically kills cancer

47 Moreover, expression of the kinesin family member 1B, an Mbp mRNA transport protein, was red

48 rane inner ear, calcium and integrin-binding family member 2, and ankyrins.

49 of the profibrotic transcription factor SMAD family member 2/3 (SMAD2/3).

50 ck Kids mobile application, by the patient's family member; 2) by HOTV-ATS, by study personnel; and 3

51 of CREB3L1 is blocked by transmembrane 4 L6 family member 20 (TM4SF20).

52 ears) at a single center in Canada and their family members (2305 samples total).

53 9 versus C529 change in the cadherin related family member 3 (CDHR3) receptor which underlies variabl

54 F-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone

55 orphisms (SNPs) in the gene encoding kinesin family member 3A, KIF3A, have been associated with atopi

56 of the heterodimeric motor subunits, kinesin family member 3A/3B (KIF3A/3B), and kinesin-associated p

57 Acyl-CoA synthetase long-chain family member 4 (ACSL4) is one of the main enzymes in pr

58 expression or acyl-CoA synthetase long chain family member 4 depletion diminishes necrosis and aggres

59 taining genes Acyl-CoA Synthetase Long Chain Family Member 5 (ACSL5) and Zinc Finger DHHC-Type Contai

60 itochondrial protein phosphoglycerate mutase family member 5 (PGAM5) is important for the antiviral c

61 of the GTPase-activating protein TBC1 domain family member 5 to late endosomes, which controls the co

62 0%) responded preintervention and 129 of 226 family members (57.1%) responded postintervention.

63 At 90-day follow-up, 131 of 226 family members (58.0%) responded preintervention and 129

64 Qualitative data were gathered from 75 family members, 72 clinicians, and 20 managers or hospit

65 1+/-0.7, P<0.002) and LQTS genotype-positive family members (87.5+/-7.4, difference-in-mean, 1.8+/-.7

66 ymptoms of post-traumatic stress disorder in family members 90 days after patient death or ICU discha

67 ion in the presence of activated Ras homolog family member A (RhoA) induces precocious polarization a

68 ng via the beta-arrestin-1/2 and Ras homolog family member A (RhoA) signaling pathways.

69 GTPase-signaling small molecule ras homolog family member A (RhoA).

70 constitutive activation of RhoA (ras homolog family member A) and impaired flow-induced endothelial c

71 orylation and activation of Ras homolog gene family member A.

72 sed semaphorin 6A (SEMA6A); Ras homolog gene family, member A (RhoA); phosphatase and tensin homolog

73 In humans, four VPS13 family members, A-D, are associated with different disea

74 olecule (CD44), and aldehyde dehydrogenase 1 family member A1 (ALDH1A1).

75 ally redundant with that of another TGF-beta family member, activin A.

76 y 3.7 years (SD, 1.0 years; P < 0.001), more family members affected by 0.46 members (SD, 0.11 member

77 urther replicated the maximum IOP, number of family members affected by glaucoma, and treatment inten

78 Other syntaxin family members also bind to K63-linked poly-ubiquitin ch

79 s G(2)/M arrest by degrading multiple PPP2R5 family members, an activity prevalent among diverse HIV-

80 mponents: a light chain subunit from an SLC7 family member and a heavy chain subunit from the SLC3 fa

81 protein is a Snf2-like chromatin remodeller family member and is mutated or misregulated in several

82 TAp63 is a p53 family member and potent tumor and metastasis suppressor

83 ese results highlight the importance of PARP family members and ADPRylation in gene regulation, mRNA

84 ar TCR Vgamma regions with specific BTN/BTNL family members and apparently aligns with an innate-like

85 the TLR7 agonist imiquimod as compared with family members and controls.

86 detectable in antibody-seronegative exposed family members and convalescent individuals with a histo

87 sequencing (WES) on 668 CM1 probands and 232 family members and performed gene-burden and de novo enr

88 re, we review the key properties of the IL-1 family members and provide insights into targeting or pr

89 ery similar to the GAT domain present in GGA family members and related proteins that are otherwise c

90 r differential binding between NELL and Robo family members and show that NELL2 repulsive activity is

91 sponses to Delta-like (DLL) and Jagged (JAG) family members and the extent to which Fringe enzymes mo

92 tanding of PA impact on PwPA, caregivers and family members and the need for improved PA management a

93 We found enrichment of nine Mrgpr family members and two histamine receptors in MrgprA3(+)

94 Six cross-sectional survey studies explored family members' and clinicians' perceptions and demonstr

95 emonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostati

96 ncreased abundance of BAX, a pro-death Bcl-2 family member, and activation and adipocyte cell death b

97 PRDM10 is a yet uncharacterized family member, and its function in vivo is unknown.

98 was performed in 197 probands with HLHS, 43 family members, and 813 controls.

