ライフサイエンスコーパス: farnesol

1 ase which converts farnesyl pyrophosphate to farnesol.

2 o farnesal, which is subsequently reduced to farnesol.

3 ed by altering both endogenous and exogenous farnesol.

4 e which received a control injection without farnesol.

5 s inhibited by adding either alpha factor or farnesol.

6 nation of palmitate and of the sesquiterpene farnesol.

7 uired ergosterol for growth and produced E,E-farnesol.

8 gs treated with zaragozic acid A or rats fed farnesol.

9 % starting from commercially available (E,E)-farnesol.

10 terpenes, such as citronellol, geraniol, and farnesol.

11 did aggravate the fungal apoptotic effect of farnesol.

12 but was able to target to the cytoplasm with farnesol.

13 catalyze the interconversion of farnesal and farnesol.

14 ed in the presence of geranylgeranol but not farnesol.

15 d by the C. albicans quorum-sensing molecule farnesol.

16 become diploid could derive from its use of farnesol.

17 induction of inflammatory gene expression by farnesol.

18 esol with formation of 9-hydroxyfarnesol and farnesol 10,11- and 2,3-epoxides.

19 route to the three geometric isomers of E,E-farnesol (12, 13, and 14) has been developed.

20 Mice receiving C. albicans intravenously and farnesol (20 mM) orally had enhanced mortality (P < 0.03

21 tion to the acyclic allylic alcohols (2Z,6E)-farnesol (6.7%) and nerolidol (3.6%), five cyclic sesqui

22 cAMP-Efg1 signalling cascade is inhibited by farnesol, a C. albicans autoregulatory factor, and small

23 ctivity of 3OC12HSL is compared with that of farnesol, a C. albicans-produced molecule also with a C1

24 e restores LTP to wild-type levels; however, farnesol, a chemically related compound, does not substi

25 que modulation of N-type calcium channels by farnesol, a dephosphorylated intermediate of the mammali

26 th animal and human arteries have shown that farnesol, a natural 15-carbon (C15) isoprenoid, is an in

27 ted reductase degradation by the addition of farnesol, a natural product of mevalonate metabolism, to

28 his inoculation releases the inhibition from farnesol, a quorum-sensing molecule of C. albicans, that

29 y redirecting the mevalonate pathway towards farnesol accumulation to the detriment of the accumulati

30 At micromolar concentrations, farnesol acts as a relatively non-discriminatory rapid o

31 the appearance of protein degradation after farnesol addition in vitro.

32 Within 15 min of farnesol addition, decreased transcript levels of pqsA,

33 Farnesol administration enhanced oxidative muscle capaci

34 In all experiments, mice administered farnesol alone or Tween 80 alone remained normal through

35 nthesized from newly and previously prepared farnesol analogs.

36 l regulation of vascular tone by farnesol or farnesol analogues.

37 Finally, the effect of farnesol and AFC on the NE response was reproduced in hu

38 olidol were more effective than trans, trans-farnesol and alpha-humulene.

39 dentification of GbTPS1 and GbTPS2, encoding farnesol and bisabolene synthases, respectively.

40 By feeding [1-14C]farnesol and comparing the mass of the dicarboxylic acid

41 eceptor that mediates attraction behavior to farnesol and demonstrates an effective approach to deorp

42 reover, we show that lipid alcohols, such as farnesol and detoxification products of PUFA- and choles

43 The 8 d ethylene treatment also increased farnesol and docosane contents.

44 eral cAMP-controlled outputs are affected by farnesol and dodecanol, our findings suggest that these

45 Farnesol and farnesyl phosphate kinases have also been r

46 s, including several exotic alcohols such as farnesol and geraniol.

47 New fluorescent analogues of farnesol and geranylgeraniol have been prepared and then

48 CoAR activity, or the prenylation precursors farnesol and geranylgeraniol.

49 Effects of farnesol and JH on INV and transglutaminase mRNA levels

50 Both farnesol and JH stimulated INV and transglutaminase prom

51 The isoprenoids farnesol and juvenile hormone III (JH), metabolites of t

52 The FXR activators, all-trans farnesol and juvenile hormone III, also accelerated epid

53 yl pyrophosphate (FPP)-derived side products farnesol and nerolidol.

54 lative Th1-inclination property of menthone, farnesol and oridonin may be applied to improve Th2-skew

55 secretion ratios, suggesting that menthone, farnesol and oridonin may have a relative Th1-inclinatio

56 Menthone, farnesol and oridonin treatments did not markedly increa

57 substrate oxidation toward the center of the farnesol and palmitate molecules.

