ライフサイエンスコーパス: fasciculation

1 hering together in order to produce bundles (fasciculation).

2 tivity is essential for embryonic motor axon fasciculation.

3 atalytic activity is required for motor axon fasciculation.

4 ema3D and L1 genetically interact to promote fasciculation.

5 nglion cell aggregation, and reduces neurite fasciculation.

6 fects on ENS precursor migration and neurite fasciculation.

7 dulating axon pathfinding, and driving nerve fasciculation.

8 but plays no major role in regulating their fasciculation.

9 and may play a role in axonal outgrowth and fasciculation.

10 nd unzippering behavior that regulates their fasciculation.

11 ulus (nucMLF) by repulsion and modulation of fasciculation.

12 n neural development: the regulation of axon fasciculation.

13 ciated with neurite outgrowth, guidance, and fasciculation.

14 er required for proper maintenance of axonal fasciculation.

15 on molecule that mediates axon outgrowth and fasciculation.

16 n to control growth cone motility and axonal fasciculation.

17 crossing at the optic chiasm and optic tract fasciculation.

18 ng sites were associated with olfactory axon fasciculation.

19 firm that TRIM46 is required for microtubule fasciculation.

20 xon initiation, elongation, pathfinding, and fasciculation.

21 outgrowth, neuronal pathfinding, and axonal fasciculation.

22 th of trigeminal neurites and promoted their fasciculation.

23 an essential role for TRIM46 in microtubule fasciculation.

24 er increases in cell number, clustering, and fasciculation.

25 set of axons and are needed to maintain axon fasciculation.

26 c partner selection, but are dispensable for fasciculation.

27 n nine patients, prominent pain, fatigue and fasciculations.

28 indicating no interaction between different fasciculations.

29 ng CIs that switch rapidly from avoidance to fasciculation after midline crossing.

30 use a functional spiking model to show that fasciculation allows the network to generate reliable sw

31 ith evidence for both glia-guided growth and fasciculation along a neuronal scaffold.

32 erfering at any step in this cascade affects fasciculation along pioneer axons, leading to secondary

33 es axon guidance by regulating the degree of fasciculation among axons.

34 Fasciculation and accumulation of processes suggested th

35 ann cells, collagen type V(SC) promoted axon fasciculation and association of axons with Schwann cell

36 igrations, and induce various axon-guidance, fasciculation and branching errors.

37 tant in contact-mediated axon guidance, axon fasciculation and cell migration.

38 immobilized DS and CSA/C displayed increased fasciculation and decreased branching, whereas KS caused

39 in vivo confirms the hypothesis that axonal fasciculation and defasciculation are controlled by adhe

40 Secondly, glia direct the fasciculation and defasciculation of axons, which patter

41 ped pathway undergoing coordinated rounds of fasciculation and defasciculation, which are critical to

42 of axonal material in addition to cycles of fasciculation and defasciculation.

43 IMPORTANCE As a hub protein, fasciculation and elongation factor zeta 1 (FEZ1) intera

44 Fasciculation and elongation factor zeta 1 (FEZ1), a mul

45 tein), a Golgi protein, which interacts with fasciculation and elongation protein zeta 1 (FEZ1), an U

46 ssion of schizophrenia-associated gene Fez1 (fasciculation and elongation protein zeta 1), a gene pre

47 responding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and l

48 Here, we show that Fasciculation and Elongation Protein Zeta-1 (FEZ1) inter

49 show that NBR1 interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PK

50 involved in neuronal differentiation such as fasciculation and elongation protein zeta-1 (FEZ1), plat

51 One of the candidate gene products, FEZ1 (fasciculation and elongation protein zeta-1), a protein

52 We identified fasciculation and elongation protein zeta1 (FEZ1) as a b

53 IP1) to the light chains (LCs) or binding of fasciculation and elongation protein zeta1 (FEZ1) to the

54 itical for vomeronasal sensory neuron axonal fasciculation and for segregation of these sensory affer

55 equired during embryonic development for the fasciculation and growth of RGC axons.