99 scripted ACP conversations between patients, family members, and certified facilitators; standardised

100 Wishes from dying patients, family members, and clinicians were elicited and impleme

101 or protein function are conserved among gene-family members, and genetic variants within these region

102 raise the evidence on outcomes for patients, family members, and healthcare professionals.

103 responses in unexposed individuals, exposed family members, and individuals with acute or convalesce

104 Purified PLY, several other CDC family members, and the alpha-toxin of Clostridium septi

105 The expression of the app family member, appa, was also found to be altered in app

106 Nebulin family members are best known for their role in regulati

107 The heterochromatin protein 1 (HP1) family members are canonical effectors and propagators o

108 NLR family members are central regulators of pathogen recogn

109 ng enzyme, catalytic polypeptide 3 (APOBEC3) family members are cytidine deaminases that play importa

110 As transcription factors, MYC family members are difficult to target with small-molecu

111 Huntingtin-interacting protein family members are evolutionarily conserved from yeast t

112 Epa family members are lectins with binding pockets containi

113 ases, and, as we describe here, other myosin family members are likely to be potentially unique targe

114 Interactions with FXR family members are mediated by the C-terminal repeating

115 D proteins are strain dependent and that NPD family members are not redundant with regard to their ef

116 PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional reg

117 ntracellular molecular chaperones; some sHsp family members are upregulated under stress conditions a

118 al relationships of these complexes with MYC family members, as well as their future potential as the

119 f FMRP's role in suppressing Argonaute (AGO) family members' association with mRNAs by mapping the in

120 the time of death, 20 patients (44.4%) had a family member at the bedside.

121 rane protein (VAMP)-associated protein (VAP) family member AtVAP27-1.

122 mmation, the loss of the anti-apoptotic BCL2 family members BCL2 and BCL2L1 has no effect on intestin

123 blood (PB) and display major shifts in Bcl-2 family members between those compartments.

124 Several S100 protein family members bind PPP5C increasing PPP5C catalytic act

125 ocytes (IEL) in gut and skin depends on Btnl family members, Btnl1 and Skint1, respectively.

126 factor (VEGF) through activating Ras homolog family member C (RhoC), leading to subsequent angiogenes

127 is demonstrated that depletion of Src kinase family members (c-Src, Yes, and Fyn) or cav-1 clearly re

128 smembrane domain (TMD) of some Bcl-2 protein family members can modulate apoptosis; however, the tran

129 s deficit, as the specific metal used by any family member cannot be predicted.

130 t into disease pathology, impact patient and family members' care, and potentially identify new cance

131 e, number of nurses present at the handover, family member, carer or trusted friend (of the patient)

132 DUOX1, an NADPH oxidase family member, catalyzes the production of hydrogen pero

133 Other CTRPs and C1q family members (Cbln1, CTRP1, CTRP5, and CTRP13) also bo

134 the increased expression of the tetraspanin family member, CD82, in response to the chemotherapeutic

135 istructured interviews and focus groups with family members, clinicians, and managers.

136 RS-CoV-2-specific antibody features of these family members compared to healthy controls.

137 The SMC family member condensin is best known for establishing l

138 discuss how misregulation of the RAD51 gene family members contributes to disease and consider new a

139 ant predictors of colonoscopy use across all family members controlling for carrier status.

140 IM, MITF-M, melan A, and TYRP1 (a tyrosinase family member critical for melanin biosynthesis) were re

141 Nerve biopsies from 2 affected family members demonstrated ultrastructural mitochondria

142 In Drosophila, the BMP family member Dpp is produced in a limited set of imagin

143 Increased psychosocial support for family members during and after cancer therapy is warran

144 olreductase (GILT), and lymphocyte antigen 6 family member E (LY6E), the three cellular proteins iden

145 trom resolution crystal structure of the EAP family member EapH1 bound to neutrophil elastase.