58 the substrate, and in the case of C(73-84), farnesol and palmitate oxidation was inhibited by 1 and

59 and GC-MS were used to identify products of farnesol and palmitate oxidation.

60 Farnesol and squalene are without effect.

61 ndida albicans secretes micromolar levels of farnesol and that accumulation of farnesol in vitro prev

62 attraction behavior to low concentrations of farnesol and that Or83c receptor mutants are defective f

63 ls and raise the possibility that endogenous farnesol and the mevalonate pathway are implicated in ne

64 This mutant (KWN2) produced six times less farnesol and was ca. 4.2 times less pathogenic than its

65 eed1Delta/Delta also excretes 10X more farnesol and while able to form hyphae, it cannot mainta

66 mpounds include certain sterols, oxysterols, farnesol, and geranylgeraniol, as well as the diphosphat

67 c terpenoid polyalkenes, including geraniol, farnesol, and geranylgeraniol, providing an efficient an

68 d -deficient terpenes derived from geraniol, farnesol, and nerol, thereby enabling the effective synt

69 y were partially reversed in the presence of farnesol, and treatment of mesothelioma cells with a spe

70 Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process

71 Moreover, the effects of farnesol appear to be mediated by the FadA heterotrimeri

72 further evidence that the in vivo effects of farnesol are physiologically meaningful and specific for

73 eine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse

74 We identified farnesol as a potent and specific activator for the orph

75 Candida albicans excretes E,E-farnesol as a virulence factor and quorum sensing molecu

76 ives prenol, nerol, phytol, solanesol, and E-farnesol as allyl surrogates is reported.

77 Here, we identify farnesol as an inhibitor of PARIS.

78 ssion in recombinant yeast cells established farnesol as the preferred substrate of the FOLK-encoded

79 screening and identified a natural compound, farnesol, as a potent inducer of PGC-1alpha.

80 t (1) that leads to selective epoxidation of farnesol at the 6,7-position, remote from the hydroxyl d

81 ation of MrBI-1 reduced fungal resistance to farnesol but not to hydrogen peroxide, suggesting that M

82 r formation of sesquiterpenes hedycaryol and farnesol by up to 25-fold.

83 ays, we now show that the pathway derivative farnesol causes Hmg2p to undergo a change to a less fold

84 Our findings demonstrate that in vitro, farnesol causes reductase to become detergent insoluble

85 n Candida albicans, exposure to the oxylipin farnesol causes the regulation of specific genes involve

86 chemical structures were tested: trans,trans-farnesol, cis-nerolidol, (-)-alpha-bisabolol, trans-beta

87 of the sesquiterpenic compounds trans, trans-farnesol, cis-nerolidol, alpha-humulene and guaiazulene,

88 Thus, reduced endogenous farnesol decreased virulence, while providing exogenous

89 tification and characterization of an insect farnesol dehydrogenase (AaSDR-1) that oxidizes farnesol

90 Farnesol dehydrogenase activity was not detected in the

91 , Arabidopsis membranes are shown to possess farnesol dehydrogenase activity.

92 n, growth and development were impaired in a farnesol-dependent manner when A. nidulans was co-cultiv

93 d polyketide aromatization of a trans, trans-farnesol-derived beta,delta-diketodioxinone into the cor

94 esol, then to farnesoic acid, and finally to farnesol-derived dicarboxylic acids (FDDCAs) which would

95 ently synthesized by anionic coupling of two farnesol-derived diepoxides, which have arisen from elec

96 tablishing that these dicarboxylic acids are farnesol-derived.

97 /L geraniol from prenol as well as limonene, farnesol, diaponeurosporene, and lycopene.

98 We finally demonstrated that farnesol did not affect Ca2+-sensitive pathways implicat

99 e IL-12/IL-10 milieu restores the ability of farnesol-differentiated DC to activate invariant NKT, Th

100 What does farnesol do in vivo?

101 e of this study was to determine the role of farnesol during infection with a well-established mouse

102 ectedly, at the levels detected (25-50 muM), farnesol enhanced S. mutans-biofilm cell growth, microco

103 To determine whether farnesol enhances the virulence of C. albicans by modula

104 BChls c were found to be farnesol esterified and geranylgeraniol esterified.

105 In contrast, mice pretreated with farnesol exhibited an unexpected elevation in IL-5 level

106 In species of Aspergillus, farnesol exposure induces apoptosis-like changes and alt

107 f Nicotiana tabacum cell cultures to utilize farnesol (F-OH) for sterol and sesquiterpene biosynthesi

108 Apigenin (Api) and tt-farnesol (Far) are two naturally occurring agents that a

109 With regard to exogenous farnesol, farnesol was administered either intraperitone

110 Farnesol (FOH) and other isoprenoid alcohols induce apop

111 of lovastatin with geranylgeraniol (GGOH) or farnesol (FOH) to investigate the role of protein prenyl

112 Interestingly, addition of farnesol (FOL) with lovastatin, to stimulate protein far

113 mone, which could potentially also transport farnesol for virulence and quorum sensing.

