ライフサイエンスコーパス: fatty acid desaturase

1 emN, and desF (the latter encodes a putative fatty acid desaturase).

2 re domain of OLE1, the S. cerevisiae Delta-9 fatty acid desaturase.

3 enzymes such as ribonucleotide reductase and fatty acid desaturase.

4 g a unique delta 9 14:0-acyl carrier protein fatty acid desaturase.

5 ated acyl-CoA precursors by Ole1p, a delta-9 fatty acid desaturase.

6 abditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase.

7 coli to support the activities of the plant fatty acid desaturase.

8 at are characteristic of a group of membrane fatty acid desaturases.

9 fs that are characteristic of membrane-bound fatty acid desaturases.

10 scriptional network that upregulates delta-9 fatty acid desaturases.

11 resembling those of metalloproteins such as fatty acid desaturases.

12 4 is the founding member of a novel class of fatty acid desaturases.

13 nserved histidine clusters characteristic of fatty acid desaturases.

14 uishes them from all known Delta12 or omega3 fatty acid desaturases.

15 as soluble methane monooxygenase (sMMO) and fatty acid desaturases.

16 t the tumor-stroma interface that upregulate fatty acid desaturase 1 (Fads1) to produce arachidonic a

17 fatty acid biosynthesis enzymes showed that fatty acid desaturase 1 (FADS1) was highly expressed acr

18 ucleotide polymorphisms were assessed in the fatty acid desaturase 1 (FADS1-rs174556) and 2 (FADS2-rs

19 Fatty acid desaturase 1 and 2 (FADS1 and FADS2) code for

20 74547 within the FADS1 gene, encoding FADS1 (fatty acid desaturase 1), with risk of several cardiovas

21 ut also by the polymorphisms of coding genes fatty acid desaturase 1-3 for the desaturase enzymes tha

22 of serum omega-6 containing lipids with the fatty acid desaturase 1/2 locus and identify these metab

23 luding stearoyl-coenzyme A desaturase (SCD), fatty acid desaturases 1 and 2 (FADS1 and FADS2), and di

24 umans identified a network of gene products (fatty acid desaturases 1 and 2, epoxide hydrolase 2, lys

25 UFA isomer profiles associated with aberrant fatty acid desaturase 2 (FADS2) activity, including elev

26 chemical pathway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta

27 aturase 1 (SCD), fatty acid synthase (FASN), fatty acid desaturase 2 (FADS2), elongation of very long

28 the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations

29 Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to

30 the transferrin (TF), hemochromatosis (HFE), fatty acid desaturase 2 (FADS2)/myelin regulatory factor

31 so observed for eSNPs in 3 additional genes: fatty acid desaturase 2 (FADS2; P = .002), N-acetyl-alph

32 e of broodstock with different expression of fatty acid desaturase 2 gene (fads2) a key enzyme in syn

33 hFAD2A and AhFAD2B, which are genes encoding fatty-acid desaturase 2.

34 anolamine (LPE) 18:1, which is suppressed by fatty acid desaturase-2 (FAD2), is positively correlated

35 netetrahydrofolate dehydrogenase-1 (MTHFD1), fatty acid desaturase-2 (FADS2), and adiponectin recepto

36 Delta-6 desaturase, also known as fatty acid desaturase-2 (FADS2), is a component of a lip

37 The fatty acid desaturase-2 rs1535 variant, associated with

38 iation study (GWAS) revealed variants in the fatty acid desaturase 3 (FADS3) gene to be significantly

39 In parallel, the expression of Fatty Acid Desaturase 3-2 (FAD3-2; converts 18:2 fatty a

40 ces cerevisiae OLE1 gene encodes the Delta-9 fatty acid desaturase, a highly regulated integral membr

41 ers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane

42 provides a rapid means of isolating variant fatty acid desaturase activities for modification of see

43 is the first study to demonstrate decreased fatty acid desaturase activity in humans with asthma.