146 The ErbB receptor tyrosine kinase family members EGFR (epidermal growth factor receptor) a

147 ch, following a baseline observation period, family members enrolled in the intervention phase were g

148 ates resistance toward the inhibition of its family member epidermal growth factor receptor with smal

149 TET catalytic domains (hTETCDs) from the TET family members, especially for hTET3CD, significantly at

150 ardiac GCs to recommend clinical testing for family members even though testing in the scenario is ex

151 e potential, as well as staff and subsequent family members exposure to severe acute respiratory synd

152 DME) is upregulated, which can activate PRC2 family members FIS2 and MEA, and may suppress the expres

153 agents, therapeutic blockade of select IL-1 family members for periodontitis has only been partially

154 rely on unpaid support from their partners, family members, friends, or neighbors as caregivers to h

155 a potential tool to help protect patients or family members from harming themselves or others by rest

156 SFK Unique domains act to differentiate the family members from one another.

157 sequencing was performed on 412 probands and family members from our DCM cohort, identifying several

158 Two major human AlkB family members, FTO and ALKBH5, both act as oxidative de

159 the repertoire of functions Polo-like kinase family members fulfill in regulating pivotal cell cycle

160 We further show that other zfyve family members (FYCO1, WDFY3, Hrs) also distribute to nu

161 of action and pathway connectivities of EDS1 family members go some way to explaining their central r

162 Both BD1 and BD2 are highly conserved across family members (>70% identity), whereas BD1 and BD2 from

163 Family members had significantly higher mean polygenic l

164 Fifty-one of 66 CASQ2 heterozygous family members had undergone clinical evaluation, and 17

165 , double and triple mutants implied that SRG family members have additive functions in plant immunity

166 Several family members have been found to restrain rather than a

167 Although several JAZ family members have been placed in this pathway, the rol

168 All family members have salivary anti-SARS-CoV-2 antibodies

169 l actin to stabilize MTs, suggesting several family members have the potential to contribute to infec

170 natural peptide ligand for the ErbB protein family members HER3 and HER4.

171 cal adhesions, all of which recruit Ena/VASP family members hitherto thought to antagonize efficient

172 epidermal differentiation pathways and IL-1 family members (i.e. IL36RN) but not elements of the IL-

173 of the patients and segregation in available family members identified loss-of-function variants of t

174 nipavirus genus and possibly Paramyxoviridae family members.IMPORTANCE The Paramyxoviridae family inc

175 the Plasmodium-tailored role of a lipocalin family member in hemozoin formation and underscore the h

176 ovides first evidence for the role of a DYRK family member in sustaining promastigote stationary phas

177 Rsp5, the Nedd4 family member in yeast, is an E3 ubiquitin ligase involv

178 nsive phylogenetic analysis of the CBF/DREB1 family members in 20 plant species from the Asterid or R

179 ed crystal structures of all three human RGM family members in complex with GDF5, as well as the tern

180 r used as an intervention the involvement of family members in daily critical care team rounds.

181 we report that selective inactivation of APP family members in excitatory neurons of the postnatal fo

182 is review, we focus on the roles of the PARP family members in inflammation and host-pathogen interac

183 Ferroportin family members in model legume Medicago truncatula were

184 We investigated expression of Bcl-2 family members in patients under ibrutinib or venetoclax

185 standing of the physiological roles of EPSIN family members in plants and provides novel insight into

186 However, specific role(s) of individual FoxO family members in stress-induced growth and remodeling o

187 War migrants without family members in Sweden or with more recent immigration

188 mbers to be involved with providing care for family members in the ICU was associated with reduced sy

189 The involvement of family members in the ward rounds is a novel but under-r

190 dissecting functional interactions of Bcl-2 family members, in an in vitro model of venetoclax resis

191 All other APOBEC3 family members, including APOBEC3B, fail to promote live

192 and IRF1, which are known to regulate IL-12 family members, including IL-12 and IL-23.

193 Rho family members, including Rac family small GTPase 1 (RAC

194 regarding the pathways influenced by Ikaros family members, including the end-to-end regulation of c

195 EXO70D family members interacted with type-A ARR proteins, like

196 bias, detailed analysis on the whole TaCLPB family members is important to understand the genetic ba

197 its impact on the long-term mental health of family members is not well characterized.