114 alysis, thus suggesting a possible action of farnesol from within the intracellular space.

115 was reversed by geranylgeraniol, but not by farnesol, further confirming that inhibition of geranylg

116 titate incorporation of exogenously provided farnesol, geranylgeraniol, and unnatural analogs of thes

117 farnesol synthesis, and relationships among farnesol, germ tube formation and hyphal maintenance.

118 To determine whether farnesol has a direct effect on macrophage production of

119 An alpha-phosphono lactone derivative of farnesol has been prepared, in both racemic and nonracem

120 We show that externally added farnesol has no effect on hyphal morphogenesis; instead,

121 nsible for the sequential phosphorylation of farnesol have not been identified and the physiological

122 016) identified eed1Delta/Delta as the first farnesol hypersensitive mutant of C. albicans.

123 The eed1 farnesol hypersensitivity can be explained by higher int

124 mice (n = 40) injected with 1.0 ml of 20 mM farnesol i.p. had enhanced mortality (P < 0.03), and the

125 er capacity against DPPH, while trans, trans-farnesol (IC50=1.81mM) and cis-nerolidol (IC50=1.48mM) w

126 Therefore, the role of farnesol in systemic candidiasis is likely due to its ab

127 nal experiments demonstrated the presence of farnesol in the brain (rodents and humans) at physiologi

128 Background farnesol in the cell-free extract was also retained by t

129 In this study we examined the effect of farnesol in the filamentous fungus Aspergillus nidulans.

130 levels of farnesol and that accumulation of farnesol in vitro prevents the yeast-to-mycelium convers

131 Taken together, our data suggest that farnesol, in addition to its quorum-sensing function tha

132 Finally, topical applications of farnesol increased mRNA and protein levels of the differ

133 creased virulence, while providing exogenous farnesol increased virulence.

134 Farnesol increases resistance to oxidative stress in C.

135 In particular, farnesol increases the expression of the Ag-presenting g

136 reactive oxygen species (ROS) participate in farnesol-induced apoptosis.

137 Additional studies implicate PrpA in farnesol-induced cell death and in the initiation of ase

138 ght be part of a prosurvival response during farnesol-induced ER stress.

139 ckdown of MEK1/2 or MSK1 expression inhibits farnesol-induced expression of CXCL3, IL-1alpha, and COX

140 We provide evidence indicating that the farnesol-induced phosphorylation of p65/RelA at Ser(276)

141 However, at 250 nM, farnesol induces an N-type channel-specific hyperpolariz

142 of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune re

143 h transcriptional and functional assays that farnesol influences several signaling pathways during DC

144 It was further demonstrated that AFC and farnesol inhibited KCl and NaF-induced contractions, sug

145 promoter fused to lacZ similarly showed that farnesol inhibited PQS-stimulated transcription.

146 Farnesol inhibited production of both IL-12 p40 and p70

147 The latter is triggered by the release from farnesol inhibition of Cup9 degradation and consequently

148 repression of SOK1 expression in response to farnesol inhibition.

149 Interestingly, farnesol inhibits Cup9 degradation mediated by the N-end

150 Here, we show that farnesol inhibits hyphal initiation mainly through block

151 rnesol dehydrogenase (AaSDR-1) that oxidizes farnesol into farnesal, a precursor of JH, in the CA.

152 g the highest affinity for the conversion of farnesol into farnesal.