44 Neuronal overexpression of fatty acid desaturases also suppressed stressor-induced

45 Saccharomyces OLE1 gene encodes the Delta-9 fatty acid desaturase, an enzyme that converts saturated

46 ntial yeast chromosomal gene encoding delta9 fatty acid desaturase, an integral ER membrane protein a

47 e dehydrogenases, a fatty-acid-CoA ligase, a fatty acid desaturase and associated oxidoreductases.

48 -carrier protein synthetase, and two each to fatty acid desaturase and either desaturase or fatty acy

49 r protein thioesterase, or by suppression of fatty acid desaturases and elongases, resulted in new ov

50 led that tung FADX is grouped with delta(12) fatty acid desaturases and hydroxylases rather than conj

51 s, laccases (AA1_1), xylanases (GH10, GH11), fatty acid desaturases and tannases.

52 d by heme oxygenase, squalene monooxygenase, fatty acid desaturase, and 48 human cytochrome P450 enzy

53 ty acid elongases, fatty acid 2-hydroxylase, fatty acid desaturases, and specific keratins that may c

54 Membrane fatty acid desaturases are responsible for inserting dou

55 We developed a fatty acid desaturase assay based on measurement of desa

56 rs to be unrelated to classic membrane bound fatty acid desaturases based on overall sequence conserv

57 In animals, fatty acid desaturases catalyze key reactions in the syn

58 tion of gene-transcript abundance within the fatty acid desaturase cluster demonstrated a potentially

59 na and a concomitant upregulation of several fatty acid desaturases controlled by sterol regulatory e

60 X5 was shown to physically interact with the fatty acid desaturases CrDelta4FAD and CrFAD6, likely do

61 FATTY ACID DESATURASE7 (FAD7), SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1 (SFD1) and SFD2 genes

62 sor, we identified and cloned three putative fatty acid desaturases, designated SbDES1, SbDES2, and S

63 erver identified a low stringency match to a fatty acid desaturase domain in the N-terminal sequence

64 a robust BPD risk locus encoding a family of fatty acid desaturase enzymes that are responsible for c

65 urons of C9 ALS/FTD flies, by overexpressing fatty acid desaturase enzymes, led to a substantial exte

66 ein), encodes a member of the SUR4 family of fatty acid desaturases, enzymes involved in elongation o

67 results show that CrFAD7 is the only omega-3 fatty acid desaturase expressed in C. reinhardtii, and w

68 that members of the plant integral membrane fatty acid desaturase (FAD) family, FAD2, FAD3, FAD6, FA

69 The embryo-specific Delta-12 fatty acid desaturase FAD2-1 gene was targeted because i

70 vities of the microsomal omega-6 and omega-3 fatty acid desaturases, FAD2 and FAD3.

71 endoplasmic reticulum (ER)-localized omega-3 fatty-acid desaturases (Fad3) increase the production of

72 Transgenic over-expression of a fatty acid desaturase (fad3C) gene of soybean driven by

73 ncestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associ

74 Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q

75 ingle nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity an

76 Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been asso

77 ymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite

78 be explained by genetic variation within the fatty acid desaturase (FADS) gene cluster that is associ

79 18:2n-6) is modified by polymorphisms in the fatty acid desaturase (FADS) gene cluster.

80 Fatty acid desaturase (FADS) genes and their variants ha

81 Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the compos

82 biosynthesis of LC-PUFAs is regulated by the fatty acid desaturase (FADS) genes, of which a human-spe

83 ropean American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate

84 A fatty acid desaturase (FADS) insertion-deletion (Indel)

85 Among maternal fatty acid desaturase (FADS) variants genotyped, 2 candi

86 Fatty acid desaturases (FADs) are a class of enzymes tha

87 Fatty acid desaturases (FADS) are putative new zinc stat

88 to and transports a variety of lipids while fatty acid desaturases (FADs) are required for maintaini

89 l-length genes coding for microsomal Delta12 fatty acid desaturases (FADs) from the two Santalaceae s

90 ple of such an event is the evolution of the fatty acid desaturases (FADS) genes, which have been cla

91 We identified pheromone-biosynthetic fatty acid desaturases (FADs) MsexD3, MsexD5, and MsexD6

92 tinct subset of nematode C-lectin (clec) and fatty acid desaturase (fat) genes.

