ライフサイエンスコーパス: fast-acting

1 cts were transfected into mPFC neurons using fast-acting AAV8 viruses.

2 able 2-arylvinylquinolines are identified as fast-acting agents that kill asexual blood-stage parasit

3 frontline agents has fuelled the search for fast-acting agents with novel mechanism of action.

4 ween slow-acting neuromodulator peptides and fast-acting amino acid transmitters in the control of en

5 dentate granule cells normally contain two "fast-acting" amino acid neurotransmitters, one excitator

6 ttenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and

7 que position of D21Glu, not present in other fast-acting analogues, pointing inwards rather than to t

8 While 4s appeared to be fast acting and cidal in the in vitro assays, it failed

9 nity of structure-based drug design for this fast acting and extremely toxic high priority BoNT E.

10 The lead compound 1o is fast acting and highly active against intraerythrocytic

11 he antibiotics thiostrepton and rifampin are fast acting and might target additional processes outsid

12 ceptors represent a promising novel class of fast-acting and clinically viable antidepressant compoun

13 r intravenous (IV)-administered ART5803 as a fast-acting and efficacious option for anti-NMDAR enceph

14 over the last decade is the discovery of the fast-acting and long-lasting antidepressant effects of k

15 An ideal NiV vaccine would confer both fast-acting and long-lived protection.

16 of the enzymatic function of EZH2, MS177 is fast-acting and more potent in suppressing cancer growth

17 34957-a novel antimalarial molecule which is fast-acting and potent against drug resistant strains in

18 Here, we report three subseries of fast-acting and potent Plasmodium falciparum PDEbeta inh

19 n two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection,

20 4-OH-DiPT is a fast-acting and shorter-lasting derivative of psilocybin

21 of electroconvulsive shock (ECS) therapy, a fast-acting and very effective antidepressant therapy, a

22 he potential of psychedelics as a promising, fast-acting, and long-lasting treatment for some psychia

23 ng that microglia stimulators could serve as fast-acting anti-depressants in some forms of depressive

24 We hypothesized that combining a fast-acting anti-inflammatory agent with an ABT could li

25 rosocin and the attacins; unlike some other, fast-acting antibacterial peptides, diptericin did not l

26 , and drugs that activate this receptor have fast-acting antidepressant (AD)-like effects in preclini

27 l-D-aspartate (NMDA) receptor blocker, shows fast-acting antidepressant action, thus bringing fresh p

28 ific depressive phenotype that responds to a fast-acting antidepressant and (2) this model has the po

29 her psychotomimetic compound, ketamine, is a fast-acting antidepressant and induces synapse formation

30 (N(2)O) has recently emerged as a potential fast-acting antidepressant but the cerebral mechanisms i

31 R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate.

32 for treating acute and chronic pain and as a fast-acting antidepressant drug.

33 novel cellular target for the development of fast-acting antidepressant drugs.

34 Our findings also suggest that the fast-acting antidepressant effects of ketamine require r

35 fficacy of ketamine, its widespread use as a fast-acting antidepressant in routine clinical settings

36 -associated expectancies using visually cued fast-acting antidepressant infusions and controls their

37 However, application of the fast-acting antidepressant ketamine failed to demonstrat

38 ve demonstrated a greater sensitivity to the fast-acting antidepressant ketamine in female versus mal

39 the effects of isolation stress (IS) and the fast-acting antidepressant ketamine on anhedonia and dep

40 the anhedonia data, we then showed that the fast-acting antidepressant ketamine when infused into th

41 ty to chronic stress and the efficacy of the fast-acting antidepressant ketamine.

42 rtate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients sufferin

43 this same synaptic signaling pathway to the fast-acting antidepressant responses elicited by ketamin

44 l-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients sufferi

45 antagonist, which on administration produces fast-acting antidepressant responses in patients with ma

46 escribed as having either active or inactive fast-acting antidepressant-like effects) followed by a 1

47 lin infusion into the dorsal hippocampus has fast-acting antidepressant-like effects, and that some o

48 , is experiencing a clinical resurgence as a fast-acting antidepressant.

49 ial markers for treatment response with this fast-acting antidepressant.

50 behavior were rapidly rescued by ketamine, a fast-acting antidepressant.

51 -type symptoms in humans and is a potent and fast-acting antidepressant.