153 Based on these results, we conclude that farnesol is a nonsterol, mevalonate-derived product that

154 Farnesol is a quorum-sensing molecule produced by C. alb

155 Altogether, our results indicate that farnesol is a selective, high affinity inhibitor of N-ty

156 Farnesol is a sesquiterpene produced by many organisms,

157 Altogether, our results indicate that farnesol is an inhibitor of vascular smooth muscle Ca2+

158 Farnesol is an intermediate in juvenile hormone biosynth

159 that the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB

160 The quorum-sensing molecule farnesol is produced by the opportunistic human fungal p

161 The three farnesol isomers were converted to the corresponding iso

162 Arabidopsis harbors one paralog of VTE5, farnesol kinase (FOLK) involved in farnesol phosphorylat

163 hese questions, we confirmed the presence of farnesol kinase activity in Arabidopsis (Arabidopsis tha

164 unction mutations in the FOLK gene abolished farnesol kinase activity, caused an abscisic acid-hypers

165 These observations demonstrate a role for farnesol kinase in negative regulation of abscisic acid

166 falciparum-infected erythrocytes with [(3)H]farnesol labels 50- and 22-28-kDa proteins, whereas [(3)

167 these enzymes do not explain differences in farnesol levels implicating involvement of additional fa

168 We further show that intracellular farnesol levels increase significantly after mevalonate

169 Thus, farnesol may be beneficial in the treatment of PD by enh

170 om these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fl

171 Taken together, these data suggest that farnesol may play a role in disease pathogenesis, either

172 on, and overexpression of SOK1 overcomes the farnesol-mediated inhibition of hyphal initiation.

173 rovide molecular evidence for a link between farnesol metabolism, abiotic stress signaling and flower

174 These results suggest that oxidation of farnesol might be a rate-limiting step in JH III synthes

175 The activation of the NF-kappaB pathway by farnesol might be part of a prosurvival response during

176 netheless, the molecular mechanisms by which farnesol modulates DC differentiation and maturation rem

177 Our results show that farnesol modulates nuclear receptors, NF-kappaB, and MAP

178 NAD(+)-dependent dehydrogenase that oxidizes farnesol more efficiently than other prenyl alcohol subs

179 The beneficial effect of farnesol on aged muscle was mediated through enhanced PA

180 ersible, dose-dependent inhibitory effect of farnesol on L-type Ca2+ currents (IC50 = 2.2 microM).

181 vitro system was used to study the effect of farnesol on reductase degradation.

182 ns grown with intermediate concentrations of farnesol or dodecanol indicated a link between cells wit

183 In cultures containing farnesol or dodecanol, hypha formation was restored upon

184 e increased in abundance in cells grown with farnesol or dodecanol.

185 ssary for the repression of hyphal growth by farnesol or dodecanol.

186 ducing stimuli, grew as yeast in medium with farnesol or dodecanol; the heat shock sensitivity of the

187 armacological regulation of vascular tone by farnesol or farnesol analogues.

188 uman keratinocytes (NHK) treated with either farnesol or JH, even at low calcium concentrations (0.03

189 oleic acid), farnesoid X-activated receptor (farnesol or juvenile hormone III), or liver X receptor (

190 plained by higher internal concentrations of farnesol or lower thresholds for response.

191 ontrast, isoprenoids, such as nerolidol, cis-farnesol, or geranylgeraniol, or metabolites in the chol

192 een identified and the physiological role of farnesol phosphorylation has not been fully elucidated.

193 of VTE5, farnesol kinase (FOLK) involved in farnesol phosphorylation.

194 bition of isoprenylation, geranylgeraniol or farnesol prevented accumulation in S phase.

195 Farnesol prevented dopaminergic neuronal loss and behavi

196 and Th2 cytokines, mice were pretreated with farnesol prior to intravenous infection with a sublethal

197 peritoneal macrophages were pretreated with farnesol prior to stimulation with IFN-gamma plus lipopo

198 of farnesol, we propose that it responds to farnesol produced by other fungi.

199 P. aeruginosa, suggesting that the amount of farnesol produced by the fungus is sufficient to impact

200 travenous infection with a sublethal dose of farnesol-producing C. albicans.

201 DPP3 reconstituted (KWN4) regained both its farnesol production levels and pathogenicity.

202 acterized LysR binding site, suggesting that farnesol promoted a non-productive interaction between P

203 Farnesol promoted the farnesylation of PARIS, preventing

204 th 1,4-diphenyl-2-butene or with trans,trans-farnesol provide molecular insights into these specifici

205 ar pools of geranylgeranyl pyrophosphate and farnesol pyrophosphate and thereby inhibits both geranyl

206 enoid geranylgeraniol, but not the 15-carbon farnesol, raising the possibility that the nonsterol pot

207 stions, including the existence of potential farnesol receptors and transporters, regulation of farne

208 We report here that farnesol reduced KCl- and norepinephrine-dependent cytos

209 In these cells, farnesol reduced KCl-induced [Ca2+]i transients and mimi

210 that mevalonate and geranylgeraniol, but not farnesol, released the lovastatin G1 block.