56 These results suggest that defective axonal fasciculation and guidance may be primary responses to t

57 ly (IgCAMs) have been implicated in both the fasciculation and guidance of axons, but direct genetic

58 eased branching, whereas KS caused decreased fasciculation and increased branching.

59 tterns of slit1 and slit2 correlate with the fasciculation and innervation patterns of RGC axons with

60 uf cause defects in growth cone guidance and fasciculation and loss of expression of several neuronal

61 vel mechanism by which a semaphorin promotes fasciculation and modulates axon-axon interactions by re

62 teins has been implicated in axon outgrowth, fasciculation and neuronal cell migration, as well as in

63 scribed here range from abnormalities in the fasciculation and outgrowth of axons to defects in the d

64 esis and neurite outgrowth as well as axonal fasciculation and pathfinding.

65 phB proteins which helps maintain tight axon fasciculation and prevents aberrant axon growth into ven

66 expressing the same receptor display reduced fasciculation and project to multiple targets in the olf

67 Here, we show that radial bundle fasciculation and synapse formation are disrupted when P

68 een shown to play a prominent role in axonal fasciculation and synapse formation during motor neuron

69 asal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of th

70 ors Neurod2 and Neurod6 as key regulators of fasciculation and targeted axogenesis in the mouse neoco

71 may mediate cell movement as well as process fasciculation and that different regions of the protein

72 anti-N-cadherin each decreased the amount of fasciculation and that sensory axons are less able to tr

73 geting of retinal axons, the control of axon fasciculation and the intrinsic organization of the tect

74 idance within specific cell types to prevent fasciculation and to preserve mosaic spacing.

75 tion of glia results in abnormalities in SAT fasciculation and trajectory.

76 with additional clinical features including fasciculations and elevated serum creatine kinase.

77 minant ataxia, the MJD phenotype with facial fasciculations and lid retraction, and early-onset ataxi

78 the development of clinical features such as fasciculations and neurodegeneration.

79 e classical signs of MND, including wasting, fasciculations and severe bulbar symptoms, occurred over

80 this study was to determine first, if benign fasciculations and those in amyotrophic lateral sclerosi

81 n molecule 1 (Dscam1) show aberrant overlap, fasciculation, and accumulation of dendrites and axons,

82 In vitro DSCAM promotes RGC axon growth and fasciculation, and can act independently of cell contact

83 s, including motor neuron hyperexcitability, fasciculation, and differential vulnerability of motor n

84 Thus, olfactory axon trajectory, fasciculation, and growth cone morphology change within

85 including cell migration, axon guidance and fasciculation, and growth control and tumorigenesis.

86 positions, neurite neighborhood topology and fasciculation, and localization of synapses in many part

87 ns function together in cell migration, axon fasciculation, and morphogenesis.

88 diversity in neuron-target recognition, axon fasciculation, and neuron self-recognition.

89 S), including axon outgrowth, axon guidance, fasciculation, and neuronal migration during cortical de

90 lecule L1, which mediates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor va

91 ial cells are required for axon guidance and fasciculation, and pioneer neurons for trophic support o

92 d semaphorins and slits in axonal targeting, fasciculation, and segregation of olfactory sensory neur

93 o be important in controlling axon guidance, fasciculation, and synapse formation.

94 hat mediates mechanosensory axonal guidance, fasciculation, and synaptic target selection within the

95 ture, L1 stimulates axon growth and enhances fasciculation, and that these processes contribute to th

96 unctional roles in olfactory axon outgrowth, fasciculation, and/or guidance.

97 ve proximal and distal muscle weakness, oral fasciculations, and pyramidal signs.

98 phagia, diffuse skeletal muscle atrophy with fasciculations, and tongue atrophy were absent or mild i

99 fects on ENS precursor migration and neurite fasciculation appear to be mediated at least in part by

100 ddition, we find that axonal pathfinding and fasciculation are abnormal in corticospinal tracts of Sc

101 Fasciculations are distinct from the recurrent trains of

102 In conclusion, benign and malignant fasciculations are not distinguishable on the basis of w

103 evidence of multifocal distal generation of fasciculations, axonal conduction block in the motor uni

104 lthough midline fusion was normal, selective fasciculation between commissural axons was inhibited, a

105 cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsyn

106 'generic' neural functions, such as neurite fasciculation, branching, and synapse formation.