93 We have isolated a cDNA encoding the Delta5-fatty acid desaturase from M. alpina via a polymerase ch

94 Further, fatty acid desaturases from different kingdoms and with

95 r (GhSLRF) to prevent its binding on Omega-3 fatty acid desaturase gene (GhFAD3) promoters, thereby i

96 zed with loci associated with MDD within the fatty acid desaturase gene cluster.

97 led multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages

98 erexpression as well as silencing of Omega-3 Fatty Acid Desaturase gene from Glycine max (GmFAD3) to

99 these processes, we have studied the Delta9 fatty acid desaturase gene OLE1 in Saccharomyces cerevis

100 e many lipid metabolism genes, including the fatty acid desaturase gene OLE1, which is essential for

101 3p, which direct transcription of the Delta9-fatty acid desaturase gene OLE1.

102 anisms is achieved by feedback regulation of fatty acid desaturase gene transcription through signall

103 eved through overexpressing a C. elegans n-3 fatty acid desaturase gene, mfat-1.

104 x-ray mutant, M23, with a known FAD2-1A (for fatty acid desaturase) gene deletion.

105 turated fatty acids and strongly express two fatty acid desaturase genes, omega3 FATTY ACID DESATURAS

106 It was found that a C. albicans fatty acid desaturase homolog (Ole2) and a multicopper o

107 tifies Delta-6 desaturase/FADS2 as the major fatty acid desaturase in human sebaceous glands and sugg

108 GF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic process

109 ScOle1p is the only long chain fatty acid desaturase in Saccharomyces and its membrane

110 ory machinery governing the transcription of fatty acid desaturases in bacteria, yeasts and animals t

111 The three putative fatty acid desaturases in the M. tuberculosis genome, de

112 phyll content suggests a role for plastidial fatty acid desaturases in thylakoid formation.

113 habditis elegans fat-1 gene encoding an n--3 fatty acid desaturase into mammalian cells can quickly a

114 Fatty acid desaturases introduce a double bond in a spec

115 nstrate here that Spr2 encodes a chloroplast fatty acid desaturase involved in JA biosynthesis.

116 ineage and an indicus-specific extra copy of fatty acid desaturase is under positive selection.

117 DS) gene family contains nine genes encoding fatty acid desaturase-like proteins.

118 lentivirus-mediated expression of an omega-3 fatty acid desaturase, mfat-1, normalized blood glucose

119 Taking advantage of an Arabidopsis thaliana fatty acid desaturase mutant (fad5) that constitutively

120 to have temperature-related phenotypes (e.g. fatty acid desaturase mutants, uvh6).

121 Introduction of the ER fatty acid desaturase mutation, fad2, and to a lesser ex

122 ene-specific activator, SWI5, and the Delta9 fatty acid desaturase of yeast, OLE1, as multicopy suppr

123 ist of Rsp5, which promotes synthesis of the fatty acids desaturase Ole1.

124 Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known

125 ycerol molecular species lacks the necessary fatty acid desaturase, or a component thereof.

126 Fatty acid desaturases regulate the unsaturation status

127 present results strongly suggest that these fatty acid desaturases represent key enzymes involved in

128 We predicted that inhibiting the fatty acid desaturase SCD1 may selectively kill cancer c

129 tearoyl-coenzyme A desaturase 1 is a delta-9 fatty acid desaturase that catalyzes the synthesis of mo

130 We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acid

131 cOLE1, a gene that encodes scOle1p, a Delta9 fatty acid desaturase that forms cis-monounsaturated fat

132 the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels.

133 A fatty acid desaturase triple mutant that is defective in

134 c acid (11Me-12t-18:1) by a newly identified fatty acid desaturase, UfaD.

135 nzymes function, whereas Ole1, the essential fatty acid desaturase, was resistant to iron depletion.

136 express the fat-1 gene encoding for omega-3 fatty acid desaturase, which leads to an increase in end

137 e OLE1 gene encodes a membrane-bound Delta-9 fatty acid desaturase, whose expression is regulated by

138 ae OLE1 gene encodes a membrane-bound Delta9 fatty-acid desaturase, whose expression is regulated thr