52 l presynaptic avenues for the development of fast-acting antidepressants and possibly psychoactive co

53 We then found that both typical and fast-acting antidepressants directly bind to TRKB, there

54 isms can be rapidly engaged, particularly by fast-acting antidepressants such as ketamine to trigger

55 and in the treatment of major depression by fast-acting antidepressants such as ketamine.

56 ssion, (2) how clock genes may contribute to fast-acting antidepressants, and (3) the mechanistic lin

57 mine and some metabolites are analgesics and fast-acting antidepressants, presumably through targets

58 t for the development of cell-type specific, fast-acting antidepressants.

59 harmacological target for the development of fast-acting antidepressants.

60 n the efficacy of monoamine-targeting versus fast-acting antidepressants.

61 pocampus-a characteristic of traditional and fast-acting antidepressants.

62 le therapeutic target for the development of fast-acting antidepressants.

63 some (Pf20S) B5 active site and that exhibit fast-acting antimalarial activity.

64 Herein we report a novel, in vivo active, fast-acting antimalarial chemotype based on a benzimidaz

65 itro rate of activity is comparable with the fast-acting antimalarial drug dihydroartemisinin.

66 f PfATP4 have highly attractive features for fast-acting antimalarials to be used in the global eradi

67 t of rapamycin (mTOR) kinase inhibitors, are fast-acting antiplasmodial compounds that unexpectedly t

68 of a target compound that could replace the fast-acting artemisinin component and harbor additional

69 ed SK2188 as a highly potent, selective, and fast-acting AURKA degrader capable of inducing MYCN dest

70 ketamine and other NMDAR antagonists produce fast-acting behavioural antidepressant-like effects in m

71 e find that inhibitors of eEF2 kinase induce fast-acting behavioural antidepressant-like effects.

72 A fast-acting, better-tolerated noncorticosteroid anti-inf

73 dioxide (ClO(2)), an extremely effective and fast-acting biocide.

74 s support a repression mechanism providing a fast-acting brake on burst generation.

75 ever, in the first 24 hours after treatment, fast-acting but not slow-acting drugs reduced the parasi

76 Etripamil is a fast-acting, calcium-channel blocker administered intran

77 hogens causing rapid mortality surges (i.e., fast-acting) can effectively limit the host's adaptive s

78 Here, we determined the fast-acting capacity of this vaccine in naive NHPs.

79 ells into 96- and 384-well plates, while the fast-acting CEPT cocktail minimizes cellular stress and

80 Albuterol acted as a sequential fast-acting channel blocker, increasing the mean burst d

81 The reduction in fast-acting cochlear compression associated with SNHL ex

82 clinical development candidate, SC83288, are fast-acting compounds that can cure a P. falciparum infe

83 he activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neu

84 Given their capacity to generate fast-acting currents, I suggest that the monoamine trans

85 ile the suppressive effect was mediated by a fast-acting, direct G-protein action, the facilitatory e

86 s tend to consistently focus at first on the fast-acting direction, and overlook the slower process i

87 of HOXA1-induced leukemia to the aggressive fast-acting disease elicited by HOXA9 and vice versa.

88 Fast-acting disruptive IgE inhibitors demonstrate the fe

89 potent, selective, metabolically stable and fast-acting DREADD agonist with utility in both mice and

90 nfections from aerosol exposure will require fast-acting drugs that rapidly penetrate the blood-brain

91 of viruses that cause encephalitis requires fast-acting drugs that rapidly penetrate the blood-brain

92 rticular, about the possible connectivity of fast-acting (e.g., glutamate and GABA) and slow-acting (

93 acute elevation of UA acts as "physiologic," fast-acting endogenous mediator of EPC mobilization and

94 These findings reveal a new fast-acting energy conservation strategy halting growth

95 tive antimalarial effect in combination with fast-acting epidrugs and dihydroartemisinin.

96 Fast-acting excitatory neurotransmission in the retina i

97 scopy of the excised specimens, stained with fast-acting fluorescent histology dyes, could be an attr

98 and 10 mum spatial resolution, revealing the fast-acting focussing electric field.

99 s transforming the thrombin from a slow to a fast acting form toward fibrinogen.