107 t it plays an important role in sensory axon fasciculation, but the relative contributions of its int

108 nd had a greater number of turns than benign fasciculations, but, although irregular in both conditio

109 a3D), a classic repulsive molecule, promotes fasciculation by regulating L1 CAM levels and axon-axon

110 Fasciculation can be regulated by cell adhesion molecule

111 We show how fasciculation can help to ensure axons grow in the corre

112 lisation and breathing, and possibly diffuse fasciculation, characteristic of ALS.

113 stem development, growth cone pioneering and fasciculation contribute to nerve bundle structure.

114 axonal development and caused aberrant tract fasciculation, corresponding to the abnormal expression

115 2, indicate that it influences the circadian fasciculation cycle within pacemaker neurons, and sugges

116 ow here that Mef2 is required for this daily fasciculation-defasciculation cycle.

117 tolloid-related (tlr) is required for proper fasciculation/defasciculation of motor axons in the CNS

118 toneuron subclass and can also rescue the TN fasciculation defects observed in islet and Lim3 mutants

119 We describe fasciculation defects of animals with mutations in the C

120 lly, Efnb2 deletion in SGNs leads to similar fasciculation defects, suggesting that ephrin-B2/EphA4 i

121 of enteric NCCs, leading to defective axonal fasciculation, delayed gut colonization, or intestinal h

122 of fasciculation in ALS remains incomplete, fasciculations derive from ectopic activity generated in

123 on molecule L1 regulates axonal guidance and fasciculation during development.

124 n molecule L1 mediates neurite outgrowth and fasciculation during embryogenesis and mutations in its

125 SPG in the regulation of axon trajectory and fasciculation during hippocampal axon tract formation.

126 d by Slit, ranging from branch formation and fasciculation during neurite outgrowth to tumor progress

127 monstrate that En1 regulates pathfinding and fasciculation during the second phase of EN1 axon growth

128 er important functions required for neuronal fasciculation, fertility, and normal viability.

129 Fasciculation firing rate and the frequency of double fa

130 Thus the characteristics of 430 fasciculations from patients with amyotrophic lateral sc

131 nt roles in the developing brain during axon fasciculation, growth cone guidance, and neuron survival

132 del of neural development in which selective fasciculation helps to define accurate axonal projection

133 2-year-old brother had progressive weakness, fasciculations, hyperreflexia, and active denervation on

134 has been demonstrated to play a role in axon fasciculation in a number of other neural systems.

135 clearly regulates cell spacing and dendritic fasciculation in a specific class of retinal ganglion ce

136 A 3-minute scan revealed florid fasciculation in ALS patients, involving both superficia

137 While an understanding of the role of fasciculation in ALS remains incomplete, fasciculations

138 r, the precise role of TRIM46 in microtubule fasciculation in neurons has not been studied.

139 Although we study fasciculation in one particular organism, our approach t

140 GN defects, and exogenous EphA4 promotes SGN fasciculation in the absence of Pou3f4.

141 cules involved in axon growth, guidance, and fasciculation in the central nervous system (CNS).

142 o play a necessary role in axon guidance and fasciculation in the developing nervous system.

143 It is necessary for correct axon routing and fasciculation in the Drosophila visual system.

144 ms likely to contribute to the generation of fasciculation in the early stages of ALS, while distal s

145 e and nerve layer as well as abnormal axonal fasciculation in the sorting zone.

146 gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown.

147 f imminent reflexive defects, such as muscle fasciculations in ALS.

