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1 (nBPs) are bone-specific agents that inhibit farnesyl diphosphate synthase.
2 her gene involved in cholesterol metabolism, farnesyl diphosphate synthase.
3 IP and DMAP can also competitively inhibit farnesyl diphosphate synthase.
4 a2 T cells as a consequence of inhibition of farnesyl diphosphate synthase (a key enzyme of the meval
5 e levels of geranyl diphosphate synthase and farnesyl diphosphate synthase activities did not correla
6 y by the targeted overexpression of an avian farnesyl diphosphate synthase along with two versions of
7 gen-containing BPs (N-BPs) was identified as farnesyl diphosphate synthase, an enzyme in the mevalona
8 expression in either compartment of an avian farnesyl diphosphate synthase and an appropriate terpene
9 ylamines were found to be weak inhibitors of farnesyl diphosphate synthase and caused accumulation of
11 a subgroup of prenyltransferases, including farnesyl diphosphate synthase and geranylgeranyl diphosp
12 is of the pathway revealed that two enzymes, farnesyl-diphosphate synthase and geranylgeranyl-diphosp
13 iguration, indicating that Rv1086 (omega,E,Z-farnesyl diphosphate synthase) and Rv2361c act sequentia
14 lglutaryl coenzyme A synthase and reductase, farnesyl diphosphate synthase, and squalene synthase.
18 eactions, chimeric proteins constructed from farnesyl diphosphate synthase (chain elongation) and chr
19 compounds revealed that the active site of Z-farnesyl diphosphate synthase differs substantially from
21 stimulate Vgamma2Vdelta2 cells by inhibiting farnesyl diphosphate synthase (FDPS) in the mevalonate p
24 nts of the first two enzymes in the pathway, farnesyl diphosphate synthase (FDS) and carotenoid synth
25 res of one sulfonium bisphosphonate bound to farnesyl diphosphate synthase, finding that it binds exc
30 r therapeutic agents involving inhibition of farnesyl diphosphate synthase (FPPS) and geranylgeranyl
31 alysis and pharmacophore modeling studies of farnesyl diphosphate synthase (FPPS) inhibition, human V
34 to the isoprene biosynthesis pathway enzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphos
39 ted mutagenesis to transform wild-type avian farnesyl diphosphate synthase (FPS) into synthases capab
40 e CRISPR/Cas9 knockouts of each of the three farnesyl diphosphate synthases (FPS) in Z. mays and exam
42 sphate synthase differs substantially from E-farnesyl diphosphate synthase from pig brain (Sus scrofa
43 We screened 26 bisphosphonates against a farnesyl diphosphate synthase from Plasmodium vivax, fin
44 of the x-ray structure of homodimeric avian farnesyl diphosphate synthase (geranyltransferase, EC 2.
45 ncer cells to pitavastatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeran
48 at of the chain elongation prenyltransferase farnesyl diphosphate synthase rather than squalene synth
49 nate (MVA) pathway by a bifunctional geranyl/farnesyl diphosphate synthase, RcG/FPPS1, producing both
50 3-hydroxy-3-methylglutaryl-CoA reductase or farnesyl diphosphate synthase, reduced endometrial organ
51 related Z-prenyl diphosphate synthases, E,Z-farnesyl diphosphate synthase (Rv1086) and decaprenyl di
55 l diphosphate synthase (but not, apparently, farnesyl diphosphate synthase) to favor the production o
57 ogen-containing bisphosphonates that inhibit farnesyl diphosphate synthase were effective in inhibiti
58 ar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, which also contains two a
59 similar in some respects to that of dimeric farnesyl diphosphate synthase, which is not a cyclase.
60 re excellent competitive inhibitors of avian farnesyl diphosphate synthase with KI = 1.0 +/- 0.12 muM
61 neryl diphosphate synthase1 (NDPS1) and Z,Z-farnesyl diphosphate synthase (zFPS), which are encoded