198 Activin A, a TGF-beta family member, is a strong pro-metastatic cytokine in th

199 cularly define progestin and adipoQ receptor family member IV (PAQR4) as a Golgi-localized ceramidase

200 However, recent studies of the JAM family members JAM-A and JAM-C have expanded the roles o

201 further show that overexpression of the AP-1 family members Junb and Fosl1 can promote changes in mam

202 ed to the cluster of differentiation 1 (CD1) family members, known as CD1-restricted T cells, and muc

203 ite the high amino acid identity between RAS family members, KRAS employs an intriguing differential

204 quiescent markers: Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) and Glutamate Aspartate Trans

205 Here, we present evidence that the nebulin family members LASP1 and LASP2 play an important role in

206 The two smallest family members, LASP1 and LASP2, are more structurally d

207 Separate genetic reclassification in family members led to downgrading of n=5 (38.5%) variant

208 ion for axon guidance and shed light on Robo family member ligand binding specificity, conformational

209 often responsible for helping and supporting family members manage their heart failure symptoms at ho

210 esults suggested that highly homologous gene family members may function antagonistically in the same

211 These studies provide insight into how Akt family members may promote the maintenance of lifelong l

212 These experiences, and experiences of family members, may drive whether patients seek care or

213 otional needs of those staying behind when a family member migrates.

214 dy to have evaluated the association between family member migration status and cognitive decline; fu

215 Family member migration status may be a unique societal

216 emotional risk factor for cognitive decline: family-member migration status.

217 We show that MLX and glucose-sensing family members MLXIP/MondoA and MLXIPL/ChREBP bind LDs v

218 ctor (LIF) cytokine mRNA, but not other IL-6 family member mRNAs, was up-regulated by anti-E2 antibod

219 The MTMR6 family member MTMR8 has a similar function in autophagy

220 M. truncatula bHLH protein MtTT8 and the WDR family member MtWD40-1, and this interaction facilitates

221 The membrane deforming dynamin family members MxA and MxB are large GTPases that convey

222 Family members (n = 147) were most commonly spouses (n =

223 e, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily l

224 tau (MAPT) and their first-degree biological family members (n=588).

225 source of the epidermal growth factor (EGF) family member NEUREGULIN1 (NRG1).

226 to an accumulation of the proapoptotic Bcl-2-family member Noxa.

227 Data show that family members of ICU patients may have high levels of a

228 sen the burden of stress-related symptoms in family members of ICU patients.

229 Family members of patients who had an attending predicte

230 Of 37 family members of positive individuals, 17 (35%) were al

231 , 28,062 (48.8%) had a survey completed by a family member or close contact.

232 d to the critically ill patient and/or their family member, outcomes related to the healthcare profes

233 ble targets of FIPC-1, we identified the PDI family member P4HB and the functionally uncharacterized

234 The p53 family member p73 has a complex gene structure, includin

235 The PKA-inhibitor (PKI) family members PKIalpha, PKIbeta, and PKIgamma bind with

236 L-Lactate-transporting SLC16 family members play essential roles in the metabolism of

237 d heterozygotes and 12 heterozygotes) and 76 family members possessing at least 1 presumed pathogenic

238 denafil also induces the expression of PGC-1 family member PRC and can compensate for PGC-1alpha acti

239 sanguineous families, each with two affected family members presenting with progressive heart valve d

240 nique biological properties of the three Akt family members promote the maintenance of latency in dif

241 , catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins can deaminate cytosines in single

242 GoCheck Kids as checked by a family member provided a modest correlation of visual ac

243 high-resolution structure of a SctK protein family member, PscK from Pseudomonas aeruginosa, as well

244 synthase (cGAS) and the pyrin and HIN domain family member (PYHIN) protein interferon-gamma-inducible

245 Phosphorylation of the FAK family member Pyk2 at tyrosine 402 is decreased in NK92

246 eating a complex network through which Bcl-2 family members regulate cell survival and death.

247 ly repressed the expression of the NF-kappaB family member RELA/p65.

248 We evaluated the levels of family members relative to the internal control miR-103a

249 position of a range of solutes, eight SLC22A family members remain classified as orphans.