100 approach has uncovered a previously unknown, fast acting, GluN2A-dependent neuroprotective signaling

101 port the presence of a remarkably robust and fast-acting glycinergic inhibitory system capable of sup

102 Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for me

103 We sought to develop potent and fast-acting IgE inhibitors with the potential to rapidly

104 neonatal T cells are well adapted to provide fast-acting immune protection against foreign pathogens,

105 These encoded fast-acting immune responses including coagulation, phag

106 te steroid treatment or the immediate use of fast-acting immune therapies, such as rituximab.

107 Treatment of PG typically starts with fast-acting immunosuppressive drugs (corticosteroids and

108 how the LION platform offers a customizable, fast-acting, inexpensive, and accessible mechanism for e

109 he serpin superfamily of proteins and is the fast acting inhibitor of both urinary plasminogen activa

110 rfamily protein characterized initially as a fast-acting inhibitor of neutrophil elastase.

111 Here, we leverage a fast-acting inhibitor of SWI/SNF remodeling to elucidate

112 cin B (LMB), a noncompetitive, specific, and fast-acting inhibitor; and HTLV1-Rex protein, a potent c

113 been a limiting factor in the development of fast acting insulin analogues, creating a demand for exc

114 Devices containing aspart, a fast-acting insulin analog, could achieve glycemic contr

115 lbulin therapy in combination with available fast-acting insulin derivatives.

116 control of blood glucose; for instance, the fast-acting insulin lispro contains two point mutations

117 Fast-acting insulins are central to the regulation of pr

118 Current fast-acting insulins require 20-30 min for the onset and

119 that is faster than the currently available fast-acting insulins.

120 elf-healing smart grids are characterized by fast-acting, intelligent control mechanisms that minimiz

121 Etripamil is a fast-acting, intranasally administered calcium-channel b

122 The fast acting ionotropic Glu receptors (iGluRs) are ligand

123 ponse through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynapt

124 A conditional gene expression system that is fast-acting, is tunable and achieves single-gene specifi

125 ike proteases that are abundantly available, fast-acting ligases are rare.

126 of these elements is most likely mediated by fast-acting long-term potentiation (LTP), which relies o

127 Most neurons release a single fast-acting low-molecular-weight transmitter at synapses

128 Syt1 is a fast-acting, low-affinity Ca(2+) sensor that penetrates

129 This constitutes an important, fast-acting mechanism of ligand-controlled transcription

130 e, we monitored metaphase I spindles after a fast-acting mei-1(ts) mutant was shifted to a nonpermiss

131 ion to meet the physiologic requirement of a fast-acting membrane fission apparatus.

132 Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification o

133 and covalent modification are major means of fast-acting metabolic regulation.

134 formulations both for native insulin and for fast-acting monomeric insulin analogues through ligand-m

135 viding novel targets for a new generation of fast-acting, more efficacious therapeutic agents.

136 ue HMBPP-specific Vgamma2Vdelta2 T cells are fast-acting, multi-functional, and protective during inf

137 The fast-acting nature highlights VSV-SUDV as an ideal count

138 togen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose resp

139 osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 th

140 ctive prey capture in C. catus requires both fast-acting neurotoxins and a delivery system quick enou

141 nthesis of gamma-aminobutyric acid (GABA), a fast-acting neurotransmitter implicated in the modulatio

142 study reveals that STAT3 signaling, but not fast-acting neurotransmitter release, is required for le

143 Neurons that contain a fast-acting neurotransmitter, such as glutamate or GABA,

144 citation of the eyeblink circuit by way of a fast-acting neurotransmitter.

145 s in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine, GABA, or g

146 Neural communication requires both fast-acting neurotransmitters and neuromodulators that f

147 Fast-acting neurotransmitters and slow, modulatory neuro

148 Most fast-acting neurotransmitters are rapidly cleared from s

149 To examine the role of fast-acting neurotransmitters glutamate and gamma-aminob

150 and by regulating the efficiency with which fast-acting neurotransmitters produce their effects on p

151 Fast-acting neurotransmitters, e.g., glutamate (excitato

152 Unlike fast-acting neurotransmitters, neuropeptides can elicit

153 ally regarded as neuromodulators rather than fast-acting neurotransmitters.