148 n neurological practice, with an emphasis on fasciculations in amyotrophic lateral sclerosis (ALS), a

149 sent on electromyography, the firing rate of fasciculations in amyotrophic lateral sclerosis was high

150 The waveforms of fasciculations in amyotrophic lateral sclerosis were on

151 d initiate reflexive defects, such as muscle fasciculations in amyotrophic lateral sclerosis, as sugg

152 iew considers the origin and significance of fasciculations in neurological practice, with an emphasi

153 Double fasciculations in which the second discharge was differe

154 Double fasciculations in which the waveforms of the two potenti

155 tion firing rate and the frequency of double fasciculations increases in amyotrophic lateral sclerosi

156 l mice show defective CGN axon extension and fasciculation indicating that beta1 plays a role in cere

157 dorsal root gangliogenesis and motor axonal fasciculation into ventral roots.

158 In addition, PG neuron axon fasciculation is abnormal in many gt hypomorphic larvae.

159 This suggests that although fasciculation is important in sensory axon guidance, sen

160 glomerulus, it appears that stable homotypic fasciculation is not a prerequisite for correct targetin

161 , although this correlates with abnormal TCA fasciculation, it does not induce topographical errors.

162 lly spreads to the whole neuron and involves fasciculation-like spiking events.

163 destined for the same nerve, suggesting that fasciculation may aid pathfinding.

164 Fasciculation mediated by a number of cell adhesion mole

165 together, these studies suggest that axonal fasciculation mediated by CAMs and regulated by PSA infl

166 ed in cell motility, neurite outgrowth, axon fasciculation, myelination, and synaptic plasticity.

167 1 mediates the axon outgrowth, adhesion, and fasciculation necessary for proper development of synapt

168 tion, ganglion cell aggregation, and neurite fasciculation necessary to form the enteric nervous syst

169 ts demonstrate that the somal clustering and fasciculation observed in the Dscam mutant retina are no

170 A second band of double fasciculation occurred in the tibialis anterior at an in

171 in kinase C reduced neuronal aggregation and fasciculation of axons, i.e., promoted uniform architect

172 ontrast to Sema3F, Slit-1 is dispensable for fasciculation of basal vomeronasal neuron axons but is c

173 ical lamination, suggesting that the lack of fasciculation of callosal axons is not an inherent manif

174 Mutations in Dscam cause the fasciculation of dendrites of neighboring homotypic neur

175 ibiting an aberrant clustering of somata and fasciculation of dendrites.

176 Selective fasciculation of fast- and slow-projecting motoneurons w

177 these events are essential for the selective fasciculation of follower axons along the longitudinal p

178 h the longitudinal axon tracts, to guide the fasciculation of follower neurons along specific fascicl

179 substrate gradients can regulate length and fasciculation of neurites and have a limited capability

180 ression correlates with increased growth and fasciculation of olfactory axons in vitro.

181 CAM and L1 are associated with extension and fasciculation of olfactory axons.

182 ired during embryogenesis for normal process fasciculation of one class of head sensory neuron.

183 transactivation also disrupted extension and fasciculation of parallel fibers as well as CGN migratio

184 We observed disrupted fasciculation of parallel fibers in the P5 null cerebell

185 In addition, abnormal midline fasciculation of photoreceptor axons resulted from the e

186 AM/mamFas II might play a role in growth and fasciculation of primary olfactory axons during developm

187 n the early postnatal period, L1 may support fasciculation of retinal fibers, maintaining them within

188 rmissive signal that promotes the growth and fasciculation of RGC axons, controlling the timing of wh

189 sion mediated by DM-GRASP may play a role in fasciculation of secondary motoneuron axons but not in p

190 Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerve

191 settling patterns in the neural tube, or the fasciculation of spinal nerves.

192 etically by its effect on axon outgrowth and fasciculation of the Bolwig nerve, encodes a new Drosoph

193 ited normal crossing at the optic chiasm and fasciculation of the optic nerve.

194 g range migrations of three neuron types and fasciculation of the ventral nerve cord are defective.

195 n or misguidance of axon tracts, or abnormal fasciculation of tracts that normally form separate path

196 PolySias promote fasciculation of trigeminal axons in vivo and in vitro,

197 d neuronal polarity through the bundling, or fasciculation, of microtubules in the proximal axon.