250 in addition to the [4Fe-4S] cluster that all family members require for the reductive cleavage of SAM

251 Arrestin-1 is the arrestin family member responsible for inactivation of the G prot

252 set point angle, while loss of all three DRO family members results in upward, vertical root growth.

253 Comparisons with the structure of other FOX family members revealed that the FKH and FHL DNA sequenc

254 The archetypal family members RhoA, Rac1, and Cdc42 arose early in euka

255 In mammals, the divergent family member Robo3 does not bind Slits, but instead sig

256 The coronavirus family member, SARS-CoV-2 has been identified as the cau

257 Family members show a variety of functional roles rangin

258 ouble-mutant NPCs also overexpressed the SIX family member Six1 However, in this context, SIX1 failed

259 ied a gene encoding a novel class III lipase family member, Sl-LIP8, that is associated with accumula

260 PIKK family member SMG1 orchestrates progression of an RNA qu

261 he intracellular NADPH-binding domain of its family member STEAP4, suggesting that STEAP1 functions a

262 on of costimulation through ligation of TNFR family members, such as OX40 (CD134), provides essential

263 even G6PD mutations) and RNA (let-7 microRNA family members) targets while retaining the same signal

264 n-eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperacti

265 ome critical region gene 6 (DSCR6), a RIPPLY family member that induces dorsal mesoderm by releasing

266 a transforming growth factor-beta (TGF-beta) family member that normally acts to limit muscle growth.

267 , encoding a cyclin-dependent kinase protein family member that predominantly regulates gene transcri

268 each chromatin-modifying enzyme has multiple family members that are typically all coexpressed during

269 in small alarmone synthetases (SASs) are RSH family members that contain the (p)ppGpp synthesis (SYNT

270 s a unique charge distribution among the FET family members that enhances its interactions with the C

271 ADP-ribose (ADPR) transferase enzymes (PARP family members) that catalyze it.

272 abundance and high sequence homology between family members they are challenging to detect using stan

273 identified increased expression of the TTSP family member, TMPRSS13 (transmembrane protease, serine

274 pportunities such as family care rituals for family members to be involved with providing care for fa

275 immune cells isolated from the patients and family members to characterize any immune defects.

276 uit their own novel and divergent kinesin-14 family members to form neocentromeres.

277 b might then be compensated for by other app family members to maintain normal development.

278 eport a high level of concern about exposing family members to severe acute respiratory syndrome coro

279 e binding of CD2AP, SH3KBP1, and FXR protein family members to VEEV HVD uncovers important aspects of

280 er, we tested the hypothesis that GR and KLF family members transactivate the bICP0 E promoter.

281 e examined the role of FoxM1, a forkhead box family member transcription factor in tubular repair aft

282 One TRIM protein family member, TRIM5alpha, has been shown to form cytopl

283 ing affinities among closely related protein family members underlie many biological phenomena, inclu

284 As a result, several family members underwent genetic testing.

285 orms and a subset of prenylated small GTPase family members using a live-cell quantitative split luci

286 an outward-facing model of a bacterial DASS family member, VcINDY from Vibrio cholerae, predict an e

287 3 (HSFTF13, a HEAT SHOCK FACTOR A6B [HSFA6B] family member) was compromised in bzip60-2, and the HSFT

288 FGF 2 and the mRNA expression pattern of EGR family members were documented.

289 Family members were evaluated in 74 studies (18%).

290 Muscle biopsies from 4 family members were used for analysis of muscle histolog

291 e other is an LTR/Gypsy transposable element family member, which generates long non-coding RNAs.

292 GSH upregulated RhoU/Wrch1, a Wnt signaling family member, which then mediated an increase in Hey2 i

293 a-catenin regulated the expression of miR-29 family members, which, in turn, repressed PDGFR expressi

294 ith hematologic abnormalities, including one family member who died of acute leukemia.

295 eases the likelihood that patients and their family members will receive antibiotics for future ARIs.

296 resence of EoE increasing the risk for other family members with EoE.

297 of nine tea plant amino acid permease (AAP) family members, with six exhibiting transport activity.

298 These data indicate that available TGF-beta family members within the lesional psoriatic epidermis p

299 sting selectivity between BD1 and BD2 of all family members would be more straightforward to achieve.

300 cturally similar to the immunosuppressive B7 family members, yet how they regulate and coordinate alp