154 The data revealed a fast-acting NHEJ and a slow-acting alterative end joinin

155 Intranasal etripamil, is an investigational fast-acting, nondihydropyridine, L-type calcium channel

156 Visual predators rely on fast-acting optokinetic responses to track and capture a

157 patients without dyskinesias received 200mg fast-acting oral levodopa following prolonged withdrawal

158 KVD900 is a fast-acting oral PKa inhibitor that rapidly inhibits PKa

159 Whereas the fast-acting P2X channels have well-established roles dri

160 ed a role in this pathway for the relatively fast-acting p38 mitogen-activated protein kinase (MAPK).

161 opes for suitable immune modulations against fast-acting pathogens.

162 esembled the slow rate of adaptation against fast-acting pathogens.

163 ling function via two distinct mechanisms: a fast-acting, perforin-mediated process and a slower, Fas

164 mparison across species of [(18) F]Nifene, a fast acting PET imaging agent for alpha4beta2* nAChRs.

165 There are currently no fast-acting pharmacological treatments for OCD.

166 that GLO1 inhibitors may provide a novel and fast-acting pharmacotherapy for depression.

167 ght a lack of muscle contraction per se as a fast-acting physiological insult to FGU.

168 ight be bi-directional: A causes B through a fast-acting physiological process, while B causes A thro

169 verned by a regulatory network composed of a fast-acting positive feedback loop and a delayed negativ

170 pport the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

171 ogical products are currently registered for fast-acting pre-exposure protection in case of spillover

172 In conclusion, VSV-EBOV remains a potent and fast-acting prophylactic vaccine but demonstrates only l

173 us VesiculoVax vaccine (rVSV-Filo) to elicit fast-acting protection against MARV, EBOV, SUDV, and BDB

174 A fast-acting recalibration mechanism provides a means for

175 k enhanced by dopamine relied on a positive, fast-acting recurrent corticoefferent loop, most likely

176 e shown that a low dose of ketamine exhibits fast-acting relatively sustained antidepressant action,

177 tional activator Gal4p absent, the system is fast-acting, resulting in readily detectable transcripti

178 t aid in improving formulation regarding its fast-acting role and reducing side effects of this drug.

179 e area of endemicity highlights the need for fast-acting, safe, and efficacious vaccines.

180 rally occurring scrapie samples, including a fast-acting scrapie inoculum for which incubation time i

181 NF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to

182 e propose that this rapid recalibration is a fast-acting sensory effect, rather than a higher-level c

183 dulation of spontaneous synaptic activity by fast-acting serotonin receptors is reflected in an inhib

184 l emerging and promising approaches leverage fast-acting small-molecule fluorescent stains to replica

185 effective coagulation control system with a fast-acting, specific reversal agent showing promise for

186 We describe a new, fast-acting, specific, single-molecule reversal agent (a

187 ation and brief culture in vitro, implying a fast-acting "switch".

188 New, fast-acting T2-targeting biologics (already used for pre

189 To take full advantage of fast-acting temperature-sensitive mutations, thermal con

190 Here we recapitulate the fast-acting therapeutic effect of ketamine on compulsive

191 To date, there are no fast-acting therapeutic tools capable of terminating sec

192 otor adaptability ranges from the simple and fast-acting to the complex and long-lasting and is a req

193 should be considered a relatively simple and fast-acting tool to facilitate or even enable liver tran

194 These compounds display a "fast-acting" toxicity in the traditional mouse bioassay

195 ntestine, establish CPB as a very potent and fast-acting toxin in the small intestines, and confirm a

196 Due to the potential use of ricin and other fast-acting toxins as agents of bioterrorism, there is a

197 prime word processing, hence generating very fast-acting translation priming effects when primes are

198 at develop together largely express only one fast-acting transmitter (acetylcholine, glutamate, or GA

199 As the fast-acting transmitters GABA and glutamate underlie the

200 sters of receptors that respond to different fast-acting transmitters with opposing functions may rep

201 novel neurosteroid therapeutics will provide fast-acting treatment for these impairing disorders and

202 These types of fast-acting treatment plans are necessary for rehabilita

203 enous immunoglobulin and plasma exchange are fast-acting treatments used for disease exacerbations, a

204 avenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and po

205 n cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is in

206 iquid droplets and its utility for tough and fast-acting underwater adhesives.

207 irus (VSV)-EBOV, also known as rVSV-ZEBOV, a fast-acting vaccine against EBOV and so far the only vac

208 res the development of safe, efficacious and fast-acting vaccines.

209 A fast-acting water-soluble cyclodextrin-encapsulated E(2)