198 Regardless of origin, fasciculations often present as the initial abnormality

199 characteristics, and second to determine how fasciculation parameters evolved with progression of amy

200 pathway revealed normal growth kinetics and fasciculation patterns between embryonic days 17.5 and 1

201 The fasciculation phenotype in the Dscam-/- retina was parti

202 nd Dscam+/- retinas, also had clustering and fasciculation phenotypes that were intermediate to retin

203 While axon fasciculation plays a key role in the development of neu

204 amyotrophic lateral sclerosis was higher but fasciculation potential amplitude, area and indices of w

205 Fasciculation potential amplitude, area, turns, duration

206 Fasciculation potentials (FPs) may arise proximally or d

207 ble on the basis of waveform; highly complex fasciculation potentials can be seen in both conditions.

208 cle, at a single site, up to 15 identifiable fasciculation potentials could be recognized.

209 Fasciculation potentials recorded from 63 muscles of 28

210 within the diencephalon by regulating their fasciculation, preventing them or their branches from in

211 s or fascicles, but the molecules regulating fasciculation remain incompletely characterized.

212 Fasciculation represents a brief spontaneous contraction

213 fy enteric neurons and glia and analyze axon fasciculation, respectively.

214 esenchyme establishes an Eph/ephrin-mediated fasciculation signal that promotes inner radial bundle f

215 hosphorylation may play an important role in fasciculation, suggesting that complex intracellular pat

216 spinal origin, were most frequent in benign fasciculation syndrome (44%) (P < .001) and amyotrophic

217 ients with ALS and five patients with benign fasciculation syndrome (BFS) underwent 1-7 assessments e

218 ely to arise distally and that FPs in benign fasciculation syndrome more frequently arise proximally.

219 a, neuromyotonia, Isaacs' syndrome and Cramp-Fasciculation Syndrome to describe the motor manifestati

220 increased tendon reflexes suggests a benign fasciculation syndrome, even when of sudden onset.

221 om 21 muscles of 11 patients with the benign fasciculation syndrome.

222 ophic lateral sclerosis (ALS), and in benign fasciculation syndromes.

223 ema3F) and Slit-1, in olfactory sensory axon fasciculation, targeting, and segregation.

224 1 mediates the axon outgrowth, adhesion, and fasciculation that are necessary for proper development

225 PSA removal may cause an increase in fasciculation that forces sensory axons to track along n

226 siae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaem

227 ceptors and ephrins mediate axon sorting and fasciculation through repulsive axon-axon interactions.

228 tro, Slit2 secreted by motoneurons regulated fasciculation through Robo1 and Robo2.

229 these variants in these multiple steps: axon fasciculation, trajectory choice, and synaptic partner s

230 ts support the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mec

231 ach occasion, suggesting reactivation of the fasciculation via the F-wave route.

232 aveform was variable in shape but the second fasciculation was the same on each occasion, suggesting

233 -sigma, or PTPRO, this nerve showed abnormal fasciculation, was reduced in size, or was missing entir

234 patients, second motor neuron signs, such as fasciculations, wasting, weakness, or a neurogenic patte

235 Here, the first fasciculation waveform was variable in shape but the sec

236 In support of the model that MMPs promote fasciculation, we find that the defasciculation observed

237 amyotrophic lateral sclerosis and 191 benign fasciculations were analysed.

238 variability and propensity to produce double fasciculations were measured.

239 otoneurons, SPON-1 acts in axon guidance and fasciculation, whereas in interneurons SPON-1 maintains

240 ctions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat

241 Giant Fibre morphogenesis normally relies on fasciculation with its major motorneuronal target.

242 adjustments that may be due to differential fasciculation with longitudinal axons.

243 th guidance cues, and, in trailing axons, by fasciculation with pioneer fibers.

244 in is involved in guidance through selective fasciculation with pre-existing axons within the ganglio

245 ility of the EP cells as well as maintaining fasciculation with their pathways.

246 These axons show increased fasciculation within the internal capsule, as well as ab

247 Fasciculation within the optic tract and adhesion within

248 In the vomeronasal system, axonal fasciculation within the vomeronasal nerve is affected;

249 Fasciculation without weakness, muscle atrophy or increa