211 he CD36 homolog Snmp1 is required for normal farnesol response kinetics.

212 aintenance of hyphal growth may increase the farnesol response threshold.

213 uncation and deletion experiments revealed a farnesol-responsive region (-2452 to -1880 base pairs (b

214 the AP-1 site at -2116 to -2110 bp abolished farnesol responsiveness, identical to effects by peroxis

215 atin-treated cells, geranylgeraniol, but not farnesol, restored replication complex assembly and vira

216 E,E-farnesol results in up to an 8.5-fold increase in macrop

217 , quercetin, trans-ferulic acid, trans,trans-farnesol, rutin, gallic acid or sinapic acid).

218 Therefore, modulation of farnesol secretion to stimulate host immune recognition

219 Farnesol signaling was characterized as a quorum-sensing

220 Pretreatment with farnesol significantly reduced the elevation of both IFN

221 to chocolate, but not lavender, butanol, or farnesol, so that an interaction of route and odorant ma

222 mobility shift assays showed that, like PQS, farnesol stimulated PqsR binding to the pqsA promoter at

223 Here, we show that farnesol stimulates robust activation of Or83c-expressin

224 nt by numerous criteria, highly specific for farnesol structure, and requires an intact Hmg2p sterol-

225 ol receptors and transporters, regulation of farnesol synthesis, and relationships among farnesol, ge

226 on-specific pyrophosphatases responsible for farnesol synthesis.

227 detected in kidneys from mice receiving i.p. farnesol than in those from mice receiving control i.p.

228 Two farnesyl analogues were used: farnesol, the natural dephosphorylated form of farnesyl

229 or farnesyl diphosphate is its conversion to farnesol, then to farnesoic acid, and finally to farneso

230 In the presence of farnesol, there is reduced secretion of the Th1-inducing

231 DPH, the purified CYP4C7 metabolized (2E,6E)-farnesol to a more polar product that was identified by

232 However, after the addition of farnesol to cells in vivo, calnexin remains stable, wher

233 Here, we report that the addition of farnesol to cultures of Pseudomonas aeruginosa, an oppor

234 d with mammalian enzymes, the ability to use farnesol to label both farnesyl and geranylgeranyl moiet

235 Finally, direct addition of trans,trans-farnesol to the culture medium caused the rapid inductio

236 erved in them by the addition of geraniol or farnesol to the media.

237 ed in explants incubated with clofibrate and farnesol together in suboptimal concentrations which alo

238 Moreover, farnesol treatment accelerated the recovery of muscle in

239 a pathway is linked to muscle aging and that farnesol treatment can restore muscle functionality in a

240 d receptor mRNA was not detected in NHK, but farnesol treatment increased activities of both a PPAR r

241 Farnesol treatment reduces the level of IkappaBalpha and

242 With regard to exogenous farnesol, farnesol was administered either intraperitoneally (i.p.

243 urthermore, the increase in PPRE activity by farnesol was dependent upon PPARalpha in CV-1 cells.

244 Farnesol was measured using gas chromatography-mass spec

245 The effect of i.p. farnesol was more pronounced (P < 0.04) when mice were i

246 frq(10) or wc-2Delta effect, i.e., geraniol/farnesol was not required for a visible rhythm.

247 of urinary dicarboxylic acids from rats fed farnesol was virtually identical to that produced by tre

248 For endogenous farnesol, we created a knockout mutation in DPP3, the ge

249 ulans does not secrete detectable amounts of farnesol, we propose that it responds to farnesol produc

250 e dimorphic fungus Candida albicans secretes farnesol, which acts as a quorum-sensing molecule and pr

251 Exogenous farnesol, which enhances membrane protein prenylation, r

252 responsible for catalyzing the production of farnesol, which in turn dictates the aromatic diversity

253 The C. albicans quorum sensing molecule farnesol, which inhibits Cyr1 and represses filamentatio

254 formate and the presence of Candida-derived farnesol, which is commonly known to exhibit antibacteri

255 E,E-Farnesol, which is secreted by white cells only, is a po

256 Farnesol, which is toxic to plant cells at high concentr

257 osed models showing possible interactions of farnesol with a protected Thr side chain and backbone NH

258 cro Prep High Q and conversion of FPP to E,E-farnesol with alkaline phosphatase.

259 activities for phytol, geranylgeraniol, and farnesol with different specificities.

260 all chimeric proteins catalyzed oxidation of farnesol with formation of 9-hydroxyfarnesol and farneso

261 ncubation with geranylgeraniol, but not with farnesol, with concurrent reversal of the inhibition of